Tbio BCAS1 Breast carcinoma-amplified sequence 1

Protein Summary

Description

Required for myelination. This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• O75363
• A0AVG5
• Q68CZ3

Gene Name

• BCAS1

Ensembl ID

• ENST00000395961
• ENSP00000379290
• ENSG00000064787

Symbol

• AIBC1
• NABC1
• AIBC1
• NABC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
cell type or tissue	0.76
cell line	0.62
disease	0.56
small molecule perturbation	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.59   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.59   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0