Property Summary

NCBI Gene PubMed Count 1,797
PubMed Score 6683.73
PubTator Score 7221.94

Knowledge Summary

Patent (193,439)

TINX Plot

  Disease (10)

Disease Target Count Z-score Confidence
Carcinoma 2147 4.804 2.4
Disease Target Count Z-score Confidence
Prostate cancer 172 8.057 4.0
Alopecia universalis 10 0.0 2.0
Disease Target Count Z-score Confidence
Kennedy's disease 13 7.484 3.7
Androgenic alopecia 10 4.923 2.5
Disease Target Count Z-score Confidence
Pseudohermaphroditism 16 4.091 2.0
Neurodegenerative disease 383 0.0 4.0

Expression

Synonym

Accession P10275 A0A0B4J1T2 A2RUN2 B1AKD7 C0JKD3 C0JKD4 E7EVX6 Q9UD95
Symbols KD
AIS
AR8
TFM
DHTR
SBMA
HYSP1
NR3C4
SMAX1
HUMARA

Gene

AR

PDB

3L3X   3L3Z   1T5Z   4OED   4OH6   4OKB   1E3G   1GS4   1T63   1T65   1XJ7   1XOW   1XQ3   1Z95   2AM9   2AMA   2AMB   2AO6   2AX6   2AX7   2AX8   2AX9   2AXA   2HVC   2OZ7   2PIO   2PIP   2PIQ   2PIR   2PIT   2PIU   2PIV   2PIW   2PIX   2PKL   2PNU   2Q7I   2Q7J   2Q7K   2Q7L   2YHD   2YLO   2YLP   2YLQ   2Z4J   3B5R   3B65   3B66   3B67   3B68   3BTR   3RLJ   3RLL   3V49   3V4A   3ZQT   4HLW   4K7A   4OEA   4OEY   4OEZ   4OFR   4OFU   4OGH   4OH5   4OHA   4OIL   4OIU   4OJ9   4OJB   4OK1   4OKT   4OKW   4OKX   4OLM   4QL8   5CJ6  

  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG Inparanoid

 GWAS Trait (1)

MLP Assay (14)

AID Type Active / Inconclusive / Inactive Description
2277 screening 14 / 0 / 0 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors.
504934 other 1 / 0 / 0 Late stage assay provider results from the probe development effort to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors
624355 other 0 / 0 / 0 Late stage results from the probe development efforts to identify dual inhibitors of signal transducer and activator of transcription 3 (STAT3) and nuclear factor NF-kappa-B (NF-kB): Cell-based radioligand binding assay to determine the binding affinities for selected transporters, receptors, and GPCRs
624406 other 0 / 0 / 0 Late stage results from the probe development effort to identify inhibitors of Hepatitis C Virus (HCV) core protein dimerization: Cell-based radioligand binding assay to determine the binding affinities for selected transporters, receptors, and GPCRs
686924 other 0 / 0 / 1 ML347 Eurofin Panel Assay for BMP Inhibitor (Probe Compound)
686925 other 0 / 0 / 1 ML352 Eurofin Panel Assay for Choline Transporter Inhibitor (Probe Compound)
686926 other 0 / 0 / 1 ML354 Eurofin Panel Assay for PAR4 Antagonists Inhibitor (Probe Compound)
686927 other 0 / 0 / 1 ML353 Eurofin Panel Assay for mGlu5 SAM Inhibitor (Probe Compound)
743249 screening 1 / 0 / 0 Development of the First Potent, Selective and CNS penetrant M5 Negative Allosteric Modulator (NAM)
743250 screening 1 / 0 / 0 Discovery and characterization of a small molecule allosteric agonists of mas-related G-Protein coupled receptor X1 ( MrgX1)
More...

Gene RIF (1628)

