ATG13
Autophagy-related protein 13
Protein Summary
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]
- ENST00000359513
- ENSP00000352500
- ENSG00000175224
- ENST00000524625
- ENSP00000433543
- ENST00000526508
- ENSP00000431974
- ENST00000528494
- ENSP00000432412
- ENST00000529655
- ENSP00000433756
- ENST00000530500
- ENSP00000434390
- KIAA0652
- KIAA0652
- PARATARG8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.96 | ||
histone modification site profile | 0.89 | ||
kinase perturbation | 0.84 | ||
transcription factor binding site profile | 0.77 | ||
tissue sample | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 124.81 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 534 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 124.81 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 534 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0