Tchem BCL2A1 Bcl-2-related protein A1

Protein Summary

Description

Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity). This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16548
• Q6FGZ4
• Q6FH19
• Q86W13
• Q99524

Gene Name

• BCL2A1

Ensembl ID

• ENST00000267953
• ENSP00000267953
• ENSG00000140379
• ENST00000335661
• ENSP00000335250

Symbol

• BCL2L5
• BFL1
• GRS
• HBPA1
• GRS
• ACC1
• ACC2
• BFL1
• ACC-1
• ACC-2
• HBPA1
• BCL2L5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
protein domain	0.73
transcription factor perturbation	0.68
PubMedID	0.67
biological term	0.65

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Bcl-2-related Protein A1

DTO Classes

Protein / Signaling / Bcl-2-related Protein A1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1253.69   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 384   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1253.69   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0