PMID Text
27522732 Increased frequency of CAG repetitions of Androgen receptor gene was directly proportional to the level of psychological development, social adaptation and professional activity but inversely proportional to the masculine sexual traits.
26986969 Data show that the down-regulation of androgen receptor protein by tocopherylquinone (TQ) was abrogated by co-treatment with antioxidants.
26928463 AR activity was inversely associated with cell proliferation, whereas the expression of Fa complex genes was correlated with elevated cell cycle progression, expression of the E2F transcription factor 1 (E2F1) and loss of RB1.
26928323 AR expression was higher in radical prostatectomy-prostate cancer and radical prostatectomy-benign samples than in benign cystoprostatectomy samples.
26910733 The correlation between the number of CAG triplets in androgen receptor and hyperactivity symptoms in boys with autism spectrum disorders
26862755 When a human AR transgene is conditionally expressed in bladder urothelium, male and female transgenic mice have a higher incidence of N-butyl-N-(4-hydroxybutyl)- nitrosamine-induced urothelial cell carcinoma than age and sex matched control littermates.
26848581 The Presence of Clitoromegaly in the Nonclassical Form of 21-Hydroxylase Deficiency Could Be Partially Modulated by the CAG Polymorphic Tract of the Androgen Receptor Gene
26813233 This work demonstrates the feasibility of a prognostic and/or diagnostic platform combining the direct identification of AR mutants from patients' serum in order to provide personalized recommendations regarding the best future therapy.
26808578 Functional analysis revealed that miR-34c and miR-297 overexpression down-regulated AR expression and inhibited the expression of downstream AR targets and that PlncRNA-1 overexpression rescued these effects.
26805759 By suppressing AR and up-regulating ULBP2 in HCC, cisplatin could up-regulate cytotoxicity of NK cells to better target HCC.
26751641 These data link the assembly of methylated KDM1A and CHD1 with AR-dependent transcription and genomic translocations, thereby providing mechanistic insight into the formation of TMPRSS2-ERG gene fusions during prostate-tumor evolution.
26709083 activation of AR-variant 7 in the prostate is associated with increased severity of benign prostatic hyperplasia.
26688387 androgen receptor mutation in cohort of patients with androgen insensitivity syndrome
26649804 This novel nuclear localization of TM4SF3 depends on androgen-induced nuclear localization of androgen receptor (AR) in both androgen-dependent and androgen-independent prostate cancer cell lines
26648519 A promising drug for treatment of AR-negative PC stages.
26647441 In men, androgen receptors SNPs (rs1337080; rs5918764) were significantly associated with all right ventricular function measures and modified the relationship between testosterone and RV ejection fraction.
26560244 These studies revealed a relationship between TOP2A and androgen receptor signaling pathway that contributes to prostate cancer progression and confers sensitivity to treatments.
26554309 Androgen receptor splice variants are expressed in human breast cancers and regulate response to androgen antagonists.
26552477 Our study supports the notion that targeting AR could be effective for many breast cancer (BC) patients and that re-testing of AR status in formerly negative or mixed type BC's is recommended.
26541420 Androgen receptor may stimulate or inhibit breast cancer growth depending on estrogen receptor status.
26537882 Finally, it is possible that AR-V7 may represent a therapeutic target in mCRPC if drugs can be designed that degrade or inhibit AR splice variants or block their transcriptional activity
26537258 AR copy number gain and point mutations in plasma were inversely correlated in abiraterone-resistant prostate cancer patients
26511871 GGN repeat polymorphism in the AR gene is associated with PCOS.
26510590 The mechanisms of drug resistance in prostate cancer are mainly represented with mutations of the androgen receptor as well as up-regulation of genes involved in androgens synthesis. (Review)
26506594 Studies indicate that prostate cancer stem cells lack the androgen receptor, and express classical alpha and/or beta and GPR30 estrogen receptors.
26506516 Data show that the combination of a phosphatidylinositol 3-Kinase (PI3K)/mTOR protein inhibitor with an androgen receptor {AR) inhibitor results in a synergistic anti-tumor response in non-castration-resistant prostate cancer (CRPC) and CRPC models.
26491675 AR pathway plays an important role in regulation of CX43 expression in prostate cancer cells. AR may be the upstream signal of CX43.
26473737 results demonstrate that AR inhibits autophagy via transactivation of miR-101, thus combination of miR-101 mimics with celastrol may represent a promising therapeutic approach for treating prostate cancer.
26467701 This study showed that nuclear androgen receptor and expression of FKBP5 is associated with decreased survival in esophageal adenocarcinoma.
26459575 LMO1 appears to be a coactivator of AR involved in the progression of prostate cancer
26457646 Data show that transcription factor FOXA1 and homeodomain protein HOXB13 colocalize with androgen receptor (AR) at tumor-specific AR binding sites.
26453288 This study identify novel polyglutamine-expanded AR aggregates in spinal and bulbar muscular atrophy.
26448047 overlapping regulatory elements that bind antagonistic transcription factors may facilitate rapid changes in expression of androgen receptor in response to the relative amounts of Sp1 and pur-alpha.
26431497 Studies indicate relief from SUMO-mediated inhibition through mutation of the acceptor lysines to arginines abrogated polyQ androgen receptor SUMOylation.
26411689 HOTAIR binds to the AR protein to block its interaction with the E3 ubiquitin ligase MDM2, thereby preventing AR ubiquitination and protein degradation thus promoting prostate cancer cell growth and invasion.
26410037 Data show that compared to those with shorter CAG repeat length, women with of longer CAG repeats had a 34% decreased epithelial ovarian cancer risk. These findings suggest that androgen signaling contributes to the development of ovarian cancer.
26406407 More CAG repeats of the AR gene are associated with breast cancer mortality.
26404660 Results show that long CAG repeat lengths in the AR were associated to significant attenuated levels of androgens and an increased conversion of testosterone into oestradiol, in human small antral follicles.
26404510 Androgen receptor (AR)-mediated induction of the miR-29 family, which targets TET2, are markedly enhanced in hormone refractory prostate cancer.
26397136 High AR expression is associated with endometrial cancer progression.
26393301 SOST production is decreased via the androgen receptor activation.
26378044 PP-1 and Akt have roles in AR-v7 protein expression and activities when AR is functionally blocked
26378018 Androgen receptor splice variant, AR-V7 expression is associated with drug resistance in prostate cancer.
26372468 insight into AR-mediated regulation of prostate epithelial cell proliferation
26345963 These findings indicate a role for AR gene (CAG)n variations in breast cancer.
26342197 CCL5 signals from infiltrating bone marrow mesenchymal stem cells to HIF2alpha signals within prostate cancer (PCa) cells might play a key role to increase PCa stem cell population and PCa metastasis via altering the androgen receptor signals
26339363 ER negative breast cancer showed different expression of sarcosine metabolism related proteins according to AR and HER-2 status.
26336819 Data suggests that androgen receptor variants (AR-Vs) are dependent on forkhead box A1 protein (FOXA1) for sustaining a pro-proliferative gene signature.
26336104 ATM inhibitor induces apoptosis in AR-inactivated cells by blocking the repair of damaged DNA at telomeres
26327810 ligand-independent activation of the AR signaling is a critical mechanism underlying prostate cancer progression and castration-resistant prostate cancer development[review]
26318424 the AR represents a critical driver of gene expression involved in taxol resistance in ovarian neoplasms
26314494 These findings identified a biochemical and functional link between miR-190a with reduced expression in advanced prostate cancer, YB-1 and AR signaling in prostate cancer.
26311513 Twist1 mediates TGF-beta-induced expression of both full-length and splice-variant AR expression. Twist1/AR signaling was augmented in castration resistant as well as mesenchymal-phenotype prostate cancer.
26310125 Sam68 has separable effects on the regulation of AR-V7 expression and transcriptional activity, through its RNA-binding capacity.
26305679 a novel AR-interacting protein, Src homology 3 (SH3)-domain containing, Ysc84-like 1 (SH3YL1), whose interaction with the receptor is dependent upon this polyproline domain, was identified.
26305549 Data show that blocking the interleukin-8 (IL-8)/androgen receptor (AR)/matrix metalloproteinases (MMPs) signals partially reversed the infiltrating B cells capacity to increase the bladder cancer (BCa) cell invasion.
26304926 AR-suppressed miRNA-145 is a key player in renal cell carcinoma progression by regulating HIF2alpha/VEGF/MMP9/CCND1 expression levels, irrespective of VHL status.
26299772 Numerous significant correlations were found between CAG or GGN repeats and blood hormones or circulating proteins and semen parameters.
26297988 Re-expressing androgen receptor suppresses migration and invasion of PC-3 cells via regulation of epithelial-mesenchymal transition marker proteins and MMP2/9 activity.
26291982 Fewer AR CAG repeats predicted greater aggression, and Tanzanian Datoga men reported more aggression than did Tanzanian Hadza men. In addition, aggression mediated the identified negative relationship between CAG repeats and number of children born.
26267320 Data show that transcriptomic profiling of mutant androgen receptor AR(W741L) highlighted key genes markedly up-regulated by the mutant receptor.
26260807 TNBC with coexpression of AR and FOXA1 seems to behave like luminal tumors with a morphological profile distinct from other TNBC.
26249023 Proteosome-mediated degradation and poly-ubiquitination of AR were increased with the knock-down of DBC1.
26247526 Breast cancer patients with androgen receptor immunonegativity survived 3 years without metastases after adjuvant trastuzumab therapy.
26231735 Tumor infiltrating neutrophils modulate AR/c-Myc signals to promote renal carcinoma cell proliferation.
26219822 Results show that apocrine breast cancer and prostate cancer cells share a core AR cistrome and target gene signature linked to cancer cell growth, and PIAS1 plays a similar coregulatory role for AR in both cancer cell types.
26216079 both serum testosterone levels and AR CAG repeat polymorphism can influence erectile function concomitantly. In subjects with normal testosterone concentration, those with longer AR CAG repeat lengths have a higher risk of developing erectile dysfunction.
26186973 Cell hypoxia enhances the complex formation between p62 and androgen receptor by promoting phosphorylation of p62 at serine 403.
26181238 Circulating tumor cell-based AR splice variant 7 detection may serve as a treatment selection biomarker in castration resistant prostate cancer.
26178169 Our results do not confirm a possible correlation or linkage disequilibrium between the CAG/GGC haplotypes of the androgen receptor gene and androgenetic alopecia.
26176602 PABPC1 is a novel co-regulator of the AR
26175158 USP7 associates with AR in an androgen-dependent manner and mediates AR deubiquitination.
26160840 constitutively active androgen receptor splicing variants (AR-Vs) maintain the AR signaling axis by evading the inhibitory effects of microtubule-targeting agents, suggesting that these AR-Vs play a role in resistance to taxane chemotherapy
26160177 A catalysis-independent role for AKR1C3 on AR activity via Siah2 has been identified.
26097556 The expression of AR in coronary artery was reduced in coronary heart disease patients, which suggested that androgen may have favorable effects on the cardiovascular system.
26083457 These results suggest that selective AR degradation may be an effective therapeutic prostate tumor strategy in the context of AR mutations that confer resistance to second-generation AR antagonists.
26076967 AR is not associated with the proliferation marker Ki-67, but is associated with lower 21-gene recurrence score in estrogen receptor positive/HER2 negative breast cancer.
26063731 Authors show a significant androgen-dependent increase of Foxp3 expression in human T-cells from women in the ovulatory phase of the menstrual cycle but not from men and identify a functional androgen response element within the Foxp3 locus.
26062412 AR is a direct target gene of miR-141-3p
26060018 Our results clarify the mechanism by which AR-Vs mediate gene regulation and provide a pivotal pathway for rational drug design to disrupt AR-V signaling as a rational strategy for the effective treatment of advanced prostate cancer.
26052614 The identification of laminin gamma 1 (LAMC1) and myeloid cell leukemia 1 (MCL1) as direct targets of miR-22 and miR-29a, respectively, suggested a tumor-suppressive role of these miRNAs.
26050226 Androgen deprivation downregulates Gabarapl1 in an AR dependent manner, resulting in the increase of autophagy flux
26044568 Data show that AR is a ligand-inducible transcription factor that regulates target gene expression. Its activation up-regulates EGFR and HER2 expression contributing to urothelial carcinoma progression through epithelial to mesenchymal transition.[review]
26040853 Androgen receptor genetic mutations could be used for molecular targeted therapy in patients with prostate cancer.
26039245 Univariate analyses showed that AR, CDH1 and Ki-67 expression levels were significantly associated with overall survival in triple-negative breast cancer patients.
25979597 The loss of heterozygosity in the regulatory regions of ESRa, ESRb, and AR genes is an early genetic alteration in breast carcinoma and has possibly synergistic effects on tumor proliferation, histological aggressiveness and down-regulation of these genes in tumor samples.
25977336 NKX3.1, a prostate tumor suppressor that accelerates the DNA repair response, binds to androgen receptor at the ERG gene breakpoint and inhibits both the juxtaposition of the TMPRSS2 and ERG gene loci.
25953903 The contrastingly reduced conformational plasticity of the corresponding FK1 domain of FKBP52 is consistent with the current model in which FKBP51 binds to both the apo- and hormone-bound forms of the steroid receptor
25950519 Y267F mutation inhibits recruitment and DNA binding of truncated AR to the androgen responsive enhancers and transcription of target genes.
25943311 androgen receptor plays a suppressive role in epithelial- mesenchymal transition of human prostate cancer stem progenitor cells
25925349 CAG repeat length of the Androgen Receptor gene is a marker for increased androgen sensitivity with shorter lengths predicting smaller stature in non-Prader-Willi Syndrome adult males.
25907805 demonstrates that miR-135b regulates ERalpha, AR and HIF1AN protein levels through interaction with their 3'UTR regions, and proliferation in ERalpha-positive BCa and AR-positive PCa cells
25904752 Prediction of breast cancer prognosis and treatment response was improved by combining AR and ER status
25899828 ERG-positive tumors increase in proportion with increasing stage of disease, but strength of ERG expression in ERG-positive patients shows a significant decline, or "loss," in patients with stage 4 disease.
25897673 CNVs of AR and CYP17A1 genes would appear to be associated with outcome of CRPC patients treated with abiraterone.
25884570 RNA interference experiments revealed functional interactions between AR and CXCR7 in these cells
25883222 Data show that silencing of PMEPA1 protein facilitates the growth of prostate cancer cells and modulates androgen receptor (AR) through NEDD4 ubiquitin protein ligase and PTEN protein.
25867301 the longer CAG repeats were associated with the risk of isolated hypospadias, and that longer CAG polymorphisms may be related to the etiology of isolated hypospadias (Meta-Analysis)
25860954 found a negative feedback loop between androgen receptor and miR-124 expression in prostate cancer cells
25851605 Androgen responses through AR are controlled in prostate cancer cells by CDK5.
25846647 Report effects of androgen agonists/antagonists on microRNA expression in prostate cancer cells.
25825716 Findings indicate that alternative splicing of androgen receptor (AR) in granulosa cells (GCs) as the major pathogenic mechanism for hyperandrogenism and abnormal folliculogenesis in polycystic ovary syndrome (PCOS).
25822367 mixed-lineage leukemia protein (MLL) complex, a well-known driver of MLL fusion-positive leukemia, acts as a co-activator of AR signaling
25808853 Findings suggest that regulation of the AR signaling pathway, cell proliferation, and migration through FOXA1 represents an important mechanism of EAF2 suppression of prostate carcinogenesis.
25799006 The decrease in PRMT10 was canceled by knockdown of AR or an AR antagonist. These results indicate that PRMT10 plays an important role in androgen-dependent proliferation of prostate cancer cells
25796442 Data demonstrate that the activation of both the Notch and AR signalling pathways is involved in PLCepsilon-mediated oncogenic effects in PCa.
25796113 In patients with localized renal cell carcinoma the androgen receptor mRNA expression level is associated with prognosis
25781993 results provide new insights into the mechanism by which AR promotes breast cancer progression.
25759396 Results indicate that nuclear FLNA promotes androgen-dependent AR-regulated transcription in PCa, while loss of nuclear FLNA in CRPC alters the AR-regulated transcription program.
25744782 PCGEM1 was uniformly distributed in PCa cell nucleus and cytoplasm which remained unaltered upon AR transcriptional activation.
25730905 prostate cancer cell invasion is stimulated by a rapid but sustained increase in Src activity, mediated non-genomically by cytoplasmic AR, leading to rapid activation and shedding of the laminin protease Matriptase
25724186 AR knockdown led to substantial reductions in matrix metalloproteinase 2 (MMP2) and p-AKT levels in Esophageal squamous cell carcinoma cell lines, but no significant change in AKT and MMP9 expression
25712683 Androgen receptor gene aberrations in serum DNA are associated with resistance to enzalutamide and abiraterone in metastatic castration-resistant prostate cancer.
25695063 AR, EGFR, and BRCA1 might be unique biomarkers for targeted therapy and prognosis in TNBC.
25691442 Phosphorylation of the AR on S308 by CDK1 during mitosis regulates AR localization and correlates with changes in AR transcriptional activity
25631336 These results illuminate the complex interplay of AR, ETV1, and PTEN pathways in pre-cancerous neoplasia and early tumorigenesis
25605250 Simultaneous targeting of androgen receptor and MNK1 by novel retinamides inhibits growth of human prostate cancer cell lines.
25563353 Although a role for AR in the modulation of HUVEC biology is evident, the molecular mechanisms by which AR regulates HUVEC homeostasis and disease processes are not fully understood.[review]
25537508 Data show that sepression of runt-related transcription factor (RUNX1) is important for the growth promotion ability of enhancer of zeste homolog 2 (EZH2) in androgen receptor (AR)-independent cells.
25500996 Clinical and experimental analyses have identified novel AR-signalling defects associated with mutations in the structurally disordered AR-N-terminal domain in patients with androgen insensitivity syndrome.
25500540 TXDNC5-mediated CRPC growth can be fully abolished by AR inhibition, suggesting TXDNC5 up-regulation as an escape pathway for aberrant AR re-activation and CRPC growth in the milieu of low androgen
25482560 LSD1 functions broadly as a regulator of AR function.
25476896 The androgen-triggered AR/filamin A complex controls, through Rac 1, the decision of cells to halt cell cycle and migration.
25471060 there is a weak positive association between dietary lignans and AR expression in breast cancer
25461807 BCAS2 is a novel androgen receptor-interacting protein.
25460502 These results indicate that the FKBP5/AR complex may affect ovarian cancer cell sensitivity to taxol
25449081 An expanded CAG repeat in the AR gene was associated with a family with Kennedy disease.
25433476 Androgen receptor expression has significant association with stage and grade of Urinary bladder cancer.
25432062 Current evidence suggests that stromal AR may play positive roles to promote BPH and PCa progression, and targeting stromal AR selectively with AR degradation enhancer, ASC-J9
25409505 Data shows that specific ligand complexes of the mutant T877A-AR were significantly enriched between normal and primary prostatic tumors, ethnic dependent and predictive of survival outcome.
25376484 Higher numbers of ESR2 CA repeats are potentially associated with a small increase in colorectal cancer risk. Our study does not support an association between colorectal cancer prognosis and the investigated repeat polymorphisms.
25351819 Androgen receptor is involved in prostate cancer initiation and the early stages of cancer growth. [Review]
25347744 Studies indicate that activated CDC42 kinase 1 (ACK1) interacts with the estrogen receptor (ER) and regulates the activity of androgen receptor (AR) to promote the growth of breast cancer and prostate cancer.
25327559 Report role of GSK-3/AR/NFkappaB signaling in prostate cancer.
25315188 Taken together, our study suggests that AR signaling may promote tumorigenesis of GBM in adult men by inhibiting TGFbeta receptor signaling.
25307492 Androgen recptor splice variants contribute to prostate cancer progression through induction of epithelial-to-mesenchymal transition.
