Property Summary

NCBI Gene PubMed Count 1,540
PubMed Score 123.84
PubTator Score 12509.20

Knowledge Summary


No data available


  Disease (7)

Disease Target Count
Chronic lymphoid leukemia, disease 10
Disease Target Count Z-score Confidence
Immune system cancer 38 0.0 1.0
Lymphoid leukemia 69 0.0 1.0
Disease Target Count Z-score Confidence
Cancer 2346 3.452 1.7
Disease Target Count Z-score Confidence
beta-mannosidosis 9 3.921 2.0


  Differential Expression (20)

Disease log2 FC p
chronic lymphocytic leukemia 1.534 7.5e-04
gastric cancer 1.200 3.0e-03
urothelial carcinoma -2.000 6.4e-03
malignant mesothelioma 6.100 7.1e-10
psoriasis -1.700 7.0e-09
osteosarcoma -1.824 1.4e-03
glioblastoma -1.100 1.5e-02
medulloblastoma, large-cell -1.900 1.8e-06
tuberculosis 1.700 1.4e-04
intraductal papillary-mucinous carcinoma... -1.800 7.9e-03
intraductal papillary-mucinous neoplasm ... -1.900 1.9e-02
lung cancer -3.600 3.9e-06
colon cancer -2.500 8.9e-03
sarcoidosis 1.100 1.3e-02
Breast cancer 2.500 2.5e-02
group 4 medulloblastoma -1.800 1.7e-04
primary Sjogren syndrome 1.300 1.4e-03
ductal carcinoma in situ -1.200 4.9e-02
ovarian cancer -3.200 7.9e-10
pituitary cancer -3.000 5.6e-09

Protein-protein Interaction (5)

MLP Assay (4)

AID Type Active / Inconclusive / Inactive Description
950 screening 116 / 437 / 194222 Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2.
1328 confirmatory 9 / 0 / 825 Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
2075 confirmatory 6 / 0 / 36 Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2
504627 other 0 / 0 / 0 Bcl-2 family members Fluorescence polarization assay with Set1 of powder compounds

Gene RIF (1440)

27141571 Renal Bcl-2 expression is decreased in diabetes.
27008505 RBP2 promotion of overexpression and activation in acute lymphoblastic leukemia development and progression
26963620 This study examined the immunohistochemical expression of ki-67, p53 and BCL2 in infiltrating lobular breast carcinoma.
26956214 Bcl-2 is required for efficient intestinal transformation.
26884845 Bcl-2 may play a role in vasculogenic mimicry through miRNAs by targeting angiogenesis associated genes in hepatocellular carcinomas.
26884837 MiR-15b can inhibit HepG2 cell proliferation and down-regulate BCL2 mRNA and protein expression.
26881923 These results indicate that the BCL2 -938C>A polymorphism influences the occurrence and course of aseptic loosening.
26874859 Bcl-2 dependent NB cell lines are exquisitely sensitive to ABT-199 . Treatment with ABT-199 displaces Bim from Bcl-2 in NB to activate caspase 3, confirming the restoration of mitochondrial apoptosis
26858413 These observations suggest that HBx may modulate Bcl-2 function in a way that is different from that of the classical BH3-only proteins.
26841249 Authors found a new 28-mer G-quadruplex-forming sequence, P1G4, immediately upstream of the human BCL2 gene P1 promoter.
26823859 the results indicated that there is a close correlation between the BCL2 rs17757541 C>G polymorphism and coronary artery disease
26823709 Rare bcl-2 overexpression suggests that this anti-apoptotic protein is unlikely to play a role in the apoptotic resistance of non-small cell lung carcinomas.
26795455 Jmjd3 regulates osteoblast apoptosis through targeting Bcl-2 expression and Bim phosphorylation.
26782527 Transvaginal sonography can potentiate the apoptosis of human chorionic villus cells by increasing the Bax/Bcl2 protein ratio.
26725534 Case Report: mutations in BCL2 occur in an ongoing process in follicular lymphoma which can give rise to unusual immunohistochemical staining patterns.
26722459 MiR-16 mediated temozolomide-resistance in glioma cells by modulation of apoptosis via targeting Bcl-2
26717387 single or combined genomic alterations and survival in diffuse large B-cell lymphomas
26707131 The potent antitumor activity of RHL may be mediated through downregulation of Bcl-2 and cyclin D expression and upregulation of BAX and Bim expression.
26697569 Suggest miR-375 as a new player in controlling the pathways responsible for inhibiting the natural history of colorectal carcinoma tumor cells, via the Bcl-2 pathway.
26681053 Survivin, Bcl-2, and KAI1 are metastasis-related factors in cervical cancer. Overexpression of survivin and Bcl-2, and low expression of KAI1 promotes cervical cancer progress and metastasis.
26676786 Human cytomegalovirus induces a biphasic regulation of cellular Bcl-2 proteins to promote host cell survival, leading to viral dissemination and the establishment of persistent virus infection.
26658664 A subset of primary cutaneous follicle center lymphomas harbor BCL2 breaks and 1p36 deletion.
26656462 the BCL2-938C>A and BAX-248G>A SNPs significantly associated with platinum-based chemotherapy response, PFS and OS of patients with advanced NSCLC.
26653553 positive expression of p53 and Bcl-2 and amplification of c-erb-B2 gene were detected in transitional cell carcinoma and squamous cell carcinoma and they were correlated with urinary bladder cancer advanced tumor grades
26639348 Selective targeting of BCL2 with venetoclax had a manageable safety profile and induced substantial responses in patients with relapsed CLL or SLL, including those with poor prognostic features.
26638586 The expressions of p53, Bcl-2, and p-glycoprotein were not significantly correlated with advanced stage, high prognostic scores, ORR, and OS
26638529 H. pylori associated development of the gastric adenocarcinoma is determined by abnormalities of p53 protein function and overexpression of bcl-2 protein.
26634708 Many exciting new small molecule inhibitors such as BCL-2 and MYC inhibitors are in development and are exciting for these diseases and attempts are underway to combine them with effective immunochemotherapy platforms.
26621338 Similar clinical features in follicular lymphomas were observed with and without breaks in the BCL2 locus.
26612919 Thus, this study demonstrated effective chemotherapeutic potential of SFE by inducing apoptisis as well as inhibiting migration and their preliminary mechanism for human gastric cancer management.
26599017 Notch 1, pAkt and Bcl-2 proteins have roles in radioresistance of tumor cells
26575826 These results suggest that combination of HDAC inhibitors and BCL-2 inhibitors could be an alternative and effective regimen for SCLC treatment
26573127 CD10 and Bcl2 expression in tumor cells could give convincing diagnostic value to distinguish squamous cell carcinoma from seborrheic keratosis
26567361 we discuss the biology of the intrinsic pathway of apoptosis, early attempts to target BCL-2 clinically, and the recent promising results with the BCL-2 antagonist venetoclax (ABT-199) in clinical trials in hematologic malignancies
26565895 Non-Hodgkin lymphomas with MYC+/BCL2+/BCL6- gene rearrangements was more likely to have a non-germinal center cell of origin than MYC+/BCL2-/BCL6+ and MYC+/BCL2+/BCL6+ lymphomas.
26565002 the recently proposed new therapies employing bcl-2 inhibitors prompted the potential use of bax/bcl-2 ratio to identify patients putatively resistant to these molecules.
26558423 study showed that De novo MYCyBCL2 double-hit BCP-ALL is a rare disease that also occurs in pediatric and young adult patients and associated with complex karyotypes and poor prognosis. Younger patients may benefit from intensified chemotherapy.
26556865 PPARalpha functions as an E3 ubiquitin ligase to induce Bcl2 ubiquitination and degradation, leading to increased cancer cell sensitivity in response to chemotherapy drugs.
26554163 Studied six SNP loci: (rs2279115 of BCL2 gene, rs804270 of NEIL2 gene, rs909253 of LTA gene, rs2294008 of PSCA gene, rs3765524 and rs10509670 of PLCE1 gene) to evaluate gastric cancer risk using magnetic nanoparticles and universal tagged arrays.
26549519 these data indicate that IL-6 inhibits starvation-induced autophagy and that p-STAT3 mediates the signal transduction from IL-6 to downstream proteins including Bcl-2 and Beclin1
26546525 oligonucleotide-mediated treatment could be more effective when directed towards KI-67 and BCL2. This could be accomplished by dual monospecific targeting KI-67 and BCL2
26516138 Increased miR-451 expression may negatively regulate Bcl-2 mRNA and protein expression, followed by affecting the protein expression of caspase 3, and accelerate the apoptosis in breast cancer
26515759 Data confirmed the validity of the RC cell line as a representative model of proto-oncogene proteins MYC/BCL2 double-hit diffuse large B cell lymphoma.
26491047 Increasing the Bcl-2/Bax ratio by exposure to high extracellular ATP may, therefore, be an important selective pressure promoting transformation and cancer progression.
26482649 Determination of cytoplasmic light chains, Bcl-2 expression and PCR clonality analysis of B cells improved accuracy of cytological diagnoses in B-cell lymphomas.
26475474 The expression of p38, p-p38, Bcl2 and the ABC subtype are significant risk factors both p38 and p-p38 expressions remain independent prognostic factors.
26474854 Cervical cancer cells upregulate Bcl-2 when treated with a non-cytotoxic concentration of cisplatin, which when silenced, effectively enhanced cisplatin sensitivity
26472348 favorable prognosis previously associated with Bcl-2-positive breast cancer probably reflects the indirect effect of frequently coexpressed hormone receptors and adjuvant endocrine therapy
26464626 BCL2 was not an independent prognostic indicator of infiltrating ductal carcinoma of the breast
26458963 Dysadherin-silenced side population cells exhibited reduced expression of Bcl-2 and Bax compared with that prior to silencing.
26452980 Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation.
26448193 High-grade B-cell lymphoma with MYC rearrangement and without BCL2/BCL6 rearrangements is associated with high P53 expression and a poor prognosis.
26422397 SATB1 as a Dual Regulator of Anti-Apoptotic BCL2 and Pro-Apoptotic NOXA Genes
26397843 miR-205 suppresses the growth of adrenocortical adenoma SW-13 cells via targeting the anti-apoptotic gene Bcl-2.
26397390 ABL-N administration induced apoptosis of PC3 cells in a dose-dependent manner, along with the enhanced activity of caspases and increased Bax/Bcl-2 ratio. Expression of KLF5, Stat5b and ICAM-1 was significantly downregulated in PC3 cells.
26350953 The authors detected that hypoxia induced cell apoptosis via HIF-1alpha/miR-204/BCL-2 in neuronal cells.
26341138 provide evidence that Bcl-2 enhances the role of Twist-1 in vasculogenic mimicry and provide evidence that Bcl-2 enhances the role of Twist-1 in vasculogenic mimicry and epithelial-mesenchymal transition through miRNAs through miRNAs
26335622 the methylation levels of MBR CpG sites were higher in individuals with BCL2/JH translocation, in contrast to our expectations, these levels decreased with the age.
26325180 miR-206 suppressed c-Met and Bcl2 expression in NSCLS and could function as a potent tumor suppressor in c-Met/Bcl2-over expressing tumors.
26320497 Low Expression of the bcl2 Gene is associated with Gastric Adenocarcinomas.
26307351 Dual-poly-siRNA carrying glycol chitosan nanoparticles demonstrated successful VEGF/Bcl2 gene silencing in prostate tumors.
26301506 In cells with functional KEAP1, RTA 405 increased NRF2 levels, but not IKKb or BCL2 levels, and did not increase cell proliferation or survival.
26297542 miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer cells via targeting BCL2, BCL2L12 and Mcl-1.
26272263 No statistical difference in the genotype and allelic frequency of the BCL-2-938C>A polymorphism was observed. BCL2-938C/A and A/A homozygotes carriers had higher distribution of BCL-2-expressing cells in stroma.
26261629 Suggest that combination of Bcl-2 and Ki67 to detect gastric cancer is more effective.
26241894 A novel mechanism of autophagy resistance via post-translational modification of Bcl-2 protein by nitric oxide.
26239087 These data suggest that pre- and posttreatment Bcl-2/IgH levels from peripheral blood have significant prognostic value for progression-free survival in follicular lymphoma patients receiving first-line immunochemotherapy.
26214636 Patients with BCL2+ and BCL6- diffuse large B cell lymphoma patients benefit from R-CHOP therapy.
26204652 Expression of BCL2 was correlated with Figo stage and tumor grade.
26191195 miR-204 targets JAK2 and suppressed JAK2 and p-JAK2 expression in breast cancer, which further inhibit the activation of STAT3, BCl-2 and survivin.
26173295 Bcl-2 overexpression enhances secretion of angiogenic growth factors by adipose-derived stem cell deprived of oxygen and glucose.
26172269 BCL2 inhibitors may be a therapeutic candidate in vivo for patients with ETP-ALL with high expression levels of MEF2C.
26158410 Data indicate that diffuse large B-cell lymphoma (DLBCL) patients with proto-oncogene proteins MYC or BCL2 copy number aberration (CNA) constituted a unique group with extremely poor outcome and may require more aggressive treatment regimens.
26132559 BCL-2 rs2279115 polymorphism contributes to esophageal squamous cell carcinoma susceptibility in Chinese populations.
26111591 Marine steroids as potential anticancer drug candidates: In silico investigation in search of inhibitors of Bcl-2 and CDK-4/Cyclin D1.
26110568 antiapoptotic proteins of the Bcl-2 family including BCL2 regulate mantle cell lymphoma sensitivity to acadesine
26108665 Co-expression of BCL2 family members rescued APOL1-associated toxicity.
26099430 Report differential expression of TP53/Bcl-3/c-kit protein in pure versus combined Merkel cell carcinomas.
26099171 An increase in expression of BAX and no change for BCL2.
26091803 Bcl-2 is also involved in the epithelial-mesenchymal transition (EMT), a fundamental mechanism in normal morphogenesis and pathogenesis of some diseases.
26091620 astrocytic miR-34a in shedding vesicle was involved in this progress via targeting anti-apoptotic protein Bcl-2 in dopaminergic neurons.
26081683 The expression ratio of BCL2/BAX was found to be significantly decreased (2.76fold) in the osteoarthritis group compared with the normal cartilage control group.
26056043 anti-apoptotic proteins Mcl-1 and Bcl-2 are suppressed by metformin combined with aspirin, which significantly inhibit pancreatic cancer cell growth
26044564 this study provides the evidence of Rab31 overexpression in HCC, and Rab31 is potentially used as a novel biomarker of poor prognosis in patients with HCC. PI3K/AKT/Bcl-2/BAX axis was involved in Rab31-promoting HCC progression.
26035796 targeting of the ADM/ADM acceptors/ERK1/2/Bcl-2 pathway may provide a potential strategy through which to induce the apoptosis of osteosarcoma cells.
26011836 Bcl-2 gene reveals tumor aggressiveness and treatment response.
26009182 Binding of Bcl-2 to IP3Rs dampened its Ca2+-flux properties via a direct interaction as well as via the recruitment of calcineurin
26002578 High BCL2 expression is associated with osteosarcoma.
25991504 Results suggest that A allele of rs4645878 could be a biomarker of high risk of developing proliferative vitreoretinopathy (PVR) in patients undergoing RD surgery.
25982455 BCL2 and BAX could be effectively used for an enhanced prediction of Berlin-Frankfurt-Munster-treated patients' outcome.
25975837 ALK-negative anaplastic large cell lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2.
25962755 Additionally, its mechanism may partially be associated with the downregulation of miR-214, upregulation of p53 protein expression and suppression of the Bcl-2/Bax signaling pathway.
25957891 BCL2-938C>A gene polymorphism is significantly associated with increased risk for acute myeloid leukemia.
25957473 Bcl-2's hydrophobic cleft is not involved in binding to and regulating ryanodine receptors.
25955534 our data suggested that the JNK-Bcl-2 pathway was the critical regulator of gartanin-induced protective autophagy and a potential drug target for chemotherapeutic combination.
25943894 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
25910896 Upregulated miR-34a potentiates Fas-mediated endplate chondrocyte apoptosis via repression of BCL-2.
25885284 Simultaneous targeting of Bcl-2 proteins and the autophagy pathway may be an efficient new strategy to overcome their "autophagy addiction" and acquired resistance to current therapy
25882699 High BCL2 expression is associated with diffuse large B-cell lymphoma.
25879558 It was indicated, that index of maturation correlates with level of bone marrow cells, containing Philadelphia chromosome, so as with percentage of CD34+, Bcl-2+, Pgp-170+ and Ki67+ cells in bone marrow of CML patients.
25867342 We observed decreased Bcl-2 expression and increased Bax and Pten expression induced by TIEG1 in 4 different leukemia cell lines.
25864810 Bax and Bcl-2 expression was most predictive of outcome when combined as Bax/Bcl-2 expression ratio in colorectal tumors compared to expression levels of Bax and/or Bcl-2 genes alone.
25862909 Of the two postulated miR-7 target genes we examined, BCL2, but not EGFR, seems to be a possible miR-7 target in OC.
25857445 MicroRNA-29a induces apoptosis via increasing the Bax:Bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis
25857363 heat stress(HS) and aspirin + HS does not act as a co-inducer of HSP70 in HepG2 cells, but promotes Bcl-2 protein expression during prolonged treatment
25855960 Results show that PCAF can induce cell apoptosis by modulating a GLI1/Bcl-2/BAX axis that in turn suppresses HCC progression.
25854572 NDRG2 was negatively correlated with Bcl-2 in gastric cancer tissues.
25845681 Notably, miR-21 regulated the potential anticancer effects of icariin on cell proliferation and apoptosis by targeting PTEN, RECK and Bcl-2 in the ovarian cancer A2780 cells
25844633 Mcl-1 binding is particularly perturbed by only four mutations of the 12 tested (V220A, N260A, R263A, and F319A), while Bcl-xL and Bcl-2 have a more diverse set of important residues depending on the bound helix.
25840688 LN metastatic colorectal carcinomas have a tendency of being less differentiated, with a higher incidence of diffuse p53 staining, lower incidence of bcl-2 staining, and less aneuploidy in comparison to their primary counterparts
25829398 ibrutinib and ABT-199 combination targets the three antiapoptotic BCL-2 family proteins that drive the survival and proliferation of CLL cells.
25828391 Triple hit B-cell lymphoma with MYC, BCL2, and BCL6 translocations/rearrangements are clinically aggressive tumors associated with a poor prognosis.
25828389 Although immunohistochemical assessment for MYC and BCL2 may be a helpful initial screen to identify higher-risk patients, FISH analysis for MYC remains important for further risk stratification in patients with diffuse large B-cell lymphoma.
25826088 Bcl-2 protein stabilization by phosphorylation at Serine 87 via paxillin-mediated ERK activation is responsible for cancer cell invasiveness and occurs via upregulation of MMP2 expression.
25824726 Downregulation of beta 3 -integrin with cRGD peptide resulted in enhanced LC3-II and Beclin-1 and decreased Bcl-2 expression.
25821312 Bleomycin A5 does not affect Bcl-2 levels in ECV304 cells.
25815518 VPA and ATO had synergistic effects on the proliferation of RPMI8226 cells, which may have been associated with the decreased expression of Bcl-2 and the increased expression levels of Bcl-2-associated X protein, Caspase 8 and Caspase 9
25815462 the present study indicated that the p38 and ERK pathways, as well as modulation of Bcl-2 family and survivin proteins were key regulators of apoptosis induced in HL-60 cells in response to AA.
25754349 Our study provides new insights into the mechanisms of acquired resistance of Bcl-2 and MDM2 inhibitors in acute leukemia models
25748272 Data suggest that BCL2 and proteins in the BCL2 family either reside at mitochondria or can translocate to this organelle and may be involved in normal mitochondrial physiology/homeostasis and energy metabolism. [REVIEW]
25744832 IL-8 inhibits apoptosis by up-regulating Bcl-2 and down-regulating caspase-3 in breast cancer cell.
25744050 Treatment of CoCl2 and HK-2 cells treated with DPI, but not NAC, significantly induced ERK activation and Bcl2 expression.
25741152 MYC+/BCL-2+ primary gastrointestinal diffuse large B-cell lymphoma patients have worse chemotherapy response and poorer prognosis than patients who only express one of the two proteins.
25738398 Neither Bcl-2 or b-catenin were shown to be useful biomarkers for the prognosis of colorectal cancer. nuclear b-catenin expression may be a biomarker for the prediction of improved responses to chemotherapy
25735328 There was no relation between Bcl-2 expression and the lesion accompanying Paget's disease
25726913 Lewis y leads to inhibition of apoptosis and enhancement of CAM-DR by activation of the FAK signaling pathway and upregulation of Bcl-2/Bcl-XL expression in ovarian cancer cell lines.
25715028 the BH3 mimetic ABT-737 induces autophagy through a BAX and BAK1-independent mechanism that likely involves disruption of BECN1 binding to antiapoptotic BCL2 family members
25687653 BCL2 translocations are associated with diffuse large B-cell lymphoma.
25684204 Data indicate that proto-oncogene proteins c-bcl-2 BH4 domain helices inhibit BCL2-associated X protein BAX at a novel interaction site.
25684043 Quinacrine-induced K562 cell apoptosis is mediated through mitochondrial alterations triggered by p38 MAPK-mediated BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression.
25682239 High Bcl-2 expression is associated with Squamous Cell Carcinomas of the Uterine Cervix.
25682076 The expression of Bcl-2 was an independent, favorable prognostic factor in breast cancer patients with the HR+/HER2- subtype.
25672608 The results demonstrated that calycosin up-regulated the Bax/Bcl-2 ratio and cleaved caspase-3, cleaved caspase-9 expression in a dose-dependent manner.
25665064 Silver nanoparticles biosynthesized using Achillea biebersteinii flower extract: apoptosis induction in MCF-7 cells via caspase activation and regulation of Bax and Bcl-2 gene expression.
25652864 The down-regulated of Bcl-2 inhibited the proliferation of liver cancer cells.
25652855 MiR-204 inhibits hepatocellular carcinoma cell proliferation and induce apoptosis by down-regulating the expressions of Bcl-2 and Sirt1.
