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  5. BPI fold-containing family B member 6

Tdark BPI fold-containing family B member 6


 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 1.23
PubTator Score 1.03

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
osteosarcoma 7933 5.2e-06
psoriasis 6685 1.3e-03
Disease Target Count Z-score Confidence
Aseptic Meningitis 6 3.34 1.7

Expression

  Differential Expression (2)

Disease log2 FC p
osteosarcoma 1.002 5.2e-06
psoriasis 1.900 1.3e-03

Synonym

Accession Q8NFQ5
Symbols BPIL3
LPLUNC6

Gene

BPIFB6

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (7)

 GO Function (1)

 GO Component (1)

 Compartment GO Term (2)

 HCA RNA Cell Line (2)

Pathway (3)

Gene RIF (2)

PMID Text
20237496 Observational study of gene-disease association. (HuGE Navigator)
12185532 BPIL3 maps to Chromosome 20q11; thus, these novel genes form a cluster with BPI and two other members of the LT/LBP gene family on the long arm of human Chr 20. AA sequence is reported.

AA Sequence 

MLRILCLALCSLLTGTRADPGALLRLGMDIMNQVQSAMDESHILEKMAAEAGKKQPGMKPIKGITNLKVK      1 - 70
DVQLPVITLNFVPGVGIFQCVSTGMTVTGKSFMGGNMEIIVALNITATNRLLRDEETGLPVFKSEGCEVI     71 - 140
LVNVKTNLPSNMLPKMVNKFLDSTLHKVLPGLMCPAIDAVLVYVNRKWTNLSDPMPVGQMGTVKYVLMSA    141 - 210
PATTASYIQLDFSPVVQQQKGKTIKLADAGEALTFPEGYAKGSSQLLLPATFLSAELALLQKSFHVNIQD    211 - 280
TMIGELPPQTTKTLARFIPEVAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAARWRSKAP    281 - 350
MSLFLLEVHFNLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPVVNDVL    351 - 420
QVGLPLPDFLAMNYNLAELDIVENALMLDLKLG                                         421 - 453
//

Text Mined References (10)

PMID Year Title
26962226 2016 BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication.
21787333 2011 Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily.
21076407 2010 A de novo paradigm for mental retardation.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
15790807 2005 Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.
14739326 2004 Phylogenetic and evolutionary analysis of the PLUNC gene family.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12185532 2002 Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP).
11780052 2001 The DNA sequence and comparative analysis of human chromosome 20.