25301736 Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9.
25301365 Membrane AR activation regulates late expression and/or activity of the tumorigenic gene products c-Src, GSK-3beta. and beta-catenin.
25277659 Treatment of AZD1152-HQPA decreased expression of AR. Moreover, we found weak positive correlations between the expression of Aurora B and AR in both benign prostatic hyperplasia and prostate cancer specimens (r = 0.25, r = 0.41
25274033 studies highlight the AR axis as the key transcriptional output of SPOP in prostate adenocarcinoma and provide an explanation for the prostate-specific tumor suppressor role of wt-SPOP
25241384 Two brothers diagnosed with androgen insensitivity syndrome and their mother were hemizygous and heterozygous respectively for c.2522G>A variant for AR.
25229569 Could not demonstrate a significant changes in the expression of androgen/estrogen receptors in apocrine glands in skin biopsies of patients with hidradenitis suppurativa.
25228652 results show how CtBP2 contributes to prostate cancer progression by modulating AR and oncogenic signaling
25217983 This study found an association between longer androgen receptor CAG repeat lengths and hepatocellular carcinoma risk among Asians
25216524 Authors investigated the relationship between Usp12, PHLPP and PHLPPL tumour suppressors in the regulation of AR transcriptional activity in prostate cancer.
25215939 There was no association between ErbB2-IR and the androgen receptor (AR)-IR in the tumours, but an interaction between the two parameters was seen with respect to their association with the tumour stage.
25200184 A highly bone metastatic RANKL-overexpressing prostate cancer cell line, LNCaP(RANKL)used as a model to study increased adhesion of prostate cancer (PCa) cells to collagens and found 3-D suspension culture and in vivo PCa tumor growth restore AR through downregulation of AP-4, enhancing integrin alpha2 expression and adhesion to ColI which is rich in bone matrices.
25187224 Polymorphisms of the androgen receptor gene is associated with hormonal contraceptive induced vestibulodynia.
25184630 Detection of AR-V7 in circulating tumor cells from patients with castration-resistant prostate cancer may be associated with resistance to enzalutamide and abiraterone.
25182772 Determined are the conformations of the full-length wild-type and mutant AR and revealed is the conformation of the mutant AR that causes spinal bulbar muscular atrophy.
25180665 Report role of androgen receptor polymorphisms in testicular cancer risk.
25178713 Increased androgen receptor activity and cell proliferation in aromatase inhibitor-resistant breast carcinoma
25178514 Androgen receptor collaborates with estrogen receptor alpha to promote resistance to aromatase inhibitors in breast cancer cells.
25175748 Nanog is a novel oncogenic AR target gene in prostate cancer cells, and stable expression of Nanog increases proliferation and growth of prostate cancer cells, but not resistance to enzalutamide or docetaxel
25148265 this is the first report of combining chromosomal analysis of PCOS patients with full sequencing of the human AR gene and linking codon usage to PCOS.
25145503 High AR expression is associated with triple-negative breast cancer.
25138562 Glucocorticoid receptor expression is negatively regulated by androgen receptor (AR) signaling and may serve as a marker for AR signaling in prostate tumors.
25135278 these results concluded that infiltrating CD4(+) T cells could promote PCa metastasis via modulation of FGF11-->miRNA-541-->AR-->MMP9 signaling.
25132524 Findings indicate that Gli2 overexpression in PCa cells might support development of castration resistant PCa through AR co-activation and suggests that AR might modulate transcription from Gli2.
25132238 Androgen receptor splice variants can bind to DNA independent of full-length androgen receptor in the absence of androgen and modulate a unique set of genes that is not regulated by full-length androgen receptor
25132193 PAX2 promotes cancer cell growth in androgen-independent prostate cancer by regulating androgen receptor gene expression through an epigenetic mechanism.
25131556 genetic association study in population of oocyte donors in Spain: Data suggest AR gene CAG repeat length/polymorphism does not affect ovarian response to gonadotrophins in ovulation induction; ovarian reserve is associated with CAG polymorphism.
25124466 Molecular analysis showed no association between sex hormone gene AR and MtF transsexualism. Variable regions analysed are not associated with MtF.
25121964 Data shoe that 3-alkoxy-pyrrolo[1,2-b]pyrazolines compound 26 bound to androgen receptor (AR) with an IC50 of 0.7 nM with great selectivity over other nuclear hormone receptors.
25121586 Data indicate that nuclear translocation of androgen receptor (AR) was effected by androgen receptor pan-antagonists.
25109335 A new role for Arr2 in the expression and activation of AR and its potential relevance as a target for therapeutic intervention and monitoring of disease progression.
25108912 We examined the transcriptional regulation of autophagy and observed a functionally significant physical interaction between TFEB and AR in spinal and bulbar muscular atrophy.
25103771 IL-1B can drive prostate cancer (PCa) progression in an inflammatory microenvironment through androgen receptor repression and p62 induction to promote the development and survival of androgen independent PCa.
25095606 associations between the lengths of CAG repeats and relative AR transactivations;the described polymorphism and clinical parameters of various medical conditions characterized by hyper/hypoandrogenism (Review)
25088980 During prostate carcinogenesis and progression, the stromal cells begin to lose AR expression as early as at the stage of high-grade prostatic intraepithelial neoplasia.
25087467 Androgen receptor is often overexpressed in salivary duct carcinoma, and androgen deprivation therapy is safe and should be considered for treatment.
25078541 DXS1194-DXS1111 haplotype, in linkage disequilibrium with AR-(CAG)n expanded allele is associated with Atrophic Muscular Disorders.
25043756 Castration-resistant prostate cancer cell activation is induced regardless of presence of AR; in cells devoid of AR, glucocorticoid receptor GR interacts directly with p-STAT5.
25043157 Tissue microarray of tumor sites from prostate cancer patients correlates with ERG, prostate-specific antigen (PSA), and androgen receptor (AR) expression and ERG gene rearrangement.
25034089 Frameshift mutation in AR in a family with 46,XY females and complete androgen insensitivity syndrome.
25032861 Through the PI3K/Akt pathway, AR enhances the expression of the antiapoptotic protein Mcl-1.
25031696 These results suggest that while AR nuclear import relies on karyopherin activity, AR nuclear export and/or cytoplasmic localization may require other undefined mechanisms.
25027083 Our observation suggests that the CAG and GGN repeat length is shorter in women with RSAs as compared with controls and that shorter CAG and GGN repeats may be pathogenic for RSAs in Chinese women
25012998 A-allele of the SNP rs1204038 of the androgen receptor gives a 65% higher risk of having PSA above 3 ng/mL than the G-allele in men without prostate cancer
25011927 Data indicate that the effect of testosterone on fetuin-A (alpha-2-HS-glycoprotein, AHSG) mRNA levels was abrogated by silencing of the androgen receptor in HepG2 cells.
25008967 Androgen receptor and its splice variant, AR-V7, differentially regulate FOXA1 sensitive genes in prostate cancer.
25003216 Authors propose the presence of a negative feedback loop in prostate cancer cells whereby AR activates AMPK and AMPK feeds back to limit AR-driven transcription.
24986529 Polymorphism of CAG repeat lengths within the AR gene may contribute to hyperandrogenism in polycystic ovary syndrome.
24972028 Combined ERG/AR overexpression signifies a class of patients at highest-risk of prostate cancer specific mortality with specific key genetic alteration likely responsible for disease progression.
24956378 Androgen receptor plays a key role in calcium oxalate crystal formation in the kidney.
24951107 A better understanding of AR signalling in this disease is critical given the current resurgence in interest in utilising contemporary AR-directed therapies for breast cancer.[review]
24948877 data may support the idea that AR-specific hypermutator phenotype in combination with other genes, might serve as a contributing factor to ethnic differences in prostate cancer and potentially different clinical outcome in African Americans as a high-risk population
24942741 Mutation of cysteine 611 and cysteine 614 in the second zinc finger module of AR-DNA binding domain diminished the effects of H(2)S on AR S-sulfhydration and AR dimerization.
24937452 Therefore, we conclude that SET8 is involved in AR-mediated transcription activation, possibly through its interaction with AR and H4K20me1 modification.
24930483 Expression of AR significantly impacts prognosis and is thus promising prognostic marker in periocular SGC.
24928520 Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens.
24925673 data suggest that shorter androgen receptor CAG repeats are specifically associated with development of TMPRSS2:ERG-positive prostate cancer.
24913829 Androgen receptor (AR) suppresses normal human prostate epithelial cell proliferation via AR/beta-catenin/TCF-4 complex inhibition of c-MYC transcription.
24913494 Promotion of AR, in addition to enhancement of the Akt-, NFkappaB-, and Hh-pathways by sustained MID1-upregulation during androgen deprivation therapy provides a powerful proliferative scenario for PCa progression into castration resistance
24897063 AR and ER expression status in invasive breast carcinomas reflects that of their progenitor cells in terminal duct lobular units
24884994 AR overexpression is associated with myelolipomas.
24877132 In vitro chronic administration of ERbeta selective ligands and prostate cancer cell growth: hypotheses on the selective role of 3beta-adiol in AR-positive RV1 cells.
24875621 Cooperativity and equilibrium with FOXA1 define androgen receptor(AR) cistrome. FOXA1 also functions in inhibiting AR signalling and castration-resistant prostate cancer growth via opening chromatin for binding with AR.
24874833 High AR expression is associated with prostate cancer.
24845419 Dehydroepiandrosterone increased ERbeta and AR recruitment to the miR-21 promoter.
24845031 demonstrates that Chrebp interacts with AR and regulates its transcriptional activity
24824408 Our findings suggested that AR CAG repeats are not associated with TMPRSS2:ETS formation in prostate cancer.
24793306 AR might play a ligand-independent role in the development of OVTC.
24786235 The pharmacological effects of 6012, including AR binding, androgen-induced AR translocation.
24779793 Our results describe the expression of the AR in TNBC as a druggable target and further suggest the combination of bicalutamide with inhibitors of EGFR, PDGFRbeta or Erk1/2 for future development.
24777847 High AR gene copy number emerges during the development of Small cell carcinoma of the prostate, often in association with TMPRSS2-ERG rearrangement.
24742458 The data of this study revealed a crucial role for muscle expression of polyQ-AR in spinal and bulbar muscular atrophy and suggest muscle-directed therapies as effective treatments.
24737870 HES6 is up-regulated in aggressive human prostate cancer and drives tumour growth by enhancing the transcriptional activity of the AR, which is preferentially directed to a regulatory network enriched for transcription factors such as E2F1.
24737579 study concludes a significant proportion of children with presumptive diagnosis of androgen insensitivity syndrome (AIS) has normal AR gene; a significant number of children with presumptive diagnosis of AIS have mutations in SRD5A2 gene and are clinically and biochemically indistinguishable from AIS
24715382 a relationship between androgen receptor loss in triple-negative breast carcinoma and it's more aggressive phenotype
24703723 AR protein expression in Estrogen Receptors - negative disease may have a favorable effect on the outcome of patients receiving adjuvant taxanes-based regimens.
24699278 Interfering in their interactions with AR.
24691874 study showed that the outliers of AR-CAG repeat length seem to influence the function of AR, affecting testis volume and Sertoli cell function and consequently sperm production in both fertile and idiopathic infertile men
24680642 Results indicate a combination of decreased expression of ERs, AR and SRC-3 but not SRC-1 may be involved in the tumorigenesis of gliomas, ERalpha/SRC-3 axis may play central role in the regulation these tumors.
24665929 We con fi rmed that the AR gene polymorphism (SNP rs6152 G>A) is associated with the development of androgenetic alopecia and higher prostate-specific antigen levels in patients with benign prostate hyperplasia but not cancer.
24662746 Androgen receptor signaling promotes bladder cancer metastasis through Slug mediated epithelial-mesenchymal transition.
24648349 Findings suggest cooperation between AR and RUNX in the stimulation of oncogenes such as SNAI2, which might be targeted for individualized prostate cancer therapy.
24634161 Significant agreement between blood and tissue AR-E211 G > A polymorphism only in non-tumor tissue focus was confirmed.
24634055 AR expression was common in IBC tumors, and AR positivity was significantly associated with lymphovascular invasion.
24626777 Results indicate that the interaction between the AR and hnRNP K has an important role in the progression of prostate cancer.
24615402 Data indicate that glucocorticoid receptor (GR) expression increases in prostate cancer following androgen receptor (AR)-inhibition.
24607544 Membrane androgen receptor activation activates cariporide-sensitive Na(+)/H(+)-exchangers, an effect requiring SGK1 and ROCK activity.
24596370 Overexpression of androgen receptor is associated with apocrine breast carcinoma.
24593124 Shorter length AR gene CAG repeat number is associated with the recovery of sexual function after TRT in postsurgical male hypogonadotropic hypogonadism, independently of the effects of concomitant pituitary-replacement therapies.
24589466 serum total testosterone (T) level was positively associated with the AR CAG repeat length, whereas no significant correlation of T or AR CAG repeat polymorphism with penile length was found
24583551 These results provided new evidence for the regulatory mechanism of aberrant CDC6 oncogene transcription by FOXM1 and AR, two highly expressed transcription factors in prostate cancer cells
24574517 Data indicate that prostate cancer progression regulated by Jagged1 can be dramatically enhanced by combining with AR through promoting Akt activity.
24570075 Data indicate there were four androgen receptor splice variants (V1, V3, V7, V9) were detected to some degree in almost all cell lines and tissues.
24561445 AR has an impact on prostate cancer development through the regulation of transcription networks, genomic stability and DNA repair.[review]
24553861 The majority of SDCs express AR, HER2, and/or EGFR.
24552459 Collectively, these data provide evidence for a novel mechanism by which activated androgen receptor, through an up-regulation of estrogen receptor-beta gene expression, inhibits breast cancer cell growth.
24523409 GARRPR in Bag-1L as a novel BF-3 regulatory sequence important for fine-tuning the activity of the AR
24522616 Synergistic effect of Androgen receptor mutation and eNOS (glu298Asp) variant on seminal parameters in oligoasthesozoospermia.
24512546 Downstream targets of androgen receptor in endometrial cancer are promoted by FOXA1 upregulation.
24507681 Studied the relation between the polymorphism of repetitive sequence in gene CAG of androgen receptor (AR) and the susceptibility and clinical stages as well as pathological grading of prostate cancer among Han population.
24505496 Androgen receptor mRNA expression is down-regulated in triple negative breast cancer.
24495604 Results indicate that androgen receptor CAGr may interact with T to impact navigation performance.
24484909 Androgen receptors are an important indirect target of metformin in prostate cancer cells.
24480624 P300 acetyltransferase is a molecular determinant of androge receptor degradation.
24465978 Weak associations between serum testosterone levels and the rs5965433 and rs5919392 single nucleotide polymorphisms in the androgen receptor.
24441043 Findings indicate that sLZIP negatively regulates AR transactivation in androgen-dependent PCa cells and functions as a positive regulator in tumor progression of androgen-independent PCa. sLZIP contributes to the malignant phenotype of PCa.
24440747 Hic5 coordinates AR signaling with adhesion and extracellular matrix contacts to regulate cell behavior in the tumor microenvironment.
24424504 we review the AR phosphorylation sites, the kinases responsible for these phosphorylations, as well as the biological context and the functional consequences of these phosphorylations
24422631 VHL enhances androgen receptor (AR) de-ubiquitination rather than inducing AR ubiquitination.
24403250 AR expression is associated with a less aggressive phenotype and a better prognosis in patients aged 51 or older with ER-positive breast cancer.
24391916 The median CAG repeats in AR gene exon 1 were associated with lower serum testosterone levels in asymptomatic hepatitis b virus carriers and an increased susceptibility to HBV-related acute liver failure.
24379448 Data reveals that amplification of the AR is tightly linked to amplification of the AR-regulated common amplified region region on 20q13.
24356815 Data indicate that NVP-BEZ235-induced androgen receptor (AR) suppression resulted in decreased expression of both tumor suppressor proteins PTEN and KLLN in AR+/ER+ breast cancer cells.
24336678 Increased androgen receptor levels, along with kindlin 2 expression, were identified in patients with polycystic ovary syndrome.
24336349 This study demonstrated taht a significant relationship between AR CAG repeat number and neural responses, which suggested that fathers who are less sensitive to T have increased neural responses in regions important for empathy.
24329492 suppression of AR expression decreased the production of TGF-beta, inhibiting EMT and bladder cancer cell growth in vitro and in vivo
24324816 The present analysis indicated that AR expression was associated with lower risk of recurrence in patients with all breast cancer types and better OS in cases with ER positive.
24321103 Data from daughter/mother pairs implicate AR mutations (missense, exon 7; deletion, exons 1/2; nonsense, exon 1) in 3 cases of androgen-insensitivity syndrome in Japan; mother is genetic carrier in each of 3 cases in teenage patients. [CASE REPORT]
24297183 AR3 is a driver of prostate cancer, at least in part, through modulating multiple tumor-promoting autocrine/paracrine factors.
24292680 In an androgen-depleted state, elevated levels of FOXA1 enhance androgen receptor (AR) binding at genomic regions not normally occupied by AR, which in turn facilitates prostate cancer cell growth.
24271034 This work shows that the AR and the POMC gene might functionally interact with each other and subsequently mediate craving in alcohol-dependent patients.
24258347 Data show that the decrease in androgen receptor (AR) levels induced by mahanine occurs posttranslationally by proteasomal degradation, without any change in the AR gene expression.
24244276 Characterization of prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants.
24243687 TBLR1 physically interacts with AR and directly occupies the androgen-response elements of the affected AR target genes in an androgen-dependent manner.
24229697 The sequencing of the AR gene revealed the presence of novel nucleotide substitution in the three patients with complete androgen insensitivity syndrome.
24201121 assess the human androgen receptor alpha (HUMARA) gene in 29 female patients with hyaline vascular Castleman disease and compared the results with three cases of plasma cell Castleman disease and 20 cases of age-matched lymphoid hyperplasia
24193094 The number of CAG repeats in the AR gene was negatively correlated with physical aggression, anger, and hostility.
24177177 An opposing role of AR and STAT3 in prostate Cancer stem-like cell development.
24173286 the negative correlation between Androgen receptor and total DNA methyltransferase activity is one of mechanisms to influence the methylation status of miR-375 promoter, which in turn regulates the expression of miR-375.
24172884 Androgen-induced AR activating signal upregulates let-7a that targets CMYC and KRAS and contributes to ER-, PR-, AR+ breast cancer pathogenesis.
24167630 These findings suggest that genistein, at physiological concentrations, potentially act as an agonist and activate the mutant AR that can be present in advanced PCa after androgen ablation therapy.
24165020 study indicates that androgen receptor CAG repeat polymorphism does influence the clinical response to testosterone replacement therapy in metabolic syndrome and type 2 diabetes
24130878 These results demonstrate that androgen-stimulated PAK6 activation is mediated through a direct interaction between AR and PAK6 and PAK6 activation promotes prostate cancer cells motility and invasion.
24124902 expression of AR3 mRNA lower in testicular tissues with impaired spermatogenesis when compared to normal tissues
24123015 Androgen responsiveness is attenuated in 2'-hydroxyflavanone treated prostate cancer cells through down-regulation of androgen receptor.
24116069 AR CAG bi-allelic mean length did not differ between controls and polycystic ovary syndrome cases/case sub-groups nor did the allele distribution.
24103312 CKbetaBP2/CRIF1 is expressed with STAT3 in prostate cancer where STAT3 may help to offset the AR repressor effect of CKbetaBP2/CRIF1.
