Tchem BRSK2 Serine/threonine-protein kinase BRSK2

Protein Summary

Description

Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.

Uniprot Accession IDs

• Q8IWQ3
• B3KVE9
• E9PLM7
• O60843
• O95099
• Q5J5B4
• Q6ZMQ4
• Q8TB60

Gene Name

• BRSK2

Ensembl ID

• ENST00000308219
• ENSP00000310697
• ENSG00000174672
• ENST00000382179
• ENSP00000371614
• ENST00000526678
• ENSP00000433370
• ENST00000528710
• ENSP00000433235
• ENST00000528841
• ENSP00000432000
• ENST00000529433
• ENSP00000433684
• ENST00000531197
• ENSP00000431152

Symbol

• C11orf7
• PEN11B
• SADA
• STK29
• SAD1
• SADA
• STK29
• PEN11B
• C11orf7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
protein domain	0.73
tissue sample	0.71
transcription factor	0.71
biological process	0.7

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Serine/threonine-protein Kinase Brsk2

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Camkl Family / Brsk Subfamily / Serine/threonine-protein Kinase Brsk2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.57   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.57   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0