| Tbio | Bromodomain-containing protein 8 |
May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]
The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Endometriosis | 540 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 6.0e-11 |
| ovarian cancer | 8520 | 2.1e-05 |
| dermatomyositis | 966 | 8.9e-05 |
| lung cancer | 4740 | 6.7e-04 |
| osteosarcoma | 7950 | 3.5e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 7.0e-03 |
| oligodendroglioma | 2850 | 9.2e-03 |
| ependymoma | 4679 | 1.5e-02 |
| Multiple myeloma | 1332 | 1.7e-02 |
| Waldenstrons macroglobulinemia | 765 | 2.1e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Distal muscular dystrophy | 8 | 3.128 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| dermatomyositis | 1.600 | 8.9e-05 |
| ependymoma | 1.100 | 1.5e-02 |
| juvenile dermatomyositis | 1.011 | 6.0e-11 |
| lung cancer | 1.300 | 6.7e-04 |
| Multiple myeloma | 1.269 | 1.7e-02 |
| oligodendroglioma | 1.100 | 9.2e-03 |
| osteosarcoma | -1.114 | 3.5e-03 |
| ovarian cancer | -1.400 | 2.1e-05 |
| pancreatic ductal adenocarcinoma liver m... | 1.135 | 7.0e-03 |
| Waldenstrons macroglobulinemia | 1.069 | 2.1e-02 |
MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFSQKHCASQYSE 1 - 70 LLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDE 71 - 140 LCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEE 141 - 210 ATSGVNESEMAVASGHLNSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTT 211 - 280 PLASFTTVASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGDPHT 281 - 350 VTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYTGEELDFETVGDII 351 - 420 AIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEET 421 - 490 ENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAGVVPATSMEPPELRSQDLDEELGSTAAGEIVEAD 491 - 560 VAIGKGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGED 561 - 630 EEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCS 631 - 700 EDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTA 701 - 770 EFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQD 771 - 840 ASEKDSVPMGSPAFLLSLFMGHEWVWLDSEQDHPNDSELSNDCRSLFSSWDSSLDLDVGNWRETEDPEAE 841 - 910 ELEESSPEREPSELLVGDGGSEESQEAARKASHQNLLHFLSEVAYLMEPLCISSNESSEGCCPPSGTRQE 911 - 980 GREIKASEGERELCRETEELSAKGDPLVAEKPLGENGKPEVASAPSVICTVQGLLTESEEGEAQQESKGE 981 - 1050 DQGEVYVSEMEDQPPSGECDDAFNIKETPLVDTLFSHATSSKLTDLSQDDPVQDHLLFKKTLLPVWKMIA 1051 - 1120 SHRFSSPFLKPVSERQAPGYKDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVY 1121 - 1190 HMAVEMRQEVLEQIQVLNIWLDKRKGSSSLEGEPANPVDDGKPVF 1191 - 1235 //