24101480 Findings indicate that androgen receptor (AR) gene rearrangements are a unique resistance mechanism by which AR transcriptional activity can be uncoupled from endocrine regulation in castration-resistant prostate cancer (CRPC).
24100013 Importin 7 contributes to the regulation of androgen receptor import by restraining import until androgen is detected in the cytoplasm.
24099702 The role of the N-terminal domain of androgen receptor in protein localization.
24098470 Up-regulation of SOX9 in sertoli cells from testiculopathic patients accounts for increasing anti-mullerian hormone expression via impaired androgen receptor signaling.
24056413 Usp12 acts in a pro-proliferative manner by stabilizing AR and enhancing its cellular function.
24054868 CACNA1D gene overexpression is associated with prostate cancer progression and might play an important role in Ca(2+) influx, AR activation, and cell growth in prostate cancer cells
24053684 Persistent organic pollutants disrupt the function of AR through binding to three possible biding sites on AR; one of them shares the same binding site of its natural ligand.
24046116 Low AR expression is associated with breast cancer progression.
24037531 Results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2, hence inhibiting the tumor-suppressive activity of TGFbeta pathway.
24027196 Results demonstrate that the AR regulates a network of DNA repair genes, providing a potential mechanism by which androgen deprivation synergizes with radiotherapy for prostate cancer.
24023855 normal and aberrant androgen receptor function is associated with distinct patterns of DNA-methylation marks in genital tissues
24019458 AR and beta-catenin-signaling pathways inihibition in prostate cancer was investigated.
24012099 Data indicate that fallopian tube and the epithelial component of Brenner tumours (BTs) expressed AKR1C3 and androgen receptor, but the tumour stromal cells showed strong expression of calretinin, inhibin and steroidogenic factor 1 in the majority of BTs.
23996526 Significant androgen receptor expression was found in patient with juvenile angiofibromas.
23993415 Androgen receptor modulates prostate cancer cell death. [Review]
23982944 Molecular mechanism dissection revealed that targeting prostate cancer cell AR with siRNA promoted cell migration/invasion via CCL2-dependent STAT3 activation and epithelial-mesenchymal transition pathways.
23970793 AR and pAR213/210 can be independent prognostic markers in breast cancer.
23962788 Androgen receptor increases CD133 expression in endometrial cancer stem cells.
23961993 VHL-UXT interaction and VHL-induced ubiquitination of androgen receptor(AR) regulate transcriptional activation of the AR.
23959643 To investigate the evolutionary history of the EDA2R/AR intergenic region, we characterized the haplotype structure of 52 of its highly differentiated SNPs. Nearly all human X chromosomes carry one of two modal haplotypes for these 52 SNPs.
23954086 No positive results have been derived from our findings, suggesting that AR might not serve as a potential marker for classification or prognosis of bladder cancer
23945560 high pAR308 is associated with longer time to death; high pAR791 expression is associated with longer time to disease recurrence in hormone naive prostate cancer tumors and longer time to death from disease recurrence in castrate resistant prostate cancer
23941877 Data suggest that in prostate cancer cells CDK5 (cyclin-dependent kinase 5) regulates interaction of STAT3 (signal transducer and activator of transcription 3) with AR through phosphorylation of Ser727-STAT3 and thereby up-regulates AR stability.
23933691 Data suggest that AR exists as isoforms/mutants; androgen deprivation induces apoptosis in early prostate cancer, however, the majority of patients later develop castration-resistant prostate cancer (CRPC); 60% of CRPC tumors overexpress AR. [REVIEW]
23929266 Our study suggests that loss of androgen receptor in triple-negative breast cancers augurs a worse prognosis
23906537 Fer contributes to aberrant androgen receptor signaling via pSTAT3 cross-talk during castrate-resistant prostate cancer progression.
23893242 SAFB1 acts as a novel AR co-regulator.
23884765 CAG and GGN repeat polymorphisms in the AR gene are no associated with male infertility in Chinese men.
23877345 The results indicated that long-term androgen deprivation resulted in a signaling pathway switch from AR to c-Met in androgen-sensitive cells, which was confirmed by immunofluorescence imaging and western blot analysis
23851510 High androgen receptor splice variant 7 expression is associated with prostate cancer.
23844628 Review: androgen receptor CAG repeat number's relationship with the presence or absence of hypogonadal symptoms remains unclear.
23842682 The study uncovered an F876L agonist-switch mutation in androgen receptor that confers genetic and phenotypic resistance to the antiandrogen drug MDV3100.
23817021 Expression of ERG and ETV1 correlated with higher AR transcriptional output in PTEN-deficient prostate cancer specimens.
23814488 Cross modulation between the androgen receptor axis and protocadherin-PC in mediating neuroendocrine transdifferentiation and therapeutic resistance of prostate cancer.
23811403 Incubation of rat myoblasts expressing human AR with testosterone reduces mRNA levels for ankryn repeat domain protein (Ankrd)1 by approximately 50% and increases those for Ankrd2 by 20-fold.
23801747 Ligand-independent activation of AR variants.
23792449 A novel CCL5-androgen receptor signaling axis increases prostate cancer stem cell populations and metastatic ability.
23790802 Findings demonstrate a novel role for Lin28 in prostate cancer development and activation of the androgen receptor axis.
23786771 When combined with MDV3100, CLU knockdown accelerated AR degradation.
23786676 Id4 regulates NKX3.1, Sox9 and PTEN.
23775496 Androgen receptor knockdown increased cellular sensitivity of castration-resistant prostate cancer cells to docetaxel.
23775437 We conclude that AR is an important marker as it is best able to distinguish between poorly differentiated urothelial and prostate carcinoma.
23775364 AR might play a negative role during prostate cancer progression via influencing entosis by modulating Rho/ROCK pathway.
23766127 Data from gain-of-function transgenic mice expressing human and mouse AR in Sertoli cells (SC) suggest SC AR regulates Leydig cell (LC) differentiation, testicular development, synthesis of testosterone/other androgens, and absolute number of LC.
23755100 These findings characterize PKG as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function.
23734213 Data indicate a transcription complex androgen receptor (AR)-p44-Smad1, and confirmed for physical interaction by co-immunoprecipitaion.
23729616 Data from two cousins (raised as girls) suggest that a novel mutation in AR can result in complete androgen insensitivity syndrome; both subjects exhibited point mutation in exon 4 (c.1890delG) followed by frameshift mutation and stop codon.
23729601 genetic association study in population of boys in China: Data suggest mutations in SRD5A2 [steroid-5a-reductase, alpha peptide 2] (and possibly SF1/NR5A1 [steroidogenic factor 1]; probably not AR [androgen receptor]) are associated with hypospadias.
23727571 In a group of intellectually gifted boys mental rotation is affected by the genetic polymorphisms of the androgen receptor.
23724116 The glycosylation of IGF-1R is necessary for the full activation of the receptor in response to androgen treatment and that perturbing this process can break the feedback loop between AR and IGF-1R activation in prostate cells.
23719921 Cell biological approaches to investigate polyglutamine-expanded AR metabolism.
23715826 AR-enhanced migration and invasion of UUTUC cells.
23704919 These results define a new link between two critical proteins in prostate cancer - AR and c-Myc.
23674566 functional AR variant signaling does not confer resistance to HSP90 inhibition, yields insight into the interaction between AR and HSP90 and provides further impetus for the clinical application of HSP90 inhibitors in advanced prostate cancer.
23661607 Protein degradation of androgen receptor and decreased nuclear accumulation of androgen receptor is found following Plk1 phosphorylation in prostate cancer cells.
23658830 novel consequences of constitutively active AR variants on the regulation of mesenchymal markers in prostate cancer
23631840 A whole-exome analysis of a multiplex family with dilated cardiomyopathy (DCM) exhibiting gender difference revealed a DCM-linked LMNA mutation, p.R225X. LMNA-linked DCM patients demonstrated a nuclear accumulation of androgen receptor.
23628801 There is no evident relationship between the CAG repeat length variants in AR gene and polycystic ovary syndrome risk. [meta-analysis; review]
23620780 Acetylcholine activates STAT3 and AKT pathways and acts on AR to promote the migration and invasion but inhibit the apoptosis of hepatocarcinoma cells.
23609189 Role of MAZ in prostate cancer and its interaction with androgen receptor were investigated. siRNA knockdown of AR significantly decreased MAZ expression, and knockdown of MAZ significantly increased the expression of AR.
23604126 DAB2IP is a unique intrinsic androgen receptor modulator in normal cells, and likely can be further developed into a therapeutic agent for rpostate cancer.
23602133 The number of CAG repeats in Androgen receptor was neither related to depression scores nor to mortality in older men.
23600948 Identifying androgen receptor downstream signaling events and investigating the regulation of androgen receptor activity is critical for understanding the mechanism of carcinogenesis and progression to castration-resistant prostate cancer.
23599814 androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of polycystic ovary syndrome
23589550 Studies indicate ETS transcription factors, PTEN protein and androgen receptor as tumor markers for diagnosis and therapy of prostate cancer.
23589523 A novel AR mutation, c.2214T>G;p.Ile738Met, was identified in the family members affected by a mild disorder of sex determination
23580588 ERa and pAR210 are differentially expressed in hormone-naive (HN) and castration-resistant prostate cancers and that high levels of AR, ERb and pAR210 in HN prostate cancer correlate with a poor clinical outcome.
23573315 Androgen-STAT3 activation may contribute to gender disparity in human simply renal cysts.
23571770 the AR rs5919436 (g.67024320C>G) polymorphism may act as a novel genetic marker for increased susceptibility to severe hypospadias in Caucasians
23565754 This can occur through reactivation of AR signaling.
23554889 Celastrol can significantly inhibit the growth of T/E fusion expressing PCa cells both in vitro and in vivo through targeting three critical signaling pathways: AR, ERG and NF-kB in these cells.
23549873 Data established a seven-gene (AR, ESR2, GATA3, GBX2, KRT16, MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC).
23539448 Data indicate that FoxA1 regulates two distinct oncogenic processes via androgen receptor depnedent and independent pathways.
23536722 important roles of endothelial cells within the prostate cancer microenvironment to promote the prostate cancer metastasis and provide new potential targets of IL-6-->AR-->TGFbeta-->MMP-9 signals to battle the prostate cancer metastasis
23523566 The inhibition of androgen receptor by c-Jun occurs in both hormone naive and castration-resistant prostate cancer cells.
23518348 study found the ubiquitin ligase Siah2 enhances transcriptional activity of AR by degrading a transcriptionally-inactive pool of AR on select gene promoters/enhancers; consequently, Siah2 promotes expression of select AR target genes, leading to growth of castration-resistant prostate cancer cells under androgen-deprivation conditions
23510718 study has shown that a range of markers of reproductive function in fertile healthy men are related to AR CAG and GGN repeat lengths in a curvilinear manner
23503510 The co-treatment with Aza-dC and NaB was the most effective in demethylation and re-expression of the AR gene.
23493387 Prostaglandin E receptor 3 (subtype EP3) downregulation contributed to prostate carcinogenesis and to progression from androgen-dependent prostate cancer to castration-resistant prostate cancer by regulating AR expression.
23479164 The identification of elevated AR mRNA quantitation in hair follicles is a useful tool for identifying potentially abnormal androgen sensitivity in androgenetic alopecia patients.
23476140 Androgen receptor can be related to the increased expression of cancer related survival markers.
23449888 These results reveal a novel function of ARF in modulation of AR transactivation in prostate cancer.
23443946 Collectively, our results suggest that SGTA can influence AR signaling in ovarian cancer cells and that AR signaling capacity may be reduced with the development but not metastatic progression of serous ovarian cancer.
23441776 None of the genotyped SNPs in androgen receptor gene are detected to be polymorphic in male Taiwanese, indicating that the effect of AR gene on ankylosing spondylitis may be ethnic-specific in East Asians.
23437213 Together, these observations suggest a novel role of AR as a component of the pre-RC to exert control over progression of LNCaP cells from G(1) to S phase through a mechanism that is independent of its role as a transcription factor.
23435425 The physical interaction between ELF3 and androgen receptor (AR) inhibits the recruitment of AR to specific androgen response elements within target gene promoters.
23433069 Increased expression of androgen receptor in observed in granulosa-luteal cells of patients receiving luteinizing hormone supplementation.
23430227 These results indicated that the androgen receptor G1733A polymorphism is strongly associated with increased risk for recurrent spontaneous abortion
23426362 The ETS domain transcription factor ELK1 directs a critical component of growth signaling by the androgen receptor in prostate cancer cells.
23426182 In prostate cancer, ERG redirects androgen receptor to a set of genes including SOX9 that are not normally androgen stimulated.
23418075 Q640X mutated androgen receptor may have an important regulatory role in mediating the PSMA and PSA genes expression during the progression of prostate cancer from androgen-dependence to androgen-independence.
23417242 miR-185 could function as a tumor-suppressor gene in prostate cancer by directly targeting androgen receptor.
23414681 On the basis of the aforementioned evidence, we postulate that AR exhibits oncogenic properties in gastric cancer via several possible mechanisms, which may partly explain the higher prevalence of gastric cancer among males.
23410945 the PKA pathway is functionally linked to androgen receptor in the progression of prostate cancer
23410127 The role of truncated AR variants (ARVs) and their corresponding genomic origins.
23393169 Associations between AR (CAG)n and peripubertal fat accumulation and serum SHBG concentrations indicate that this genetic polymorphism may influence the androgen-dependent fine-tuning of metabolic and reproductive factors at a young age.
23392859 AR expression is associated with chemotherapy responsiveness in ER-positive patients.
23388696 the androgen receptor (CAG)n polymorphism is not related to the development of systemic lupus erythematosis, but it could modulate the severity of the lupus chronic damages as well as the androgen levels in women.
23386643 KLLN is a transcription factor directly regulating AR, TP53, and TP73 expression, with a role in prostate carcinogenesis.
23386417 Androgen receptor is downregulated in the urethral mucosa of patients with middle idiopathic hypospadias.
23377847 study to examine the significance of intratumor genetic heterogeneity of the androgen receptor gene in breast cancer; results suggest that preferential selection of 18-25 CAG repeat length variants in breast tumors may be associated with breast cancer and support the observation that shorter CAG repeats may protect against breast cancer
23364790 enhanced androgen receptor aggregation is the prominent neuron phenotype of spinal and bulbar muscular atrophy.
23363843 AR plays an important role in telomere stability and replication of telomere DNA in prostate cancer cells.
23349811 Data show that p68/DdX5 immunoprecipitated with RNA polymerase II (RNAP II) and suggest p68 is important in facilitating beta-catenin and androgen receptor (AR) transcriptional activity in prostate cancer cells.
23334200 no linear relationship was found between anogenital distance and androgen receptor CAG repeat length overall
23326489 These data propose a model of elevated Sox2 expression due to loss of AR-mediated repression during castration.
23320115 Overall cholesterol homeostasis is unaffected by changing AR activity in prostate cancer cells. This does not negate the relationship between androgens and cholesterol homeostasis, but rather suggests that other factors compensate for altered AR activity.
23318417 Our findings suggest that AR contributes to prostate cancer progression is through inhibition of key tumor-suppressor genes
23272232 The presence of long CAG repeat sequence and AR protein expression were in relation to survival of MBC patients. The CAG repeat length and AR expression were two independent prognostic indicators in MBC patients.
23246967 The E3 ligase CHIP modulates cell cycle arrest via proteasomal degradation of ubiquitinated androgen receptor.
23227263 AR is implicated as a potential novel fetal susceptibility gene for spontaneous preterm birth.
23212659 Emodin downregulated AR in LNCaP under normoxic and hypoxia-like conditions and LRP1 under normoxia. Emodin upregulated LRP1 in other cell lines, except HCT-15, under normoxic, and even more markedly under hypoxia-like conditions.
23201383 Androgen receptor expression was significantly decreased in infertile men with varicocele.
23199240 Data indicate that estrogen receptor alpha, estrogen receptor beta, progesterone receptor and androgen receptor may be partly involved in gastric carcinogenesis but their clinicopathological and prognostic significance appears to be limited.
23193666 The AR gene CAG length showed polymorphism in men with late-onset hypogonadism.
23184046 the presence of a high number of polymorphic GGC repeats in the AR gene is associated with an increased risk of developing PCa and BPH.
23182796 Polymorphism of the AR gene seems to be a promising biomarker for polycystic ovary syndrome because shorter repeats may be linked to the disorder. [review]
23172223 MAGE-A11 increases AR transcriptional activity by linking androgen receptor dimers.
23171135 PTEN deletion was also linked to diminished expression of PTEN (P<0.01) and AR (P=0.02).
23167717 Evidence was provided that a higher number of the CAG repeat sequence in the androgen receptor gene has a clear effect on the risk of hypospadias in Caucasians.
23160479 The onset and level of local sertoli cell androgen receptor expression is pivotal for optimal testicular development and spermatogenesis.
23159636 these data suggest that AR primes androgen-independent prostate cancer cells to DNA damage-induced apoptosis through the PIRH2-p53-p21 axis.
23146908 ZIPK has a crucial role in regulation of ubiquitination and degradation of the AR
23145034 Activity of the AR was confirmed in prostate progenitor cells.
23132866 PAK6 phosphorylates Mdm2 on Thr-158 and Ser-186, which is critical for AR ubiquitin-mediated degradation.
23132707 However, we found that both CAG and GGN androgen receptor alleles were not associated with the left hand, right hand, right minus left-hand or mean hand 2D:4D ratios.
23117885 these studies highlight AR-Vs as key mediators of persistent AR signaling and resistance to the current arsenal of conventional and next generation AR-directed therapies.
23106833 report that, in addition to its functions in nuclear import, DNA binding, acetylation, N/C-termini interactions and transactivation, the AR-NLS region also functions as 'mitotic chromatin binding-determining region'
23095762 Data indicate that targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and modulation of androgen receptor (AR) transcriptional activity in prostate cancer (PCa) cells.
23093490 AR is a key regulator for myometrial cell proliferation, suggesting its critical role in myometrium phenotype programming during pregnancy.
23088973 The AR-V1 or V7 transcript level does not predict recurrence in patients with high grade prostate cancer at indeterminate risk for progression. Grade 3 cancer in mixed grade tumors may differ from 100% grade 3 cancer, at least in AR-V1 expression.
23069658 found that (i) miR-124 directly targets the androgen receptor (AR) and subsequently induces an upregulation of p53
23044881 More than 800 mutations in AR gene have been reported in androgen insensitivity syndrome (AIS) patients. [REVIEW]
23041906 androgen-deprivation induced a decrease in AR and PSMA levels in androgen-sensitive LNCaP cells, which may be associated with the development of more aggressive disease-state following androgen deprivation therapy.
23041672 Nuclear export signal of androgen receptor (NESAR) plays a key role in AR ubiquitination and proteasome-dependent degradation in prostate cancer cells
23030067 Data indicate that the persistent organic pollutants (POPs)-related receptors estrogen-, androgen- and aryl hydrocarbon-receptortransactivities can be used as effect biomarkers.
23023562 The genomic and transcriptional cross talk between AR and ERalpha signaling in a luminal breast cancer cell line, was investigated.
23023312 With pull down assay and co-immunoprecipitation assay, the study demonstrated that KLF8 bound directly to AR, and KLF8 enhanced AR target gene transcription in human prostate cancer cells.
23013557 This study has shown the synergistic effect of FSHR 307(T/A), FSHR 680(N/S) and AR(CAG)n polymorphisms on sperm motility probably due to alterations of FSH and AR sensitivity, certifying the significance of FSHR and AR genes in spermatogenesis.
