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Tbio
ARNTL
Aryl hydrocarbon receptor nuclear translocator-like protein 1

Protein Summary
Description
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389707
  • ENSP00000374357
  • ENSG00000133794
  • ENST00000401424
  • ENSP00000385915
  • ENST00000403290
  • ENSP00000384517
  • ENST00000403482
  • ENSP00000385897
  • ENST00000403510
  • ENSP00000385581

Symbol
  • BHLHE5
  • BMAL1
  • MOP3
  • PASD3
  • TIC
  • JAP3
  • MOP3
  • BMAL1
  • PASD3
  • BMAL1c
  • bHLHe5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.96
kinase perturbation
0.84
virus perturbation
0.79
PubMedID
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1505.61   (req: < 5)
Gene RIFs: 174   (req: <= 3)
Antibodies: 479   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1505.61   (req: >= 5)
Gene RIFs: 174   (req: > 3)
Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0