| Tbio | Basic leucine zipper transcriptional factor ATF-like 2 |
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 8.8e-106 |
| juvenile dermatomyositis | 1187 | 4.7e-08 |
| sarcoidosis | 370 | 2.6e-05 |
| ulcerative colitis | 1819 | 2.9e-05 |
| urothelial carcinoma | 318 | 4.8e-05 |
| head and neck cancer | 271 | 3.3e-03 |
| active Crohn's disease | 922 | 8.5e-03 |
| tuberculosis | 2010 | 1.3e-02 |
| Multiple Sclerosis | 540 | 2.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | 1.132 | 8.5e-03 |
| head and neck cancer | 1.300 | 3.3e-03 |
| juvenile dermatomyositis | 1.129 | 4.7e-08 |
| Multiple Sclerosis | 1.900 | 2.6e-02 |
| psoriasis | 3.000 | 8.8e-106 |
| sarcoidosis | 1.400 | 2.6e-05 |
| tuberculosis | 1.300 | 1.3e-02 |
| ulcerative colitis | 1.400 | 2.9e-05 |
| urothelial carcinoma | -1.100 | 4.8e-05 |
MHLCGGNGLLTQTDPKEQQRQLKKQKNRAAAQRSRQKHTDKADALHQQHESLEKDNLALRKEIQSLQAEL 1 - 70 AWWSRTLHVHERLCPMDCASCSAPGLLGCWDQAEGLLGPGPQGQHGCREQLELFQTPGSCYPAQPLSPGP 71 - 140 QPHDSPSLLQCPLPSLSLGPAVVAEPPVQLSPSPLLFASHTGSSLQGSSSKLSALQPSLTAQTAPPQPLE 141 - 210 LEHPTRGKLGSSPDNPSSALGLARLQSREHKPALSAATWQGLVVDPSPHPLLAFPLLSSAQVHF 211 - 274 //