23012352 induced AR expression, via alteration of its methylation pattern, led to suppression of the self-renewal/proliferation of prostate stem/progenitor cells and PCa tumorigenesis
23010705 Decreased androgen receptor expression is associated with distant metastases in patients with androgen receptor-expressing triple-negative breast carcinoma.
23001776 findings are indicative of the synergistic effect of AR(CAG)n and CYP19(TTTA)n polymorphisms on semen quality, confirming the significance of AR and CYP19 genes for spermatogenesis.
22986532 Data indicate that androgen receptor (AR) phosphorylation by PIM1 at S213 impacts gene transcription and is highly prevalent in aggressive prostate cancer.
22982153 Cell line transfection experiments and survival analyses of histological samples suggest that the presence of AR in breast cancer is either benign or predicts better survival. Review.
22899854 p23 increases activity of the androgen receptor (AR), and appears to involve steps both in the cytoplasm and the nucleus.
22894932 ARSer81 is involved in the interaction with Pin1.
22890844 The results suggested that the androgen-induced SUMOylation is linked to chromatin binding, whereas stress-induced SUMO-2/3 modifications protect the androgen receptor from proteotoxic insults.
22885105 Dysregulation of epithelial PAGE4 modulates AR signaling.
22882535 case-control study comprising 651 TC cases and 313 controls in a Norwegian population was conducted for investigation of polymorphisms in the LHR, SRD5A and AR genes and their possible association with TC
22877366 Data indicate two recognition helixes of the androgen receptor (AR) homodimer showed that the hydrophobic interactions between the recognition helix B and the major groove containing -158 A:T of KLK3 changed that helix's motion.
22851332 Data suggest that in ureter specimens, higher AR expression is exhibited in superficial or lower grade UUTUC (upper urinary tract urothelial carcinoma); overexpression of AR in tumor cells reduces chemosensitivity, but increases cell migration.
22846800 DDB2 can inhibit cell growth rate in AR-expressing cells (LNCaP) but not in AR-null cells (PC3).
22829593 alterations in AR SUMOylation play significant roles in AR-based diseases and offer novel SUMO-based therapeutic opportunities.
22821817 The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way.
22819977 the variable number of tandem repeats inhibits DAT1 expression
22819717 Ectopic expression of AR in HepG2.2.15 cells increases cell migration and invasion, whereas shRNA knockdown of AR in SNU-449 cells decreases cell migration and invasion.
22799610 A novel splice site and two known mutations of androgen receptor gene in sex-reversed XY phenotype.
22796525 androgen receptor is a polyglutamine expanded protein and a substrate of chaperonin CCT6 alpha subunit.
22771493 Direct cooperation between androgen receptor and E2F1 reveals a common regulation mechanism for androgen-responsive genes in prostate cells.
22765868 We found no evidence for an association between AR CAG repeat length in benign prostatic hyperplasia risk in a population-based sample of Brazilians.
22745193 There is a reciprocal regulation between Slug and AR not only in transcriptional regulation but also in protein bioactivity, and Slug-AR complex plays an important role in accelerating the androgen-independent outgrowth of CRPC.
22745190 Androgen receptor signaling exerts an antiestrogenic, growth-inhibitory influence in normal breast tissue, and this role may be sustained in estrogen receptor alpha positive luminal breast cancers. [Review]
22736030 Polyglutamine expansion AR sequesters PTIP to attenuate DNA repair and increase genomic instability.
22734680 Four AR variants [ARDelta2(Stop) , ARDelta2(23Stop) , ARDelta3 and ARDelta4(120)] were identified in human testis.
22733359 findings show that the HERV-K(HML-2) Rec protein binds to human small glutamine-rich tetratricopeptide repeat protein (hSGT)and interferes with its role as a negative regulator of the AR, resulting in enhanced AR activity
22731640 significantly higher risk estimates for CaP were observed for the combined analysis of short AR CAG and CYP19 genotypes (
22724574 genetic association studies in a population of girls in Chile (daughters of women with polycystic ovary syndrome): AR CAG repeat polymorphism appears unrelated to serum androgen levels. However, AR CAG repeats may have association with lipid profile.
22719059 An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity.
22695532 current systematic review and meta-analysis found that the AR CAG microsatellite repeat polymorphism is unlikely to be a major determining factor in the development of polycystic ovary syndrome
22665497 ATF3 is a novel repressor of androgen signaling that can inhibit AR functions, allowing prostate cells to restore homeostasis
22654108 Results suggest that in PCa progression, CaMKK2 and the AR are in a feedback loop in which CaMKK2 is induced by the AR to maintain AR activity, AR-dependent cell cycle control, and continued cell proliferation.
22653923 investigatd whether BF-3 mutations affect AR ligand-binding do function and dynamics possibly via allosteric conversation between surface sites; data indicate AF-2 conformation is indeed closely coupled to BF-3 and provide mechanistic proof of their structural interconnection
22653589 CAG and GGC repeats in the AR and PSA gene polymorphisms may be associated with prostate cancer risk and BPH in the Turkish population.
22608750 Adenosine dialdehyde suppressed the monomethylation and dimethylation of histone H3 lysine 9 and inhibited Twist1 as well as androgen receptor expression, which are critical for the survival and growth of androgen dependent
22608749 AR transcript expression inversely correlates with bladder cancer clinicopathological characteristics.
22590818 The epithelial estrogen receptor expression in phyllodes tumors was correlated with the proliferative rate in the stromal component.
22584579 As AR turnover has been previously shown to be critical for cell cycle progression in prostate cancer cells, PIM-1 kinase isoforms may promote prostate cancer cell growth, at least in part, through modulating AR activity via distinct mechanisms.
22579704 males with mixed handedness exhibited a weaker androgen receptor than right-handers as evidenced by longer AR-CAG repeat length.
22578234 Smoking is associated with altered semen quality, endocrine hormonal status, and number of CAG repeats in the androgen receptor gene in infertile Indian men.
22570967 Boys with isolated hypospadias have longer CAG alleles in their AR, which may be related with the development of this congenital malformation.
22568330 AR expression decreases in penile skin of patients with congenital hypospadias and simple chordee, especially in the urethral plate.
22562653 Data indicate that androgen receptor activation by dihydrotestosterone (DHT) inhibits basal secretion of proinflammatory cytokines/chemokines and growth factors by benign prostatic hyperplasia (BPH) cells.
22532567 the AR splice variant core consisting of the AR NH(2)-terminal domain and DNA binding domain is sufficient for nuclear localization and androgen-independent transcriptional activation of endogenous AR target genes.
22531679 ERalpha positivity, ERbeta negativity, and AR expressions are associated with a more aggressive phenotype of differentiated thyroid cancer.
22508987 identified a novel mechanism for E2F factors in the regulation of cell cycle gene expression and cell cycle progression under the control of AR signaling
22508765 AR and ESR1 have distinct modes of interaction with chromatin and that DNase I hypersensitivity dynamics provides a general approach for predicting cell-type specific cistromes.
22495974 Epigenetic regulation of PITX2 during the course of the disease may lead to orchestrated control of the AR and IGF signaling pathways.
22494987 the role of CRH in apoptosis via androgen receptor and vitamin D receptor
22493003 Studies indicate that the androgen-androgen receptor (AR) system plays an important role in homeostasis of various organs in males.
22487869 in a family with a familial complete androgen insensitivity syndrome, a large unique deletion/insertion mutation in the N-terminal domain that resulted in the frameshift and consequently the formation of a premature stop codon was identified
22471922 study shows AR expression is associated with 10-year survival outcome in patients with Stage III breast cancer; hypermethylation of the AR promoter is associated with loss of AR expression in breast cancer cells but not in primary breast tumours; a new somatic mutation in the AR 5'UTR found in 2 independent tumours and is not a normal polymorphism is described
22456197 Data suggest that TACC2 (acidic coiled-coil containing transforming protein 2) expression can be induced by androgen/AR signal transduction in prostate cancer cells.
22456196 Data suggest that androgen/AR signal transduction depends on RhoA (rhoA GTP-binding protein) expression in androgen-responsive prostate cancer; androgen/AR signal transduction is increased by overexpression of RhoA.
22426480 these findings point to BLT2 as a key regulator of AR expression and will contribute to the development of novel therapies for AR-positive prostate cancers, including androgen-responsive and castration-resistant prostate cancers.
22403669 role of point mutation in androgen receptor function
22403609 senescence response caused by a nuclear hormone receptor
22392544 This is first study on variation in aggression, digit ratio (ratio between the second and fourth digits, 2D:4D), directional asymmetry in 2D:4D (D(R-L)) and polymorphisms of the AR, DRD4, and 5-HTTL genes in simple hunter-gatherers, the Hadza of Tanzania
22391641 Androgen receptor is overexpressed in boys with severe hypospadias, and ZEB1 regulates androgen receptor expression in human foreskin cells
22386953 AR status in thyroid tissues of men and women may predispose to the gender specific incidence of thyroid tumors and miR-124a plays a significant role in determining the AR gene expression pattern and thus, androgen mediated thyroid tumor growth.
22385118 genetic association study in Italy: Data suggest that length of AR CAG repeat polymorphism affects response to gonadotropin replacement therapy in hypogonadotropic hypogonadism in particular in those male subjects with prepubertal-onset hypogonadism.
22362749 The presence of the androgen receptor, but not its transcriptional transactivation activity, is critical for human prostatic transglutaminase transcription.
22360658 data suggest that AR-NH1 (the N-terminal fragment of AR cleaved in the neighborhood of helix 1 of the ligand-binding domain)is produced under hormone therapy and contributes to the development of castration-resistant prostate cancer due to its ligand-independent transcriptional activity
22344533 shorter alleles of the (CAG)n in exon 1 of the AR gene enhanced the susceptibility to PCOS, either by upregulating AR activity or by causing hyperandrogenism.
22334658 the functional defect associated with an AR exon 1 missense mutation
22328501 Regulation of gene expression by AR homodimers and monomers is mediated by AR domain interactions.
22327304 study hasshown that androgen receptors are not present in either Barrett esophagus mucosal tissue or to any substantial degree in normal esophageal mucosa
22321971 In human breast epithelial cells, androgen receptor signaling requires p21 for MAPK activation.
22315407 ARD1 functions as a unique AR regulator in prostate cancer cells.
22309306 Data show that SGK1 regulates cell migration via vinculin dephosphorylation, a mechanism that is controlled by membrane androgen receptor function.
22286197 The molecular basis of incomplete correlation with the pattern of DNA methylation of this X chromosome AR gene locus.
22282656 It was found that the protein tyrosine phosphatase PTP1B, a well-established regulator of metabolic signaling, was induced after androgen stimulation of androgen receptor-expressing prostate cancer cells.
22281759 Tanshinones from Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling.
22275373 Ser-81 phosphorylation by CDK9 stabilizes AR chromatin binding for transcription.
22272301 Data show that activation of androgen receptor (AR) signaling by intratumoral AR ligands is required for castration-recurrent prostate cancer (CaP) growth.
22266865 structural alterations in the androgen receptor (AR) gene are linked to stable gain-of-function splicing alterations in castration-resistant prostate cancer (CRPCa).
22266320 These results provide evidence that hypoxia may stimulate as yet unknown factors, which further stimulate AR signal transduction pathways.
22264502 Data suggest reciprocal regulation of PlncRNA-1 and androgen receptor contribute to prostate cancer (CaP) pathogenesis and that PlncRNA-1 is a potential therapy target.
22245783 The androgen receptor gene copy number is elevated in up to 80 percent of castration resistant prostate cancers. [Review]
22245379 these studies identify CXCL12 as a novel, non-steroidal growth factor that promotes the growth of prostate epithelial cells through AR-dependent mechanisms in the absence of steroid hormones.
22233359 Our findings do not support a role of the AR CAG repeat length in amyotrophic lateral sclerosis .
22212979 androgen receptor signaling pathways are reactivated in castration resistant prostate cancer
22188741 Androgen receptor genotypes encoding moderate functional variation may influence cryptorchidism risk
22179855 our data reveal an unexpected role of AR as a transcriptional repressor inhibiting non-prostatic differentiation and, upon excessive signaling, resulting in cancerous dedifferentiation.
22174412 Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells.
22155408 HN1 maintains a balance between the androgen-regulated nuclear translocation of androgen receptor and steady-state Akt phosphorylation, predominantly in the absence of androgens.
22154085 0.5 muM CTS effectively suppresses the growth of AR-positive PCa cells.
22128178 MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells.
22114732 Androgen receptor variants occur frequently in castration resistant prostate cancer metastases.
22107839 genetic association studies in a population of Croatian women: AR CAG repeat polymorphisms in exon 1 are not associated with polycystic ovary syndrome; these polymorphisms are associated with elevated serum testosterone levels in this population.
22102282 Regulation of androgen receptor-dependent transcription by coactivator MED1 is mediated through a newly discovered noncanonical binding motif.
22095517 Hexim-1 protein expression and cellular distribution significantly influence AR activation and transforming growth factor (TGF)-beta signaling in prostate cancer progression.
22089459 Results suggest the association of short androgen receptor (CAG)(n) alleles with earlier onset and a more aggressive course of rheumatoid arthritis.
22086872 Androgen-mediated androgen receptor signals promote bladder carcinogenesis by down-regulating the expression of UDP-glucuronosyltransferases in the bladder.
22083957 NKX3-1 and androgen receptor directly regulate each other in a feed-forward regulatory loop.
22081303 AR CAG repeat length in a subgroup of subjects previously shown to have varied GnRH pulse generator sensitivity to Progesteron-mediated slowing
22074952 data demonstrate that GnRH transcription is repressed by AR via multiple sequences in GnRH-P, including three Oct-1 binding sites, and that this repression requires the complex interaction of several transcription factors
22068615 The CAG repeat polymorphism could constitute one of the genetic factors modulating the syndrome's phenotype, contributing to its clinical heterogeneity and associated metabolic consequences.
22064655 A novel molecular mechanism by which SREBP-1 promotes prostate cancer growth and progression through alterations in the concerted intracellular metabolic and signaling networks involving AR, lipogenesis, and ROS in prostate cancer cells.
22039288 Results suggest that co-expression of androgen and estrogen receptors can provide a protective effect based on phenotypical presentation of HER2-positive carcinomas.
22027692 EZN-4176 specifically downmodulated AR mRNA and protein, and this was coordinated with inhibition of the growth of both androgen-sensitive and castration-resistant prostate tumors in vitro as well as in animal models.
22021428 GATA2 not only blocks androgen receptor (AR)-induced PTEN expression by preventing AR nuclear translocation, but also directly represses PTEN transcription independent of AR.
22020793 the elevation of AR-A and -B, and the AR-A/B ratio, is associated with prostate cancer occurrence and progression.
22007000 Data show that signaling via the androgen receptor and ATF4 pathways regulates expression of the amino acid transporters LAT1 and LAT3, thereby coordinating their increased expression in prostate cancer cells.
21977989 study concludes that CAGn polymorphism in AR explains some of the phenotypic variation in Klinefelter syndrome, whereas skewed X-chromosome inactivation did not; impact of CAGn on final height may be caused by later reactivation of the pituitary-gonadal axis
21966451 Results suggest that DNMT1 operates either as a functional intermediary or in cooperation with E2F1 inhibiting AR gene expression in a methylation independent manner.
21965718 These studies suggest that one pathway of EBP1 down-regulation of AR levels may be lost in castration-resistant prostate cancer.
21962961 Case Report: novel mutation A240S of androgen receptor is involved in mild androgen insensivity syndrome associated with azoospermia.
21958043 Zyflamend inhibited Insulin-Like Growth Factor I stimulated cell growth, IGF Type 1 Receptor, and androgen receptor expression and its nuclear localization in CWR22Rv1 cells.
21956655 It was shown that prostate-specific antigen localizes to the nuclei of androgen-stimulated PrCa cells, and controls androgen receptor mRNA and protein levels. This regulatory loop does not involve known androgen receptor activators such as Src and AKT.
21950590 the importance of asparagine at amino acid position 771 of human AR in normal ligand binding and normal receptor function, and a mutation at this position results in androgen insensitivity in subjects affected with androgen insensitivity syndrome
21950564 The study identified the androgen receptor CAG repeat length polymorphism as a risk factor of incident low total testosterone concentrations and as a contributing factor of testosterone-related cardiometabolic effects.
21950206 Reduced CAG repeat length is a risk factor for prostate cancer in Nigerians.
21940984 that the AR repeat polymorphism has little influence on absolute and relative fat mass or its regional distribution in physically active men. In young women, GGN length is positively associated with adiposity, leptin, and osteocalcin.
21937623 The AR gene in target tissues from patients with hypospadias is more methylated than in control children, resulting in a decreased expression of the AR.
21935435 The results suggest that Pax6 represses AR activity by displacing and/or inhibiting recruitment of coactivators to AR target promoters.
21924870 Androgen receptor transactivity is potentiated by TGF-beta1 through Smad3 but checked by its coactivator Hic-5/ARA55 in balding dermal papilla cells.
21912077 VEGF-A expression increased with prostate tumor grade and was inversely related to stromal AR expression.
21909421 FUS is a novel co-activator of AR in prostate cancer cells.
21885566 Inhibitor of beta-catenin and T-cell factor (ICAT), a beta-catenin binding protein that inhibits the canonical Wnt/beta-catenin signaling pathway, in AR signaling, was investigated.
21878636 the membrane-associated AR8 isoform may contribute to castration resistance by potentiating AR-mediated proliferative and survival responses to hormones and growth factors.
21871886 study demonstrates a novel role of the Raf/MEK/ERK pathway in regulating AR expression in certain PCa types and provides an insight into PCa responses to its aberrant activation
21868758 Anderogen receptor activity in castration-resistant VCaP tumor xenografts can be restored through CYP17A1-dependent de novo androgen synthesis.
21844951 The androgen independent prostate cancer cell line was established by androgen deprivation, in which the protein expression of AR was dramatically decreased. Expression was related to the Wnt and proteasome signaling pathways.
21837479 Patients with an androgen receptor-negative tumour have a higher chance of achieving a pathological complete response than those with an androgen receptor-positive one
21828246 AR polyglutamine repeat length is directly associated with transcriptional activity and alters the growth and development of C2C12 cells.
21820033 [review] how post-translational modification contributes to AR function as a transcription factor with particular emphasis on phosphorylation and dephosphorylation mechanisms
21799006 Cdk5 is an important modulator of AR and contributes to prostate cancer growth.
21795710 Conditional activation of transgenic AR expression by Osr1 promoter induces prostate tumor formation in mice.
21784131 [REVIEW] summarize molecular mechanisms of AR-mediated gene repression, thereby differentiating between direct and indirect DNA/chromatin recruitment and between genomic and non-genomic effects.
21782001 [REVIRW] AR-cell cycle interplay and associated cancer relevance
21781458 Different expression patterns of AR and estrogen receptor alpha mRNAs in malignant tissues of oral mucosa suggest an involvement of these sexual hormones in oral cancer
21781227 Overexpression of AR in R2Ad cells regenerated an androgen-repressed phenotype; knockdown of AR in 104-R2 cells generated an androgen-insensitive phenotype. Overexpression of c-Myc in 104-R2 cells blocked the growth inhibition caused by androgens.
21773856 Data show that AR gene T877A mutation was detected both in LNCaP and AIDL cells.
