Tbio ASTL Astacin-like metalloendopeptidase

Protein Summary

Description

Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity).

Uniprot Accession IDs

• Q6HA08
• Q3KNT0

Gene Name

• ASTL

Ensembl ID

• ENST00000342380
• ENSP00000343674
• ENSG00000188886

Symbol

• SAS1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.58
molecular function	0.56
cell line	0.48
transcription factor binding site profile	0.43
cell type or tissue	0.42

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Astacin-like Metalloendopeptidase

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Astacin-like Metalloendopeptidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.66   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 45   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.66   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0