Property Summary

NCBI Gene PubMed Count 21
PubMed Score 11.52
PubTator Score 8.33

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (14)

Disease log2 FC p
Rheumatoid Arthritis 1.800 6.6e-03
gastric cancer 1.300 4.6e-03
Waldenstrons macroglobulinemia 1.432 1.1e-02
osteosarcoma 2.624 2.9e-06
glioblastoma 1.200 1.5e-03
Duchenne muscular dystrophy 1.171 4.0e-09
juvenile dermatomyositis 1.216 5.1e-12
primary pancreatic ductal adenocarcinoma 1.004 3.2e-03
intraductal papillary-mucinous adenoma (... 1.100 3.6e-02
intraductal papillary-mucinous carcinoma... 1.400 6.4e-03
Breast cancer 3.400 3.7e-02
cystic fibrosis -1.300 1.9e-04
primary Sjogren syndrome 1.500 2.5e-03
ovarian cancer -2.100 3.3e-08

Protein-protein Interaction (207)

IGKV2-28   IGKV2D-30   IGKV3D-20   IGKV1-12   IGLC7   WIPF3   MYO1C   HIP1   WASL   PIK3C2A   PIK3R2   BIN1   FCHO1   DVL2   HGS   GAK   SYNJ2   ARPC1B   ARPC2   ARPC3   EPHB6   SYNJ1   TGOLN2   WIPF1   DNAJC6   HIP1R   VAMP4   STAM2   EPN2   ABL1   EGFR   LDLR   EGF   AVP   IGKV1D-33   IGKV1-33   IGKV1-39   IGKV1-17   IGKV1D-16   IGKV1-5   IGKV1D-12   IGKV2D-40   IGKV2D-28   IGKV3-20   IGKV3-15   IGLV1-44   IGLV1-47   IGLV1-51   IGLV1-40   IGLV2-14   IGLV2-23   IGLV2-11   IGLV2-8   IGLV3-19   IGLV3-1   IGLV3-25   IGLV3-27   IGLV6-57   CD4   IGHV1-69   IGHV1-46   IGHV3-11   IGHV3-48   IGHV3-23   IGHV3-13   IGHV3-53   IGHV3-30   IGHV3-33   IGHV3-7   IGHV3-9   IGHV2-70   IGHV2-5   IGHV4-39   IGHV4-59   IGKC   IGHG1   IGHG2   IGHG3   IGHG4   TFRC   TF   IGLV7-43   CD3D   IGKV1-16   IGKV1D-39   IGKV3-11   IGKV2-30   IGKV4-1   IGKV5-2   IGHV4-34   ADRB2   FCGR3A   CLTA   CLTB   CD3G   IGLC6   IGLC1   IGLC2   IGLC3   UBB   UBC   HSPA8   IGF2R   FCGR1A   FCGR2A   CFTR   NCK1   RAB5A   M6PR   CD247   SYT1   CBL   IGHV1-2   PIK3R1   EPHB2   AVPR2   ARRB2   WNT5A   PIK3CA   PIK3CB   EPS15   WAS   SYK   ARRB1   AMPH   DNM2   VAMP7   AGFG1   EFNB2   CLTCL1   EPHB3   EPHB4   EPHB1   NCKAP1L   ARPC4   CDC42   ACTR3   ACTR2   RPS27A   UBA52   GRB2   RAC1   VAMP2   IGLV3-21   DAB2   LRP2   EFNB1   CLTC   OCRL   PTK2   FCHO2   LCP2   PICALM   SCARB2   CTTN   GAPVD1   TRIP10   EFNB3   ITSN1   VAMP3   SLC18A3   AAK1   LDLRAP1   FNBP1L   KIAA0319   CYFIP1   SYT9   ABI1   SYT2   NECAP1   REPS2   WIPF2   BRK1   STON2   ARPC1A   STAM   SH3KBP1   REPS1   CYFIP2   FNBP1   SH3GL2   SGIP1   VAMP8   MYO10   SLC2A8   NCKIPSD   EPS15L1   MYH2   FZD4   PACSIN2   BAIAP2   NCKAP1   SNX9   EPN1   WASF2   VPS13A   TRO   VPS13C   HUS1   TUBA4A   ACTR3B   POLA2   CBWD3   RAD21   PRKD2   RBCK1   MKS1  

Gene RIF (2)

PMID Text
22378351 Levels of ARPC5 expression were significantly higher in invasive cancer cells and gene expression was directly regulated by miR-133a.
12829704 identified as a substrate of MAPK-activated protein kinase 2(MAPKAPK2); the ability of MAPKAPK2 to phosphorylate one isoform of p16-Arc suggests a possible mechanism by which the p38 MAPK cascade regulates remodeling of the actin cytoskeleton

AA Sequence

MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQA      1 - 70
VKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGS     71 - 140
IVRVLTARKTV                                                               141 - 151
//

Text Mined References (26)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22378351 2012 Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma.
22089643 2012 Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma.
22016387 2011 GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A.
21423176 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
21281821 2011 Rear polarization of the microtubule-organizing center in neointimal smooth muscle cells depends on PKC?, ARPC5, and RHAMM.
21269460 2011 Initial characterization of the human central proteome.
20458337 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
19056867 2009 Large-scale proteomics and phosphoproteomics of urinary exosomes.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12829704 2003 Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis.
12665801 2003 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11741539 2001 Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity.
11721045 2001 Crystal structure of Arp2/3 complex.
11162547 2001 Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub.
9359840 1997 Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins.
9230079 1997 The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.