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  7. Pre-mRNA-splicing factor SPF27

Tbio Pre-mRNA-splicing factor SPF27

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

 Comments

Property Summary

NCBI Gene PubMed Count 23
PubMed Score 14.50
PubTator Score 27.74

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
Multiple myeloma 1332 1.8e-03
oligodendroglioma 2850 3.9e-02
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.5

Expression

  Differential Expression (2)

Disease log2 FC p
Multiple myeloma 1.243 1.8e-03
oligodendroglioma -1.400 3.9e-02

Synonym

Accession O75934 Q6FGS0
Symbols DAM1
SPF27
Snt309

Gene

BCAS2

PANTHER Protein Class (4)

  Ortholog (14)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA

 UniProt Keyword (12)

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 GO Component (8)

 GO Process (3)

 Compartment GO Term (49)

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 MGI Phenotype (3)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (5)

Protein-protein Interaction (31)

PLRG1   CWF19L2   GCC2   XAB2   GPATCH1   DHX35   GCFC2   PRPF19   CRNKL1   CWF19L1   CDC5L   AQR   RBM22   WDR83   SNW1   ZDBF2   CDC40   LINS1   ISY1   ESS2   PPIE   USP34   INPPL1   KNSTRN   CCDC12   SYF2   TFIP11   DHX8   RABGAP1   PCP4   ZBTB8B  

PDB (2)

Gene RIF (8)

AA Sequence 

MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEF      1 - 70
ERLAARQPIELLSMKRYELPAPSSGQKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNE     71 - 140
NLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIK    141 - 210
QQHGEANKENIRQDF                                                           211 - 225
//

Text Mined References (28)

PMID Year Title