Tbio BAHD1 Bromo adjacent homology domain-containing 1 protein

Protein Summary

Description

Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.

Uniprot Accession IDs

• Q8TBE0
• Q8NDF7
• Q9Y2F4
• BAH domain-containing protein 1

Gene Name

• BAHD1

Ensembl ID

• ENST00000416165
• ENSP00000396976
• ENSG00000140320
• ENST00000560846
• ENSP00000454101
• ENST00000561234
• ENSP00000454150

Symbol

• KIAA0945

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
transcription factor	0.78
cell type or tissue	0.72
microRNA	0.67
transcription factor binding site profile	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.23   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.23   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0