Property Summary

NCBI Gene PubMed Count 23
PubMed Score 32.42
PubTator Score 35.08

Knowledge Summary


No data available



Accession Q12982 B4DS94
Symbols NIP2


  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Protein-protein Interaction (5)

Gene RIF (11)

25472445 BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine.
25378581 BNIP-2 directly interacted with the motor and tail domains of KIF5B via its BCH domain.
21130087 Data imply that SIRT1 may mediate MPP(+)-induced cytotoxicity, possibly through the regulation of BNIP2.
20855536 Observational study of gene-disease association. (HuGE Navigator)
20704564 Inhibition of BNIP-2 expression did not affect the susceptibility to NK cell-mediated killing.
20677014 Observational study of gene-disease association. (HuGE Navigator)
17961507 Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities.
15652341 BNIP-2 in vivo induces cell dynamics by recruiting Cdc42
12944407 BNIP-2 has a role in regulating cell dynamics with a novel Rho GTPase-activating protein, BPGAP1
12901880 BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.
11744098 Transfection of the bnip2 cDNA in neuroblastoma cell line results in massive cell death counteracted by Bcl-2 overexpression; bnip2 is the mediator of the anti-apoptotic activity of estrogens in a variety of cells

AA Sequence

LAELVPMEYVGIPECIKQVDQELNGKQDEPKNEQ                                        281 - 314

Text Mined References (33)

PMID Year Title
25472445 2015 BNIP-2 binds phosphatidylserine, localizes to vesicles, and is transported by kinesin-1.
25416956 2014 A proteome-scale map of the human interactome network.
25378581 2015 KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21516116 2011 Next-generation sequencing to generate interactome datasets.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21130087 2011 SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells.
20855536 2010 Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.
20704564 2010 Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing.
20677014 2010 An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18088087 2008 Phosphoproteome of resting human platelets.
17961507 2007 Cleavage of BNIP-2 and BNIP-XL by caspases.
16572171 2006 Analysis of the DNA sequence and duplication history of human chromosome 15.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15923648 2005 Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
15652341 2005 BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12944407 2003 Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1.
12901880 2003 BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11741952 2002 The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence.
10954711 2000 The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP.
10799524 2000 Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2.
10551883 1999 Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42.
10381623 1999 A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.
7954800 1994 Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.