21765461 Data show the importance of Vav3 in castration-resistant prostate cancer (CRPC) and define a nuclear function of Vav3 in regulating androgen receptor (AR) activity.
21748469 [review]Targeting the AR pathway remains a sound strategy in the clinical management of prostate cancer.
21741601 AR is enriched in ER- breast tumors that overexpress HER2.
21730289 Data show that while Art-27 can bind AR directly, URI is bound to chromatin prior to hormone-dependent recruitment of AR, suggesting a role for URI in modulating AR recruitment to target genes.
21730049 Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen receptor.
21722642 The CAG repeat polymorphism in the androgen receptor gene is important in explaining a broad range of individual differences in human males.
21714804 study concluded that Egyptian populations did not differ from others regarding AR-CAG repeats; nonobstructive azoospermic (NOA) cases showed significant increase of AR-CAG repeats compared with either oligoasthenoteratozoospermic (OAT) or control groups
21712734 Shorter polyglutamine stretch in the androgen receptor correlates with more severe coronary artery disease and worse predisposing factors in postmenopausal women undergoing coronary angiography.
21701558 These findings show that androgen receptor binds and regulates, in a FoxA1 dependent manner, oestrogen receptor cis-regulatory elements in molecular apocrine tumours.
21681193 NEU3 regulates tumor progression through AR signaling, and thus be a potential tool for diagnosis and therapy of androgen-independent prostate cancer.
21680704 BR-DIM and CDF inhibited the signal transduction in the AR/TMPRSS2-ERG/Wnt signaling network, leading to the inactivation of Wnt signaling consistent with inhibition of prostate cancer cell invasion
21677876 Data show a link between inhibition of androgen receptor signaling, down-regulation of Skp2, and the appearance of secretory, tumor-promoting senescent cells in prostate tumors.
21667251 The AR CAG repeat polymorphism with >/= 20 repeats might confer a protective effect in prostate cancer patients 45 years or older but not all the prostate cancer patients.
21652770 YB-1 induces castration resistance in androgen-dependent prostate cancer cells via AR expression.
21642359 Shorter CAG repeats in androgen receptor is associated with seminoma.
21617230 High AR in the nucleus is associated with upper urinary tract urothelial carcinoma.
21613411 Androgen receptor activation upregulates the expression of EGFR and ERBB2 in bladder cancer
21609552 The peripheral lymphocyte AR level was positively correlated with the risk of coronary artery diseases in elderly males.
21606347 Results establish that relative changes in PSMA expression levels can be quantitatively measured and could serve as a biomarker of AR signaling to noninvasively evaluate AR activity in patients with CRPC.
21602788 The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.
21597087 Report significant ethnic differences in allele distribution of the androgen receptor (CAG)n repeat polymorphism.
21575859 Report reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer.
21572438 cell-lineage-specific factors, such as FoxA1, can simultaneously facilitate and restrict key regulated transcription factors, exemplified by the androgen receptor (AR), to act on structurally and functionally distinct classes of enhancer
21552559 Expression of androgen receptor variants is increased in castration-resistant prostate cancer compared to hormone-naive bone metastases and associated with a particularly poor prognosis
21552212 Overall, 77% of the invasive breast carcinomas studied were androgen receptor positive
21539911 Prx2 expression in nucleus and cytoplasm distinctively regulates androgen receptor signaling, is involved in prostate cancer growth, and may promote castration resistance in prostate cancer.
21532617 It was shown for the first time that androgen receptor inhibits PTEN transcription in prostate cancer cells, whereas androgen receptor upregulates PTEN transcription in breast cancer cells.
21528410 Low AR gene expression is associated with treatment response in breast cancer.
21525791 androgen receptor controls expression of neuropilin-1
21521258 Data show that AR CAG repeat length is inversely associated with longitudinal height in young boys, before the onset of puberty.
21519872 Loss of AR is associated with triple-negative breast cancer.
21506119 AR is a calpain target and AR-bound calmodulin plays an important role in protecting AR from calpain-mediated breakdown in prostate cancer cells.
21505847 The near absence of short tracts in cases suggests a possible protective effect of very short polyglutamine tract lengths against male breast cancer.
21489984 Cross-talk between the androgen receptor and the liver X receptor: implications for cholesterol homeostasis.
21486420 long stretches of CAG repeat may be associated with lower AR function with derangement of sperm production, and this may contribute to male infertility in Egyptian men
21470285 a trend to alteration in HDL-C across groups of repeat polymorphism in men with type 2 diabetes CAG
21454491 Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.
21445561 IgG autoantibodies were more frequently observed in male lupus patients with longer AR CAG repeat length, while IgM autoantibodies were more prevalent in subjects with shorter CAG repeat length
21444647 in men, testosterone and the AR CAG repeat length polymorphism interacted with respect to insulin resistance
21423805 Longer CAG repeat lengths are associated with increased odds for recurrent spontaneous abortions with statistical power estimated to be ~90%.
21410629 This is the largest published study to date investigating the association of germline AR-CAG repeat lengths and efficacy of ADT in prostate cancer. * Germline AR-CAG repeat lengths do not predict response to ADT
21410621 AR-CAG repeats, in conjunction with epigenetic factors, can help determine which women with hair loss will respond to finasteride therapy.
21400613 JMJD2A and AR levels were significantly lower in malignant versus benign urothelium, while increased LSD1 levels were observed in malignant urothelium relative to benign; a significant reduction in all three proteins occurred with cancer stage progression
21393548 the CAG 21 allele, which appears to be associated with male infertility, is observed at a significantly higher proportion among the less common androgen receptor haplotypes
21368712 The androgen receptor CAG and GGN polymorphisms might influence impulsive-disinhibited personality traits.
21359179 The extra nuclear AR/FlnA/integrin beta 1 complex is the key by which androgen activates signaling leading to cell migration. Assembly of this ternary complex may control organ development and prostate cancer metastasis.
21352305 Polymorphic CAG repeat numbers in the androgen receptor gene of female pattern hair loss patients.
21343391 Analyses predicted that most of the miRNA regulation of the Androgen Receptor (AR) gene would target an extended 6 kb 3' UTR of AR that is much longer than currently used in miRNA target prediction programs.
21327417 The androgen receptor gene CAG repeat has a different allele distribution among Israeli soldiers with stress fractures than in control subjects.
21311178 Androgen receptor mutations are associated with altered epigenomic programming as evidenced by HOXA5 methylation.
21310761 AR is significantly associated with favorable features in breast cancers and related to better outcomes in estrogen receptor (ER)-positive not in ER-negative tumors.
21284948 Pathologic manifestations of variations in polyQ chain length have been associated with prostate cancer susceptibility, and the Spinal and Bulbar Muscular Atrophy. [review]
21273441 Set9 directly acts on AR at the amino acid level. Chromatin recruitment of Set9 to AREs is suggestive of its additional role as a transcriptional coactivator.
21270324 Testosterone levels and AR CAG polymorphism are not associated with bone mass phenotype in Klinefelter syndrome.
21264529 Low EGFR expression is associated with triple-negative breast cancer.
21248069 Data show that AR intragenic rearrangements in CRPCa and an association with pathologic expression of truncated AR isoforms in a cell-based model of PCa progression.
21218636 The expression of AR is higher in prostate cancer than in normal prostate and prostatic hyperplasia tissues, and is correlated with the pathological grade and clinical stage.
21215164 Androgen receptor has a high positive rate in breast carcinoma. Expression was positively correlated with ER, PR and HER2 status.
21212260 Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function.
21211271 Breast cancer patients with AR-positive tumors have a better prognosis than those with AR-negative tumors.
21193722 AR CAG repeat polymorphism is not associated with Erectile dysfunction complaints, gonadal steroids, and sleep parameters in men from a population-based sample in Brazil.
21172305 GLI1, which has been shown to play a central role in SHH signaling in prostate cancer, can act as a co-repressor to substantially block androgen receptor (AR)-mediated transactivation, at least in part, by directly interacting with AR.
21172304 These findings, for the first time, demonstrate that BTG2 complexes with AR via an LxxLL-dependent mechanism and may play a role in prostate cancer via modulating the AR signaling pathway.
21171262 The expressions of AR and VCL are gradually reduced with the progression of prostate cancer.
21166701 study has shown that ARs are expressed commonly in about 80% of BRCA2-related and in about 75% of BRCA1/2-negative breast cancers, as opposed to 30% of BRCA1 mutated breast cancers
21159020 a strong overall association between per CAG repeat increments in average repeat length and the risk of breast cancer [OR=3.56; 95% CI, 2.80-5.29]
21154321 The 1910delA mutation of the androgen receptor gene is a novel mutation that leads to complete androgen insensitivity syndrome.
21134350 results indicate involvement of the JNK/c-jun pathway in AR-mediated upregulation of CYP27A1. The link to JNK signaling is interesting since inflammatory processes may upregulate CYP27A1 to clear cholesterol from peripheral tissues.
21117024 hepatitis B virus X protein-induced high expression of AR plays a role during hepatocarcinogenesis, but is not involved with its promoter methylation
21107681 CAG repeat length polymorphism shows association with breast cancer risk in a population-specific manner
21099110 RB controlled nuclear receptor networks critical for tumor progression and that it did so via E2F transcription factor 1-mediated regulation of androgen receptor (AR) expression and output.
21089003 we investigated whether CAG repeat length in androgen receptor gene and GSTM1 and GSTT1 polymorphisms influence prostate cancer risk in Iranian newly diagnosed cancer patients
21089003 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
21073542 Two single nucleotide polymorphisms (rs16990427 and rs12007830) downstream of the AR gene were found yo be associated with androgenetic alopecia.
21073542 Observational study of gene-disease association. (HuGE Navigator)
21070797 The individual changes of androgen receptor protein concentration in skeletal muscle following resistance training may have an impact on training-induced muscular adaptations in both younger and older men.
21050150 AR-CAG variations and XCI pattern exert an effect on FSH and LH values, and also have the potential to influence the etiopathogenesis of polycystic ovarian syndrome.
21047772 a complex role for HOXC8 in prostate cancer, promoting invasiveness while inhibiting AR-mediated gene induction at androgen response element-regulated genes associated with differentiated function of the prostate
20980437 CDK9 phosphorylation of AR S81 is an important step in regulating AR transcriptional activity and prostate cancer cell growth
20967566 Observational study of gene-disease association. (HuGE Navigator)
20952028 There is no association of AR CAG repeat length with prostate cancer risk. Knowledge of AR CAG repeat length provides no clinically useful information to predict prostate cancer risk
20952028 Observational study of gene-disease association. (HuGE Navigator)
20922474 Longer GGC repeats and c.211G>A variant in the AR gene are associated with increased susceptibility to the risk of preeclampsia.
20922474 Observational study of gene-disease association. (HuGE Navigator)
20888558 Novel Arg615Ser mutation of androgen receptor DNA-binding domain in three 46,XY sisters with complete androgen insensitivity syndrome and bilateral inguinal hernia.
20880698 The AR polymorphisms might be involved in gene-environment interaction by increasing the susceptibility to the effect of endocrine disruptors.
20880698 Observational study of gene-disease association. (HuGE Navigator)
20869592 The findings of this study indicated SBMA pathogenesis is mediated by misappropriation of native function of the androgen receptor, a mechanism that may apply broadly to polyglutamine diseases.
20865044 CAG repeat polymorphism is not associated with Polycystic Ovary Syndrome.
20865044 Observational study of gene-disease association. (HuGE Navigator)
20846920 Androgen receptor gene polymorphisms are associated with breast cancer and fibrocystic breast conditions.
20846920 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20843821 AR mRNA expression in granulosa cells and the follicular fluid content of androgens both showed a highly significant positive association with the expression of FSHR mRNA in granulosa cells.
20831839 a decrease in mRNA level of AR gene related to the chemotherapy-induced apoptosis could serve as an important independent predictor of response to NACT.
20826791 Data show that an interdomain interaction of the AR is required for AR aggregation and toxicity.
20823083 Hematopoietic differentiation is permissive to the reversal of methylation status of HUMARA in some terminally differentiated progenitors.
20808127 results point to associations between the genetic AR polymorphism and vulnerability to depressive symptomatology.
20808127 Observational study of gene-disease association. (HuGE Navigator)
20734064 Observational study of gene-disease association. (HuGE Navigator)
20716560 Observational study of gene-disease association. (HuGE Navigator)
20711217 germline mutations and their known functional significance in prostate cancer (Review)
20691435 Longer AR (CAG)(n) alleles were related to more normalization of the androgen and lipid levels after therapy.
20680031 Expression levels of AR and CRISP3 were not affected by short-term ADT but were high in castration-resistant prostate cancer (CRPC) and metastases.
20672904 mutational and genetic association studies in populations of women in India: data suggest that AR gene mutations and polymorphisms play roles in genetic cause of premature ovarian failure; genetic basis of primary amenorrhea was also investigated
20672904 Observational study of gene-disease association. (HuGE Navigator)
20634949 AR polymorphisms have an influence on BMC and BMD in healthy adult humans, which cannot be explained through effects in osteoblastic activity.
20634949 Observational study of gene-disease association. (HuGE Navigator)
20634197 Meta-analysis of gene-disease association. (HuGE Navigator)
20632874 Data shoe that polymorphisms in AR and PSA genes may be indicated as potential biomarkers for prostate cancer.
20632874 Observational study of gene-disease association. (HuGE Navigator)
20628746 Androgen receptor polymorphism is linked to genetic susceptibility to urinary incontinence.
20628746 Observational study of gene-disease association. (HuGE Navigator)
20628607 Data highlight that loss of AR-mediated growth suppression is an independent process, and that, without additional changes, is insufficient for acquiring oncogene addiction to AR signaling.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20615892 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20610535 Binding sequences for the Mef2 family of transcription factors were enriched in the AR-bound regions, and data show that several Mef2c-dependent genes are direct targets of AR, suggesting a functional interaction between Mef2c and AR in skeletal muscle.
20588308 Observational study of gene-disease association. (HuGE Navigator)
20579136 Observational study of gene-disease association. (HuGE Navigator)
20551262 Along with other markers and morphologic features, AR can be helpful in the diagnosis of SEB and its differentiation from SCC and BCC.
20534771 No association between androgen receptor germline variants and prostate cancer risk, but relation between CAG repeats and circulating levels of sex steroid hormones.
20534771 Observational study of gene-disease association. (HuGE Navigator)
20519371 PCBP1 plays a major role in the dynamic expression of AR in both male and female androgen-responsive cells.
20507730 The positive rate of AR was significantly lower in triple negative breast cancer than in non-triple negative breast cancer. Expression was correlated with menorrheal status, tumor grade, and survival rate.
20493947 2329G>C substitution resulted in partial ( approximately 40%) loss of ligand-binding and significant ( approximately 70%) loss of downstream transactivation function in a case of partial androgen insensitivity syndrome.
20491624 Studies indicate that a detailed understanding of the structural interactions between AR and the components of pre-RC and replitase may lead to the development of new strategies for the treatment of prostate cancer.
20479013 Observational study of gene-disease association. (HuGE Navigator)
20478527 found that ERG disrupts androgen receptor (AR) signaling by inhibiting AR expression, binding to and inhibiting AR activity at gene-specific loci, and inducing repressive epigenetic programs via direct activation of the H3K27 methyltransferase EZH2
20458976 Our data suggest an association between CAG repeats number and impaired spermatogenesis in azoospermic and oligozoospermic males.
20458976 Observational study of gene-disease association. (HuGE Navigator)
20450840 individuals carrying the androgen receptor rs6152A allele had significantly higher susceptibility to polycystic ovary syndrome
20450840 Observational study of gene-disease association. (HuGE Navigator)
20448036 MAGE-11 links NH(2)-terminal domains of AR and p300 to promote transcriptional synergy through a cadre of FXXLF-related interacting motifs
20439495 These results identify a conserved and novel function for Hsp27 with potential as a target for interrupting signaling from estrogen receptor alpha and androgen receptors to tumor biology in hormone-responsive cancers.
20436506 The phyto-oestrogens genistein, daidzein and flavone, and the xeno-oestrogens bisphenol A and DES can be regarded as androgenic effectors. The xeno-oestrogens DDT and 4-nonylphenol bind only weakly to AR.
20432460 Recent advances in understanding the physiological functions of Ack1 signaling in normal cells and the consequences of its hyperactivation in various cancers, are discussed.
20431938 Found that a long CAG sequence has a protective effect on breast cancer using an a priori determined cutoff (< 22 or >/= 22) in a dominant model analysis [SL-LL vs. SS, odds ratio (OR) = 0.86, 95% confidence intervals (CI): 0.67-1.10].
20431938 Observational study of gene-disease association. (HuGE Navigator)
20420697 The finding that Gli2 co-immunoprecipitates with androgen receptor protein suggests that an interaction between these proteins might be the basis for Hedgehog/Gli support of androgen signaling
20417685 Results suggest that prostate cancer progression is associated with a decrease in insulin-like growth factor-I receptor (IGF-IR) expression that could be the result of impaired ability of androgen receptors to stimulate IGF-IR gene expression.
20410235 Observational study of gene-disease association. (HuGE Navigator)
20388792 NF-kappaB2/p52 may play a critical role in the progression of castration-resistant prostate cancer through activation of the androgen receptor
20381444 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20378930 CAG 21 allele seems to increase the susceptibility for idiopathic Sertoli cell-only syndrome, and the GGN 24 allele may contribute to deranged AR function, associated with cryptorchidism and spermatogenic failure.
20378930 Observational study of gene-disease association. (HuGE Navigator)
20378615 Observational study of gene-disease association. (HuGE Navigator)
20374306 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20369693 Increased AR and VEGF in the prostatic tissues may be one of the important causes of recurrence of benign prostatic hyperplasia after TURP.
20353269 Observational study of gene-disease association. (HuGE Navigator)
20351714 Observational study of gene-disease association. (HuGE Navigator)
20338164 Methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene is associated with Progression to metastatic stage in a cellular model of prostate cancer.
20333878 The two point mutations were in exon 5: p.M742I, familial in patient 1 and p.V746M de novo in patient 2 for androgen insensitivity syndrome
20308360 HP1beta is involved in the proliferation of AR-expressing prostate cancer cells and progression to CRPC as an AR coactivator.
20305676 Two known mutations, P390S and A870V, were identified in patients 1 and 2, respectively. Mutations in the AR gene can be associated with isolated micropenis without other features of PAIS, such as hypospadias or gynecomastia.
20299092 CpG islands aberrant hypermethylation of androgen receptor is associated with leukemia.
20233785 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20231367 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20215828 Pim1 overexpression increases AR transcriptional activity in a ligand-dependent manner in prostate cancer cell lines, resulting in enhanced cell survival at castrate levels of androgen
