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Tdark Rho guanine nucleotide exchange factor 19

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase.

Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390).[supplied by OMIM, Dec 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 4.10
PubTator Score 3.31

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
non-small cell lung cancer 2890 1.5e-17
lung adenocarcinoma 2716 1.4e-07
invasive ductal carcinoma 2951 2.4e-02
Disease Target Count Z-score Confidence
Specific language impairment 34 3.844 1.9
Blepharitis 23 3.603 1.8

Expression

  Differential Expression (3)

Disease log2 FC p
invasive ductal carcinoma 1.200 2.4e-02
lung adenocarcinoma 1.500 1.4e-07
non-small cell lung cancer 1.209 1.5e-17

Synonym

Accession Q8IW93 A6NJ04 Q5TEV2 Q6PJQ4 Q8N244
Symbols WGEF

Gene

ARHGEF19

  Ortholog (11)

Species Source Disease
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
OMA EggNOG
OMA EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (7)

 GO Function (3)

 GO Component (1)

 GO Process (7)

 Compartment GO Term (9)

 GWAS Trait (2)

 HCA RNA Cell Line (55)

See all...

Pathway (10)

Gene RIF (2)

AA Sequence 

MDCGPPATLQPHLTGPPGTAHHPVAVCQQESLSFAELPALKPPSPVCLDLFPVAPEELRAPGSRWSLGTP      1 - 70
APLQGLLWPLSPGGSDTEITSGGMRPSRAGSWPHCPGAQPPALEGPWSPRHTQPQRRASHGSEKKSAWRK     71 - 140
MRVYQREEVPGCPEAHAVFLEPGQVVQEQALSTEEPRVELSGSTRVSLEGPERRRFSASELMTRLHSSLR    141 - 210
LGRNSAARALISGSGTGAAREGKASGMEARSVEMSGDRVSRPAPGDSREGDWSEPRLDTQEEPPLGSRST    211 - 280
NERRQSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGS    281 - 350
TFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWL    351 - 420
FSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRF    421 - 490
PGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNAS    491 - 560
VQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLL    561 - 630
LSRRKELGKFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLLHGQHMKHQFLLRARTESEKQRWISALC    631 - 700
PSSPQEDKEVISEGEDCPQVQCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAY    701 - 770
VEEISSLSARLRNLRENKRVTSATSKLGEAPV                                          771 - 802
//

Text Mined References (10)

PMID Year Title