Tbio ARMCX2 Armadillo repeat-containing X-linked protein 2

Protein Summary

Description

May regulate the dynamics and distribution of mitochondria in neural cells. This gene encodes a protein containing a potential N-terminal transmembrane domain and multiple armadillo (arm) repeats. Proteins containing arm repeats are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is located in a cluster of related genes on chromosome X. There is a pseudogene for this gene on chromosome 7. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q7L311
• O60267
• Q5H9D9

Gene Name

• ARMCX2

Ensembl ID

• ENST00000328766
• ENSP00000331662
• ENSG00000184867
• ENST00000330154
• ENSP00000328631
• ENST00000356824
• ENSP00000349281

Symbol

• ALEX2
• KIAA0512
• ALEX2
• GASP9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.83
small molecule perturbation	0.8
PubMedID	0.72
transcription factor perturbation	0.68
tissue	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.47   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 136   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.47   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0