| Tbio | Bcl-2-associated transcription factor 1 |
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Small Cell Lung Carcinoma | 41 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Small cell carcinoma of lung | 45 |
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 2.9e-53 |
| osteosarcoma | 7950 | 1.6e-06 |
| tuberculosis | 2010 | 1.2e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 6.0e-05 |
| ovarian cancer | 8520 | 6.4e-05 |
| glioblastoma | 5792 | 4.8e-04 |
| psoriasis | 6694 | 4.9e-04 |
| dermatomyositis | 966 | 9.8e-04 |
| Multiple myeloma | 1332 | 1.0e-02 |
| progressive supranuclear palsy | 676 | 1.2e-02 |
| Rheumatoid arthritis | 1191 | 2.9e-02 |
| hereditary spastic paraplegia | 318 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Emery-Dreifuss muscular dystrophy | 23 | 3.964 | 2.0 |
| Tinea pedis | 29 | 3.676 | 1.8 |
| Superficial mycosis | 1 | 3.14 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.300 | 6.0e-05 |
| Breast cancer | -2.600 | 2.9e-53 |
| dermatomyositis | 1.100 | 9.8e-04 |
| glioblastoma | -1.300 | 4.8e-04 |
| hereditary spastic paraplegia | -1.023 | 4.4e-02 |
| Multiple myeloma | 1.309 | 1.0e-02 |
| osteosarcoma | -2.440 | 1.6e-06 |
| ovarian cancer | -2.000 | 6.4e-05 |
| progressive supranuclear palsy | -1.100 | 1.2e-02 |
| psoriasis | 1.200 | 4.9e-04 |
| Rheumatoid arthritis | 1.100 | 2.9e-02 |
| tuberculosis | 1.400 | 1.2e-05 |
MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRDYRNNRGMRRP 1 - 70 YGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSVSSQRSRSRSRRSYRSSRSPR 71 - 140 SSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLKSKSQEEPKDTFEHDPSESIDEFNKSSATSG 141 - 210 DIWPGLSAYDNSPRSPHSPSPIATPPSQSSSCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNG 211 - 280 SSRYSPSQNSPIHHIPSRRSPAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLL 281 - 350 DRGNTRDKEASKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQG 351 - 420 KSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTKDKHKEEDKNSERITV 421 - 490 KKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMIASDSHRPEVKLKMAPVPLDDSN 491 - 560 RPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKSTSESFIQHIVSLVHHVKEQYFKSAAMTLNE 561 - 630 RFTSYQKATEEHSTRQKSPEIHRRIDISPSTLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRR 631 - 700 RKERSKERGDSKGSRESSGSRKQEKTPKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSSPSSREEKESK 701 - 770 KEREEEFKTHHEMKEYSGFAGVSRPRGTFFRIRGRGRARGVFAGTNTGPNNSNTTFQKRPKEEEWDPEYT 771 - 840 PKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVEDEEETMENNEE 841 - 910 KKDRRKEEKE 911 - 920 //