25648135 The combined Ki67/Bcl2 phenotyping was useful in luminal cancers prognostication. It also refined prognostication in intermediate groups (grade 2 and stage 2 cancers) of luminal cancers; and aided in further classification of luminal A cancers.
25641608 Report novel Mcl-1/Bcl-2 dual inhibitors that effectively induces apoptosis in a dose-dependent, mechanism-based manner in multiple cancer cell lines.
25631043 Tetherin interacts LRPPRC and prevents LRPPRC from forming a ternary complex with Beclin 1 and Bcl-2 so that Beclin 1 is released to bind with PI3KCIII to activate autophagy.
25616695 BCL2 expression analysis could facilitate decision making on adjuvant treatment in -negative breast cancer patients.
25611382 BMCC1 negatively regulates phosphorylation pathway of AKT, resulted in apoptosis and the BNIP2 homology region of BMCC1 interacts with BCL2.
25604244 High levels of Bcl-2 is associated with cisplatin-resistance in head and neck cancer.
25596645 Bcl-2 overexpression in chemotherapy-naive primary bladder cancer is related to poor chemotherapy response and might help to select likely nonresponders.
25572805 Our data suggested that tumor-associated macrophages might induce drug resistance through IL-10/STAT3/bcl-2 signaling pathway
25565814 Magnetic iron oxide nanoparticles can induce the autophagy in blood cells by regulating the Beclin 1/Bcl-2/Atg14/VPS34 complex.
25563670 Our results suggest that Bcl-2 levels might be an indicator of severity of manic symptoms in bipolar patients in a manic phase.
25549806 These data indicate that blood BCL2-MBR translocations represent lymphoma precursor clones with malignant potential.
25499851 indicated that it was more common for MnSOD-positive, nuclear p65-positive, or high Bcl-2 mRNA tumors to have an unfavorable response to cisplatin-based chemotherapy than their counterparts
25499217 Stroma-induced apoptosis resistance is mediated through signaling proteins that regulate transcriptional and translational expression and post-translational modification of Mcl-1 in CLL cells in context to bone marrow stromal microenvironment.
25492486 this activity proceeded via a mechanism involving metformin-induced downregulation of Bcl2. A combination of ATO and metformin is therefore a potentially promising approach for Hepatocellular carcinoma therapy.
25492481 Our findings suggested that hsa-miR-143 could modulate cisplatin resistance of human gastric cancer cell line at least in part by targeting IGF1R and BCL2.
25484022 lactate is an important determinant of the sensitivity of tumors to glucose starvation, and reducing lactate or inhibiting the PI3K/Akt/mTOR/Bcl-2 signaling pathway may influence the response of cancers to glucose starvation
25471003 this study documented down-regulation of galectin-3 and Bcl-2 (antiapoptotic molecules) and stepwise increase of survivin (inhibitor of apoptosis), during thyroid tumor progression from PTC to ATC.
25452615 BCL2 mutations can affect antiapoptotic Bcl-2 function, are associated with increased activation-induced cytidine deaminase expression, and correlate with increased risk of transformation and death due to lymphoma.
25449296 LRIG1 can enhance chemosensitivity in glioblastoma by inhibition of BCL-2 and MnSOD
25446991 findings reveal a previously unidentified target of LRRK2 G2019S, showing that Bcl-2 serves as a point of crosstalk between LRRK2 G2019S-mediated mitochondrial disorder and dysregulation of autophagy
25436317 A positive linear correlation was found between bcl-2 and p53 suggesting that bcl-2/p53 co-expression pattern may be prognostic in hepatocellular carcinoma.
25435366 CHIP masks genetic variations to suppress heterogeneous Bcl-2 expression levels and prevents augmentation of the anticancer drug-resistant population of breast cancer cells.
25430556 This study indicates that the Bcl-2 -938C>A polymorphism might be associated with increased cancer risk and this association might exist in Asians but not in Caucasians (meta-analysis).
25411208 Annona muricata has antiproliferative effects on BPH-1 cells and reduces prostate size, possibly through apoptosis
25410484 In breast cancer, some GATA3 effects shift from tumor suppressing to tumor promoting during tumorigenesis, with deregulation of three genes, BCL2, DACH1, THSD4, representing major GATA3-controlled processes in cancer progression.
25388617 Regulation of mitochondrial outer membrane permeabilisation via the BCL2 family of proteins is an important and influencing checkpoint in acute response to neoadjuvant treatment in rectal cancer.
25385144 Our results imply that autophagy contributes to the reduction of radiosensitivity in hypoxic environment, and the process is mediated through the HIF-1alpha/miR-210/Bcl-2 pathway in human colon cancer cells
25384499 Chidamide treatment significantly decreased the expression of p21 and increased the ratio of Bax/Bcl-2 expression.
25384217 BCL2-overexpressing B cells required multiple GC transits before acquiring FL-associated developmental arrest and presenting as GC B cells with constitutive activation-induced cytidine deaminase (AID) mutator activity.
25382610 data demonstrate that nimbolide is highly active in WM cells, as well as other B-cell cancers, and engages BCL2 to exert its cytotoxic activity.
25381338 Circulating tumor cells expression of ER, BCL-2, HER2, and Ki67 can be reproducibly measured with high analytical validity using the CellSearch System.
25374220 Low expression of Bcl-2 protein is associated with non-small cell lung cancer.
25374001 The review focuses on BCL2 protein as a prognostic marker and its potential as a predictor of sensitivity to chemotherapy in triple negative breast cancer patients. [review]
25362242 follicular lymphoma shows increased basal autophagy activity, regardless of overexpression of BCL-2 in this disease
25355727 The findings of the present study provided insight into the molecular mechanisms underlying ferruginol-induced apoptosis in non-small cell lung cancer (NSCLC) cells, indicating that this compound may be a potential candidate drug for anti-NSCLC.
25342468 findings suggest that Tra2beta regulates apoptosis by modulating Bcl-2 expression through its competition with miR-204. This novel function may have a crucial role in tumor growth.
25336632 This study has identified novel mechanisms of opposing BCL2 and BIM gene regulation that control glucocorticoid-induced apoptosis in pediatric acute lymphoblastic leukemia cells in vivo
25333710 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
25323586 Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer.
25311206 Bcl-2 directly interacts with the N-terminus of p62, but not the C-terminus (UBA domain). Bcl-2 affects the affinity of p62 to poly-ubiquitin chains and suppresses the aggregation of poly-ubiquitinated proteins such as mutant huntingtin.
25301704 Data indicate B-cell lymphoma (BCL)-2 (BCL-2) as a molecular target in specific subtypes of T-ALL that could be exploited by ABT-199.
25301444 the present study demonstrated that waltonitone induced apoptosis of lung cancer cells through, at least partly, miR-663-induced Bcl-2 downregulation.
25284608 Combination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways.
25284491 Data indicate that combined analyses of genetic aberrations and protein expression of neoplasm proteins MYC, BCL2 and TP53 identified a larger proportion of diffuse large B-cell lymphomas patients with poor outcome.
25263458 Here, we explore the interrelationship between these signaling pathways and the cellular effectors that influence cardiac cell fate.
25257838 Genetic polymorphism in the inhibitory P2 promoter region of anti-apoptotic BCL-2 genes contributes to the risk of developing non-small-cell lung cancer in Indian population.
25231749 These results demonstrated that Gos induces apoptosis in MM cells not only through displacing BH3-only proteins from Bcl-2, but also through inhibiting IL-6 signaling, which leads to Bcl-2 dephosphorylation and Mcl-1 downregulation.
25230140 Therefore, we suggest that miR-135a regulation of LPS-induced apoptosis in A549 cells may depend in part on the regulation of Bcl-2.
25227106 The proliferation inhibition and apoptosis of EC9706 cells mediated by SIRT3 downregulation may be closely associated with the expression levels of p21, Bcl-2 and Bax proteins.
25216797 High receptor tyrosine kinase (FLT3, KIT) transcript versus anti-apoptotic (BCL2) transcript ratio independently predicts inferior outcome in pediatric acute myeloid leukemia.
25179840 Our results suggest that positive expression of Bcl-2 predicts no benefit from adjuvant anthracycline-based chemotherapy in non-basal TNBC patients.
25177684 Therefore, the Bcl-2 family of proteins may also be involved in the mechanism of tumor chemotherapy resistance by influencing crosstalk between the ER and mitochondria. In this review we will briefly discuss evidence to support this concept. [review]
25168538 Seminal BAX demonstrates significant negative correlation with sperm concentration, sperm motility, and sperm normal forms, whereas seminal BCL2 demonstrates significant reverse positive correlations in infertile men with varicocele
25127509 Loss of Bcl-2 expression in colorectal cancer is associated with decreased disease-specific and overall survival.
25111376 Silencing Bcl-2 in PTEN-mutated prostate cancer cells enhances the apoptotic effects of combined starvation and taxol treatments, indicating that inhibition of Bcl-2 may be of significant value in PTEN-mutant tumor therapy.
25103070 a small subset of large B-cell lymphomas have concurrent MYC and BCL2 abnormalities other than translocations
25090026 high MYC/BCL2 DHS, high MYC/BCL6 DHS and high THS were associated with inferior OS and PFS in both CHOP and R-CHOP cohorts
25086254 The newly identified G-quadruplex in the Bcl-2 P1 promoter may be a novel anticancer therapeutic target.
25084985 the simultaneous treatments for 24 h with quercetin plus ELF-MF increased Bcl-2 protein expression and prevented quercetin-induced downregulation of Mcl-1 and Bcl-xL.
25082878 Bcl-2 phosphorylation at Ser70 by selective tyrosine nitration of PP2A-B56delta stabilizes its antiapoptotic activity
25066397 Studied expression heterogeneity of ITGB3 and BCL-2 in lung adenocarcinoma tissue and adenocarcinoma cell line.
25032846 CHOP is critical for mediating ASPP2-induced autophagic apoptosis by decreasing Bcl-2 expression and maintaining nuclear ASPP2-Bcl-2 complexes.
25031780 miR-21 inhibitor down-regulated BCL2 expression level, suggesting that BCL2 might be a target gene for the initiation and development of NPC cells.
25016705 The Bcl-2/IgH recombination rate in stage III lymphomas was not significantly different compared to the rate observed in stage I/II lymphoma, respectively showing no statistical differences between stage IV and I/II.
25014217 ZFP36L1 interacts with and mediates degradation of anti-apoptotic BCL2 mRNA as its important target in malignant B-cells.
24903407 Data show that taxifolin and quercetin dissociate the apoptosis regulatory proteins Bcl-2-Bax complex during 12 ns molecular dynamics simulation.
24870742 BCL2 expression was higher in urothelial bladder cancer tissue than in adjacent normal tissue. MicroRNA29c induces apoptosis in bladder cancer cells by down-regulating BCL2.
24870739 BCL2 mRNA expression level did not differ significantly between thymic tumor and normal tissues.
24870731 Bcl-2 expression was positive in 13.3% of tumors in a cohort with colorectal adenocarcinoma. Bcl-2 expression was unrelated to AKAP12 expression.
24841128 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
24814047 p53 negatively modulates Bcl-2 by controlling miR-1915.
24802382 Results suggest that CIP exerts its effect in TK6 cells by promoting p53 phosphorylation and inhibiting Bcl-2 production and in PBMCs by inhibiting p53 phosphorylation and increasing Bcl-2 production.
24786774 In resistant Bcl2-expressing mouse lymphoma cells, 2 missense mutations within the Bcl2 BH3 domain were identified. Both F101C and F101L mutations impeded ABT-199 binding to the BH3 domain, therefore suppressing mitochondrial apoptosis
24782650 The mRNA expression level of TLR8 in the patients with cervical cancer and Hela cells were up-regulated, it consistent with the increased expression of VEGF and Bcl-2.
24768714 At the mitochondria, Bcl-2 scaffolds the Bcl-2-homology domain 3 (BH3) of pro-apoptotic Bcl-2-family members. At the endoplasmic reticulum, Bcl-2 modulates Ca2+ signaling, thereby promoting proliferation while increasing resistance to apoptosis. (Review)
24762814 Bcl-2 is an inhibitor of RyR-based intracellular Ca(2+)-release channels.
24745187 The investigation revealed natural course of chronic HBV and HCV infection and in its outcomes (chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma), by determining the expression of proapoptotic (Fas, FasL) and antiapoptotic (bcl-2) factors
24741635 The Bcl-2 expression correlated with the stage pT3 and T4 gastric cancer and with local lymph node metastases.
24739951 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
24723333 the stability of different G-quadruplex folds of the 23-mer bcl2 promoter region and G-quadruplex ligand, is reported.
24717877 The significant positive correlations were observed between Bcl-2 protein and Ki-67 antigen in sinonasal inverted papilloma and sinonasal carcinoma groups and between Bcl-2 protein and CD34 antigen in the chronic rhinosinusitis group.
24706857 provides the first structural information, to our knowledge, for future targeting of the NAF-1-Bcl-2 complex in the regulation of apoptosis/autophagy in cancer biology
24690321 Our results suggest an association between bcl-2 and beclin 1 expressions in malignant transformation of prostate tissue
24679006 TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and BCL2 but not MYC and BCL6 translocations
24646834 A structural basis for a conserved binding mechanism between p53DBD and the anti-apoptotic Bcl-2 family proteins.
24642270 Bcl-2 regulates the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes. (Review)
24630927 Autophagy in a tumor cell line induced by cardiac glycoside is dependent on reduction of Bcl-2 and activation of JNK mitogen-activated protein kinase pathway.
24626299 Our results revealed an interaction between BEX1 and BCL-2 and a novel mechanism of imatinib resistance mediated by the BEX1/BCL-2 pathway.
24622325 Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity.
24621205 no association between BCL2 gene polymorphisms with immunoglobulin A nephropathy
24614958 We observed higher expression levels of BCL-2, BCL-XL, BAX, and BAD genes in postmenopausal patients with pelvic organ prolapse compared with controls as well as overexpression of all four genes in parametrial tissue compared with vaginal tissue.
24608435 Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAF(V600E) inhibition and can be targeted to reduce resistance.
24606718 HA/CD44-induced c-Jun signaling plays a pivotal role in miR-21 production leading to Bcl-2 upregulation and chemoresistance in triple negative breast cancer cells
24576507 In sum, this study indicated that the activation of the ROS-JNK-autophagy pathway may be an important mechanism by which HCC cells with high levels of Bcl-2 are resistant to ABT-737.
24555747 Negative expression of bcl-2 is associated with recurrence after curative resection in gastric carcinoma.
24549219 Genetic variants of BCL2, GNAO1, and CHD2 are associated with non-obstructive azoospermia risk.
24516200 Data suggest that when a Bcl-2 inhibitor is combined with active immunotherapy, immunotherapy should precede administration of the Bcl-2 inhibitor to allow T cells to become mature, and thus resistant to the cytotoxic effects of the Bcl-2 inhibitor.
24503791 study evaluated the effect of bcl-2 expression on the local control and overall survival of patients with early stage laryngeal cancer treated with radiotherapy alone; no correlation was observed between bcl-2 expression and local control or overall survival
24503222 Many players in BCL-2 family affairs. [review]
24496723 Results indicate high levels of clonal BCL2 mutations in t(14;18) positive follicular lymphomas (FLs).
24496691 Results suggest that dioscin possessed potential anti-tumor activity in LNCaP prostate carcinoma cells through the apoptosis pathway, which might be associated with caspase-3 and Bcl-2 protein family.
24496564 High Bcl-2 expression is associated with resistant and relapsed non-Hodgkin lymphoma.
24491548 Results sugggest applications in dual-targeting anticancer therapy for MDM2 and anti-apoptotic Bcl-2 family proteins.
24489003 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
24461648 c.-717C > A polymorphism related to risk of cutaneous melanoma
24448706 Bcl-2 expression may have prognostic significance in synovial sarcoma.
24397922 the anti-apoptotic protein Bcl-2 (B-cell lymphoma 2) is up-regulated during adipogenic differentiation.
24395794 Bcl-2 and DARPP-32 have roles in regulating inositol 1,4,5-trisphosphate receptor phosphorylation and promoting cell survival
24387269 COX-2 and Bcl-2 overexpression in the CG group suggests that CG, particularly the intestinal type, may be a premalignant lesion that converts into a tumor in the presence of carcinogens.
24364474 These findings suggest that the changes in the expression of Bcl-2 on the CD8+ cells indicate the involvement of these cells and Bcl-2-regulated apoptotic pathway in the pathogenesis of Graves disease.
24338002 Studies suggest a combination therapy that targets galectin-3 (Gal-3) could be essential for improvement of the efficacy of B cell lymphoma-2 (Bcl-2) targeting therapy in cancers.
24335512 The expression of RKIP was significantly upregulated and the expression of bcl-2 was significantly downregulated in DHA-treated cells compared with control cells.
24321200 No significant differences in genotype and allele frequencies between the MDD and control groups as well as between the TRD and NTRD groups. Significant association between the rs2279115C allele and TRD in males but not in females
24314632 Dengue virus 2 subgenomic RNA induces apoptosis through the Bcl-2-mediated PI3k/Akt signaling pathway.
24299314 Inhibition of autophagy in combination with efforts to enhance apoptosis through targeting the Bcl-2 family of proteins may be a promising strategy to overcome drug resistance
24295050 Overexpression of permanently active S100P in Huh-7 cells inhibited the interaction of FKBP38 with Bcl-2, resulting in the suppression of Bcl-2 stability
24293274 Study reveals functional and mechanistic links between miRNA-30b and oncogene KRAS, PIK3CD and BCL2 in the pathogenesis of colorectal carcinoma.
24288815 In a Duke University study of breast cancer patients resistant to tamoxifen, it was found that the BCL-2 gene is weakened and switches off, detectable in blood, indicating earlier treatment with chemotherapy drugs could prevent relapse.
24287948 Our findings indicate that the BCL2-938C>A polymorphism is associated with the susceptibility to glioma in Chinese Han populations
24280866 data demonstrate the role of miR-17~92 in regulation of apoptosis, and identify BCL2 as a therapeutic target of particular relevance in BCR-ABL-positive ALL.
24278362 Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression.
24249678 Data support a model wherein DDB1 and DDB2 cooperate to repress Bcl-2 transcription. DDB2 recognizes and binds to the Bcl-2 P1 promoter, and HDAC1 is recruited through the DDB1 subunit associated with DDB2 to deacetylate histone H3K9.
24248414 miR-449a could modulate cell cycle and apoptosis through regulating cyclin D1 and BCL2 expression in gastric cancer cells.
24240096 These results support the regulatory role of Bcl-2 in autophagy and define GABARAP as a novel interaction partner involved in this intricate connection.
24232982 Decreased miR-34a expression and increased FOXP1, p53, and BCL2 coexpression predict poor overall survival for MALT lymphoma and diffuse large B-cell lymphoma patients
24228120 Overexpression of Bcl-2 may predict a loss of the efficacy of the chemotherapy drugs in patients with gastric cancer.
24223706 Dihydromyricetin induces HepG2 cells apoptosis by up-regulating Bcl-2 expression via the p53 signal pathway.
24190693 Primary EOC is associated with lower TRAIL-R2 and BCL2 expression levels, while metastatic EOC is associated with higher expression of these genes.
24157866 PDCD4 as tumor suppressor regulated miR-184-mediated direct targeting of BCL2 and C-MYC.
24141421 results suggest that Mst1 coordinately regulates autophagy and apoptosis by phosphorylating Beclin1 and consequently modulating a three-way interaction among Bcl-2 proteins, Beclin1 and Bax
24127964 There is significant difference in Bcl-2 expression between cystic endometriotic stromal cells and endometrial stromal cells
24118498 MYC translocation partner gene determines survival of patients with large B-cell lymphoma with MYC- or double-hit MYC/BCL2 translocations.
24098503 antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro.
24097825 Phosphorylated Bcl-2, Bcl-2 S70E, and Bcl-2 S70A exhibit enhanced binding to Bim and Bak compared with unmodified Bcl-2.
24091677 Knockdown of Cdc20 in HeLa cells stably overexpressing untagged wild-type Bcl-2, Bcl-xL or Mcl-1 promoted phosphorylation of the overexpressed proteins in parallel with their endogenous counterparts.
24088574 BCL2-938C > A genotyping may be beneficial for therapy response prediction in ALL patients, and warrant examination in a larger cohort to validate its usefulness for treatment stratification of pediatric ALL patients.
24069951 suggesting that the changes in AKT/BCL2 signaling molecules might mediate growth and anti-apoptosis processes at least in part, thus increasing the survival potential of Congenital Giant Nevi melanocytes and maintaining their integrity
24065086 Our findings demonstrate that OPN/Bcl-2 expression is a promising independent predictor of recurrence and survival in HCC. Additionally, Bcl-2 levels may be regulated by OPN in the HCC microenvironment
24050266 Bcl-2 and Bcl-xL interact with mortalin and activate p53 function leading to an induction of senescence in cancer cells.
24048795 The t(14;18)/IGH-BCL2 chromosomal translocation occurred frequently in gastrointestinal follicular lymphomas.
24038028 Using gene reporter assays, we show that promoter variations in 11 intrinsic apoptosis genes, including ADPRT, APAF1, BCL2, BAD, BID, MCL1, BIRC4, BCL2L1, ENDOG, YWHAB, and YWHAQ, influence promoter activity in an allele-specific manner.
24036132 High BCL2 expression is associated with small-cell lung cancer.
24028527 the core and the flexible loop domain are crucial components of Bcl-2 in its function of regulating access to the recognition sites of kinases and caspases
24025186 Authors authors hypothesize that Porphyromonas gingivalis HmuY plays a role in the pathogenesis of chronic periodontitis, possibly by reducing or delaying apoptosis in T cells through a pathway involving the Bcl-2 protein.
24024471 The present study demonstrated that the - 938AA genotype of the BCL-2 gene may be a susceptible genotype for non-Hodgkin lymphoma.
24023670 BCL2 is not involved in lobular breast carcinogenesis and is unlikely to represent an important determinant of tumor development driven by CDH1 inactivation.
24014050 Moreover, inhibition of Bcl-2 expression can efficiently enhance the cytotoxic effect of, and sensitivity to, GEM in uveal melanoma cells cells.
