| Tbio | BMP/retinoic acid-inducible neural-specific protein 3 |
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.
This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3232 | 1.1e-09 |
| colon cancer | 1478 | 4.1e-08 |
| ependymoma | 4679 | 5.9e-08 |
| ulcerative colitis | 1819 | 2.3e-06 |
| pituitary cancer | 1972 | 1.6e-05 |
| medulloblastoma, large-cell | 6241 | 1.9e-05 |
| Astrocytoma, Pilocytic | 3081 | 5.6e-03 |
| group 3 medulloblastoma | 4104 | 5.8e-03 |
| active Crohn's disease | 922 | 3.2e-02 |
| primitive neuroectodermal tumor | 3035 | 3.4e-02 |
| ductal carcinoma in situ | 1745 | 4.0e-02 |
| subependymal giant cell astrocytoma | 2287 | 4.4e-02 |
| glioblastoma | 5792 | 4.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Alzheimer's disease | 658 | 0.0 | 0.8 |
| Heart disease | 306 | 0.0 | 1.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Aggressive Periodontitis | 12 | 3.819 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | -2.031 | 3.2e-02 |
| Astrocytoma, Pilocytic | 1.600 | 5.6e-03 |
| colon cancer | -3.100 | 4.1e-08 |
| ductal carcinoma in situ | 3.000 | 4.0e-02 |
| ependymoma | -2.900 | 5.9e-08 |
| glioblastoma | -1.900 | 4.6e-02 |
| group 3 medulloblastoma | -2.400 | 5.8e-03 |
| malignant mesothelioma | -4.400 | 1.1e-09 |
| medulloblastoma, large-cell | -4.000 | 1.9e-05 |
| pituitary cancer | 4.800 | 1.6e-05 |
| primitive neuroectodermal tumor | -2.200 | 3.4e-02 |
| subependymal giant cell astrocytoma | -1.393 | 4.4e-02 |
| ulcerative colitis | -1.700 | 2.3e-06 |
MIWRSRAGAELFSLMALWEWIALSLHCWVLAVAAVSDQHATSPFDWLLSDKGPFHRSQEYTDFVDRSRQG 1 - 70 FSTRYKIYREFGRWKVNNLAVERRNFLGSPLPLAPEFFRNIRLLGRRPTLQQITENLIKKYGTHFLLSAT 71 - 140 LGGEESLTIFVDKRKLSKRAEGSDSTTNSSSVTLETLHQLAASYFIDRDSTLRRLHHIQIASTAIKVTET 141 - 210 RTGPLGCSNYDNLDSVSSVLVQSPENKIQLQGLQVLLPDYLQERFVQAALSYIACNSEGEFICKENDCWC 211 - 280 HCGPKFPECNCPSMDIQAMEENLLRITETWKAYNSDFEESDEFKLFMKRLPMNYFLNTSTIMHLWTMDSN 281 - 350 FQRRYEQLENSMKQLFLKAQKIVHKLFSLSKRCHKQPLISLPRQRTSTYWLTRIQSFLYCNENGLLGSFS 351 - 420 EETHSCTCPNDQVVCTAFLPCTVGDASACLTCAPDNRTRCGTCNTGYMLSQGLCKPEVAESTDHYIGFET 421 - 490 DLQDLEMKYLLQKTDRRIEVHAIFISNDMRLNSWFDPSWRKRMLLTLKSNKYKSSLVHMILGLSLQICLT 491 - 560 KNSTLEPVLAVYVNPFGGSHSESWFMPVNENSFPDWERTKLDLPLQCYNWTLTLGNKWKTFFETVHIYLR 561 - 630 SRIKSNGPNGNESIYYEPLEFIDPSRNLGYMKINNIQVFGYSMHFDPEAIRDLILQLDYPYTQGSQDSAL 631 - 700 LQLLEIRDRVNKLSPPGQRRLDLFSCLLRHRLKLSTSEVVRIQSALQAFNAKLPNTMDYDTTKLCS 701 - 766 //
