Property Summary

NCBI Gene PubMed Count 14
PubMed Score 7.60
PubTator Score 11.73

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
pilocytic astrocytoma 3086 5.1e-10
malignant mesothelioma 3163 2.5e-08
ulcerative colitis 2087 9.4e-06
colon cancer 1475 1.2e-04
lung cancer 4473 2.3e-04
psoriasis 6685 1.4e-03
osteosarcoma 7933 4.3e-03
active Crohn's disease 918 2.3e-02
Disease Target Count Z-score Confidence
Ovarian serous carcinoma 7 3.373 1.7

Expression

  Differential Expression (8)

Disease log2 FC p
malignant mesothelioma -2.600 2.5e-08
psoriasis -1.100 1.4e-03
osteosarcoma 1.243 4.3e-03
lung cancer -3.100 2.3e-04
colon cancer -2.100 1.2e-04
active Crohn's disease -1.087 2.3e-02
pilocytic astrocytoma 1.300 5.1e-10
ulcerative colitis -1.400 9.4e-06

Gene RIF (7)

PMID Text
24284654 The data, for the first time, link ASAP3 with ACTG1 in the regulation of cytoskeletal maintenance and cell motility
24078447 ). These data indicate that ASAP3 is elevated in NSCLC and may contribute to cancer development and patients' poor clinical outcome, which is possibly due to its critical roles in regulating cancer invasion.
23776207 Phosphorylation of the N-terminal region of ACAP4 (named the Bin, Amphiphysin, and RSV161/167[BAR] domain at Tyr34) is necessary for epidermal growth factor (EGF)-elicited membrane remodeling.
22027826 ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration
20510928 The ArfGAP catalytic mechanism and shows a glutamine from Arf6 and an arginine fingerASAP3 as the important catalytic residues; unexpectedly the structure shows a calcium ion, liganded by both proteins in the complex interface.
18400762 ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.
16737952 ACAP4 is involved in ARF6-mediated cell migration.

AA Sequence

MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVRAIHSSGLGHV      1 - 70
ENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNLNNIVSFPLDSLMKGQLRDGR     71 - 140
QDSKKQLEKAWKDYEAKMAKLEKERDRARVTGGIPGEVAQDMQRERRIFQLHMCEYLLKAGESQMKQGPD    141 - 210
FLQSLIKFFHAQHNFFQDGWKAAQSLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLESREEH    211 - 280
LSRKNSGCGYSIHQHQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLT    281 - 350
CQVRPNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGE    351 - 420
PHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPSE    421 - 490
LLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCTPEPQRLWTAICNRDL    491 - 560
LSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAA    561 - 630
LYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGS    631 - 700
DSEEDEEEKRCLLKLPAQAHWASGRLDISNKTYETVASLGAATPQGESEDCPPPLPVKNSSRTLVQGCAR    701 - 770
HASGDRSEVSSLSSEAPETPESLGSPASSSSLMSPLEPGDPSQAPPNSEEGLREPPGTSRPSLTSGTTPS    771 - 840
EMYLPVRFSSESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSLPASSVQLLQD           841 - 903
//

Text Mined References (15)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24284654 2014 Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration.
24097068 2013 Discovery and refinement of loci associated with lipid levels.
24078447 2014 ASAP3 expression in non-small cell lung cancer: association with cancer development and patients' clinical outcome.
23776207 2013 Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation.
22027826 2011 ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin ?1 recycling in cell migration.
20510928 2010 The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism.
18400762 2008 ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
16737952 2006 Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14654939 2004 Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.