24013520 Data suggest that BCL2 expression in tumor tissue is closely associated with shorter overall survival and progression-free survival in patients with solitary plasmacytoma of bone; expression of BCL2 is observed in 47% of patients.
23998360 our results suggest that Bcl-2 might be an indicator of schizophrenia severity in the acute phase. In addition, Bcl-2 levels might be associated with positive symptoms in male patients with schizophrenia.
23994555 Safflor yellow B attenuates angiotensin II mediated HUVEC injury via up-regulating Bcl-2 expression.
23991993 BCL2 rs17757541 C>G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma.
23991978 High expression levels of the Bcl-2 gene is associated with breast cancers.
23977251 The BCL-2 3'UTR rs1564483A allele was associated with a decreased lung cancer risk and better survival in advanced-stage non-small cell lung cancer male Chinese patients.
23975374 CCKBR and Bcl-2 were identified as targets of miR-148a.
23960074 This study reveals a novel cross-talk between Bcl-2/XL and mTORC1 signaling, which is likely to contribute to cancer development.
23953419 In the present study, 5/6 cases in which FISH was successful had an IGH/BCL2 fusion as would result from the t(14; 18)(q32; q21) translocation commonly seen in follicular lymphoma of extraoral sites.
23939148 Review: clinicopathologic, immunophenotypic, cytogenetic, and prognostic features of MYC/BCL2 double-hit high-grade B-cell lymphoma.
23925400 The Bcl-2 and HO-1 proteins seem to have important roles in the antiangiogenic environment of preeclampsia.
23908177 Adding Bcl2 to the panel of markers used in current clinical practice could provide both prognostic and predictive information in triple negative breast cancer .
23907579 Data indicate that treatment of gastric cancer cells with dihydroartemisinin (DHA) increased miR-15b and miR-16 expression, caused a downregulation of Bcl-2, resulting in apoptosis of gastric cancer cells.
23906301 Overexpression of Bcl2 protein predicts chemoresistance in acute myeloid leukemia.
23900644 Data indicate that the selenium compounds increased BAX, BCL-2 and activated caspase 3 levels.
23880928 Fucoidan-induced significantly attenuated in Bcl-2 overexpressing U937 cells.
23862748 Functional analyses indicated that the restoration of miR-34a reduced cell viability, promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression.
23861345 Results show that BCL-2 hypermethylation provides a robust biomarker of response to current and next-generation cytotoxic agents in endocrine-resistant breast cancer.
23856992 miR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin by targeting Bcl-2.
23851330 Report Bcl-2 expression in classical hodgkin lymphoma.
23850692 LRIG1 inhibits EGFR expression and the downstream signaling activation, interferes with Bcl-2/Topo-2 expressions and eventually sensitizes glioma cells to TMZ
23846229 the reduced expressions of Fas and Bcl-2 proteins in CD14+ monocytes from juvenile systemic lupus erythematosus patients depict that monocyte apoptotic mechanisms may be important in lupus pathogenesis.
23832737 S100A4 plays a crucial role in proliferation and migratory, invasive processes in human renal cell cancer by a mechanism involving activation of NF-kB-bcl-2 and NF-kB-MMP-2 pathway
23828460 siRNAmediated knockdown of their expression sensitized the cells to nickel-induced apoptosis, suggesting that Bcl-2, Bcl-xl and catalase protein expression plays a critical role in apoptosis resistance
23822101 LRPPRC associates with mitochondria, interacts with Beclin 1 and Bcl-2 and forms a ternary complex to maintain the stability of Bcl-2.
23818364 Nuclear morphometry significantly correlated with p53 and bcl-2 expression in primary skin melanomas.
23812727 Results show that The apoptosis induced by human adenovirus serotype 5 (AdHu5)-apoptin was independent of anti-apoptotic Bcl-2 and Bcl-xL proteins and the p53 pathway.
23802633 BCL2 and BCLxL play a pivotal role in paclitaxel sensitivity of melanoma cells, which is attributable to apoptosis susceptibility
23784204 An important contribution of Bcl-2 to gallbladder carcinoma.
23733877 In vitro data in both humans and mice demonstrate that interleukin (IL)-10 upregulates Bcl-2 specifically in peripheral blood regulatory T (Treg) cells but not non-Treg cells.
23732112 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
23729350 Using Ki-67, Bcl-2, p53, and Cox-2 markers, we managed to distinguish fully disordered proliferative/benign hyperplastic endometrium endometrium from low-grade endometrial carcinoma.
23724505 not significantly increased in the villous trophoblasts of patients with preeclampsia, HELLP syndrome, or IUGR
23722017 Down-regulation of beclin 1 expression and also bcl-2 overexpression seems to play an important role in the progression and aggressiveness of bladder urothelial tumors.
23719266 Our novel findings add to the knowledge of RRM2 in regulating expression of the antiapoptotic protein Bcl-2 and reveal a critical link between RRM2 and Bcl-2 in apoptosis signaling.
23708869 The potent inhibitor of Bcl-2 and Bcl-xl gossypol acetate had significant antiproliferative and antiapoptotic effects on multiple myeloma.
23688426 Since Beclin 1 level is unchanged during RID-B treatment, RID-B induced autophagy pathway is Bcl-2/Beclin1 independent noncanonical pathway.
23674504 Bcl-2 expression using the c-index strongly predicts 13q14 deletion and can be used to distinguish homozygous, heterozygous, and diploid CLL clonal cells
23673926 These results suggested that the aberrant transcription factor AML1-ETO epigenetically silenced the function of the Bcl-2, CEBPA and p14(ARF) genes by inducing repressed chromatin configurations at their promoters through histone modifications.
23673452 Following treatment with sirtinol (inhibitor of SIRT1), the expression of the pro-survival protein Bcl-2 was markedly decreased in both MCF-7 and MDA-MB-231 cell lines, particularly in MDA-MB-231.
23671559 Regulation of TCF4-mediated BCL2 gene expression by BMI1 is universal.
23665993 Data indicate that the menstrual cyclic expression of bcl-2 could be controlled by either direct binding of estrogen receptor alpha (ERalpha) to estrogen-responsive element (ERE) in the c-Jun promoter or the interaction of ERalpha with c-Jun.
23658782 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
23637776 Genetic polymorphisms in the BCL2 gene may be associated with the risk of endometrial cancer in Chinese women
23628417 Data indicate that BLU could suppress the growth of ovarian carcinoma cells through down-regulation of Bcl-2 protein.
23624503 Data indicate that autophagy is activated though the Cdx1-Bcl-2-LC3 pathway.
23613627 inhibition of telomerase activity and downregulation of bcl-2 expression have a role in phosphorothioate antisense oligodeoxynucleotide inhibition of GIST growth
23613399 Concurrent evaluation of p53 and Bcl-2 in patients with gastric adenocarcinoma may have prognostic importance.
23612742 Consistent with its anti-apoptotic target BCL2, miR-205 promoted apoptosis in prostate cancer cells in response to DNA damage by cisplatin and doxorubicin in the prostate cancer cell lines PC3 and LnCap.
23610963 Antisense oligonucleotides targeting BCL-2 and C-RAF transcripts in tumor cell lines increases sensitivity to cytotoxic effect of etoposide.
23588221 BCL-2 plays a role in the lung cancer drug resistance to the EGFR kinase inhibitors.
23573235 Bcl2 expression is common in male breast cancer, but is not associated with major clinicopathologic features.
23568006 Small interfering RNA silencing of cyclin D1 and BCL-2 expression in osteosarcoma cells enhances the toxicity of doxorubicin.
23564079 p62 induces autophagy by disrupting the association between Bcl-2 and Beclin 1.
23553948 Higher BAX/BCL2 RMFI ratio was associated positively with CR rate (P = 0.03), but this study was unable to show that it translated into improved EFS or OS.
23542172 findings identify the pathway of Ron-c-Abl-PCNA as a mechanism of oncogene-induced cell proliferation, with potentially important implications for development of combination therapy of breast cancer
23527542 This review places into perspective recent studies pertaining to the BCL-2 family of proteins as critical regulators of the development and function of the immune system, with particular attention to B cell and T cell biology.
23514940 downregulation of PPAR-gamma is a possible mechanism that leads to the clinical drug resistance of cancer
23511489 High BCL-2 expression is associated with precursor B acute lymphoblastic leukemia.
23509938 The use of three distinct anti-bcl-2 antibodies together with CD10 expression data and FISH analysis for bcl-2 and bcl-6 rearrangements allowed subclassification of follicular lymphoma into four distinct subgroups.
23497522 Findings evidenced a decrease of survivin, p53, Bcl-2 expression as well as of Ki-67 proliferation index on liver biopsies collected post-(90)Y-RE as compared to pre-(90)Y-RE.
23494176 High levels of bcl-2 protein expression is associated with lymphoblastic lymphoma.
23480852 Direct inhibition of anti-apoptotic BCL2 proteins is sufficient to induce C16-ceramide synthesis in multiple cell lines, including human leukemia and myeloma cells.
23479509 These results provide new insight into molecular mechanism of bcl-2 functions and represent a rationale for the development of agents interfering with the BH4 domain of bcl-2 protein.
23479508 the balance of expression of Bcl-2 and Bax genes in circulating immune cells has a high prognostic value in head and neck cancer patients.
23471820 A novel oncogenic pathway is identified that involves aberrant activation of the TYK2 and its downstream substrate, STAT1, which ultimately promotes T-cell acute lymphoblastic leukemia cell survival through the upregulation of BCL2 expression
23463292 AQP3 is an endogenous suppressor of cell apoptosis in skin fibroblasts through up-regulation of Bcl-2.
23449635 MYC/BCL2 coexpression, rather than cell-of-origin classification, is a better predictor of prognosis in patients with diffuse large B-cell lymphoma treated with R-CHOP.
23437205 The rs956572 G-allele, which is associated with significantly higher Bcl-2 protein expression and diminished cellular sensitivity to stress-induced apoptosis
23422486 No compensation in CD44 stem cell marker occurs following BCL-2 suppression by antisense oligonucleotides.
23421973 Human mesenchymal stem cell-like cells from foreskin derived conditioned medium inhibited the expression of BCL-2 while increased the expression of BAX and caspase-3 in gastric cancer cells.
23421940 IL-17 upregulated the expression of Bcl-2 in fibroblast-like synoviocytes from rheumatoid arthritis patients
23417836 Low bcl-2 expression is associated with recurrence in breast cancer.
23403511 Data indicate that pretreatment with the MEK/ERK inhibitor U0126 prevented the rapamycin-induced increases in pCREB, Bcl-2, and VEGF-A expression.
23382671 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
23369735 we describe that the specific knockdown of Bcl-xL, but not that of Bcl-2, Bcl-w or Mcl-1, renders cells sensitive to TNFalpha-induced apoptosis.
23364875 Mitochondria integrity and bcl-2 cell content are strictly coupled in melatonin intervention.
23364796 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
23364242 Polymorphisms in BCL2 may be associated with survival in advanced-stage non-small cell lung cancer patients who received chemotherapy.
23363601 results demonstrate the critical role of Bcl-2 cysteine oxidation in the regulation of apoptosis through ERK signaling; this new finding reveals crucial redox regulatory mechanisms that control the antiapoptotic function of Bcl-2
23359184 miR-21 regulation of BCL-2 expression is inhibited by resveratrol in pancreatic cancer cells
23359021 1 non-exposed individual was positive for the chromosomal translocation, and healthy radio-exposed individuals presented lower levels of cells bearing the BCL2/J(H) rearrangement.
23358890 Bcl-2 overexpression induced up-regulation of the proapoptotic protein Bim in lung cancer cells.
23355004 The detected Merkel cell polyomavirus (prevalence in non-small cell lung cancer in combination with the deregulated expression of BRAF and Bcl-2 genes suggests that these events are likely to contribute to the pathogenesis of non-small cell lung cancer.
23352961 GrH induced cell death via a Bcl-2-sensitive mitochondrial pathway.
23335369 Protein expression patterns of MYC, BCL2 and BCL6, and MYC rearrangements were predictive of outcome and provided prognostic information independent of the International Prognostic Index (IPI) for overall survival and event-free survival.
23334076 NF-kappaB plays an important role in the process of TNF-alpha-induced apoptosis in alveolar epithelial cells, via regulation of the expression of Bcl-2 and Bax
23324193 The level of bcl-2 protein of in superficial and in deep myometrium of ectopic adenomyosis tissues was significantly higher than in eutopic tissues and in control group.
23316052 Data indicate the interactions of p53TAD2 with anti-apoptotic Bcl-2 family proteins at the atomic level by NMR, mutagenesis, and structure calculation.
23301386 Polyps in postmenopause have a high COX-2 expression that is higher in malignant polyps than in benign polyps; there was no difference in Ki-67 and Bcl-2 expression between malignant polyps and premalignant/malignant polyps.
23295106 Intracellular levels of Bcl-2 and Bax protein might regulate the final destiny of developing germ cells.
23283967 the direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells is revealed by fluorescence complementation
23272207 the phosphorylated peptides of the Bcl-2 loop can bind Pin1, further substantiating the phosphorylation-mediated conformation change of Bcl-2.
23263985 AID enzymatic activity is important for the fragility at the the human bcl-2 major breakpoint region.
23261425 Cytosine methylation greatly increased the stability of the promoter G-quadruplex in bcl-2.
23245210 Bcl-2 expression was downregulated, while Bax expression was upregulated.
23243017 Findings suggest that inhibiton of Bcl-2, Bcl-xL and PI3K, and release of Bim from Bcl-2/Bcl-xL and GSK3alpha/beta culminating in Bax/Bak activation and apoptosis.
23235765 Data show that alterations of the apoptosis-related protein Bcl-2 is common in granulosa cell tumor (GCT), and suggest that expression of Bcl-2 might play role in the pathogenesis of GCT, possibly by inhibiting apoptosis.
23216071 In non-small cell lung carcinomas, Bcl-2 protein plays an important role in the autophagic process.
23207618 Our findings support the combination of tissue-based variables with clinical parameters at diagnosis, identifying patients who are at higher risk of poor outcome.
23202514 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
23174100 Data suggest that Bcl-2 up-regulation is directly regulated by NFkappaB (nuclear factor kappa B) during apoptosis of breast cancer cells in response to tumor necrosis factor-alpha; induction of Bcl-2 is mediated by p65 subunit of NFkappaB.
23170075 Sepia ink oligopeptide induced cell cycle arrest and altered BAX/Bcl2 expression ratio and caspase-3 expression in prostate tumor cell lines.
23160675 We now report that VEGF expression is unchanged following bcl-2 suppression, implying that angiogenesis (at least the one influenced by VEGF) is not adversely stimulated.
23153525 Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes.
23152059 Downregulation of miR-204 releases aberrant expression of Bcl-2 protein in gastric tumor.
23151078 CIAPIN1 siRNA inhibited proliferation, migration and promotes apoptosis of vascular smooth muscle cells by regulating Bcl-2 and Bax.
23138847 Dihydroartemisinin was associated with the increased expression of the pro-apoptotic gene Bim and a decreased expression of the anti-apoptotic gene Bcl-2 in breast cancer cells.
23135964 upregulated in patients with cystic fibrosis nasal polyps
23126236 Nuclear survivin expression and Bcl-2 expression warrant investigation as potential predictive biomarkers to enable individualized treatments for patients whose LSCCs strongly express nuclear survivin or/and Bcl-2.
23119114 Overexpression of bcl2 and loss of PTEN expression were correlated to poor differentiation, lymph node involvement and late stages in oral squamous cell carcinoma.
23115005 Negative expression of Bcl-2 is associated with stage I non-small cell lung cancer.
23095743 ARTN promotion of the cancer stem cell-like cell phenotype was mediated by TWIST1 regulation of BCL-2 expression.
23091012 HBx targets Bcl-2 proteins through its BH3-like motif to promote cytosolic calcium elevation, cell death, and viral replication.
23076250 Function of Bcl-2 is restricted to inhibiting apoptosis. Consistent with this hypothesis, cases positive for SATB1 and Bcl-2 were associated with poor prognosis.
23072837 The Bcl-2 SNP AA genotype is associated with elevated anterior cingulate cortex glutamate in euthymic bipolar I disorder compared to controls.
23065465 In choriocarcinomas the weak Bcl-2 expression is associated with weak p16 expression.
23064052 Discusses recent data suggesting that although Bcl-2 and Bcl-x(L) block the MOMP, they can also regulate the mitochondrial Bax content. That Bax inhibition by Bcl-xL occurs at the immediate proximity of the outer mitochondrial membrane is also discussed.
23038985 study revealed that it is the reduced inhibitory activity of the Bcl-2 gene rather than an enhanced stimulatory activity of the BCL2-associated X protein gene in the background of the increased apoptosis observed in intrauterine growth restriction
23030583 Decreasing expressions of HIF-1alpha, Bcl-2 and Ki-67 were observed during chemoradiotherapy of recel cancer, whereas GLUT-1 overall was unchanged.
23018213 demonstrated that interference with the function of ATF5 could markedly increase the apoptosis of ovarian cancer cells and identified B-cell leukemia lymphoma-2 as an ATF5-targeted apoptosis-related gene
22995373 Immunohistochemical staining for bcl-2 may not provide meaningful contribution for the typing of ovarian tumors
22990545 Bcl-2 was positive in 18.18% of the cases, in distal colorectal cancer, only in men, 63.5 +/- 13.2-year-old.
22976527 Bcl-2 positivity indicates better clinical stage at the time of diagnosis and a longer survival in Merkel cell carcinoma.
22971934 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
22968395 The incidence of IgH/BCL2-positive folli- cular lymphoma in Chinese patients is relatively lower compared with that in western countries.
22967897 miR-136 might play a tumor-suppressive role in human glioma
22965228 Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins
22953646 Serum levels of HGF, Bcl-2 or nitric oxide may help in the diagnosis of breast cancer patients and may aid in disease prognosis.
22951829 Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways.
22949148 bcl-2 translocation confers worse prognosis in diffuse large B-cell lymphoma treated with CHOP
22936014 Aberrant hypermethylation and reduced expression of BCL-2 is associated with myelodysplastic syndromes.
22933114 Bcl-2 and Bcl-xL suppress glucose signaling in pancreatic beta-cells.
22929980 Patients with diffuse large B-cell lymphoma of germinal center origin with BCL2 translocations have poor outcome, irrespective of MYC status.
22926545 Data indicate that daidzein induced a change in the Bax/Bcl-2 ratios and activation of caspases-3 and -9 and the cleavage of PARP, and therefore has the potential for use as a therapeutic agent for the treatment of gastric carcinoma.
22896703 HOXC6 is an important mechanism of the anti-apoptotic pathway via regulation of Bcl-2 expression.
22895528 etoposide induces a mixed type of programmed cell death and overcomes the resistance conferred by Bcl-2 in Hep3B hepatoma cells.
22855608 BCL2 rearrangement is associated with recurrence in follicular lymphoma.
22851565 poor prognostic effect of MYC positive/BCL2 positive diffuse large B-cell lymphoma
22848417 miR-182, a p53 dependent miRNA, suppressed the expression of MITF, BCL2, cyclin D2 and functioned as a potent tumor suppressor in uveal melanoma cells.
22842544 TRAIL-induced apoptosis in human renal cancer cells by upregulation of DR5 as well as downregulation of c-FLIP and Bcl-2.
22804688 High-grade B cell lymphomas, unclassifiable, with blastoid features are clinically aggressive with poor survival. Most neoplasms have a germinal centre B cell phenotype. MYC rearrangements and IGH-BCL2 are common, and ~60% are double-hit lymphomas.
22797576 combined knockdown of BCL2, Bcl-xL, XIAP and survivin caused a 2.5-fold enhancement in apoptosis rate and reduced cellular viability by 40%.
22749322 Report increased expression of HIF-1alpha and Bcl-2 in varicocele and varicose veins and increased Bcl-2 expression especially in the endothelium under hypoxia.
22748563 cell death Bax proteins are expressed more than cell survival Bcl-2 proteins in the deeper layers of the epidermis in patients on long-term dialysis
22739157 Clofarabine inhibits proliferation of NB4 cells, which may be related with the down-regulation of Bcl-2 and induction of apoptosis.
22732796 the percentage of Bcl-2+ cases was 43.24%, with no significant statistical correlation between the Bcl-2 expression and histopathological subtype of mucinous adenocarcinoma.
22727345 No association was found between Bcl-2 expression and disease persistance/progression in endometrial hyperplasia treated with progestins.
22710204 Genotyping reveals two single nucleotide polymorphisms in the BCL2 gene and a single nucleotide polymorphism in the SERPINA4 gene associated with a decreased risk of developing acute kidney injury.
22684875 Data show that in vitro over-expression of miR-15a/16-1 in keratocystic odontogenic tumor (KCOT) primary cell cultures resulted in a decrease in Bcl-2 protein. expression.
22675938 The expression of iNOS and Bcl-2 had a positive correlation, while the expression of iNOS and Bax had a negative correlation in nasal polyps.
22668011 Low bcl-2 expression is associated with response to therapy in ovarian carcinoma.
22666341 the novel and multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of human lung epithelial cells chronically exposed to Cr(VI)
22650021 Compared with normal pancreatic tissue, pancreatic cancer, Bcl-2 expression was upregulated and Beclin-1 expression was downregulated.
22629415 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
22623155 MiR-34a inhibited Bcl-2 and SIRT1 expression in breast cancer cell.
22619347 A significant association was observed between tumor size >/=100 g and lower expression levels of the BCL2 (P=0.03) and TNF (P=0.05) genes.
22591684 Src, Akt, NF-kappaB, BCL-2 and c-IAP1 may be involved in an anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative acute lymphoblastic leukemia.
22582499 Higher frequencies of BCL-2 -938CA and AA genotypes were found in patients with lumbar disc disease compared with normal controls (p = 0.019). Furthermore, there were higher frequencies of the A allele in LDD patients than in normal controls (p = 0.005).
