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Tclin
AVPR2
Vasopressin V2 receptor

Protein Summary
Description
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the functi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337474
  • ENSP00000338072
  • ENSG00000126895
  • ENST00000358927
  • ENSP00000351805
  • ENST00000370049
  • ENSP00000359066
  • ENST00000646375
  • ENSP00000496396

Symbol
  • ADHR
  • DIR
  • DIR3
  • V2R
  • DI1
  • DIR
  • NDI
  • V2R
  • ADHR
  • DIR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
biological process
0.91
tissue
0.63
biological term
0.6
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1461.74   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1461.74   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 420
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6