You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BCL7A
B-cell CLL/lymphoma 7 protein family member A

Protein Summary
Description
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261822
  • ENSP00000261822
  • ENSG00000110987
  • ENST00000538010
  • ENSP00000445868
  • ENST00000635191
  • ENSP00000489010
  • ENSG00000282873
  • ENST00000635403
  • ENSP00000489305

Symbol
  • BCL7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
virus perturbation
0.72
transcription factor perturbation
0.68
microRNA
0.65
transcription factor binding site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.07   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.07   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0