22563025 CXCL8 and CXCR1 are involved in the pathogenesis of endometriosis by up-regulating proliferation and growth and restricting apoptosis in endometrial stromal cells by activating the PTEN/Akt pathway and mediating the expression of survivin and Bcl-2
22562824 Bcl-2-dependent VE-cadherin overexpression may be an important mechanism by which hypoxia induces Vasculogenic mimicry
22562364 brain glioma stem cells evade apoptosis through higher Bcl-2 expression
22532139 data indicates upregulation of the CD40/CD40L system in psoriatic patients despite topical treatment and suggests their possible role in the pathogenesis of psoriasis
22524261 The Bax gene was overexpressed in preterm delivery, whereas expression of the Bcl-2 gene remained unchanged.
22523079 The derived structure model of the complex between Bcl-2 and the FKBP38 catalytic domain features both electrostatic and hydrophobic intermolecular contacts and provides a rationale for the regulation of the FKBP38/Bcl-2 interaction by Ca(2+).
22517702 Bcl-2 expression is a good prognostic factor in advanced-stage patients.
22506026 Thus besides BH3-mediated interactions, there exists an additional way for mutual regulation of Bcl-2 proteins, which is independent of the BH3.
22504646 The ratio of antiapoptotic BCL-2 to BCL2-antagonist/killer (BAK) correlates best with the survival of activated DCs.
22504301 PLD acts as an important regulator in Bcl-2 expression by activating STAT3 involving the phosphorylation of Ser727 through the PLA(2)/G(i)/ERK1/2, RhoA/ROCK/p38 MAPK, and Rac1/p38 MAPK pathways.
22484426 Describes the development of humanized mouse model of MYC/BCL2-driven 'double-hit' lymphoma. By engrafting human HSCs transduced with the oncogene combination into immunodeficient mice, we generate a fatal B malignancy with complete penetrance
22464442 mechanism of proapoptotic BH3 proteins Bad and Bid binding to Bcl-XL and Bcl-2 in breast cancer cells
22462654 Loss of Bcl-2 is associated with estrogen receptor positive breast cancer patients treated with adjuvant endocrine therapy.
22446832 survivin and Bcl-2 may act synergistically in the occurrence, development, invasion and metastasis of non-small cell lung carcinoma (NSCLC), both of which are up-regulated in NSCLC tissues
22433870 novel roles for CAV1 variants in cell death; wtCAV1 promotes cell death, whereas CAV1beta promotes cell survival by preventing inactivation of BCL2 and BCLxL via JNK in paclitaxel-mediated apoptosis.
22418857 BCL2 was a powerful independent prognostic factor for breast cancer and had a strong influence on the current prognostic models.
22414090 Studies indicate overexpression of Bcl-2 family proteins has been implicated in both pathology and drug resistance in various tumors, and Bcl-2 antagonists were shown to potentiate efficacies of established drugs for combination anticancer therapy.
22406486 It may be possible on the basis of staining of follicular lymophoma to predict that the t(14;18) translocation is absent if it is either negative for BCL2 protein with different antibodies or has heterogeneous BCL2 expression.
22395515 Bcl-2 may have a role in breast cancer response to endocrine therapy
22395508 analysis of P53, Bcl-2 and Ki67 immunoexpression in follicular solid ameloblastomas
22395507 Bcl-2 and CD5 are associated in non-Hodgkin lymphoma of head and neck and may be markers of poor prognosis, while Bcl-6 is positive especially in the tumor forms associated with the predominance of small cells and is a marker of favorable prognosis
22393362 BCL-X(L) and BCL-2 but not FLIP(L) acts in synergy with MYC to drive AML development
22372356 Bcl-2 expression was strong and homogeneous in normal (proliferative, secretory and atrophic) endometrium and more frequent in low-grade endometrioid carcinomas.
22367371 evaluation of the role of apoptotic BCL-2 and TP53 genes in contributing to the phenotypic manifestation of c.521delT mutation in limb girdle muscular dystrophy type 2C patients
22366766 EBP50 gene transfection promotes 5-fluorouracil-induced apoptosis in gastric cancer cells through Bax- and Bcl-2-triggered mitochondrial pathways.
22366560 Establish BCL2 as a promising drug target in neuroblastoma.
22322190 BCL2 expression by CD105(+) neoangiogenic endothelial cells is related to tumor progression in angioimmunoblastic T-cell lymphoma.
22320961 Bcl2 genotypes were marginally associated overall with breast cancer risk.
22309998 Increased Ki-67 and bcl-2 expression plus density of new vessels are of prognostic value for disease outcome in medulloblastoma.
22293115 Bcl-2 is a target gene for miR-125b
22285729 miR-181a could play a role in the development of DNR resistance in K562/A02 cells and the over-expression of miR-181a could sensitize K562/A02 cells to DNR by targeting BCL-2
22278385 the reduction in the Bax/Bcl-2 ratio by AS-IV in our in vitro Parkinson's disease (PD) model may be the result of the suppression of upstream regulators of Bax or Bcl-2
22277792 Report apoptosis along with BCL-2 and Ki-67 expression in individuals with intestinal metaplasia, chronic active gastritis, and normal gastric mucosa.
22275374 The CCACCTCT motif dictates RAG nicking at the minor breakpoint cluster region of BCL2.
22275372 first evidence of Nrf2 in control of Bcl-2 expression and apoptotic cell death with implications in antioxidant protection, survival of cancer cells, and drug resistance.
22262057 IKK appears to directly interfere with Bcl-2 activity through phosphorylation in HNE-mediated apoptosis independent of NF-kappaB signaling
22252757 BCL-2 expression was significantly more frequent in early clinical stages in both types of endometrial cancer
22219597 Data show that insulin resistance is strictly linked to serum Bcl-2 values, which were higher in fatty liver than in nonalcoholic steatohepatitis patients.
22207524 Data show that MiR-181d may act as a glioma suppressor by targeting K-ras and Bcl-2.
22199279 analysis of expression of the apoptosis-related genes Bcl-2 and p53 in clinical samples from endometrial carcinoma patients
22198673 Bcl-2 rs956572 SNP may modulate cognitive function and regional GM volume in non-demented elderly men, and that this polymorphism may affect language performance through its effect on the right MTG.
22194861 EZH2 mutations constitute an additional genetic "hit" in many BCL2-rearranged germinal center B cell lymphomas.
22194596 a novel role for alphaSNAP in promoting epithelial cell survival by unique mechanisms involving regulation of Bcl-2 expression and Golgi biogenesis
22189900 BCL2 mutations are associated with diffuse large B-cell lymphoma.
22187149 the -938A/A genotype of BCL2 gene is associated with susceptibility of esophageal cancer.
22174832 Human embryonic stem cells express elevated levels of the pro-apoptotic BH3-only BCL-2 family members.
22174682 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
22171982 Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner.
22160209 The miR-143 suppressed the activity of a luciferase reporter carrying the 3'-UTR of Bcl-2, which was abolished by mutation of the predicted miR-143-binding site, indicating that Bcl-2 is a miR-143 target gene.
22143957 The level or activity of Bcl-2, brain-derived neurotrophic factor, and the activities of superoxide dismutase and glutathione peroxidase are decreased in autism.
22143931 The distinct correlations of p53 and Bcl-2 with disease progression and aggressiveness (being influenced by the extent of staining and tumor site) may be clinically useful in the determination of high-risk colorectal cancer cases
22139839 miR-155 and miR-125b, which are induced by CD154 and stromal cell signals, contribute to regulating proliferation and that BCL2 is one of their target mRNAs.
22138435 Data show that ABT-737, a small molecule inhibitor of Bcl-2, Bcl-X(L), and Bcl-w, significantly induced apoptosis in HTLV-1 infected T-cell lines as well as in fresh adult T-cell leukemia/lymphoma (ATLL) cells
22121083 Taken together, our findings suggest that miR-1915 could play a role in the development of MDR in colorectal carcinoma cells at least in part by modulation of apoptosis via targeting Bcl-2
22120515 Bcl-2 (-938 C>A) polymorphism indicated to play a protective role in susceptibility to papillary thyroid carcinoma (PTC).
22109662 Treatment of cells with millimeter wave radiation significantly induced loss of mitochondrial membrane potential, upregulated proapoptotic Bax, caspase-9 and caspase-3, but did not significantly change levels of antiapoptotic Bcl-2.
22097606 The increased expression of Bcl-2 is not induced by viral LMP1 in lung cancer patients.
22081075 for optimal tumor suppressive activity, Bim must be able to interact with all and not just select pro-survival Bcl-2 family members
22072615 microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2.
22065578 the diterpenoid compound induces a structural and functional conversion of Bcl-2 through Bim to permeabilize the mitochondrial outer membrane, thereby inducing apoptosis independently of Bax and Bak.
22059351 decrease in expression in B-chronic lymphocytic leukemia correlates with clinical features in patients
22054286 Bortezomib may overcome the prognostic effect conferred by overexpression of some of the anti-apoptotic Bcl-2 family of genes in patients with relapsed/refractory multiple myeloma.
22038727 a progression to increased androgen sensitivity accompanies bcl-2 suppression in LNCaP cells
22038216 Data suggest that COX-2 and Bcl-2 may potentially be useful prognostic markers for primary fallopian tube carcinoma.
22037714 MDR1, MRP1 and BCL-2 have potential clinical relevance in adult patients with acute leukemia in the context of induction chemotherapy.
22024950 Bcl-2 expression was significantly up-regulated in prostate tumors with aggressive phenotype as indicated by high Gleason score, advanced stage, and high proliferation index.
22022968 The production of Bcl-2 by Mycobacterium tuberculosi infected monocytes is mediated by mitogen-activated protein kinases and NF-kappaB.
22020994 BNIP1-induced mitochondrial fission and the translocation of Drp1 were abrogated by Bcl-2 overexpression
22014978 Estrogen receptor-regulated microRNAs contribute to the BCL2/BAX imbalance in endometrial adenocarcinoma and precancerous lesions.
22002575 B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21) appear to behave as poorly as MYC/BCL2 lymphomas, possibly expanding the disease spectrum.
21989054 results show that aberrant Notch-1 activation, Bcl-2 overexpression and increased cell survival are likely to play a crucial role in neoplastic transformation associated with E-cadherin impairment
21988644 Results show that lenti-TRAIL-shBcl-2 induced apoptosis in bystander cells as well as infected lymphoma cells and inhibited the growth of lymphoma cells.
21979585 41 cases of ovarian serous carcinomas were evaluated by immunohistochemistry for VEGF, p53, and bcl-2 expression.
21978692 The relationship between up-regulation of p53 and Bcl-2 and poorly differentiated ethmoidal adenocarcinoma suggests a role of these genes
21971866 non-small cell lung cancer cells were protected from apoptosis through increasing Bag3 expression and consequently promoted the expression of Bcl-XL and Bcl-2.
21956116 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
21949016 Regulatory T cells (Tregs) from Bcl-2 transgenic mice can suppress the proliferation of conventional T cells that are resistant to apoptosis or regulated necrosis without the use of conventional programmed cell death pathways.
21940310 Hh pathway is aberrant activation in colorectal carcinoma cell line. Its inhibitor may be effectual agent for colorectal cancer chemoprevention. Gli1 maintained cell survival by binding promoter regions and facilitating transcription of IGFBP6 and Bcl-2.
21936874 this work unveiled a mechanism for the induction of Bcl-2 in lymphatic endothelial cells and suggested that endothelial cell Bcl-2 contributes to lymph node metastasis in patients with oral squamous cell carcinoma.
21933893 Data indicate that the prognostic significance of BCL2 has changed after inclusion of rituximab in the treatment protocol and is observed in germinal center B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL).
21914345 Bcl-2 expression in diffuse large B-cell lymphoma was closely related to the gene amplification and NF-kappaB activation. Bcl-2 positive patients had more short overall survival times.
21907236 Fluazinam-induced apoptosis of SH-SY5Y cells is mediated by accumulation of TP53, reduced levels of Bcl-2 and increased levels of Bax.
21901143 Knockdown of cellular Bcl-2 by lentivirus-delivered small hairpin RNA (shRNA) resulted in increased cell apoptosis and decreased virion production in KSHV-infected cells.
21890444 the expressions of p53, c-MYC, BCL-2 protein and apoptotic index could be used as potential biomarks for predicting the progression and prognosis of osteosarcoma
21878650 ethanol-induced neuronal apoptosis follows both the mitochondria-mediated (miR-497- and BCL2-mediated) and non-mitochondria-mediated (miR-302b- and CCND2-mediated) pathway.
21868312 The apoptosis-inducing effect of Caspase-8 was a dominant feature in the cartilage pathology of Kashin-Beck disease compared to the apoptosis-suppressing effect of Bcl-2.
21861179 Data suggest that the joint detection of these three genes (Beclin1, Bcl-2, and Bax) contributes to the early diagnosis of and predicts prognosis for breast cancer.
21855110 In our series, BCL-6 breaks were infrequent in BCL-2-negative follicular lymphoma.
21850486 Bcl-2 gene transcription is regulated by Ap2alpha-Rb complex binding to the Bcl-2 promoter.
21841772 H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERalpha ligand dependency
21819468 evaluted gene expression in primary tooth pump with root resorption and control permanent teeth; bcl-2 mRNA level was incipient and similar between groups
21808961 A significant decrease in Bcl-2 expression was observed(p = 0.015), as well as an inverse association between Bcl-2 and p53 expression (p < 0.0001).
21793937 results suggest that the high expression of BCL2 in patients with tongue carcinoma indicates that intrinsic drug resistance may exist in tongue carcinoma, and is associated with tumor differentiation and cisplatin resistance in tongue carcinoma.
21785112 Data indicate that NGA could increase the expression of the apoptosis-related proteins FasL, caspase-3, caspase-8, caspase-9, and Bax and decrease the expression of anti-apoptotic protein Bcl-2 accompanied by the mitochondrial transmembrane damage.
21778226 AITC-induced Bcl-2 phosphorylation was caused by c-Jun N-terminal kinase (JNK), and AITC activates JNK
21777944 Our results establish the value of using Bcl-2 in prognostic stratification of patients and its potential therapeutic implications in selecting patients for treatment.
21772052 A highly significant BCL-2 expression index for predicting the response of chronic lymphocytic leukemia to ABT-737.
21771706 siRNA of Pokemon was applied to inhibit the expression of Pokemon and NF-kappa B p65 and apoptotic rate was determined by flow cytometric analysis
21753125 specific suppression of the apoptosis inhibitor BCL-2 in prostate cancer cells does not affect non-targeted BAX or caspase 3 expression
21748764 We report functional and structural interactions between Bcl-2 and the transcription factor Twist1 in the relationship with metastasis and vascular mimicry in hepatocellular carcinoma.
21748337 The expression of PHD genes and their relationship with the tumor behavior and apoptosis-associated factors in non-small cell lung cancer, was investigated.
21738398 The expression levels of PCNA, Ki-67, Bcl-2 and mP53 are significantly increased in the pterygium samples as compared to the normal conjunctiva samples.
21729540 The expression of BCL-2 protein was down-regulated in K562 cells treated with Clostridium difficile toxin A.
21717192 Data indicate that the induction of apoptosis appears to occur through the upregulation of Fas/FasL and Bax, downregulation of Bcl-2.
21713707 Expressions of COX-2 and BCL-2 are non-specific in the transitional mucosa at the distal rectum adjacent to rectal carcinoma.
21708043 Apoptosis was blocked by the pan-caspase inhibitor, ZVAD, and in HeLa cells stably expressing the anti-apoptotic protein, Bcl-2.
21706237 transcription of BAX and BCL-2 mRNAs in central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL)of the jaw; increased expression was found in both PGCL and CGCL; giant cells are probably the main source of these events
21704150 A C to T polymorphism in a putative miRNA target site of BCL2 was significantly conspicuous for the aberrant SNP allele in cancer tissues.
21682651 andrographolide induces apoptosis via inhibiting NF-kappaB-induced bcl-2-mediated survival signaling and modulating p53-induced caspase-3-mediated proapoptotic signaling.
21680733 Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway.
21674599 Increased expression of Bad, Bax, and decreased ratios of Bcl-2/Bax, Bcl-2/Bad suggest increased apoptotic activity or sensitivity to induction of apoptosis in vaginal tissues of women with pelvic organ prolapse.
21669575 Injectable Coix lacryma-jobi seed extract did not influence Bcl-2 expression in hepatocellular carcinoma cells.
21659544 Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cells.
21658611 The deregulated expression of BCL2 appears to play a key role in the development of follicular Non-Hodgkin Lymphoma and may thus be a promising target in the treatment of this lymphoma.(Review)
21640710 MiR-365 potentiates ox-LDL-induced endothelial cells apoptosis by regulating the expression of Bcl-2.
21640157 Data suggest that Bcl-2 is a better therapeutic target than c-Myc, but attacking both Bcl-2 and c-Myc would be an even more effective treatment strategy for diffuse large B-cell lymphomas.
21628855 Translocation of the BCL2 gene on the chromosome band 18q21.3 and MYC translocation to 14q32/IGH or less commonly to 2p11/IGK in an identical cell is termed BCL2 and MYC dual-hit lymphoma/leukemia[review]
21624464 Up-regulation of Bcl2-A1 by mutant superoxide dismutase (SOD)1 is mediated by activation of the redox sensitive transcription factor AP1; Bcl2-A1 interacts with pro-caspase-3 via its carboxyl-terminal helix alpha9.
21622563 GRP78 can decrease BCL-2 sequestration by BIK at the endoplasmic reticulum
21621926 Negative expression of bcl-2 correlated with poorly differentiated breast carcinomas, as well as with positive expression of p53 and Ki-67.
21618512 Data suggest a regulation pathway of B-cell-lymphoma-2 (Bcl-2) by cisplatin, via the activation of PKC and Akt2, which has impact on resistance to cisplatin-induced apoptosis in endometrial cancer cells.
21589877 expression of Bcl-2 depends on cellular differentiation and can be either pro- or anti-apoptotic. Bcl-Xl, on the other hand, exhibits an anti-apoptotic activity under all conditions
21560252 Concurrent IGH/BCL2 and MYC rearrangements are associated with non-Hodgkin lymphoma.
21560251 Concurrent IGH/BCL2 and MYC rearrangements are associated with B-cell lymphomas.
21556123 ll patients with co-overexpression of bcl-2 and c-myc oncogenes will have PVU invasive carcinoma
21518495 BAFF and BCL-2 may be involved in occurrence and development of multiple myeloma.
21508398 Overexpression of BCL-2 is associated with poor response to paclitaxel-based lung cancer chemoradiation.
21506333 Evaluating the activity of the apoptosis-regulating genes from Bcl-2, Bax expression, and caspase-3 activity in bronchial epithelial cells in patients with asthma
21483469 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
21474673 Rac1 to inhibit intracellular superoxide production as well as overcome Bcl-2-mediated drug resistance in human leukemia cells and cervical cancer cells.
21463514 study provides evidence for role of miR-24-2 in guiding H2AFX gene expression in the background of the differential status of gene copy number; study identifies antiapoptotic gene BCL-2 as a cellular target of miR-24-2 and provides mechanistic insight into the apoptotic induction caused by miR-24-2 overexpression
21457555 AA genotype of BCL-2 (-938C > A) is associated with susceptibility of breast cancer, and this genotype is only associated with the nodal status and pathological diagnosis of breast cancer
21455217 miR-148a can posttranscriptionally silence Bcl-2
21454712 Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells.
21448217 Cerebrospinal fluid Bcl-2 and cytochrome C levels are elevated in adults after severe traumatic brain injury.
21444675 Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes
21442307 Inhibition of Bcl-2 and XIAP has a non-linear effect on sensitization towards apoptosis in leukemia and lymphoma cells.
21434524 Bcl-2 expression is supported by the KIT pathway and that its imatinib-mediated down-regulation contributes to autophagic cell death in gastrointestinal stromal tumors
21424069 The purpose was to correlate markers expression of apoptosis (p53 and bcl-2) and cell proliferation (Ki-67 and PCNA) with histological indicators of tumor severity.
21412927 This is the first report that shows the involvement of both BCL2L1 and the transcription factor BACH2 in a chromosomal rearrangement.
21393866 hypoxic tumor cell are sensitized to BH-3 mimetic-induced apoptosis via downregulation of the Bcl-2 protein Mcl-1
21388911 EGFR, like Bcl-2 and p53, was significantly up-regulated in tumors from elderly patients.
21385902 Data show that PrLZ elevated the phosphorylation of Akt and Stat3 and upregulated Bcl-2 expression.
21380782 High BCL2 is associated with colorectal adenocarcinoma.
21376256 Data show that upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis, chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells.
21358617 In this study, the authors show that AMBRA1 binds preferentially the mitochondrial pool of the antiapoptotic factor BCL-2, and that this interaction is disrupted following autophagy induction.
21336967 mdr1 expression enhanced radiation-induced apoptosis in HepG2 cells, SK-HEP-1 cells, MiHa cells, and furthermore, induced miR-16 and suppressed its target gene Bcl-2 in HepG2 cells.
21320534 A molecular model of the experimentally observed Bcl-2 homomeric complex has been developed.
21320251 genetic variation in Bcl-2 affecting its expression impacts intracellular calcium homeostasis in bipolar disease; this interactive effect is diagnostically specific to bipolar disease-1
21317312 The Bcl-2 family of proteins is crucial for airway epithelial homeostasis.
21289092 Data suggest that the binding of Galectin 7 to Bcl-2 may constitute a new target for enhancing the intrinsic apoptosis pathway.
21258880 miR-497 could play a role in both gastric and lung cancer cell lines at least in part by modulation of apoptosis via targeting BCL2
21250804 The CC genotype of the regulatory BCL2 promoter polymorphism was a survival prognosticator among patients with glioblastoma multiforme who underwent gross-total resection.
21233846 bcl-2 regulates HIF-1-mediated VEGF expression does not require BH1 and BH2 domains, and it is independent of antiapoptotic and prosurvival function of bcl-2.
21223758 Paeoniflorin can significantly induce the apoptosis of HeLa cells through a down-regulation of anti-apoptotic gene Bcl-2 and an up-regulation of pro-apoptotic genes Bax and Caspase-3.
