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Tchem
AURKA
Aurora kinase A

Protein Summary
Description
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cell ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312783
  • ENSP00000321591
  • ENSG00000087586
  • ENST00000347343
  • ENSP00000216911
  • ENST00000371356
  • ENSP00000360407
  • ENST00000395911
  • ENSP00000379247
  • ENST00000395913
  • ENSP00000379249
  • ENST00000395914
  • ENSP00000379250
  • ENST00000395915
  • ENSP00000379251

Symbol
  • AIK
  • AIRK1
  • ARK1
  • AURA
  • AYK1
  • BTAK
  • IAK1
  • STK15
  • STK6
  • AIK
  • ARK1
  • AURA
  • BTAK
  • STK6
  • STK7
  • STK15
  • PPP1R47
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
interacting protein
0.99
biological term
0.98
molecular function
0.98
transcription factor perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1114.4   (req: < 5)
Gene RIFs: 659   (req: <= 3)
Antibodies: 972   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1114.4   (req: >= 5)
Gene RIFs: 659   (req: > 3)
Antibodies: 972   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1097
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2