Tbio B3GAT1 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

Protein Summary

Description

Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group. The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9P2W7
• B7Z5Z8
• Q96FS7

Gene Name

• B3GAT1

Ensembl ID

• ENST00000312527
• ENSP00000307875
• ENSG00000109956
• ENST00000392580
• ENSP00000376359
• ENST00000524765
• ENSP00000433847

Symbol

• GLCATP
• NK1
• CD57
• HNK1
• LEU7
• NK-1
• GLCATP
• GLCUATP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.69
virus perturbation	0.68
cellular component	0.67
biological term	0.62
pathway	0.62

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 837.16   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 1392   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 837.16   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 1392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0