Tbio BLID BH3-like motif-containing cell death inducer

Protein Summary

Description

Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death. This gene encodes a BH3-like motif containing protein involved in cell death. The encoded protein may induce apoptosis in a caspase-dependent manner. The protein is localized in both the cytoplasm and the mitochondrion. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q8IZY5
• A1L416

Gene Name

• BLID

Ensembl ID

• ENST00000560104
• ENSP00000453153
• ENSG00000259571

Symbol

• BRCC2
• BRCC2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.5
biological term	0.37
cell line	0.37
disease	0.37
phenotype	0.37

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.36   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 59   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.36   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0