21212266 BCL-2 is an essential mediator for the cancer-specific cell survival function of ATF5 in glioblastoma and breast cancer cells
21207420 We conclude that the BCL2 -938C>A polymorphism is an independent predictor of relapse-free and overall survival in patients with prostate cancer.
21203533 Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells
21199860 Over-expressing BCL2 ameliorates muscle weakness in a mouse model of oculopharyngeal muscular dystrophy.
21174060 RC-RNase-induced cell death of ER-positive breast tumors is through regulation of ER and Bcl-2.
21171016 antiapoptotic gene Bcl-2 enhances tumor formation in a PDGFB-dependent model system of oligodendroglioma.
21167476 in patients with bipolar disorder, abnormal Bcl-2 gene expression contributes to dysfunctional Ca(2+) homeostasis through a specific ER inositol 1,4,5-trisphosphate receptor-dependent mechanism.
21159314 conclude that BCL-2 gene polymorphism at codon 43 (127G/A) is a new biological marker to potentially identify responders and non-responders of HCV genotype 4 patients to achieving a sustained virological response to treatment with IFN with ribavirin
21151158 VAV1 protects Jurkat cells from apoptosis by promoting Bcl-2 transcription through its guanine nucleotide exchange factor activity.
21148799 Bcl-2 regulates the balance of survival versus apoptosis in peripheral T cells undergoing recombination-activating gene (RAG)-dependent T cell receptor rearrangements during TCR revision, thereby ensuring the utility of transgenic postrevision repertoire.
21148306 The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.
21131755 BCL-2 gene expression showed a significant correlation with FAS, while such a correlation was not observed between BCL-2 and TP53 in breast cancer patients
21130495 Data indicate an inverse correlation between miR-16-1, miR-181a, miR-181b, and level of expression of TCL-1 and BCL-2, which suggest that these miRNAs may implicate in negatively regulating target mRNA at transcriptional level.
21122152 Glioma cell apoptosis induced by boron neutron capture therapy may be related to activation of Bax and downregulation of Bcl-2.
21117871 the expression of anti-apoptotic factor Bcl-2 and Survivin in transferred HepG2 cells and evaluate the synergistic effect of IFN-gamma gene on LIGHT-induced apoptosis signal transduction pathways
21115898 Increased frequency of expression of BCL2 is associated with steatohepatitis.
21110823 Bcl-2 targeted-therapy for the treatment of head and neck squamous cell carcinoma.
21108607 p53 and p16INK4a proteins and bcl-2 oncoprotein correlate with the proliferative index and tumor thickness in malignant skin melanoma
21107291 BCL-2 -938CC genotype is associated with small cell lung cancer
21104343 The protein expression of Bcl-2 was downregulated, while that of Bax was markedly upregulated in maxillofacial squamous cell carcinomas.
21090097 Abnormal expression of Bcl2, Bax and PKC in nasal polyp tissues might play an important role in the occurrence and progression of nasal polyps.
21076048 B1 overcomes the resistance conferred by Bcl-2 in human promyelocytic leukemia HL60 cells
21072044 both Lmo2 and Bcl-2 are required for the action of E2A-HLF in leukemogenesis
21068757 Axl promotes cutaneous squamous cell carcinoma survival through negative regulation of pro-apoptotic Bcl-2 family members.
21067292 L-arginine could reduce the expression of Bax, and enhance the expression of bcl-2, which may be associated with reduced placental apoptosis and improved placental function and fetal development.
21061795 Bcl-2 (B-cell CLL/lymphoma 2 apoptosis regulator) expression was 20% in normal cervical tissue, 42.9% in CIN grade II, then dropped to 33% in invasive disease. Bcl-2 was not expressed in patients with advanced disease
21060336 apoptotic activity of the BAX variant could not be restrained by BCL-2 and BCL-w, pointing that the observed tight interactions are critical for regulating BAX activation
21029589 Di-(2-ethylexyl) phthalate could induce apoptosis of cytotrophoblast cells by increasing bax gene expression, but had no effect on Bcl-2 expression.
20981461 The reason for the aggressive behaviour is the overexpression of pro-proliferative (MYC) and anti-apoptotic (BCL2, BCL6) oncoproteins at the same time.
20976415 Bcl-2 is expressed by cutaneous granular cell tumors.
20969490 We found that down-regulation of Bcl-2 which is mediated by NF-kappaB activation may be the underlying mechanism of apoptosis in H. pylori-infected gastric epithelial cells.
20962079 We show that HIV-1 infection induced a proapoptotic profile in blood mDCs, defined as reduced Bcl-2 expression and increased frequencies of caspase-3+ mDCs in a subset of subjects that was associated with viral replication.
20959405 Observational study of gene-disease association. (HuGE Navigator)
20952062 this is the first report that describes variant rearrangements of IGH/BCL2 genes associated to atypical FISH patterns in follicular lymphoma
20951945 Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1, and ICAM1 in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.
20936988 In early rheumatoid arthritis, the rate of apoptosis and p-53-immunostaining intensity were low, and Bcl-2-immunostaining intensity was high. The sFas level in synovial fluid was high.
20929131 Matrine can dose- and time-dependently inhibit the proliferation of PA-1 cells by reducing the bcl-2/bax mRNA ratio.
20929130 Pseudolaric acid B can inhibit proliferation and induce apoptosis of Hela cells by upregulating Bax and downregulating Bcl-2.
20929126 After UVB treatment, Bcl-2 levels increased and casp3 and survivin levels decreased in patients with psoriasis vulgaris, restoring expression to near-normal.
20890735 Survival analysis showed that BCL2 expression was positively correlated with patients survival in a breast carcinoma cohort.
20889974 parkin mono-ubiquitinates Bcl-2 and regulates autophagy via Bcl-2.
20885445 The anti-autophagic property of Bcl-2 is a key feature of Bcl-2-mediated oncogenesis.
20877624 Observational study of gene-disease association. (HuGE Navigator)
20869096 No association of tumor necrosis with expression of p53, bcl-2, and mismatch repair protein status was observed in colorectal cancers.
20855536 Observational study of gene-disease association. (HuGE Navigator)
20841355 Phosphorylated alphaB-crystallin interacts with Bcl-2 and prevents the translocation of Bcl-2 to mitochondria.
20836993 Bcl-xL can substitute for the loss of Mcl-1 whereas Bcl-2, incapable of forming a high affinity complex with Bak, could not.
20822926 Data indicate that the expression of Bax mRNA was up-regulated, while the expression of Bcl-2 and survivin were decreased in both cell lines following zinc treatment.
20732674 Bcl-2 expression had following pattern: strong in proliferating cells, moderate in tooth germs and dental crest and weak in ectomesenchyme. Bcl-2 in the tooth germ and dental crest; in reticulum and inner enamel epithelium
20723300 Bortezomib can inhibit the proliferation and induce the apoptosis of CA46 cells, which may involve the reduction of BCL-2 and the activation of caspase 3.
20723294 The mechanisms by which crocin induced apoptosis in HL-60 cells may be related to the inhibition of bcl-2 and activation of bax.
20716950 both cancer and non-cancer cells, BCL2 can form a complex with actin and gelsolin that functions to decrease gelsolin-severing activity to increase actin polymerization
20716276 This review describes a novel mechanism of Bcl-2 regulation by reactive species of superoxide anion and nitric oxide which provide a new dimension of involvement in apoptotic cell death and cancer development.
20699221 Results suggest that end joining in cancer cells could be negatively regulated by the anti-apoptotic protein, BCL2, and this may contribute toward increased chromosomal abnormalities in cancer.
20691103 Low BCL-2 is associated with lymph node metastasis and chemosensitivity in breast carcinoma.
20683843 Taspine can inhibit the proliferation of, and induce apoptosis in, A431 cells by activating caspase-3 expression and up-regulating the ratio of Bax/Bcl-2.
20668868 expression higher in carcinomatous components than in sarcomatous components ofuterine cervical carcinosarcoma
20668552 Study identified the stabilization of HIF-1alpha protein as a mechanism through which bcl-2 induces the activation of HIF-1 in hypoxic tumour cells involving the beta isoform of molecular chaperone HSP90.
20668314 BCL-2 expression measured by PCR in tsticular cancer cells is as effective as a monospecific oligonucleotide against BCL-2 expression.
20664977 RON-targeted siRNA could be therapeutically efficacious by inducing cell apoptosis through the modulation of the NF-kappaB and Bcl-2 family in gastric cancer cells.
20658730 Overexpression of Bcl-2 may play an important role in cervical carcinogenesis.
20652449 eIF4E siRNA increased Bax/Bcl-2 ratio in a breast cancer cell line
20648653 Down-regulation of the brain-derived neurotrophic factor (BDNF)-Akt-Bcl2 antiapoptotic signaling pathway in the autistic brain could be one of the underlying mechanisms responsible for the pathogenesis of autism.
20644561 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20631638 High Bcl-2 is associated with squamous cell carcinoma in non-small cell lung cancer.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20627094 HCV patients (with cirrhosis and ascites) had a statistically significantly low Bcl-2 expression, a significantly high Bax expression and a significantly decreased Bcl-2/Bax ratio
20610805 A single nucleotide polymorphism protects against azoospermia by influencing the balance of pro- aand antiapoptosis in spermatogenesis in a Han Chinese population.
20610805 Observational study of gene-disease association. (HuGE Navigator)
20608924 Bcl-2 protein was immunolocalized in the cytoplasm of syncytiotrophoblast. Bcl-2 expression was significantly higher at term cases than in first and second trimester cases.
20594261 Bcl-2 overexpression protected hepatic stellate cells against oxidative stress but it did not induce replicative senescence and may play a role in the progression of liver fibrosis.
20584903 Bcl-2 binds Bax through two interdependent interfaces to inhibit the pro-apoptotic oligomerization of Bax.
20571027 the degradation of bcl-2 mRNA induced by AS1411 results from both interference with nucleolin protection of bcl-2 mRNA and recruitment of the exosome by AUF1.
20564216 Findings indicate that PARP-1 is a component of BCL2 37 mbr-protein complexes, and PARP-1 is involved in the regulation of BCL2 expression.
20530713 ARTN increased BCL2 expression by transcriptional upregulation, and inhibition of BCL2 abrogated the oncogenic properties of ARTN in non-small cell lung carcinoma cells.
20518070 Bcl-2 overexpression prevents odontoblast apoptosis and impairs dentin formation, partially via an inhibition of odontoblast differentiation
20514538 mRNA expression levels of BCL2 may represent a novel unfavorable and independent tumor biomarker for nasopharyngeal carcinoma.
20504155 genetic variability for pro-survival proteins, particularly genetic variation in the BCL2 gene, impacts outcomes after severe traumatic brain injury
20504155 Observational study of gene-disease association. (HuGE Navigator)
20503275 BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1
20495005 Akt prevents the translocation of BRCA1 to DNA damage foci and, thereby, inhibits the activation of Chk1 following DNA damage
20468060 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20460269 Mutant SOD1 induces mitochondrial morphological changes and compromises mitochondrial membrane integrity leading to release of Cytochrome C only in the presence of Bcl-2.
20459695 Bcl-2 expression defines a subgroup of patients with a favorable outcome and may be useful for prognostic stratification of non-small cell lung cancer patients.
20459572 In low-grade lymphomas, including those that are transformed, Bcl-2 expression is lost when cell proliferate.
20453000 Observational study of gene-disease association. (HuGE Navigator)
20448381 Increase Bcl-2 expression is associated with oral squamous cell carcinoma.
20442586 High BCL2 is associated with high-grade ovarian serous carcinomas.
20434805 Alterations of the p53 and Bcl-2 proteins occur during the development of recurrent laryngeal and pharyngeal ssquamous cell carcinoma.
20423844 Kidney-Tonifying plus Blood-Promoting Recipe regulates CD11b/CD18 and Bcl-2/Bax expression in blood leukocytes and improves microcirculatory status in aged patients with kidney deficiency and blood stasis syndrome.
20423464 Bcl2 expression did not differ between smokers with/without chronic obstructive pulmonary disease.
20416158 Docetaxel induces apoptosis of HL-60/ADR cells, decreases the expression of BCL-2 protein and increases the expression of BAX protein.
20415745 PUVA-induced apoptosis in MF cases may occur through pathways other than bcl-2 inhibition.
20411301 Lactoferrin exploits the control mechanism of E2F1-regulated target genes or Bcl-2 family gene networks involved in the apoptotic process in Jurkat human leukemia T lymphocytes.
20409521 Bcl-2 had no significant correlation with all the clinical and pathologic factors in colon cancer. There was a positive correlation between Bag-1 and Bcl-2 in the development of colon cancer.
20404322 Mitochondrial p53 functions as a Bim derepressor by releasing Bim from sequestrating complexes with Mcl-1, Bcl-2, and Bcl-XL, and allowing its engagement in Bak/Bax activation.
20401641 This study investigated the expression of Cox-2, Survivin and Bcl-2 in hepatocellular carcinoma.
20399529 increased level of expression in autistic lymphoblasts
20392693 analysis of selectivity of MCL-1 in binding BCL-2 homology 3 (BH3) ligands of interest for mammalian biology
20382751 Although Bcl-2 overexpression is able to prevent hyperoxia-induced cell death at single cell level in vitro and ex vivo, it is not sufficient to prevent cell death of parenchymal cells and to protect the lung from acute damage in mice.
20368567 Postinduction BCL2/IgH major break point status is not useful for decisions on subsequent therapy for patients with relapsed/resistant follicular lymphoma.
20368071 The expression of survivin and bcl-2 in cervical intraepithelial neoplasia stage III were obviously higher than those in stage I/II.
20352700 in quiescent human fibroblasts cytomegalovirus regulates mitochondrial apoptosis at the level of bcl-2 gene transcription, exerting both pro- and anti-apoptotic effects.
20352431 BCL2 expression (and P53) are found to be unfavorably associated with survival in extranodal non-Hodgkin's lymphoma.
20350212 This study suggests that some somatic mutations of the translocated BCL2 gene may prevent epitope recognition by BCL2 antibodies
20340172 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
20307495 these results showed that hypoxia induces Bcl-2 expression in human aortic endothelial cells via p38 MAPK pathway.
20237496 Observational study of gene-disease association. (HuGE Navigator)
20233885 Independent of HPV status, pretreatment Bcl2 expression identifies a subset of oopharyngeal squamous cell carcinoma patients having increased risk of treatment failure, particularly through distant metastasis, after concurrent chemoradiation.
20223826 screened the entire Bcl-2 network for its involvement in DNA damage-induced apoptosis in HeLa cells
20200776 Bcl-2 expression in skin biopsy cells was significantly higher in the controls than in type 2 diabetics
20198332 PKCepsilon regulates Bcl-2 induction through activation of the transcription factor CREB in breast cancer cells.
20193114 Expression of MRP2 and Bcl-2 was significantly higher in esophageal squamous cell carcinoma than in normal mucosa.
20189983 Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling.
20189848 study showed that 34betaE12 is the most appropriate negative marker to combine with alpha-methylacyl coenzyme A racemase as a positive marker for the diagnosis of prostate adenocarcinoma[34betaE12]
20189848 we suggest that keratin 5/6 and bcl-2 should not be used to identify benign glands in prostate biopsy
20181625 There is no statistically significant association between the expression of Bcl-2 and overall survival or relapse of patients with laryngeal cancer.
20180421 Polypeptide K237 may induce apoptosis of PC-3M cells by affecting the expressions of bax and bcl-2, and thus suppress the proliferation of prostate cancer cells.
20178647 Data suggest that modulation of Bcl-2 with 13-cis retinoic acid/interferon-alpha2b with paclitaxel or mitoxantrone, estramustine and vinorelbine will have clinical activity in men with metastatic castrate-resistant prostate cancer.
20177797 High Bcl-2 expression is associated with colorectal polyps from women with breast cancer.
20160358 BCL2, BCL6 expression, and BCL2/IGH translocation had no impact on overall survival in adult, diffuse large B-cell lymphoma patients
20157331 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20146885 A mathematical model was developed which combined coded staining intensity data for Bcl-2 and silver-stained nucleolar organizing regions, as markers of proliferation, and for p53, as a marker of apoptotis.
20142237 colorectal microadenoma showed high levels of Caspase-3 active and low levels of Bcl-2 expression
20140889 Elimination of the Ca(2+)-binding capacity by substitution of the respective aspartate residues in a D92N/D94N double-substituted variant reduces the Bcl-2 affinity of the FKBP38(35-153)/CaM complex
20139069 FKBP38 is a key player in regulating the function of Bcl-2 by antagonizing caspase-dependent degradation through the direct interaction with the flexible loop domain of Bcl-2, which contains the caspase cleavage site
20132430 H. pylori VacA p58 (vacuolating cytotoxin A p58 domain) induced apoptosis in gastric epithelial carcinoma cells and was associated with the up-regulation of Bax/VDAC1 (voltage-dependent anion channel 1) and the downregulation of Bcl-2
20128283 Bcl-2 may play a synergic role with Survivin in progression of sinonasal inverted papilloma.
20118770 Double-hit lymphoma with concurrent IGH-BCL2 and MYC rearrangments is a high-grade B-cell neoplasm with a poor prognosis, resistance to multiagent chemotherapy, and clinical and pathologic features distinct from other high-grade B-cell neoplasms.
20090905 unlike Bcl-2, Bcl-xL and Atg7 manipulation gave identical phenotypes suggesting they could be components of the same signalling pathway; Bcl-xL subcellular localisation was modified upon starvation, and importantly Bcl-xL acted independently of Beclin 1
20087644 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20082279 Association of the AA genotype of the BCL2 (-938C>A) promoter polymorphism with better survival in ovarian cancer.
20082279 Observational study of gene-disease association. (HuGE Navigator)
20072652 Data show that LLL12 inhibited STAT3 phosphorylation, induced apoptosis as indicated by the increases of cleaved caspase-3 and poly (ADP-ribose) polymerase, and also downregulated cyclin D1, Bcl-2, and survivin at both protein and messenger RNA levels.
20068093 ERBB2 influences the expression of Bcl-2 family members to induce an antiapoptotic phenotype.
20048149 Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL
20045442 Data show that EriB inhibited lymphoma cell proliferation and induced apoptosis in association with caspase 3 activation, and reduced Bcl-2/Bax and Bcl-xL/Bax ratios.
20042890 The expression of Bcl-2 was lower in melanomas than in benign melanocytic tumours
20036222 Bcl-2 expression represents an important and easily assayed prognostic factor in nasopharyngeal carcinoma, and it may play an important role in lymph node metastasis
20034411 results suggest that B-cell leukaemia/lymphoma gene-2 (BCL2) expression is strongly associated with the ability of oocytes to complete nuclear maturation and to be fertilized
20032416 BCL2- and BCL6-translocations correlate with particular phenotypes of follicular lymphomas. BCL6-translocations seem to affect the phenotype only when they are not accompanied by BCL2-translocations.
20025478 The decreased detection of active caspase-3 and ssDNA and the increased presence of Bcl-2 in T1 carcinomas suggest that alterations in interrelated apoptosis markers may play an important role in the progression of urothelial carcinoma.
20023428 Interplay between Beclin 1 and Bcl-2 is required for both autophagy and apoptosis modulation.
20012528 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
20010695 NAF-1 is a BCL-2-associated co-factor that targets BCL-2 for antagonism of the autophagy pathway at the endoplasmic reticulum.
20010526 patients with Gleason scale > 8 prostate cancer were characterized by the highest nuclear expression of p53, p16INK4a and Ki-67, and also by overexpression of cytoplasmic Bcl-2.
20001236 BCL-2 and CD71 have roles in apoptosis, cell proliferation, and progression of ZAP-70 negative chronic lymphocytic leukemia
19996270 Data show that small interfering RNA against JNK1, but not JNK2, exhibited similar effects to JNK inhibitors that reduced the protein levels of c-Myc and Bcl-2.
19968497 Observational study of gene-disease association. (HuGE Navigator)
19956635 Uncategorized study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19940548 Data show that the detection of both p53 and Bcl-2 proteins in cervical smears can be used as independent diagnostic marker for early-stage HPV-associated cervical cancer.
19938958 ERalpha expression and Bax/Bcl-2 ratio were similar in fresh and cryopreserved ovarian tissue
19938012 Downmodulation of Bcl-2 sensitizes metastatic LNCaP-LN3 cells to undergo apoptosis via the intrinsic pathway.
19937732 Phospholipase A(2) (PLA(2)) from Naja naja atra venom induced Bcl-2 degradation in human leukemia K562 cells
19931389 effects of progesterone metabolites on cell proliferation, mitosis, apoptosis and expression of Bcl-2, Bax and p21
19925052 Studies illustrated tools for cut-off level determination with prognostic tumor-related biomarkers Bcl-2, Bcl-6, CD10, FOXP1, MUM1, and Cyclin E in DLBCL.
19913121 Observational study of gene-disease association. (HuGE Navigator)
19908860 The complementary polypyrimidine-rich strand of bcl-2 promoter is capable of forming one major intramolecular i-motif DNA secondary structure with a transition pH of 6.6.
19895735 Fe3O4-magnetic nanoparticles down-regulates bcl-2 and survivin in ovarian carcinoma cells.
19890662 Observational study of gene-disease association. (HuGE Navigator)
19890377 WAVE1 regulates Bcl-2 localization and phosphorylation in leukemia cells.
19883311 Data show that genotypes were not associated with time to first treatment (TFT) and overall survival (OS) in univariate or multivariate analysis.
19883311 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19854241 Our current finding of decreased Bcl-2 and increased capase-3 in the cerebellum of autistic subjects further supports the suggestion that increased apoptosis may be involved in the pathogenesis of autism
19846939 The Bcl-2/bax ratio is increased in grade 3 tumors. Bax protein shows a strong tendency for expression in the third group of clinical staging (stage IIb, III and IV). Poorly differentiated tumors highly expressed mutated p53.
19838163 Correlation of LDH-5 expression with clinicopathological factors and with the expression of Bcl-2, Bcl-XL, Mcl-1 and GRP78 was examined in pigmented lesions, including nevi and melanoma at different stages of progression
19834492 Data show that Bcl-2 expression positively influences the targeting of nuclear-encoded COX Va and Vb to the mitochondria of cancer cells.
