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Tdark
BEND6
BEN domain-containing protein 6

Protein Summary
Description
Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370746
  • ENSP00000359782
  • ENSG00000151917
  • ENST00000370748
  • ENSP00000359784

Symbol
  • C6orf65
  • C6orf65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.78
transcription factor
0.77
tissue sample
0.63
cell type or tissue
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.29   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.29   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0