| Tbio | Cysteine protease ATG4C |
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 1.6e-05 |
| hepatocellular carcinoma | 547 | 3.2e-04 |
| medulloblastoma, large-cell | 6241 | 3.4e-04 |
| progressive supranuclear palsy | 676 | 1.2e-02 |
| pancreatic cancer | 2398 | 1.3e-02 |
| pancreatic carcinoma | 562 | 1.3e-02 |
| gastric cancer | 459 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| REM sleep behavior disorder | 14 | 4.894 | 2.4 |
| Parkinson's disease | 392 | 4.485 | 2.2 |
| Autistic Disorder | 364 | 4.349 | 2.2 |
| Atypical autism | 26 | 3.544 | 1.8 |
| Multiple system atrophy | 29 | 3.306 | 1.7 |
| Constipation | 181 | 3.101 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| gastric cancer | 1.100 | 4.4e-02 |
| hepatocellular carcinoma | 1.500 | 3.2e-04 |
| medulloblastoma, large-cell | -1.200 | 3.4e-04 |
| ovarian cancer | -1.100 | 1.6e-05 |
| pancreatic cancer | 1.700 | 1.3e-02 |
| pancreatic carcinoma | 1.700 | 1.3e-02 |
| progressive supranuclear palsy | -1.200 | 1.2e-02 |
MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLPAESGCTIEDH 1 - 70 VIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALN 71 - 140 IENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGDSPLA 141 - 210 LFGLHQLIEYGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMT 211 - 280 SDNADDKAVIILVPVRLGGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQ 281 - 350 SFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN 351 - 420 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL 421 - 458 //