19823588 analysis of structural and functional similarity between the bacterial type III secretion system needle protein PrgI and the eukaryotic apoptosis Bcl-2 proteins
19818125 expression of Bcl-2 solely at mitochondria, the ER, or the cytosol/nucleus did not prevent ceramide-mediated caspase-independent programmed cell death
19813621 Inhibiting the pore-forming and anti-Bax activities of Bcl2 in the membrane is strongly correlated with pro-apoptotic function in cells.
19798108 Results indicate that Coxiella burnetii infection modulates autophagy and apoptotic pathways through Beclin 1/Bcl-2 interplay to establish a successful infection in the host cell.
19797069 The Clostridium difficile TcdA toxin-induced cell death is regulated by antiapoptotic members of the Bcl-2 family.
19789190 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19786087 This study reported that apoptosis induced by esculetin was markedly blocked by Bcl-2-overexpression, but restored by HA14-1 in U937 cells; this suggests a novel strategy for increasing esculetin sensitivity in Bcl-2-overexpressing leukemia cells.
19783718 Cases of Diffuse Large B Cell Lymphoma of the non-GC type with BCL2 gene aberration are accompanied by a significantly worse prognosis as opposed to cases without such gene abnormalities.
19774948 p53(+)bcl-2(-) phenotype is significantly correlated with the basal cell-like subtype and may be associated with the biologic aggressiveness of this cohort of molecular breast cancer.
19774677 Our current findings, suggesting decreased levels of PSD95, NR2A, and LRP-1, with elevated levels of caspase-3 and Bcl2 proteins, may reflect or contribute to neuronal and synaptic loss in the amnestic mild cognitive impairment hippocampus
19773279 Observational study of gene-disease association. (HuGE Navigator)
19762066 Beclin-1 may play a role in the inhibition of the development of breast cancer and its inhibition might be due to an interaction with bcl-2 protein.
19752028 Stx1 toxin also activated prosurvival signaling through increased expression, mitochondrial translocation, and alternative phosphorylation of Bcl-2.
19737931 Interference with Puma induction or expression of MCL1 or BCL2 significantly reduced both glucocorticoid- and FAS-induced cell death in p16INK4A-reconstituted leukemia cells.
19730103 Studies indicate that downregulation of Bcl-2 and restoration of a critical apoptotic pathway in cancer cells remains an important strategy.
19725224 High Bcl-2 in combination with CD13 antigen expression is associated with adult acute lymphoblastic leukemia.
19724860 Overexpression of Notch1 in laryngeal carcinoma cell line was coupled with the downregulation of bcl2
19723066 Results indicate and support the hypothesis that the apoptosis-related genes BCL2 and BCL2L12 respond similarly to treatment.
19723039 Results show that no striking relationship was found in expression patterns of p53, Bcl-2, caspase-3, and Fas.
19717648 C/EBPbeta directly bound to the promoter region of IRF4, BLIMP1, and BCL2.
19706527 Data show that the BH4 domain mediates interaction of Bcl-2 with the inositol 1,4,5-trisphosphate (IP3) receptor on the endoplasmic reticulum.
19676105 Data show that p53-independent curcumin-induced apoptosis in ovarian carcinoma cells involves p38 MAPK activation, ablation of Akt signaling, and reduced expression of the antiapoptotic proteins Bcl-2 and survivin.
19671677 HuR seems to play a positive role in both regulation of bcl-2 mRNA translation and mRNA stability.
19664395 Upregulation of survivin in non-small cell lung cancer is associated with its neoplasm staging and correlated with p53 and Bcl-2 level.
19656156 in patients with diffuse large B-cell lymphoma (DLBCL) treated with cyclophosphamide, vincristine, doxorubicin, and prednisolone the high expression of Bcl-2 was associated with worse overall survival
19655415 Data show that magnolol inhibited H2O2-induced expressions of caspase-9 and caspase-3 and reduction of Bcl-2/Bax ratio.
19636371 Observational study of gene-disease association. (HuGE Navigator)
19634687 Oligomerization of Bcl2 is likely involved in mitochondrial outer membrane pore formation.
19627536 These parameters identify the role of ADM expression and Bcl-2 protein in relation to cell growth and vasodilating in the neoplastic changes.
19625133 HGF is a potent inhibitor of cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 through both autocrine and paracrine Epstein-Barr virus-independent pathways.
19620938 HSP70 expression in effusions may be a prognostic marker of poor survival, with a similar role for Bcl-2 in primary carcinomas.
19605509 the potential of oblimersen to lower Bcl-2 mRNA in breast cancer.
19602458 An immunohistochemical and molecular study of the BCL2, MKI67, and CCND1 genes in Synovial sarcoma (SS) was performed. The high level of BCL2 mRNA correlated with a high level of CCND1 mRNA, but not with MKI67 mRNA level.
19597184 Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival.
19589501 Genetic variation in the Bcl-2 gene modulates Grey Matter volume in areas known to play key roles in the neurobiology of reward processes and emotion regulation and in the pathophysiology of mood disorders.
19589501 Observational study of gene-disease association. (HuGE Navigator)
19585117 Data show that oroxylin A enhanced 5-FU-induced apoptosis by elevating the expressions of apoptotic-inducing proteins P53 and cleaved PARP and decreasing the expression of apoptotic-inhibitory proteins COX-2, Bcl-2, and pro-caspase3.
19582475 Gambogic acid induced human breast cancer cells MCF-7 apoptosis by reducing bcl-2 expression via p53.
19576799 Data suggest taht a better understanding of the Bcl-2/VEGF pathway may ultimately lead to the development of novel therapeutics that can synergistically target both tumor blood vessels and tumor growth.
19573080 Observational study of gene-disease association. (HuGE Navigator)
19560836 expression predicts chemoradiotherapy outcome in non-small cell lung cancer patients
19557638 Bcl-2 is targeted by Bcl-2 homology 3 mimetic ABT-737 in Hodgkin lymphoma
19556603 Hexavalent chromium-transformed cells evaded apoptosis by a mechanism involving S-nitrosylation and stabilization of Bcl-2 protein in a nitric oxide-dependent manner.
19550126 Results show that the short-term remission rate was significantly higher in patients with positive expression of Bcl-2.
19549844 These results identify an important function for BCL6 in facilitating apoptosis of germinal center B cells via suppression of BCL2, and suggest that blocking this pathway is critical for lymphomagenesis.
19541585 Observational study of gene-disease association. (HuGE Navigator)
19540934 data suggest that, in oxidative stress-induced cardiomyocyte apoptosis, PPARgamma protects cells from oxidative stress through upregulating Bcl-2 expression
19539330 Observational study of gene-disease association. (HuGE Navigator)
19537891 The bcl-2 gene rearrangement is quite frequent in follicular lymphoma, followed by diffuse large B-cell lymphoma. The commonest breakpoint in present series is icr followed by mbr.
19535901 When Beclin 1 binds to Bcl-2, it fails to inhibit Bcl-2-mediated protection against four different inducers of apoptosis.
19535347 BCL2 and MYC translocations have a role in dual-hit lymphoma/leukemia
19520857 HuR knockdown reduced the expression of endogenous bcl-2, whereas unexpectedly, a bcl-2 ARE{(AU)-rich elements} -reporter transcript increased significantly, suggesting that HuR expression has opposite effects on endogenous and ectopic bcl-2 ARE.
19520430 AML patients with the BCL2 +21 AA genotype had a significantly longer median LFS (p<0.001) or EFS (p=0.004), and OS (p=0.04
19520430 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19495739 nuclear positions of BCL2 alleles & chromosome 18 territories in neoplastic & nonneoplastic cervical squamous epithelium; results suggest a functional relevance of unequal allelic BCL2 gene positioning
19484260 study demonstrates that late tumour stages of Kaposi sarcoma in tissues from HIV-positive patients are associated with high levels of LANA-1, HIF-1alpha and of the anti-apoptotic proteins, Bcl-2 and Mcl-1
19477129 Our findings indicate that the major apoptotic protein Bcl-2 might have a hitherto unrecognized role in the protection of normal muscle.
19475409 Treatment with active matabolite of vitamin D (1alpha,25-dihydroxyvitamin D3) down-regulates BCL2 mRNA expression.
19473442 present results of the immunoprofile of OKCs (that includes the expression of the SHH-related proteins and the SHH-induced bcl-2 oncoprotein) further support the notion of OKC having a neoplastic nature
19460716 The expressions of PCNA and Bcl-2 proteins increased significantly in the lymphocytes of patients with oral lichen planus.
19453261 Observational study of gene-disease association. (HuGE Navigator)
19452318 T(reg) cells in CLL may accumulate both by increased formation, facilitated by CD27-CD70 interaction in the lymph node proliferation centres, and decreased sensitivity to apoptosis because of a shifted Noxa-Bcl-2 balance
19448593 The expression of CD10, Bcl-6, MUM1/IRF4, Bcl-2, and FOXP1 was determined immunohistochemically from 88 samples of diffuse large B-cell lymphoma patients treated uniformly with R-CHOP
19429088 bcl-2 is a key regulator in TRAIL-Daidzein mediated cell death in malignant glioma.
19417623 present in patients with higher clinical stages of chronic lymphocytic leukemia
19404232 Bcl-2, hpGH and CRH are down regulated in the small for gestational age group in comparison to the control group.
19398149 the short isoform of c-FLIP and bcl-2 are key regulators in TRAIL-Myricetin mediated cell death in malignant glioma.
19395874 DAPk phosphorylates Beclin 1 on T119, a critical residue within its BH3 domain, and thus promotes Beclin 1 dissociation from Bcl-X(L) and autophagy induction.
19390575 Observational study of gene-disease association. (HuGE Navigator)
19385591 the prevalence of CD44+ tumour cells as a subpopulation of breast cancer stem cells was of no clinicopathological significance, but was correlated with higher Bcl-2 expression
19380879 Results suggest that Puma is competent to trigger Bax activity by itself, thereby promoting cellular dependence on prosurvival Bcl-2 family members.
19379569 Gambogic acid can inhibit the growth of MUTZ-1 cells by inducing apoptosis and down-regulating the expression of bcl-2.
19360919 Data show that exogenous phosphatidylethanolamine induces apoptosis of human hepatoma HepG2 cells via the bcl-2/Bax pathway.
19351886 the ability of Bcl-2 to protect cells from activated Bak depends on two important contextual variables, the identity of the Bcl-2 present and the amount expressed
19351510 Data show there were significant changes of Bcl-2, caspase-3 mRNA and caspase-3 activity; while no changes of bax was found.
19348791 Results describe the expression pattern of p53, BCL-2 and epidermal growth factor receptor proteins in the hydatidiform moles.
19336552 Observational study of gene-disease association. (HuGE Navigator)
19318089 JNK activation essential for the autophagic cell death resulted in upregulation of Beclin-1 expression, Bcl-2 phosphorylation, and p53 phosphorylation, suggesting that these pro-autophagic signaling pathways are involved in the autophagic cell death.
19298794 CA repeats in the 3'UTR of bcl-2 mRNA interact with hnRNP L in vitro and in vivo; this physical association is partially involved in the decay of bcl-2 mRNA.
19287965 Bcl-2 and caspases are key regulators of apoptosis in response to anthocyanins in human leukemia U937 cells
19287190 This study indicates that phosphatidic acid acts as an important mediator for increasing Bcl-2 expression through STAT3 (Ser727) activation via the ERK1/2 MAPK pathway.
19280241 The over-expression of the anti-apoptotic protein Bcl-2 was against oxidation due to its effect on the redox potential, should protect cells from apoptosis starting in mitochondria.
19276283 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19272801 Findings suggest that quantitative methylation analysis of BCL2 and hTERT, but not DAPK, in urine sediment may be a useful tool in the diagnosis of NMI UCB, deserving future applicability studies.
19269343 Results indicate that Bcl-2 is an integral component of the mitotic chromosome.
19266703 peripheral blood mononuclear cells from healthy subjects and from AD patients expressed Bcl-2, Bax, and caspase-3 to about the same extent
19260506 expression of bcl-2 in chronic hepatitis B, C & hepatocellular carcinoma (HCC); no causative relation between bcl-2 positivity & HCC can be implied
19253527 Compared with control group, the expression of OX40 and Bcl-2 was significantly higher in allergic rhinitis.
19250983 EGFR activation by H pylori infection has an antiapoptotic effect in gastric epithelial cells that appears to involve Akt signaling and Bcl family members.
19240654 bcl-2 expression is prognostic for improved oversal survival and disease-specific survival in non-small cell lung carcinoma (NSCLC).
19238538 Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells.
19237173 Observational study of gene-disease association. (HuGE Navigator)
19228691 Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect
19205434 endoplasmic reticulum stress moculates Bcl-2 protein content uterine leiomyomas cultured cells
19196738 The (-938C>A) SNP represents a potential novel prognostic marker in patients with OSCC that could help to identify a group of patients at high risk for relapse and death.
19196738 Observational study of gene-disease association. (HuGE Navigator)
19195736 contributes to drug resistance in small cell lung carcinoma
19168699 Bcl-2 is an essential mediator of IL-6 cytoprotection from oxygen toxicity. Bcl-2 blocked the dissociation of Bak from mitofusion protein Mfn2 and inhibited the interaction between Bak and Mfn1.
19160418 the nongenomic effects of estrogen initiated from plasma membrane by E2-BSA cannot lead to transcriptional effect of Bcl-2 expression.
19157504 Among the 112 patients with urothelial carcinoma of the upper urinary tract 62 (55.4%)had altered expression of bax
19152170 Bcl-2 negative germinal centre patients had the most favourable prognosis among patients with diffuse large B cell lymphoma that received R-CHOP
19141860 Observational study of gene-disease association. (HuGE Navigator)
19141121 expression of Bcl-2 and FOXP1 is associated with the non-germinal center phenotype, but only Bcl-2 expression continues to be of prognostic significance in DLBCL patients treated with immunochemotherapy
19138978 Trends suggested down-modulation of cyclooxygenase-2 and Ki-67 in some tissues, increased pAKT-Ser473 expression, and an inverse relationship between PGE(2) and BCL2 expression.
19124070 These observations indicate that Bcl-2 confers apoptosis resistance to naringenin by inhibiting a mitochondrial amplification step in U937 cells.
19107861 Bcl-2 can regulate tumoral angiogenesis and lymphangiogenesis in human prostate cancer cells.
19107575 Overall, chronic exposure to matrilysin did not significantly alter the growth rates of A549 cells. A certain range of matrilysin might protect tumor cells from cisplatin-medicated death. The underlying mechanism may due to the Bcl-2 overexpression.
19107326 Up regulation of GADD-153, GRP-78, with more pronounced expression in proliferative glomerulonephritis(GN) vs. nonproliferative GN and down regulation of Bcl-2 proteins was observed in the GN as compared to minimal change disease
19080514 Apoptosis may play an important role in the pathogenesis of fetal growth restriction and may be related to reduced expression of bcl-2.
19074885 Observational study of gene-disease association. (HuGE Navigator)
19064571 Observational study of gene-disease association. (HuGE Navigator)
19060592 Serum bcl-2 was significantly higher in patients with ovarian cancer.
19058789 Observational study of gene-disease association. (HuGE Navigator)
19050681 Expression of p53, BCL-2 and Ki-67 was upregulated in clinically localized prostate cancer compared with benign prostate tissue, with no alteration in E-cadherin expression.
19048366 Human neuroblastoma CHP126 cells were employed to investigate hypoxia-induced upregulation of VEGF and Bcl-2 expression.
19035131 Bcl-2 is downregulated in placentas of preeclampsia.
19027288 The loss of Bcl-2 expression appears to be correlated with increase in number of relapses in the stage II colon cancers.
19020723 Bcl-2 and bcl-xL have roles in cell death rates in transitional cell carcinoma cell lines
19002577 Bcl-2 overexpression may alter the functional interactions among signaling pathways that regulate cell survival in response to antiestrogens
18998362 No significant association of bcl-2 expression with either overall survival or disease free survival was found in women with breast cancer.
18985814 Bcl-2 expression significantly correlates with thymidylate synthase expression in colorectal cancer patients.
18983973 The resistance of E-cadherin over-expressing cells to staurosporine may due to the up-regulation of Bcl-2/Bax ratio. When E-cadherin interference plasmids were transfected into MCF-7 cells, Bcl-2 expression was down-regulated.
18957415 PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells.
18949393 microsatellite instability Colorectal cancer patients with low Bcl-2 and hMLH1 and hMSH2 demonstrate a significantly shorter disease-free survival.
18940474 BCL2 or BCL3 are recurrent translocation partners of the IGH locus in cHL (classical Hodgkin lymphomas).
18929412 BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation
18928590 Hedyotis diffusa wild injection suppresses Bcl2 and survivin expression which inhibits the growth of HL-60 cells.
18928588 Treatment of KG-1 cells with Resveratrol increased apoptosis, downregulated Bcl2 and upregulated Bax.
18928586 Bortezomib inhibited the proliferation of SHI-1 cells. Bcl2l12 mRNA expression was up-regulated, bcl-2 mRNA expression was down-regulated and bax mRNA expression was not changed.
18838868 slow growth of BCL2 overexpressing immortalized breast cell line, with expression of CDC25A and CDC42 protein.
18835031 Report the identification of a Nur77-derived Bcl-2-converting peptide with 9 amino acids (NuBCP-9) and its enantiomer, which induce apoptosis of cancer cells in vitro and in animals.
18818203 BCL2 and BCL-xL facilitation of G0 quiescence requires BAX, BAK, and p27 phosphorylation by Mirk
18813857 Immunohistochemistry using antibodies to determine the protein expression of Fas, Fas-L, Bax, Bcl-2, p53 and c-Myc in skin of venous ulcer patients.
18806751 Higher expression of BCL2 is associated with minimal residual disease.
18788571 The expression of AQP8 protein is positively correlated with bcl-2 protein in human cervical carcinoma.
18769121 radiation sensitizers like BrdU enhance and modify radiation-induced cell death by accelerating an increased bax/bcl-2 ratio in unirradiated c
18769111 A speculative model for understanding the interrelationship between autophagy and apoptosis regulated by JNK1-mediated Bcl-2 phosphorylation was proposed.
18758641 A direct relation between the rise of tumoral proliferation index expressions of Bcl-2 and progression of the disease.
18758240 These data indicate that, in cell culture models, autophagy occurs but is not required for entrance into quiescence or for the G(0) function of BCL-2 or BCL-x(L).
18752503 Aberration tends to have an adverse effect on survival of adult diffuse large B-cell lymphoma patients.
18727869 Dimethylformamide can induce apoptosis of cultured adult normal hepatocytes in vitro by reducing expression of Bax and Bcl2 and cleaving casp3.
18719108 identifies the interaction sites of Bcl-2 and its homologues with ASPP2
18712678 Describe bcl-2 expression in developing pituitary gland.
18705844 expression & distribution of Bax & Bcl-2 molecules in term, pre-term & post-term placentas; Bax/Bcl-2 ratio was higher in both pre-term & post-term placental samples compared with term placentas
18695940 Data show that overexpression of anti-apoptotic Bcl-2 significantly increases the level of endogenous reduced glutathione, thus presrving cytoskeletal stability after metabolic stress in cells with defective respiratory complex I.
18695675 Oct-2 and its cofactor Bob-1 have an important function in mediating the IgH enhancer-bcl-2 promoter region interactions
18692524 The survival-promoting effect of CXCL12 was mediated by the up-regulation of Bcl-2 protein expression and the concomitant down-regulation of Bax protein expression
18687309 There is a strong correlation between Bcl-2 levels and resistance to Fas-mediated apoptosis.
18675369 Data show that caspase-8 participates in an anoikis-inducing process in MG-63 cells at an early time, and overexpression of Bcl-2 blocks activation of caspase-8 making MG-63 cells anoikis resistant.
18664350 Radix notoginseng extracts may inhibit the proliferation and promote the apoptosis of precancerous gastric cells through altering expressions of the bcl-2, Bax and p21WAF1 genes.
18657507 The interaction of Bcl-2 with IP3Rs contributes to the regulation of proapoptotic Ca2+ signals by Bcl-2.
18653721 GATA-4 influences granulosa cell fate by transactivating Bcl-2.
18652313 Cucurbitacin B inhibited cell proliferation and induced apoptosis of Hep-2 cells by suppressing the STAT3 signal pathway, and down regulating the expression of cyclin B1 and Bcl-2 proteins.
18651163 Bcl-2 expressions decreased immediately after marathon running, but increased in the 24 h later.
18636124 Observational study of gene-disease association. (HuGE Navigator)
18633450 We show that Bcl-2 can position on the outer cell surface membrane of B cells from patients with chronic lymphocytic leukemia (B-CLL) and certain other leukemias that do not classically possess the chromosomal breakpoint t(14;18).
18622426 A novel fusion 5'AFF3/3'BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma.
18595518 There was no correlation of survivin and Bcl2 expression in laryngeal and hypopharyngeal cancer.
18594472 Sometimes expressed in dysmorphic neurons in focal cortical dysplasia type II.
18573594 Methyl jasmonate suppressed the radiation-induced Bcl-2 expression and enhanced the radiation sensitivity of human prostate cancer cells.
18572327 Report relationship of Ki67, TP53, MDM-2 and BCL-2 expressions with WHO 1973 and WHO/ISUP grades, tumor category and overall patient survival in urothelial tumors of the bladder.
18570871 Bcl-2, binds to Beclin 1 during nonstarvation conditions and inhibits its autophagy function by phosphorylation of cellular Bcl-2 at residues T69, S70, and S87 of the nonstructured loop.
18568946 Antiapoptotic activities of BCL2 correlate with vascular maturation and transcriptional modulation of endothelial cells.
18568776 Report correlation between expression of Bcl-2 and drug resistance in glioblastomas.
18568671 was no difference in the expression of EGFR, p185(erbB-2) or Bcl-2, or in nuclear accumulation of p53 in these IDC from pre- vs. post-menopausal women.
18566606 Data show that the worm protein EGL-1 binds mammalian pro-survival proteins very poorly, but can be converted into a high-affinity ligand for Bcl-2 and Bcl-x(L) by mutation of the cysteine residue at position 62 within the BH3 domain.
