| Tbio | AT-rich interactive domain-containing protein 3A |
Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3232 | 2.2e-05 |
| osteosarcoma | 7950 | 9.9e-04 |
| pancreatic carcinoma | 562 | 2.0e-03 |
| pancreatic cancer | 2398 | 2.0e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Chronic recurrent multifocal osteomyelitis | 6 | 3.38 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 1.600 | 2.2e-05 |
| osteosarcoma | -1.116 | 9.9e-04 |
| pancreatic cancer | 1.100 | 2.0e-03 |
| pancreatic carcinoma | 1.100 | 2.0e-03 |
MKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAPDEDREPESARMQRAQMAALAAMRAAAA 1 - 70 GLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMKPKWEEEEMEEDLGEDE 71 - 140 EEEEEDYEDEEEEEDEEGLGPPGPASLGTTALFPRKAQPPQAFRGDGVPRVLGGQERPGPGPAHPGGAAH 141 - 210 VAPQLQPPDHGDWTYEEQFKQLYELDGDPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVT 211 - 280 EKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGR 281 - 350 RQSFGGSLFAYSPGGAHGMLSSPKLPVSSLGLAASTNGSSITPAPKIKKEEDSAIPITVPGRLPVSLAGH 351 - 420 PVVAAQAAAVQAAAAQAAVAAQAAALEQLREKLESAEPPEKKMALVADEQQRLMQRALQQNFLAMAAQLP 421 - 490 MSIRINSQASESRQDSAVNLTGTNGSNSISMSVEINGIMYTGVLFAQPPAPTPTSAPNKGGGGGGGSSSN 491 - 560 AGGRGGNTGTSGGQAGPAGLSTPSTSTSNNSLP 561 - 593 //
