| Tbio | Arylsulfatase B |
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Mucopolysaccharidosis VI | 6 | 0.0 | 5.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 2.6e-05 |
| tuberculosis | 2010 | 9.1e-04 |
| group 4 medulloblastoma | 1855 | 4.0e-03 |
| active Crohn's disease | 922 | 1.7e-02 |
| non primary Sjogren syndrome sicca | 891 | 2.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Alzheimer's disease | 658 | 0.0 | 0.9 |
| Attention deficit hyperactivity disorder | 278 | 0.0 | 1.0 |
| Iron metabolism disease | 20 | 0.0 | 0.8 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Mucopolysaccharidosis | 26 | 7.221 | 3.6 |
| Metachromatic leukodystrophy | 14 | 4.78 | 2.4 |
| Leukodystrophy | 55 | 0.0 | 4.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Mucosulfatidosis | 5 | 4.617 | 2.3 |
| Disease | Target Count |
|---|---|
| Mucopolysaccharidosis type VI | 1 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | 1.433 | 1.7e-02 |
| group 4 medulloblastoma | 1.100 | 4.0e-03 |
| non primary Sjogren syndrome sicca | -1.400 | 2.8e-02 |
| ovarian cancer | -1.200 | 2.6e-05 |
| tuberculosis | 1.100 | 9.1e-04 |
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTP 1 - 70 HLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTT 71 - 140 HMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMY 141 - 210 STNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNV 211 - 280 TAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHI 281 - 350 SDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP 351 - 420 EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSRE 421 - 490 YPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM 491 - 533 //
