BCKDK
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
Protein Summary
Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
- ENST00000219794
- ENSP00000219794
- ENSG00000103507
- ENST00000287507
- ENSP00000287507
- ENST00000394950
- ENSP00000378404
- ENST00000394951
- ENSP00000378405
- BDK
- BCKDKD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.93 | ||
drug perturbation | 0.87 | ||
ligand (protein) perturbation | 0.83 | ||
disease perturbation | 0.79 | ||
histone modification site profile | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.81 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 313 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.81 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 313 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0