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Tbio
ATP6V0A4
V-type proton ATPase 116 kDa subunit a isoform 4

Protein Summary
Description
Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310018
  • ENSP00000308122
  • ENSG00000105929
  • ENST00000353492
  • ENSP00000253856
  • ENST00000393054
  • ENSP00000376774
  • ENST00000645515
  • ENSP00000496421

Symbol
  • ATP6N1B
  • ATP6N2
  • A4
  • STV1
  • VPH1
  • VPP2
  • RTA1C
  • RTADR
  • ATP6N2
  • RDRTA2
  • ATP6N1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
biological process
0.94
trait
0.75
gene perturbation
0.7
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.16   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.16   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0