18561741 Progression of neoplasia in the uterine cervix is accompanied by an increase of antiapoptotic protein, bcl-2 as well as cellular proliferation.
18543286 Results indicate that HBSP interacts with Bcl-2/Bcl-xl in vitro and induces apoptosis in HepG2 cells.
18538438 among gastrointestinal MALT lymphomas, t(14;18)-(IgH;Bcl-2) translocation clusters in hepatitis C-positive patients sustaining the role of HCV infection in the lymphoma development
18534994 BCL-2 was detected from week 12 to 17 and became undetectable thereafter in the developing human ovary.
18534064 in patients with chronic myeloid leukemia, Antiapoptotic bcl-2(B-cell lymphoma protein 2) protein increased significantly with the progression of the disease
18516673 Bcl-2 expression is highly associated with an increased risk of local recurrence in patients with early stage breast cancer
18516322 Bcl-2 cannot be considered a predictive factor in colorectal adenocarcinoma.
18510726 meta-analysis strongly supports the prognostic role of BCL2 in breast cancer & shows this effect is independent of lymph node status, tumour size & tumour grade as well as a range of other biological variables on multi-variate analysis [meta-analysis]
18508827 haem oxygenase-1 plays a central role in NNK-mediated cell proliferation by promoting the expression of p21(Cip1/Waf1/Cid1), inhibitor of apoptosis protein 2 and B-cell lymphoma-2 but inhibiting the activity of Bad
18505729 Apolipoprotein L1 is a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death
18493992 Compared to published adult DLBCL studies, pediatric DLBCL demonstrated increased c-Myc protein expression (84%)and decreased Bcl2 protein expression (28%)
18478476 Positive expression rate of Bcl-2 was correlated with multiple drug-resistance of tumors.
18472157 Prolonged hypoxia-reoxygenation caused the most severe villous apoptotic changes, increased the expression of Bax and Bak mRNA and protein and reduced the expression of Bcl-2 mRNA.
18468253 Bcl-2 augmentation protected renal tubular epithelial cells from ischemia reperfusion injury, and subsequent interstitial injury by inhibiting tubular apoptosis
18465329 p53 was not associated with survival after radiotherapy in high-risk breast cancer, but BCL2 might be.
18458532 The role of Bcl-2 in the sustained phosphorylation of c-Jun-N-terminal kinase mediating melanoma apoptosis induced by 2-acetyl furanonapthaquinone is reported.
18450493 Data show that DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis.
18438339 Bcl-2 was better expressed in MCF-7 cells, while it was almost undetectable in T47D cells.
18430249 Bcl-2 expression in breast tumors is associated with improved outcome and steroid receptor positivity.
18428028 insulin-like growth factor 2 differentially regulated the intracellular translocation of Bcl-2
18427947 data suggest that HPV16 infection is correlated with bcl-2 expression in breast carcinoma
18426731 we found a substantial number of primary diffuse large B-cell lymphomas (DLBCLs) of bone cases with a rearrangement of BCL2 and c -MYC
18415689 The distribution of the bcl-2, bax and caspase-3 proteins was investigated in the cells of developing human spinal ganglia.
18415681 It is concluded that P. aeruginosa can induce apoptosis with an up-regulated expression of Bax and a down-regulated expression of Bcl-2, which resulted in increased levels of cytochrome c release and increased caspase-3 and -9 in human U937 cells.
18411730 accumulation of bcl-2 in the syncytiotrophoblast may reflect its high resistance to detrimental factors.
18410632 Bcl-2 is expressed in dermal lymphocytes in lichen planus and psoriasis vulgaris.
18407350 the presence of Bcl-2 in the proteome of cells has multiple effects on agonist-mediated Ca2+ signals, and can abrogate responses to submaximal levels of stimulation through direct control of inositol 1,4,5-trisphosphate receptors.
18398703 BCL-2 expression was not correlated with any known histological factors in endometrial carcinoma
18386458 in endometrial carcinoma Bcl-2 (B-cell lymphoma protein 2) expression was related with younger age, favorable grade and Progesterone receptor expression by tumor cells
18382371 EBV is not related to the overexpression of Bcl-2 and c-Myc (nuclear) in gastric carcinomas.
18375822 Overexpression of bcl-2 is associated with mantle cell lymphoma
18367485 chromosome region 18q21 gain including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma
18363112 our study demonstrates increased concentrations of VEGF and Bcl-2, but not MMP-3, in serum of melanoma patients
18357521 Our current study demonstrated that Bcl-2 siRNA significantly augmented taxol mediated apoptosis in different human glioblastoma cells through induction of calpain and caspase proteolytic activities.
18343029 important mechanistic insights related to Bcl-2-mediated resistance to SP600125-induced apoptosis, and induction of G2/M phase arrest and endoreduplication.
18342927 this is another negative report on the prognostic value of bcl-2 in bilharzial bladder tumors.
18334006 this study has found bcl-2 of no value as a prognostic marker in this group of serous ovarian tumors
18327814 Hyperexpression of BCL2 is associated with gliomas
18314333 BCL-2 proteins induce mitochondrial outer membrane permeabilization
18313386 Data show that Bcl2 suppresses DNA double-strand-break (DSB) repair and V(D)J recombination by downregulating Ku DNA binding activity, which is associated with increased genetic instability.
18279996 TAT-IkappaBalphaSR reduced NF-kappaB dependent transcription, Bcl-2 expression and promoted Jun-N-terminal kinase-dependent apoptosis in human and rat hepatic myofibroblasts.
18263880 Bcl2 inhibition of AP site repair may occur in a novel mechanism by down-regulating APE1 endonuclease activity, which may promote genetic instability and tumorigenesis.
18248353 overexpression acts as a strong antiapoptotic in both squamous cells and adenocystic carcinoma
18240345 Results describe the interrelationship between H pylori and Epstein-Barr virus infection in gastric carcinogenesis, focusing on p53 mutation and c-Myc, Bcl-2 and Bax expression.
18228020 CD34+ leukemic subpopulation predominantly displays lower spontaneous apoptosis and has higher expression levels of Bcl-2(B-cell CLL/lymphoma 2) genes than CD34- cells in childhood AML
18220834 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
18215418 data reveal that high cellular concentrations of Bcl-2 lead to a calcium- and ROS-dependent induction of death.
18203018 Clinical and histological differences between BCL2-/BCL6+ and BCL2+/BCL6+ tumours could reflect an interplay between both translocations.
18199533 t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism.
18189268 Sanguinarine-mediated apoptosis is blocked by ectopic expression of Bcl-2 and cFLIPs
18182854 substitution of C-terminal tail or tail & adjacent loop of Bcl-2 with equivalent regions from Bak or Bax mutant resulted in association with mitochondria. change in subcellular localization of Bcl-2 chimeras triggered cells to undergo apoptotis
18178565 distinctions in the behaviors of Bcl-B and Mcl-1 relative to the other anti-apoptotic Bcl-2 family members, where Bcl-B and Mcl-1 display reciprocal abilities to bind and neutralize Bax and Bak.
18174230 Observational study of gene-disease association. (HuGE Navigator)
18162459 In thyroid glands of patients with Graves disease the regulation of Fas/Fas ligand/Bcl-2 favors apoptosis of infiltrating lymphocytes.
18160396 cancer mutations induce APC mitochondrial localization and that APC regulation of Bcl-2 at mitochondria may contribute to tumor cell survival.
18158619 Id-1 regulates Bcl-2 and Bax expression through p53 and NF-kappaB in MCF-7 breast cancer cells
18156504 genetic variation due to ethnicity may influence prognostic value in chronic lymphocytic leukemia
18091321 study shows bcl-2 is occasionally expressed in pancreatic endocrine tumors
18079751 IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of BCL2, BCL-X(L), and survivin
18073527 In T lymphoma cells, STS induces the expression of the pro-apoptotic orphan receptor Nur77 that overcomes the anti-apoptotic effect of Bcl-2, thus enabling GCinduced apoptosis.
18063429 data indicate that in early and advanced gastric tumors, p53 and bcl-2 protein accumulation is more intense in gastric mucosa adjacent to advanced tumors and p53 immunoreactivity peaks in advanced carcinomas
18059532 These findings suggest that downregulating CIAPIN1 could sensitize leukemia cells to chemotherapeutic drugs by downregulating MDR-1 and Bcl-2 and by upregulating Bax.
18055344 BCL2 translocation is essential for the pathogenesis of follicular lymphoma in Thai patients
18046541 In human K562 cells, induction of apoptosis by sorbitol involves pro- and anti-apoptotic Bcl-2 family proteins.
18046449 GCs induce both pro- and anti-apoptotic BCL2 family member-dependent pathways, with the outcome depending on cellular context and additional signals feeding into the BCL2 rheostat.
18046447 our data do not support the use of the (-938C>A) BCL-2 polymorphism as a prognostic marker in CLL and argue against its postulated role in modulating Bcl-2 levels.
18041310 Alterations in the expression of p53, survivn, and bcl-2 take place in a concerted fashion, implying that many of these cases may share common abnormalities.
18037229 sHA 14-1 antagonizes anti-apoptotic Bcl-2 proteins and may represent a promising candidate for the treatment of drug-resistant cancers.
18026954 BP1 may regulate bcl-2 and c-myc expression
18023359 IL-10 modulated the pro-apoptotic capacity of TNF-alpha in chondrocytes as shown by the decrease in caspase activities and bax/bcl-2 ratio
18021997 Expression of antiapoptotic Bcl-2 protein occurs during the entire heart posttransplant period, being probably a preservative and adaptative response.
18006836 silencing of PrPc facilitates the activation of proapoptotic Bax by down-regulation of Bcl-2 expression, thereby abolishing the resistance of breast cancer cells to TRAIL-induced apoptosis
17989874 After the addition of 20 microg/ml DDP or 100 microM DADS, siRNA targeting of the Bcl-2 gene specifically down-regulated gene expression in A549/DDP cells, increased spontaneous apoptosis, and sensitized cells to DDP and DADS.
17981569 bcl2 and Caspase-3 have roles in Shikonin analogue (SA) 93/637 induced apoptosis of human U937 cells
17978676 Diabetic human conjunctiva, with its inflammatory and cicatricial phenomena, is a privileged target for BCL2 protein apoptotic cell death.
17960583 BCL2 functions as an activator of the AKT signaling pathway in pancreatic cancer.
17959858 BCL2 protein levels in CLL reflect a complex interplay of transcriptional and posttranscriptional controls, but do not appear to be associated with the -938C>A promoter SNP.
17957472 study concludes that the nuclear and mitochondrial intracellular pools of Bcl-2 are regulated through different mechanisms & only the cytokine-mediated regulation of the mitochondrial pool is relevant to the control of the initiation of apoptosis
17942410 interaction between the catalytic FKBP38 domain and the N-terminal CaM domain activates FKBP38 and, as a consequence, also regulates Bcl-2.
17936584 Gastrins activate members of Rho family G proteins which in turn regulate different proteins of the Bcl-2 family leading to changes in caspase 3 activity.
17920946 Bcl-2 over-expression prevented a number of DENSPM-induced apoptotic effects.
17916073 COX-2 and Bcl-2 may promote phaeochromocytoma malignancy, and these oncoproteins may be valuable surrogate markers of an aggressive tumour phenotype.
17913397 These data suggest that P1 promoter is the main driving force for transcribing the bcl-2 gene and P1 activity is modulated by M and P2 in a p53-dependent and -independent manner.
17912028 This study aimed to explore, whether polymorphisms in BCL2, Cyclin D1, FAS, EGF and EGFR genes affect survival in a cohort of patients with squamous cell esophageal cancer treated with CT+RT with a view to identify the potential therapeutic targets.
17912028 Observational study of gene-disease association. (HuGE Navigator)
17909078 a novel link between TLR4 and a calcium-dependent signaling cascade comprising CaMKIV-CREB-Bcl-2 that is essential for DC survival.
17909067 Observational study of gene-disease association. (HuGE Navigator)
17908970 Observational study of gene-disease association. (HuGE Navigator)
17908970 the AA genotype of the BCL2 (-938C>A) single-nucleotide polymorphism may play a role in increased survival in lymph node-negative breast cancer patients
17905238 Report modulation of the BCL-2/BAX ratio by interferon-gamma and hypoxia in human peritoneal and adhesion fibroblasts.
17893875 Epo has a role in reducing expression of apoptosis-related proteins Bcl-2 and Bcl-10 in ovarian cancer cells
17893147 a caspase-9 signaling cascade induces feedback disruption of the mitochondrion through cleavage of anti-apoptotic Bcl-2, Bcl-xL, and Mcl-1
17882791 p38 is necessary for Bcl-2-induced inhibition of apoptosis, induction of cell cycle arrest and accelerated senescence after DNA damage and serum starvation, but not after nocodazole treatment.
17880809 We conclude that alteration in the expression of proapoptotic (Bax, Bak) and antiapoptotic (Bcl-2, Bcl-XL) proteins on surface of thyroid follicular cells may play a role in the pathogenesis of thyroid autoimmune disorders.
17852408 IFN-alpha sensitivity of B-cell lymphomas depends on the presence or absence of BCL
17848408 overexpression of Bcl-2 may result in "oncogene addiction" of the cancer cell
17848143 p53 and Ki-67, but not bcl-2, cyclin D1 or HER-2 may have roles in the process of tumor genesis in non-small cell lung carcinoma
17825790 Therefore, these data support the hypothesis that CREB plays a critical role in the regulation of Bcl-2 expression in TCS-induced Hela cell death.
17785460 Study demonstrates that PKCepsilon forms a signaling complex and acts co-operatively with Akt to protect human vascular endothelial cells against apoptosis through induction of the anti-apoptotic protein Bcl-2 and inhibition of caspase-3 cleavage.
17785366 progesterone via progesterone receptor interacts with the bcl-2 promoter to induce its expression in leiomyoma tissue
17727680 results suggest that Fli-1 contributes to the malignancy of human breast cancer by inhibiting apoptosis through upregulated expression of the bcl-2 gene.
17713095 p53 expression may have a role in the carcinogenesis of squamous cell cervical carcinoma whereas Bcl-2 expression has no role. Ki-67 expression can not be used in determining the aggressiveness of CIN lesions
17701916 bcl-2 and p53 expression in neuroblastoma is related to DNA fragmentation
17693666 Risk for head and neck squamous cell carcinoma may be assocated with single-nucleotide polymorphism in the promoter region.
17693666 Observational study of gene-disease association. (HuGE Navigator)
17675494 Bcl-2 up-regulation is a homeostatic survival mechanism necessary for the manifestation of immunomodulatory effect of estrogen on human macrophages.
17670745 a novel role for BAD in cell cycle regulation dependent upon its phosphorylation state and independent of the BAD/BCL2 interaction and apoptosis.
17666167 Impaifred kinetics of Bax-GFP and Smac/DIABLO-GFP in caspase 8 and bid-silenced and Bcl-2-overexpressed breast cancer cells exposed to camptothecin.
17652637 Correlation of breakpoints with histology showed that major breakpoint region occur more frequently in grade 2 lymphomas.
17632732 High Bcl-2 expression is associated with osteosarcoma
17626754 HER-2 and Bax are related to poor prognosis of breast cancer, while Bcl-2 is related to good prognosis.
17616686 BCL2 repression by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells
17588340 Data show that COX-2 siRNA transfection can suppress COX-2 expression in human myeloma RPMI8226 cells, which leads to growth inhibition and apoptosis independent of Bcl-2.
17575222 These data suggest that long-term androgen deprivation + radiotherapy should be used when either Bcl-2 or Bax is abnormally expressed.
17561354 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17561354 There appears to be an influence of BCL2 ala43ala genotypes on esophageal cancer phenotype, particularly with regard to tumor location, which supports the theory of prevalence of site-specific genetic alterations
17557568 Observational study of gene-disease association. (HuGE Navigator)
17536310 immunoreactivity of p53, MDM2, WAF1, and BCL-2 were measured in soft tissue sarcomas cases consisting of 54 low-grade, 40 intermediate-grade, and 58 high-grade sarcomas
17534194 Observational study of gene-disease association. (HuGE Navigator)
17516614 Patients with active and inactive juvenile-onset systemic lupus erythematosis have a different profile of Fas and Bcl-2 expression.
17516030 CDK11(p58) down-regulates Bcl-2 in pro-apoptosis pathway depending on its kinase activity, which elicits survival signal in hepatocarcinoma cells.
17507655 Rho inactivation allows the activity of Rac to become dominant leading to stimulation of the phosphoinositide 3-kinase/Akt/IkappaB kinase/nuclear factor-kappaB prosurvival pathway.
17473827 Upregulation of bcl-2 may play a major role in therapy resistance.
17464868 Bcl-2 expression was up-regulated in cervical carcinoma (both adenocarcinomas and squamous cell cancers) associated with humanpapillomavirus (HPV) infection
17439414 Bcl-2 RNA silencing in transfected HepG2 cells induced apoptosis and increased sensitivity of cells to 5-FU and 10-hydroxycamptothecin.
17438366 BH3-only proeins and BH3 mimetics induce autophagy by competitively disrupting the interqction between BECN1 and Bcl-2/Bcl-X(L).
17434928 Cells over-expressing Bcl-2 showed evidence of increased genomic instability, consistent with the impairment of apoptosis in damaged cells.
17426248 18q21-23 copy number will be a clinically relevant predictor for sensitivity of SCLC to Bcl-2 family inhibitors. The 18q21-23 genomic marker may have a broader application in cancer because Bcl-2 is associated with apoptosis evasion and chemoresistance.
17418785 Antiapoptotic proteins Bcl-2 and Bcl-X(L) bind and suppress NALP1, reducing caspase-1 activation and interleukin-1beta (IL-1beta) production.
17404013 The level of bcl-2 expression could be a valuable predictor of tumor behavior and disease outcome.
17384650 This study is the first to show a clear dissociation between changes in Bcl-2 expression (downregulation) and Bcl-XL, Mcl-1 expression (upregulation) during progression of melanoma.
17379544 In normal HeLa cells, ectopic overexpressed Bcl-2 reduced cell apoptosis induced by overexpressed RTN3. results suggest that RTN3 could bind with Bcl-2 and mediate its accumulation in mitochondria, which modulate the anti-apoptotic activity of Bcl-2.
17372162 in breast cancer, Bcl2 protein expression parallels its mRNA level, and it has a highly significant and independent prognostic relevance.
17360176 Researchers found increased Bcl-2 positive identification after neoadjuvant therapy in patients with colorectal cancer.
17356300 HIV Tat protein increases Bcl-2 expression in monocytes which inhibited apoptosis induced by TRAIL.
17356300 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
17325632 BCL-2 expression was investigated depending on the site of the tissue material sample and the final histopathological result.
17310847 Siatistically significant value in assocation with survival or event-free survival in head and neck squamous cell carcinoma.
17301078 overexpression of Bcl-x(L) or Bcl-2 in PC12 cells markedly suppressed brefeldin A-induced activation of caspases and resulting cell death.
17295204 The delay of tumor progression is apparently determined by the ability of Bcl-2-expressing tumor cells to extinguish the cell-damaging environmental stress signals and Bax activation, while its acceleration correlates with Bcl-2 loss.
17290286 These results suggest that failure of stress-induced downregulation of Bcl-2 underlies resistance of senescent human diploid fibroblasts to apoptosis.
17272502 Kringle 5 of human plasminogen has a role in autophagic survival by up-regulating Beclin 1 and complexing Bcl-2 to Beclin 1
17259174 Bcl2 suppression of MMR may occur in a novel mechanism by directly regulating the heterodimeric hMSH2-hMSH6 complex, which potentially contributes to genetic instability and carcinogenesis
17252199 Data suggest that cytoplasmic mutant p53 increases Bcl-2 expression in estrogen receptor-positive breast cancer cells.
17241114 These findings suggest that neuroprotection by simvastatin is dependent on the drug's previously unexplored and important effect of up-regulating Bcl-2.
17207023 Observational study of gene-disease association. (HuGE Navigator)
17203183 pro-apoptotic Bax/Bcl-2 are upregulated in human leukemic HL-60 cells after treatment with ethyl acetate extract of Chinese medicinal herb Sarcandra glabra
17200714 Activator BH3-only occupation of BCL2 may prime cancer cells for death, offering a potential explanation for the marked chemosensitivity of certain cancers.
17191123 These findings indicate that RTN3 is directly involved in the endoplasmic reticulum-constituents trafficking events through dually acting as an essential and important ER-stress sensor, and a trigger for the Bcl-2 translocation.
17188136 p53 and Ki-67 were expressed with increasing frequency, and bcl-2, p21, and mdm-2 with decreasing frequency in thyroid carcinoma progression. p27 and cyclin D1 were expressed in <15% of cases, with a trend toward decreasing expression.
17145812 The Bcl-2 expression was low and showed no significant difference between laryngeal papillomatosis and normal larynxes.
17118768 In CD19+ B-cell chronic lymphocytic leukemia (B-CLL) cells of untreated patients, Bcl-2 showed over expression compared with CD19+ cells of healthy donors.
17091766 The expression of p53, Bcl-2 and Bax was altered in lung cancer tissue compared to histologically normal bronchial epithelium.
17082179 repression of BCL2 transcription is the single essential consequence of targeting the MIZ-1 pathway during apoptosis induction, which explains a copperative interaction between c-MYC and BCL2
17074584 Patients carrying BCL2 gene rearrangements showed longer telomere length (4.19 +/- 0.14 kb) than those without (3.51 +/- 0.14 kb; P = 0.05).
17050165 Bcl-2 induced by functional regulation of G-protein coupled receptors protects from oxidative glutamate toxicity by increasing glutathione
17015762 down-regulation of the neuropilin-1 transcripts by short interfering RNA caused spontaneous synoviocyte apoptosis, which was associated with both the decrease in Bcl-2 expression and the increase in Bax translocation to mitochondria.
17007374 Expression of Bax and Bcl-2 in epithelial cells was significantly higher in nasal polyps than in inferior turbinates.
16998187 Molecular model of the major G-quadruplex structure formed in the BCL2 promoter provides insights for its loop conformations and interactions with the core tetrad structures.