20204290 High levels of expression of both the androgen receptor and ZNF652 in clinically organ-defined prostate cancer are associated with a statistically increased risk of relapse
20203370 Inhibition of mTOR increases AR transcriptional activation in prostate cancer cells.
20200439 No associations between ancrogen receptor CAG repeat length and the risk of biliary tract cancers and stones were found
20200439 Observational study of gene-disease association. (HuGE Navigator)
20200161 Study describes a model that stroma-derived HGF and hyaluronan influence androgen receptor and CD44 functions in the secretory epithelia during prostate carcinogenesis.
20199557 because no frequent variant other than rs1385699 has been reported in EDA2R in the European population, it is probable that the causative variant(s) modifies the expression of one or more flanking genes, i.e. AR and EDA2R
20198568 There was no correlation between alterations in the spermogram and mutations on exons 1 and 4 of the androgen receptor gene and no association between alterations in the spermogram and alcohol drinking or smoking.
20198568 Observational study of gene-disease association. (HuGE Navigator)
20190557 (CAG)n repeat polymorphism have some influence, but have not a straight relationship in infertile women with polycystic ovary syndrome and with endometriosis in Han Chinese women.
20190557 Observational study of gene-disease association. (HuGE Navigator)
20186458 the (629)RKLKK(633) motif is a multifunctional motif that integrates nuclear localization, receptor stability, DNA binding, transactivation potential and intranuclear mobility
20184516 spinal and bulbar muscular atrophy may be present with a wide clinical spectrum in affected family members
20181722 Results indicate that increased TAF1 expression is associated with progression of human prostate cancers to the lethal castration-resistant state.
20173765 We identified a germline androgen receptor (A1675T) (T559S) substitution mutation in the DNA-binding domain in three Prostate Cancer-affected members of an African-American family with a history of early-onset disease.
20173016 Observational study of gene-disease association. (HuGE Navigator)
20160483 The role of epigenetic enzymes in AR signaling in prostate cancer is summarized.
20159969 there is an interaction between Zimp7 and PIAS proteins with higher preference for PIAS3, in androgen receptor-mediated transcription
20150575 Observational study of gene-disease association. (HuGE Navigator)
20147518 Here, it was shown that human endogenous retrovirus Rec can form a trimeric complex with TZFP and AR, and can relieve the TZFP-mediated repression of AR-induced transactivation.
20140226 Data show that the first 50 amino acids of ARN127 and the first 14 amino acids of Htt exon 1 mediate binding to filamentous actin in vitro.
20133446 CAG repeat polymorphism affects body composition in young men: absolute muscle(thigh & lower trunk) increase as CAG(n) decreases; muscle areas & lean body mass increase, while subcutaneous adipose tissues & fat mass decrease as CAG(n) decreases
20127713 The results suggest that GSK-3beta is an important element not only in AR stability but also significantly alters nuclear translocation of the AR, thereby modulating the androgenic response of human PCa cells.
20127405 AR expression is an independent prognostic factor of better outcome in patients with estrogen receptor-positive breast cancers.
20127024 Observational study of gene-disease association. (HuGE Navigator)
20126983 Vav3 may enhance non-genomic AR activity via PI3K-Akt signaling in addition to AR transcriptional activity, showing that it may have a role in androgen-independent growth in prostate cancer
20087306 The researchers found no evidence of an association between AR CAG repeat polymorphisms and physical activity levels in healthy men.
20087306 Observational study of gene-disease association. (HuGE Navigator)
20086010 SRC3/AIB1 is a preferred coactivator for hormone-activated androgen receptor
20083725 In adolescent boys, low CAG-repeat numbers in AR may be a genetic risk factor for intra-abdominal obesity and hypertension; sympathoactivation may be an underlying link between the 2 conditions
20083725 Observational study of gene-disease association. (HuGE Navigator)
20071336 molecular link between the beta2M intracellular signaling axis mediated by MAPK and SREBP-1 and involving lipid signaling, which collectively regulates AR expression and function
20069563 These results indicate that TH1 is a novel regulator to control the duration and magnitude of androgen signal transduction and might be directly involved in androgen-related developmental, physiological, and pathological processes.
20065623 report a unique and wider distribution of the GGN allele of the androgen receptor in the Nigerian population which is significantly different from the Caucasian population.
20065623 Observational study of gene-disease association. (HuGE Navigator)
20063560 Observational study of gene-disease association. (HuGE Navigator)
20056211 molecular analysis of the AR gene in 4 Chinese individuals with androgen insensitivity syndrome; 4 mutations (p.P913R, p.D732 N, p.N848 K, fs879X & p.R608 K) were identified; p.P913R mutation has not been described previously
20053928 boundaries within AR and CYP19A1 that are associated with endometrial cancer risk.
20048343 Differentiated prostate cell survival depended on E-cadherin and PI3K, but not keratinocyte growth factor, androgen, AR or MAPK.
20048160 These results indicate that androgen receptor signaling directly regulates Gas6 transcription, which leads to inhibition of vascular calcification, and provides a mechanistic insight into the cardioprotective action of androgens.
20048054 FKBP51 stimulates recruitment of the cochaperone p23 to Hsp90, forming an FKBP51-Hsp90-p23 complex. In cells, FKBP51 expression promotes complex association with AR and increases the number of AR molecules that undergo androgen binding.
20043082 These data suggest that AR and its signaling regulate hsp70-1 expression in prostate cancer cells and that HSPA1B could be an AR target gene.
20035825 Adult lung is an AR target tissue and suggest that AR plays a role in lung cancer biology.
20007693 Results indicate that the specific amino acid residue at position 701, its interaction with the backbone of Ser(778), and the steroidal 17alpha-hydroxyl group of the ligand are important for the transcriptional responses to progesterone and cortisol.
19995608 Crystals of ligand-bound full-length AR and of the AR fragment in complex with DNA elements and coactivator motifs have been obtained and diffracted to low resolutions.
19962986 Observational study of gene-disease association. (HuGE Navigator)
19956877 Etoposide induces growth arrest and disrupts androgen receptor signaling in prostate cancer cells
19954068 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19953479 The E681D mutation of the AR gene is a novel mutation of leading to complete androgen insensitivity syndrome.
19951614 Androgen receptor functioned as a suppressor in the prostate cancer cell line PC3 in vitro and in vivo.
19947564 The increased length of CAG repeats in the AR gene may be correlated with the risk of the impairment of spermatogenesis.
19947564 Meta-analysis of gene-disease association. (HuGE Navigator)
19946220 These observations reveal a transcription-independent function of AR that is essential for PCa cell viability and, therefore, is an ideal target for anti-PCa treatment.
19946123 a higher calpain/calpastatin ratio collaborates with activated ERK to promote the generation of the low molecular weight-AR
19938041 Androgen receptor CAG repeat length is not associated with the risk of incident symptomatic benign prostatic hyperplasia.
19938016 Tip60 is involved in the proliferation of prostate cancer cells as an androgen receptor coactivator.
19937586 lack of amplification of exon 1 of the AR gene by polymerase chain reaction is associated with morphological defects in the spermogram
19937586 Observational study of gene-disease association. (HuGE Navigator)
19921427 these results indicate that ZEB1 and AR regulate each other to promote cell migration in triple negative breast cancer cells
19913121 Observational study of gene-disease association. (HuGE Navigator)
19901962 DNA-bound C/EPBalpha recruits AR to activate transcription
19898421 most estrogen receptor-positive breast tumors also express androgen receptor
19885808 men with a higher number of CAG repeats (> 23 repeats) the somatic and psychological manifestations associated with signs of androgen deficiency are more common during the ageing period and that these patients score higher on the overall Heinemann scale.
19885808 Observational study of gene-disease association. (HuGE Navigator)
19884906 the investigated polymorphism CAG trinucleotide repeat mediates its effect on craving of men in alcohol withdrawal mostly through the regulation of leptin.
19884906 Observational study of gene-disease association. (HuGE Navigator)
19884383 N-terminal domain of AR interacts with PPARGC1a to enhance DNA-binding of AR to androgen-responsive elements in prostate-specific enhancer and promoter regions to increase transcription of AR target genes.
19884136 Highest AR activity was confined to the 22CAG and not 16 CAG, which may at least partly explain the discrepancy in data aiming to link physiological conditions to CAG repeat length.
19852793 Successful PG-E2 priming was followed by a progesterone and androgen withdrawal at the receptor level in the uterine cervix.
19851057 3 novel AR variants found in a cohort of Indonesian DSD patients
19833203 Results indicate that the inhibitory effects of the glutamine tracts polyQ and Q5 on AR transactivation are due, at least in part, to their negative regulation of N-C interaction.
19830810 We describe two novel variants arising from aberrant splicing of AR pre-mRNA, characterized by long mRNA transcripts that encode truncated, constitutively active proteins in PCa cell line.
19828458 Results suggest that MAGE-11 functions as a bridging factor to recruit androgen receptor coactivators through a novel FXX(L/I)F motif-F-box interaction paradigm.
19818997 AR allelotype length did not correlate with survival in this statistically representative cohort of patients with BRCA1/2 mutations. Associations between short AR and outcome in BRCA2-associated ovarian cancers remain to be determined.
19818997 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19816598 resveratrol regulates AR target gene expression, at least in part, by repressing AR transcriptional activity
19815331 Sequencing analysis of DNA of a patient in a family with complete androgen insensitivity syndrome identified a double nucleotide insertion in exon 4 that results in the frame-shift leading to premature terminal signal in the beginning of exon 6.
19815066 Aryl hydrocarbon receptor (AhR) modulation of androgen receptor activity is differentially altered by the level of FHL2 and AhR present in the cell.
19804943 Regression analysis revealed influences of CAGn on the aging male symptoms global score and the psychological and somatic subscale only in the two patient samples, while testosterone had some impact on the sexual subscale.
19802006 Data show that HEY1 Leu94Met gene polymorphism converts HEY1 from an androgen receptor corepressor to an androgen receptor co-activator, and also abolishes HEY1-mediated activation of p53.
19802001 Data suggest that modulation of castration-induced oxidative stress or Twist1/AR signaling might be a useful strategy for developing a novel therapeutics in prostate cancer.
19797017 increased AR expression may alter AR-mediated function on syncytiotrophoblasts and stromal cells in preeclampsia placentas, and be a possible mechanism for its association with preeclampsia
19794963 Data show that decorin specifically inhibits EGFR and AR phosphorylation and cross talk between these pathways in prostate cancer cells.
19790238 W741C mutation in the androgen receptor might be one of the mechanisms underlying antiandrogen withdrawal syndrome in a novel prostate cancer xenograft.
19790235 Androgen receptor (AR)-induced growth stimulation of human prostate cancer initiating cells requires AR-dependent intracellular pathways.
19787772 Results show on the binding of hydroxyflutamide, the apo form of Helix 12 of AR rearranges into the agonistic form in the T877A mutant, but into the antagonistic forms in the wild-type receptor, shedding light on hydroxyflutamide agonism/antagonism.
19786297 Observational study of gene-disease association. (HuGE Navigator)
19767773 Hsp27 is a mediator of repression of AR function by PKD1 in PC cells.
19762545 SMARCD1/BAF60a is an androgen receptor cofactor that modulates TMPRSS2 expression
19758318 Immunocytochemical study showed the expression of androgen receptor (AR) in mast cells isolated from foreskin as well as in two mast cell lines, HMC-1 and LAD2. The amount of AR was most abundant in skin mast cells.
19753540 The average number of androgen receptor gene CAG repeats and its range in the population Polish men were larger in comparison to the west European populations and more reminded the number repeats distribution meeting among Asians.
19753540 Observational study of gene-disease association. (HuGE Navigator)
19739075 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19703457 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19692168 Observational study of gene-disease association. (HuGE Navigator)
19684044 study suggests that the CAG repeat length in the androgen receptor gene is increased in women with premature ovarian failure (POF) as compared with controls, and may be pathogenic for POF, at least in a subset of Indian women
19684044 Observational study of gene-disease association. (HuGE Navigator)
19683543 AR was significantly reduced at 70 min post-exercise in men and at 10 min post-exercise in women compared to pre-exercise. There were no changes in GR following resistance exercise, but GR was significantly higher in women compared to men
19672785 Expression of co-regulators and androgen receptor gene aberrations are not involved in the carcinogenesis of carcinoma ex pleomorphic adenoma of salivary gland
19668381 only about 2.9% (190/6,629) of AR binding sites contains the canonical AR matrix M00481, M00447 and M00962 (from the Transfac database), which is derived mostly from AR proliferative responsive genes in androgen dependent cells
19656574 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19632176 The role of AR in androgen-independent cancer cells is not to direct the androgen-dependent gene expression program without androgen, but rather to execute a distinct program resulting in androgen-independent growth.
19628766 NF-kappaB can regulate AR expression in prostate cancer; NF-kappaB inhibitors may have therapeutic potential.
19627379 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19622840 AR may function as a PP1 regulatory subunit and mediate PP1a recruitment to chromatin, where it can modulate transcription and splicing.
19620824 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19617210 the lengths of CAG and GGN repeat of the androgen receptor gene do not appear to influence lean mass or fitness in young men.
19617210 Observational study of gene-disease association. (HuGE Navigator)
19604497 Observational study of gene-disease association. (HuGE Navigator)
19598235 Observational study of gene-disease association. (HuGE Navigator)
19584056 miR-331-3p regulates ERBB-2 expression and androgen receptor signaling in prostate cancer
19574343 Observational study of gene-disease association. (HuGE Navigator)
19555469 Observational study of gene-disease association. (HuGE Navigator)
19538365 In contrast with male androgenetic alopecia, no association was found between type II androgenetic alopecia in Egyptian women and the AR gene
19538365 Observational study of gene-disease association. (HuGE Navigator)
19533338 Our data suggest a role for AR overexpression as a novel mechanism of hormone resistance
19514049 NLK expression is altered during prostate cancer progression and it is involved in regulation of AR signaling in these cells
19497852 SUMO modification of the androgen receptor attenuates polyglutamine-mediated aggregation
19493626 Observational study of gene-disease association. (HuGE Navigator)
19491261 androgen (AR) mRNA levels in LNCaP cells were markedly decreased by EGF and heregulin-beta1, and experiments with actinomycin D to block new mRNA synthesis showed that AR mRNA degradation was increased
19481544 NSD2 protein is recruited to the enhancer region of the PSA gene by AR in an agonist-enhanced manner.
19463997 27% of the mutations in our cohort were localized in exon 1 versus 15% in previous works justifies the sequencing of this exon in patients with androgen insensitivity syndrome
19463689 Different groups of AR target genes have distinct requirements for coactivators and response to androgen receptor ligands.
19460858 AR can utilize the CXCL12/CXCR4 axis through induction of KLF5 expression to promote prostate cancer progression
19458261 Study concludes that betaArrestin2 acts as a corepressor of AR by serving as a scaffold for Mdm2 leading to the AR ubiquitylation and degradation.
19458022 Results supporting both the androgen and gonadotropin hypotheses of ovarian cancer development.
19453261 Observational study of gene-disease association. (HuGE Navigator)
19448851 Our results suggest that the repeat polymorphisms in the androgen receptor gene may influence personality traits in men.
19443608 dihydrotestosterone binding leads to energetic stabilization of AR-LBD domain and substantial rearrangement of residues distant from the ligand-binding pocket
19429451 acute elevations in circulating testosterone potentiated muscle AR content following resistance exercise.
19391487 The expression of androgen receptor (AR) in high-grade salivary gland cancers suggests a possible role for AR in the clinical management of these neoplasms.
19389811 androgen receptor binds Runx2 and abrogates its recruitment to DNA in osteoblasts and prostate cancer cells
19383805 this study is the first to demonstrate a significant positive association between the GGN repeat and androgen levels in a large cohort of healthy men
19383805 Observational study of gene-disease association. (HuGE Navigator)
19373488 androgen receptor/ectodysplasin A2 receptor haplotype may have a role in male pattern baldness
19372057 Loss of androgen receptor expression was associated with higher grade urothelial carcinomas and invasive urothelial carcinomas.
19366804 Treatment with antiandrogens selects for gain-of-function AR mutations with altered stability in treatment of prostate cancer.
19361789 Novel 212A-->G exchange in the CAG repeat leading to a glutamine-->arginine substitution and a change in alpha-helix structure in Sertoli cells in a patient.
19347812 We found only association between number of CAG repeat an androgen receptor gene and concentration of cholesterol LDL (which it is as we knows atherogenic factor).
19340294 There was no evidence of copy number variation (CNV) in androgen receptor (AR) in any of the cases or controls, and thus no evidence of significant association between androgenetic alopecia and AR CNV
19340294 Observational study of gene-disease association. (HuGE Navigator)
19339269 Authors observed homogeneity in ERG gene rearrangement status in CTCs in contrast to significant heterogeneity of AR copy number gain and PTEN loss, suggesting that rearrangement of ERG may be an earlier event in prostate carcinogenesis.
19301304 Systemically stable endostatin expression delays the onset of metastatic switch in transgenic mice by acting on multiple pathways involving the androgen receptor.
19282387 There are two classes of amino/carboxyl (N/C)-deficient androgen receptor variant that diverge in capacity to act in a chromatin context. This further defines the interplay between N/C interaction and coregulator recruitment via multiple receptor domains.
19279159 Polyglutamine-expanded AR must reside within nuclei in the presence of its ligand to cause spinal and bulbar muscular atrophy.
19277043 Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer.
19274665 A stromal factor-activated ERK pathway mediated by AR phosphorylation at Ser-81 could be responsible for stimulating the growth of human prostate cancer cells
19261388 Functional variation of the androgen receptor gene is able to modulate memory function in women.
19261388 Observational study of gene-disease association. (HuGE Navigator)
19257827 activation of the AR through Smads is required for activin A-promoted prostate cancer cell migration to bone matrix, thereby promoting the bone metastatic phenotype
19237573 Abnormal expansion of polyQ may potentiate innate androgen-dependent association of AR with Rb through aberrant E2F transactivation caused by suppressed histone deacetylation.
19231085 reduced length of the investigated trinucleotide repeat might aggravate craving symptoms. Moreover, an elevated number of repeats might be protective against severe craving of alcohol.
19231085 Observational study of gene-disease association. (HuGE Navigator)
19223455 Activated MEK signaling cascade inhibits functional recruitment of corepressor SMRT to cyproterone acetate-bound AR in prostate cancer cells.
19218788 the AR gene CAG repeat polymorphism may be one of the candidate genetic markers for male acne susceptibility in the Han population
19218788 Observational study of gene-disease association. (HuGE Navigator)
19207614 Observational study of gene-disease association. (HuGE Navigator)
19201527 Id-1 expression in androgen-dependent prostate cancer was negatively regulated by androgen in a receptor-dependent way.
19201267 Androgen receptor gene regions encoding the hormone binding domain did not contain any missense mutation and were not involved in hepatocarcinogenesis.
19190146 Variant alleles of 3 correlated htSNPS (rs6152, rs1204038, rs1337082) might be associated with endometrial cancer risk.
19190146 Observational study of gene-disease association. (HuGE Navigator)
