| Tbio | Arpin |
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| posterior fossa group B ependymoma | 416 | 3.2e-08 |
| osteosarcoma | 7950 | 2.8e-06 |
| tuberculosis | 2010 | 4.6e-06 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.7e-04 |
| psoriasis | 6694 | 1.4e-02 |
| Disease | log2 FC | p |
|---|---|---|
| intraductal papillary-mucinous adenoma (... | -1.300 | 2.7e-04 |
| osteosarcoma | 1.575 | 2.8e-06 |
| posterior fossa group B ependymoma | 1.100 | 3.2e-08 |
| psoriasis | 1.100 | 1.4e-02 |
| tuberculosis | 1.700 | 4.6e-06 |