16988783 Bcl-2 is a common mediator of early apoptotic and necrotic events occurring at rates that are dependent on cellular factors accumulating over time
16984978 The cooperative effects of phenotypes determined by mdm-2, p53, and bcl-2 expression may predict survival in patients with muscle-invasive TCC of the bladder
16982461 Increased serum levels of Bcl-2 is associated with advanced stage non-small cell lung cancer
16960146 Observational study of gene-disease association. (HuGE Navigator)
16960146 BCL2-938AA genotype is associated with increased Bcl-2 expression and a novel unfavorable genetic marker in patients with B-CLL.
16950491 Bcl-2 expression acts as a regulator of HSV-2 replication.
16949642 The high expression of bcl-2 in Hodgkin and Reed-Sternberg cells in most classical Hodgkin's lymphomas (HLs)indicates that this protein may play predominant role in the regulation of apoptosis in classical HLs.
16874461 Bcl-2 by competing with IP3R1 for the binding of PP1 can reduce the inositol trisphosphate-mediated calcium signal and protect cells from mitochondrial dysfunction and cell death.
16855163 anti-beta-2 glycoprotein I antibodies react with trophoblast cells and reduce the Bcl-2/Bax ratio, but without any clear apoptotic effect
16850164 Asbestos may affect the human immune system through STAT3 activation and Bcl-2 overexpression.
16841088 STAT3 activation by IL-6 provides an antiapoptotic advantage in human cord blood cells CD34+ cells, essentially owing to the expression of bcl-2.
16840204 up-regulation of bcl-2 has a role in preferential survival of acute lymphoblastic leukemia cells at 33 degrees C
16839413 The Bcl-2 protein expression has a close correlation with p27 and p53 protein expressions and the proliferation activity determined by MIB-1 counts in invasive ductal carcinoma of the breast.
16832704 We found only few Bcl-2 expressing (0.7%) and no Bax-immunopositive (0.0%) pinealocytes. Bcl-2-positive cells were mature neurons, neither young ones nor glia.
16820876 lysosomal damage by ATX-s10-PDT can initiate apoptotic response and this apoptotic pathway can be regulated by photodamage to Bcl-2 via mitochondrial damage
16799010 An analysis of clinical outcome in 23 PIOL (primary intraocular lymphoma) patients revealed no significant association between bcl-2 t(14;18) translocations and survival or relapse.
16777355 the bcl-2 mbr possessed regulatory function that was related to special AT-rich sequence-binding protein 1 (SATB1).
16761743 bcl2 and ROS1 oncogene expression in meningiomas are not concurrent and neither can be ascribed to any histologic subtype or grade of tumor.
16750039 Bcl-2 and Fas expressions were significantly higher in thymomas compared with normal thymus.
16735440 We analysed the ability of human Bcl-2 to interact with and regulate the activity of nematode apoptosis proteins, and hypothesise that Bcl-2 might suppress nematode cell death by preventing EGL-1 from antagonising CED-9, rather than by inhibiting CED-4.
16733517 Observational study of gene-disease association. (HuGE Navigator)
16733517 BCL-2 variants may be associated with a decrease in prostate cancer susceptibility.
16732934 Apoptosis of HL-60 cells induced by bufalin is related to downregulation of expressions of bcl-2 and survivin.
16717086 PP2A-mediated dephosphorylation of BCL-2 is required to protect BCL-2 from proteasome-dependent degradation, affecting resistance to ER stress
16714000 down regulation of MAD2 could promote the drug resistance of gastric cancer cells and inhibit anticancer drugs induced-apoptosis by upregulating Bcl-2 and interfering the mitochondrion apoptosis pathway
16707568 This study reveals a compartment-specific toxicity of PrP misfolding that involves coaggregation of Bcl-2 and indicates a protective role of molecular chaperones.
16690525 in diffuse large B-cell lymphoma, molecular alterations in ice, bcl-2, c-myc and p53 are present in hematopoietic cells from bone marrow as well as in primitive hematopoietic progenitors
16675913 Clusterin and bcl-2 are upregulated in laryngeal carcinomas and their expression is related to invasiveness of these tumors.
16648655 Finds a statistical significance for Bcl-2, Bax, and apoptosis with H. pylori status in gastric cancer patients in Egypt
16642033 Data suggest that Bcl-2 functions as an inhibitor of mitochondrial permeabilization by changing conformation in the mitochondrial membrane to bind membrane-inserted Bax monomers and prevent productive oligomerization of Bax.
16638864 Observational study of gene-disease association. (HuGE Navigator)
16638854 Bcl-2 is an independent predictor of breast cancer outcome and seems to be useful as a prognostic adjunct to the Nottingham Prognostic Index (NPI), particularly in the first 5 years after diagnosis.
16636671 Bcl-2 expression in MCF7 cells stabilizes p53, induces phosphorylation of p53 serine 15 (p53pSer15) and inhibits MCF7 cell growth
16575548 the ratio of Bax:Bcl-2 in the human oviduct increases significantly in the luteal phase consistent with cells undergoing apoptosis
16568081 overexpression of Bcl-2 is one of the key mechanisms to give neuroblastoma cells the resistance against ATRA-mediated apoptosis
16566921 Results suggest that Ubc9 might regulate bcl-2 expression through the ER signaling pathway, which ultimately contributes to the alterations of drug responsiveness and tumor growth.
16554306 Bcl2, in addition to its survival function, may also suppress DNA repair in a novel mechanism involving c-Myc and APE1, which may lead to an accumulation of DNA damage in living cells, genetic instability, and tumorigenesis
16550596 Expression of both bcl-2 and cyclooxygenase-2 were increased in non-dysplastic Barr
16545683 Overexpression of Bcl-2 protected primary fibroblasts against oxidative stress-mediated reduction in cell proliferation, but did not prevent premature senescence.
16541314 BCL2 has a role in growth of breast cancers with reduced capability of distant colonization
16538384 Data suggest that 2-methoxyestradiol 2 inhibits estradiol-stimulated proliferation and induces apoptosis in ovarian carcinoma cells, and that activation of p38 and phosphorylation of Bcl-2 plays a critical role in the mechanism.
16533807 AP-2alpha induces apoptosis by down-regulating Bcl-2 and utilizing a bax/cytochrome c/Apaf1/caspase 9-dependent mitochondrial pathway
16533178 Bcl-2 expression appears significantly (p<0.005) more often in cases of mild colonic dysplasia (61.1%) compared to inflammatory-regenerative mucosa (14.8%).
16520895 Data suggest that prolaction-mediated induction of ornithine decarboxylase activity enhances expression of Bcl-2 strongly enough to bring about prolactin's anti-apoptotic function.
16481323 BCL-2-overexpressing cells are sensitized to apoptosis by a pyrimidine-2,4,6-trione derivative
16479062 The expression rate of bcl-2 was relatively high in small cell lung cancer without any prognostic significance.
16472763 beta amyloid-induced neurotoxicity occurs via apoptosis regulator BAX over-expression, bcl-2 down-regulation, and caspase-3 activation, first indicating that methionine 35 redox state may alter this cell death pathway
16469847 results indicate that GATA4 positively regulates cardiac Bcl2 gene expression in vitro and in vivo
16463650 Down-regulating bcl-2 and up-regulating fas mRNA expression were also involved in the mechanism of HCMV-induced apoptosis.
16443602 WT p53, but not tumor-derived mutants, bind to BCL2 via the DNA binding domain and induce mitochondrial permeabilization.
16438077 This study aims to evaluate the expression of bcl-2, which is an antidote of apoptosis, and aims to evaluate the value of bcl-2 as a prognostic marker in papillary thyroid cancer
16358373 The expression of bcl-2 and p53 represent biological characteristics of colorectal carcinomas.
16308474 We aimed to investigate the expression pattern of p53, Bcl-2 and C-Myc in colorectal cancer(CRC)tissues obtained from Egyptian colorectal cancer patients divided in two different groups, associated with and without Schistosoma mansoni.
16273250 Bcl-2 expression was associated with better overall survival and appears to be the key biological factor influencing clinical behaviour.
16246184 Suppression of Bax and overexpression of Bcl-2 protein is an early event in gastric tumorigenesis, before gastric dysplastic
16243795 Loss of pSer70 Bcl-2 expression is closely linked to biological aggressiveness in colorectal tumors and represents a statistically significant molecular index for prognosis of patients with these tumors.
16235026 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
16228292 Bcl-2 has a role in cell death, apoptosis, and cytochrome c release independent of p53
16227396 Bcl-2-mediated apoptosis resistance in human colon cancer cells.
16215945 The low frequency of BCL-2/IgH translocation in healthy Chinese individuals of Han nationality located in Zhejiang area may be one of the reasons for the difference in the incidence of follicular lymphoma between China and Western countries.
16215670 These findings imply that some of the biological functions of Bcl-2 may be attributed to their ability to inhibit anticancer agents-induced apoptosis through the sustained Akt activation.
16204228 catalase has a critical role in CSF-independent survival of human macrophages via regulation of the expression of BCL-2 and BCL-XL
16199534 studies suggested that acetylsalicylic acid -promoted Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity is mediated through down-regulating BCL-2
16195370 IL-1Ra, Bcl-2, and iNOS are upregulated and counter the proinflammatory and proapoptotic effects of ischemia-reperfusion
16194898 We present here a case of Follicular Lymphoma with leukemic presentation and a complex translocation involving the IgH, BCL2 and BCL6 loci
16186795 Oct-2, therefore, acts as a cell survival factor in t(14;18) lymphoma cells by directly activating the antiapoptotic gene bcl-2.
16186627 Data evaluate and compare the bcl2, bax, and nestin patterns in the frontal cortices of Alzheimer and multiple-infarct dementia patients, and in normal aging.
16181427 Transducible loop deleted Bcl-2 increases survival of cortical neurons after trophic factor withdrawal and also rescues neural cell lines from staurosporine-induced death. Supports concept of protein transduction of Bcl-2 constructs for neuroprotection.
16181427 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
16173075 overall survival of post-surgical pancreatic adenocarcinoma patients seemed to be improved with Bcl-2 and Bax expression
16166262 BCL2 repression by miR-15 and miR-16 microRNAs induces apoptopsis in a leukemic cell line model.
16148027 Bax, Bad, and Bim are upregulated, while Bcl-2 is downregulated in human neuroblastoma cells treated with propargylamine
16139338 Spontaneous apoptosis is reduced in the endometrium of unexplained-infertile women, and is associated with the changed Bcl-2:Bax ratio
16133992 During tuberculosis, predisposition of CD4 T-cell subsets to apoptosis may involve both low expression of Bcl-2 and excessive expression of transforming growth factor (TGF)-beta, tumor necrosis factor(TNF)-alpha, and Fas ligand (FasL).
16132718 overexpressing an antioxidant gene such as GPX1 in endothelial cells is able to change the basal mRNA and protein Bax levels without affecting those of p53 and Bcl-2
16120388 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
16010987 Bcl-2 is antagonized by dynamin-related protein (Drp1) and mitochondrial fission protein (hFis1).
16007339 Expression of Bcl-2 in osteoblasts is important in regulating bone mass in development and in the normal aging process of bone.
15981087 in the germinal centers, most T cells are Bcl-2(-); most CD4(+) T cells are Bcl-2(-), while nearly 100% of the CD8(+)T cells are Bcl-2(+). The Bcl-2 downregulation by both B and CD4(+) T cells suggests these two subsets may undergo a selection process
15965276 Significantly higher Bcl-2 levels were associated with advanced lung cancer patients
15929186 Apoptosis-associated bcl-2 oncogene is abnormally expressed in gastric precancerous lesions
15911345 Bcl-2 provided Purkinje cell protection from SV40 Tag-induced cell death. Interestingly, RotaRod behavioral analysis demonstrated that 'rescued' Purkinje cells degrade cerebellar function.
15907209 Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl2 family proteins
15901672 lack of role in sequestering proapoptotic Bak
15889622 Bax but not Bcl-2 expression is increased after exposure to prostaglandin A2 and 2-methoxyestradiol in Hela cells
15880952 role of COX-2 in regulating the degree of apoptosis by modulating bcl-2 protein in benign and malignant parotid gland tumors
15876860 in cells synchronized at the onset of mitosis, Bcl-2 is present in a complex with nucleolin, cdc2 kinase and PP1 phosphatase
15849194 Pak1-dependent Raf-1 phosphorylation regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association
15840562 an imperfect purine/purine/pyrimidine triplex likely forms at the bcl-2 major breakpoint region of the t(14;18) translocation
15837573 Transplantation with mouse embryo stem (ES) cells overexpressing human Bcl-2 increases the survival of transplanted ES cells, neuronal differentiation, and functional outcome in ES-transplanted rats after severe focal ischemia.
15832769 p53, Bax, Bcl-2 and Mdm2 mRNA expression levels correlate with the malignant transformation of the uterine cervix
15832179 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
15830715 Expression of Bcl-2 is significantly higher in squamous cell carcinomas than in verrucous penile carcinomas.
15826766 Inhibition of bcl-2 expression may be an attractive therapeutic strategy in RCC tumors with high bcl-2 expression.
15817479 Blockage of the mitochondrial permeability transition pore and caspase-9 demonstrated that Bcl-2-modulated caspase-2 activity occurred upstream of mitochondria
15811121 Bcl-2-positive dendritic cells in epidermis of inverted follicular keratoses. Keratinocyte bcl-2 staining was significantly higher in seborrheic keratoses(SKs). Bcl-2 may be increased in SKs as anti-apoptotic mechanism.
15803126 The c-bcl-2 presence will have less mutations at A and T in B cells mutating their immunoglobulin genes.
15800682 The weak immunoreactive expression of p53, combined with a relatively strong expression of bcl-2 contributes to the characteristic slow progression of parathyroid adenoma
15763593 expression of ESRA, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast is related to nodule size, hormonal and reproductive features
15757977 BCL2-mediated apoptosis appears to play a significant role in pathogenesis of laminin alpha2 deficiency
15754411 COX-2 may regulate expression of apoptosis suppressor gene (bcl-2) through interaction of tumor cells and stromal cells
15735709 Arsenic trioxide might exert cell killing in part by inducing Bax activation through a Bcl-2-suppressible pathway in hematopoietic cells that is caspase independent and intracellular ROS regulated
15733859 Bcl-2 interacts with FKBP38 through the unstructured loop, and the interaction appears to regulate phosphorylation in the loop of Bcl-2
15720419 Bcl-2 positivity identified a subgroup with invariably fatal disease in the high-risk IPI (International Prognostic Index) patients.
15720412 Expression of bcl-2 expression has no prognostic value for gastrointestinal stromal tumours.
15716988 frequency and chromosomal features of this der(8)t(8;14;18) in a series of acute leukaemias and malignant lymphomas
15657350 Gossypol is a potent and novel therapeutic able to overcome apoptosis resistance by specifically targeting the activity of antiapoptotic Bcl-2 family members.
15657349 Gossypol induced complete cytochrome c release from mitochondria, increased caspases-3 and -9 activity, and caused apoptotic death without affecting protein levels of Bcl-2 and Bcl-X(L.)
15638363 The optic nerve axons in glaucomatous eyeballs showed statistically significant higher Bax protein expressions than those of Bcl-2 proteins.
15634885 Apoptosis is blocked by human Bcl-2 in a mouse macrophage cell line and in primary mouse macrophages.
15633216 NS-398 significantly inhibits the proliferation and induces apoptosis of hepatoma cells, which may involve decrease of BCL-2 expression.
15619620 Here we demonstrate that the Bcl-2-mediated suppression of hMSH2 expression results in a reduced cellular capacity to repair mismatches.
15605273 Skp2 in tumor cells suppresses apoptosis through Bcl-2 expression
15593417 colocalization of Human papillomavirus type 16 E5 protein with the Bcl-2 antiapoptotic protein on intracellular membranes was established
15584904 HGF and BCL-2 family proteins use a furin-dependent pathway to promote invasion via TGF-beta and MMP in human malignant glioma cells and the pro-invasive properties of TGF-beta require furin- dependent MMP activity.
15577328 Increase in serum bcl-2 is associated with melanoma
15572421 PCNA expression induces apoptosis by up-regulating cleaved caspase-3 and poly adp ribose polymerase expression and down-regulating Bcl-2 protein expression in leiomyoma cells.
15563082 The expression of AQP-1 mRNA was positively correlated with Bcl-2 mRNA expression in nasal polyps.
15561778 Bcl-2 overexpression leads to the induction of activated signal transducer and activator of transcription 3 (STAT3) and to the induction of SOCS3, which may contribute to the pathogenesis of follicular lymphoma.
15545228 p53, bcl-2 and telomerase have roles in progression of Egyptian breast cancer patients
15544840 annexin I is regulated by an anti-apoptotic Bcl-2 protein in TNF-alpha-induced renal apoptotic events
15541642 BCL2 expression is important for maintenance of hair follicle epithelial stem cells and formation of secondary hair germ
15528355 Bcl-2 transgene promotes B cell accumulation in signaling-deficient B-cell maturation defect 1 (bcmd-1) mice, but formation of white pulp areas of the spleen and follicles in the lymph nodes is severely impaired.
15498929 Bcl-2 expression markedly enhanced spontaneous lung metastasis from orthotopically implanted primary tumors.
15492114 Retinoic acid-induced apoptosis is a consequence of cellular differentiation, which leads to nucleolin down-regulation and bcl-2 mRNA instability.
15489891 overexpression does not affect apoptotic pathway triggered by the Fhit protein in lung cancer cell lines
15484294 aberrant ratio of bcl-2 to bax protein expression may be involved in the course of tumorigenesis of cholangiocellular carcinoma
15478112 Results describe the expression of Bak and Bcl-2 in primary human breast cancers.
15467450 These data show that JNK activation provides a molecular linkage from microtubule damages to the mitochondrial apoptotic machinery
15467428 Downregulation of Bcl-2 protein is associated with breast disease
15375594 Anti-apoptotic factors, Bcl-2 and Bcl-xL, were significantly decreased in epithelial cells under a hypoxic condition as assessed by Western blotting
15367432 spontaneous T-cell reactivity against Bcl-2 in peripheral blood from patients suffering from unrelated tumor types
15353294 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
15351796 evaluated the expression of Bcl-2, Bax and Bak in patients with Graves Disease (GD); findings suggest that the differential expression of Bcl-2 family proteins in both thyrocytes and lymphoid follicles may be involved in the pathology of GD
15345651 Mouse hearts overexpressing transgenic human BCL2 have a slower rate of decline in ATP during ischemia & reduced acidification. Oligomycin & Bcl-2 affect a common pathway. Bcl-2 modulates mitochondrial physiology & function.
15344336 Data expression of bcl-2 is displayed in enteric neurons and immunohistochemical analysis of bcl-2 may also be valuable for identification of the enteric neurons in HD.
15340216 We made an NG108-15 transfectant, Bcl-2(P2), that stably expressed human Bcl-2, and used it to test Bcl-2's effect on the serum-starvation-induced apoptosis in NG108-15 cells.
15339676 Bcl-2 is over-expressed in CD34+ acute myeloid leukemia (AML); conversely, MDR1 is over-expressed in CD34- AML.
15329319 Bcl-2 is significantly expressed in squamous cell carcinoma compared to those with transitional cell carcinoma type in the presence of schistosomiasis.
15314639 Down Regulation of BCL2 protein is associated with benign prostatic hyperplasia
15314290 The apoptotic effect of 11-hydroxy-15-oxokaur-16-en-19-olic acid could be significantly offset by over-expression of \ Bcl-2 in colon cancer cells.
15303767 bcl-2 expression is low in large non-polypoid colonic neoplasms
15302859 Bcl-2 interacts with activated Bax during apoptosis in an effective manner to neutralize the proapoptotic activity of Bax.
15280201 Bcl-2 overexpression led to reduced cytochrome c-mediated caspase-9-dependent cardiomyocyte apoptosis and local inflammation in cardiac allografts during ischemia-reperfusion injury and also led to reduced immune responses
15274378 Advanced stage non-small cell lung tumors or tumors with lymph node metastasis were analyzed, a more favorable survival was noted in patients with bcl-2-positive tumors than those with bcl-2-negative tumors.
15263017 Bcl-2 and InsP3Rs were detected together in macromolecular complexes, inhibiting InsP3R activation and thereby regulating InsP3-induced calcium release from the ER.
15261486 This review focuses on the mechanisms by which anti-apoptotic Bcl-2 family members control the permeability of the mitochondrial membrane and influence other aspects of mitochondrial function after brain ischemia.
15245329 direct interaction of Bcl-2 with SERCA may be involved in the regulation of apoptotic processes in vivo through modulation of cytoplasmic and/or endoplasmic reticulum calcium levels required for the execution of apoptosis
15243561 bcl-2 oncogene has not shown to be a prognostic factor for laryngeal squamous cell carcinoma of the supraglottic larynx.
15235941 Down regulation in Hep3B cell line in the presence of Ni(2+).
15225643 Extracellular signal related kinase and protein phosphatase 2A are physiological regulators of Bcl-2 phosphorylation, and these enzymes exert an influence on the anti-apoptotic function of Bcl-2.
15203866 Assessment of Bcl-2 and Fas expression at diagnosis in acute leukemia (1) could predict responsiveness to induction chemotherapy in ALL but not in AML
15196944 downregulation assists GD3 synthase's apoptotic effect on ECV304 cells
15179054 HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia
15156398 Overexpression of antiapoptotic proteins Bcl-2 and Bcl-X(L) and down-regulation of caspase-3 activity may be associated with cisplatin resistance in human ovarian cancer.
15149158 survivin, p53, and bcl-2 are elevated in breast carcinoma but not ductal intraepithelial neoplasia
15149157 mechanisms other than p53 may play a role in the regulation of bcl-2 expression in endometrial carcinoma
15124764 both Bak and Bcl-2 were found to be increased in correlation with an immune marker (beta2-microglobulin) in white and gray matter and plaque compared with corresponding cortical regions.
15123638 Data suggest that the internal ribosome entry site-mediated translation of BCL-2 may enable the cell to replenish levels of this critical protein during cell stress, when cap-dependent translation is repressed.
15115329 Increased bcl-2 protein expression in cells of 5-8 wk human embry