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Tchem
ARAF
Serine/threonine-protein kinase A-Raf

Protein Summary
Description
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377039
  • ENSP00000366238
  • ENSG00000078061
  • ENST00000377045
  • ENSP00000366244

Symbol
  • ARAF1
  • PKS
  • PKS2
  • PKS2
  • A-RAF
  • ARAF1
  • RAFA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
kinase perturbation
0.97
interacting protein
0.96
molecular function
0.96
disease perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 624.21   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 619   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 624.21   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 619   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3