Tbio ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2

Protein Summary

Description

May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase). This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 alpha subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. This gene is located within the Smith-Magenis syndrome region on chromosome 17. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8N5M1
• A6NDE5
• A8K2J2
• Q6XYC7

Gene Name

• ATPAF2

Ensembl ID

• ENST00000474627
• ENSP00000417190
• ENSG00000171953

Symbol

• ATP12
• ATP12
• ATP12p
• LP3663
• MC5DN1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
histone modification site profile	0.82
transcription factor binding site profile	0.79
transcription factor	0.68
tissue	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.17   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 119   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.17   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0