19189305 Prostatic cancer aggressiveness and efficacy of castration therapy are related to AR levels in the tumor stroma and importantly to normal prostate tissue stromal cells.
19178528 The AR mutations at residue 754 and 690 bound androgen with decreasing affinity.
19172534 Observational study of gene-disease association. (HuGE Navigator)
19168451 significant and positive correlation between CAG repeat length and serum testosterone concentration was demonstrated in infertile Egyptian men. This suggests the involvement of epigenetic regulation linked to this region.
19168451 Observational study of gene-disease association. (HuGE Navigator)
19167832 Some support for an influence of the studied polymorphisms on the susceptibility for autism, but mutations in the AR gene are not common in subjects with this condition.
19167832 Observational study of gene-disease association. (HuGE Navigator)
19167638 Observational study of gene-disease association. (HuGE Navigator)
19159685 Results suggest that longer alleles of the CAG and GGN polymorphisms in the exon-1 of the androgen receptor gene, indicative of lower androgenic signaling, respectively protect women from developing dyslipemia and men from developing insulin resistance.
19159685 Observational study of gene-disease association. (HuGE Navigator)
19147544 KLK4 is only expressed in breast and prostate cancers that express the progesterone receptor (PR) and androgen receptor (AR), respectively.
19137002 Observational study of gene-disease association. (HuGE Navigator)
19126541 Expression of DBC1 also enhanced the binding of AR to chromatinized template in vivo, whereas knockdown of DBC1 impaired the binding of AR to endogenous prostate-specific antigen (PSA) gene in the prostate cancer
19118031 knockdown of AR can decrease serum PSA, inhibit tumor growth, and frequently cause tumor regression
19116244 SENP1 reverses the ligand-induced SUMOylation of AR and helps fine tune the cellular responses to androgens in a target promoter-selective manner.
19107370 Matrine could significantly suppress the growth of prostate cancer cells and inhibit the expression of PSA and AR.
19095061 The shorter alleles of CAG and GGN repeats in the AR gene are associated to an increased AR signalling intensity in human prostate cancer, and with more aggressive forms of the disease.
19095061 Observational study of gene-disease association. (HuGE Navigator)
19094228 Observational study of gene-disease association. (HuGE Navigator)
19087565 The Arg773His mutation in the AR gene leads to complete androgen insensitivity in this family.
19075001 Drosophila CREB binding protein (dCBP) was found to corepress AR transactivation at the pericentric region whereas it led to coactivation in the euchromatic area.
19064572 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
19062046 Colorectal epithelial cells carrying AR alleles with shorter trinucleotide repeat lengths may be more androgen-sensitive and therefore have a growth advantage.
19062009 Case Report: Ala 586 Asp mutation in androgen receptor disrupts transactivation function without affecting androgen binding.
19061288 HER-2/neu, AR, and p53 are expressed in a subset of histologically and clinically benign pleomorphic adenomas. These markers cannot be used to reliably predict early carcinomatous transformation in pleomorphic adenoma.
19060910 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
19059367 putative AR co-factor, DDX17, is known to be a co-factor for estrogen receptor alpha (ERalpha), but has never been associated with AR function.
19058789 Observational study of gene-disease association. (HuGE Navigator)
19058140 The enrichment of ARORs for the Oct-binding, TTGGCAAATA-like motif may reflect a mechanism that utilizes Oct1 to keep AR activity in check at some AR-occupied regions, while augmenting AR activity in other AR-occupied regions
19052375 The ligand-binding domain of the human androgen receptor has been cloned, overproduced and crystallized in the presence of a coactivator-like 11-mer peptide and two different nonsteroidal ligands.
19022849 the single macro domain in LRP16 can serve as the AR coactivator
19017913 Observational study of gene-disease association. (HuGE Navigator)
19013180 The authors report here that CDC25A, a cell cycle-promoting phosphatase over-expressed in a number of cancers, functions as an androgen receptor (AR) coregulator suppressing the AR transcriptional activity.
19011039 IL-6 may cause growth of androgen receptor-positive tumours in vitro and in vivo through activation of the androgen receptor
18997859 androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity
18992263 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18977589 androgen receptor signaling and prostate specific antigen expression is suppressed by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells
18977241 Observational study of gene-disease association. (HuGE Navigator)
18962445 This study provides evidence that male gender identity might be partly mediated through the androgen receptor.
18962445 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18958349 there may be limited clinical use for determining AR expression in men with localized prostate cancer
18952763 Findings suggest that the GGGA repeat from ESR1 and the CAG repeat from AR may be associated with risk of late onset prostate cancer.
18852122 These findings show that AR antagonists can enhance corepressor recruitment by stabilizing a distinct antagonist conformation of the AR coactivator/corepressor binding site
18849991 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
18840639 The AR CAG repeat length correlates significantly with serum T and estradiol of aging men.
18840639 Observational study of gene-disease association. (HuGE Navigator)
18829485 down-regulation of SOD2 induces AR activity in a reactive oxygen species-dependent manner
18805913 There is an association of androgen receptor CAG repeat polymorphism length with obesity and serum leptin in men with type 2 diabetes.
18805913 Observational study of gene-disease association. (HuGE Navigator)
18801408 Dihydrotestosterone inhibits adipogenic differentiation of human mesenchymal stem cells and human preadipocytes through an AR-mediated pathway.
18799683 We found that the testosterone-related increase of white-matter volume was stronger in male adolescents with the lower versus higher number of CAG repeats in the AR gene, with testosterone explaining, respectively, 26 and 8% of variance in the volume.
18799683 Observational study of gene-disease association. (HuGE Navigator)
18794357 the activated AR can downregulate E-cadherin expression to promote the activation of epithelial-mesenchymal transition and tumor metastasis.
18787043 short-term inhibition of p42/p44 MAPK activity by depletion of kinase with small interfering RNA caused target gene-specific reductions in AR activity
18780293 Prolonged androgen receptor (AR) localization to the regulatory regions of AR targeted genes and the recruitment of p160 coactivators are a potential mechanism leading to androgen-independent activation of the AR in prostate cancer.
18776922 there are two parallel cell-survival pathways in prostate cancer cells: a strong Akt-independent, but rapamycin-sensitive pathway downstream of mTORC1, and an AR-dependent pathway downstream of mTORC2 and Akt, that is stimulated by mTORC1 inhibition
18767927 Observational study of gene-disease association. (HuGE Navigator)
18762554 Data support the view that the presence and length of the poly-glutamine repeat modulate the folding and structure of the androgen receptor amino-terminal domain.
18726991 These results demonstrate calpain involvement in proteasome inhibitor-induced AR breakdown, and suggest that AR degradation is intrinsic to the induction of apoptosis in prostate cancer cells.
18723670 the AR might function as a suppressor in epithelial cells and a proliferator in stromal cells in the primary prostate tumors
18717241 Molecular analysis of the AR and SRD5A2 genes in patients with 46,XY disorders of sex development.
18714395 coexpression of PTEN and AR should be undertaken to validate this pilot study and the utility of these biomarkers in routine histopathologic workup of patients with PC.
18708348 RNA editing of AR gene transcripts may contribute to the etiology of hormone-refractory phenotypes in advanced stage AI CaP
18703514 decreased PMEPA1 expression frequently noted in prostate cancers may lead to increased AR functions and strengthen the biological role of the NEDD4-binding protein PMEPA1 in prostate cancers
18697861 AR genes are overexpressed by granulosa cells from stimulated follicles of women with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation.
18694860 Review focuses on the clinical features and molecular pathophysiology of androgen insensitivity syndrome and explores the relationship of the molecular defects in the AR gene to their clinical expression.
18694745 Data suggest that RhoA and B small GTPases, along with ROCK, are major membrane androgen receptor effectors controlling actin reorganization and apoptosis in prostate cancer cells.
18692840 Evidence for association of the G1733A polymorphism of the androgen receptor gene with recurrent spontaneous abortions.
18692840 Observational study of gene-disease association. (HuGE Navigator)
18687691 isoflavone-induced inhibition of cell proliferation and induction of apoptosis are partly mediated through the regulation of the Akt/FOXO3a/GSK-3beta/AR signaling network.
18676362 Observational study of gene-disease association. (HuGE Navigator)
18673534 analysis of androgen regulation of the androgen receptor coregulators
18656523 A novel mutation F826L located within the ligand binding domain (LBD) of the human androgen receptor (AR) was investigated.
18651839 Results imply that androgen signalling through the androgen receptor may positively or negatively regulate TGF-beta1 expression in response to various signals or under different environmental conditions.
18645714 androgen receptor CAG repeat length is not a major determinant of metabolic syndrome in women but it contributes to ovarian androgen production
18645714 Observational study of gene-disease association. (HuGE Navigator)
18645675 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18640093 FOXP1 directly interacts with androgen receptor (AR) and negatively regulates AR signaling ligand-dependently.
18637017 A point mutation (S296R) in the amino-terminal domain of the AR can decrease the ligand specificity of the AR and alter the interaction between serine296arginine and the nuclear receptor co-repressor 1 (N-coR).
18636124 Observational study of gene-disease association. (HuGE Navigator)
18628304 androgen-receptor functions in androgen-dependent prostate-cancer cells and identify strategies to specifically target the proliferation-promoting function of androgen-receptor without compromising cancer-cell differentiation.
18624843 Observational study of gene-disease association. (HuGE Navigator)
18617186 Variation at the androgen receptor gene is associated with left ventricular hypertrophy in males with hypertrophic cardiomyopathy.
18617186 Observational study of gene-disease association. (HuGE Navigator)
18602367 These data demonstrate for the first time that PKD1 can influence AR function in prostate cancer cells.
18601603 present findings suggest that CYP17A1, CYP19, and androgen receptor polymorphisms are unlikely to be associated with an increased risk of uterine leiomyomas in Brazilian women
18599551 stimulation of AR45 receptors by androgens up-regulates HERG K+ channel abundance and activity mainly through stabilizing HERG protein in an ERK1/2 dependent mechanism, and suggest a mechanism to explain the sex difference in the long QT syndrome
18599544 Testosterone represses MAFbx expression via interactions of the AR with Oct-1.
18593950 A simple and effective mechanism by which prostate cancer cells can synthesize a constitutively active AR and thus circumvent androgen ablation.
18586675 A common motif targets huntingtin and the androgen receptor to the proteasome
18577874 The androgen receptor missense mutations P723S, P904S, and H917R, clinically associated with CAIS, which were described to have a normal maximum androgen binding (Bmax) but elevated equilibrium dissociation constants, is analyzed.
18566991 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18565325 These data demonstrate that ARA24/Ran increases AR transactivation by enhancing the androgen receptor N-C interaction in the nucleus.
18562955 These data suggest that longer Androgen Receptor (CAG)n repeat alleles may confer an increased risk of breast cancer among particular subsets of individuals, although these findings need replication in other populations.
18562955 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18560135 Here we review recent data from mouse models in which gene targeting was used to humanize the mouse Ar gene and introduce CAG/glutamine tracts of varying lengths.
18559568 The percentage of AR-positive cancer cells was higher in hereditary prostate cancer compared with sporadic cases.
18555222 The polymorphism was not found to be a major risk factor for the presence of PCOS and for hyperandrogenemia in PCOS.
18535544 Observational study of gene-disease association. (HuGE Navigator)
18535113 AR expression after heat treatment is involved in heat-induced cell junction disruption
18521741 IRS-1 is a novel AR regulator
18516299 inhibition of glycogen synthase kinase-3 in androgen-responsive prostate cancer cell lines may reduce AR transcriptional activity and AR protein levels
18511503 The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium.
18511414 AR transcriptional activity increases castration-recurrent prostate cancer cell growth in response to EGF by site-specific serine phosphorylation that regulates nuclear-cytoplasmic shuttling through interactions with the Ku-70/80 regulatory complex
18503826 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18501301 Observational study of gene-disease association. (HuGE Navigator)
18495332 allelic variation in PSA promoter activity may be androgen dependent and interaction of genes in androgen pathway may influence the risk of BPH and PC in Singapore males.
18495332 Observational study of gene-disease association. (HuGE Navigator)
18491956 Observational study of gene-disease association. (HuGE Navigator)
18484228 There is a positive association between the androgen receptor CAG repeat polymorphism and bone mineral density, which is modified by androgen levels in healthy men.
18484228 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18483883 Observational study of gene-disease association. (HuGE Navigator)
18483761 Observational study of gene-disease association. (HuGE Navigator)
18481277 These data for the first time demonstrate that not only saposin C or PSAP regulates AR expression/activity, but also function as an androgen-regulated gene in prostate stromal cells.
18479901 Inhibition by pomegranate polyphenols of gene expression involved in androgen-synthesizing enzymes and the androgen receptors may be of particular importance in androgen-independent prostate cancer cells.
18477206 men with short AR alleles had lower sperm motility compared to those with long AR alleles (P < 0.001)
18477206 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18471792 High levels of AR and AR-regulated gene expression indicate a central role for AR in growth regulation of castration-recurrent prostate cancer.
18469090 Increased androgen receptor (AR) transcriptional activity, like increased AR expression, can promote androgen-independent growth of prostate cancer cells.
18462702 New mutation of the androgen receptor gene, as a deletion in exon 1 not described previously, was identified in a case of complete androgen insensitivity syndrome.
18451177 TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.
18451148 Androgen actively evokes a nongenomic signaling pathway to activate PKA that is needed for the genomic functioning of nuclear AR.
18451096 leupaxin could serve as a potential progression marker for a subset of PCa and may represent a novel coactivator of the androgen receptor
18420738 The nuclear import of AR is regulated by the interplay between each domain of the AR.
18415690 Observational study of gene-disease association. (HuGE Navigator)
18413735 A transcriptional repressor complex that binds a specific sequence (repressor element) in the androgen recptor gene 5'-untranslated region in prostate cancer contains Pur alpha.
18402773 Overexpression of CMTM3 represses androgen receptor (AR) transactivation, while knocking down it can increase AR transactivation.
18390176 Observational study of gene-disease association. (HuGE Navigator)
18385763 The androgen receptor gene and EDA2R are significantly associated with androgenetic alopecia.
18385763 Observational study of gene-disease association. (HuGE Navigator)
18374401 These data identify an inhibitory action of AR on EGFR signaling, and support research investigating AR/EGFR antagonism in the treatment of ovarian cancers.
18372911 p85alpha and p110beta are essential for androgen-stimulated AR transactivation, and their aberrant expression or activation might play an important role in prostate cancer progression
18365230 Our study suggests that the reduced CAG repeats in the AR gene are associated with criminal behavior.
18365230 Observational study of gene-disease association. (HuGE Navigator)
18358509 the crosstalk between genotropic and non-genotropic AR signalling interferes with signalling of EGFR in response to ligand leading to a lower invasive phenotype of AR-positive PCa cells [review]
18349820 These results provide evidence using clinical specimens, that upregulation of the PI3K/Akt pathway is associated with phosphorylation of the AR during development of HRPC.
18342859 Case Reports: Sex-reversed phenotype in association with two novel mutations c.2494delA and c.T3004C in the ligand-binding domain of the androgen receptor gene.
18332867 isosilybin B treatment enhances the formation of complex between Akt, Mdm2 and AR, which promotes phosphorylation-dependent AR ubiquitination and its degradation by proteasome
18324648 The HER-2/neu signaling pathways may contribute to development of metastatic disease in prostate cancer.
18323476 No association between androgen receptor genetic variation, as measured by haplotype-tagging single nucleotide polymorphisms and CAG repeat number, and risk of CVD was observed in women.
18323476 Observational study of gene-disease association. (HuGE Navigator)
18321498 AR protein is found in both X- and Y-carrier spermatozoa, and it is translated in earlier steps of spermatogenesis and moves to Y-carrier spermatids through the cytoplasmic bridges.
18303071 Observational study of gene-disease association. (HuGE Navigator)
18302198 UGT2B15 and B17 are primary androgen-regulated genes and androgen receptor is required for both their basal expression and their androgen-regulated expression.
18297304 The data demonstrate that, in contrast to mice, no alterations in the expression of androgen and estrogen hormone receptors were evident after surgery in patients.
18284209 The androgen receptor N-terminal domain has the main transactivation function and interacts with both the N-terminal and C-terminal domains of general transcription factor RAP74/TFIIF and the C-terminal domain of coactivator SRC-1a.
18284208 Androgen receptor (AR) N-terminal transactivation domain exists in a natural disordered structure which has been called a pre-molten globule or molten globule state and is likely to have important implications for AR function on androgen-regulated genes.
18281521 Calcitriol requires a functional AR to inhibit the expression of the UGT2B17 gene in LNCaP cells.
18281036 Androgen receptor gene short CAG repeats with a relatively high receptor function may constitute a susceptibility factor for the development of premature ovarian failure.
18281036 Observational study of gene-disease association. (HuGE Navigator)
18273818 Size of the exon 1-CAG repeats of the AR gene employed as a molecular marker in the diagnosis of Turner syndrome is reported.
18270433 Novel missense mutation in the P-box of androgen receptor in a patient with androgen insensitivity syndrome.
18270197 DNA-dependent protein kinase phosphorylation of the androgen receptor, or an interacting component, helps target the androgen receptor for export from the nucleus
18266956 These results indicate a negative regulation of prostate cancer growth and invasion by stromal AR.
18252782 The androgen receptor gene CAG(n) polymorphism may have a significant role in the pathogenesis of premature adrenarche, especially in lean children.
18252782 Observational study of gene-disease association. (HuGE Navigator)
18222118 RanBP10 enhances AR transactivation as a homo-oligomer or a hetero-oligomer with RanBPM
18217192 An association between AR trinucleotide repeats and prostate cancer risk in a population-based sample of African Americans.
18217192 Observational study of gene-disease association. (HuGE Navigator)
18212060 The time-dependent EGF-induced increase in AR transcriptional activity by MAGE-11 is mediated through AR activation functions 1 and 2 in association with the increased turnover of AR and MAGE-11.
18212046 Incubation of a Sertoli cell line with testosterone triggered corecruitment of AR and GATA4 to the Rhox5 proximal promoter. GATA and AR form a complex with the Rhox5 proximal promoter in vitro.
18202763 oridonin, isoliquiritigenin and wogonin cause downregulation of AR and PSA, affecting cell proliferation, cell apoptosis, and cell cycle parameters
18196538 androgen stimulates Bcl-xL expression via the AR and that increased Bcl-xL expression plays a versatile role in castration-resistant progression of prostate cancer
18192296 The presence of long SHBG(TAAAA)n alleles is associated with increased risk for polycystic ovary syndrome and in combination with short androgen receptor(CAG)n alleles may influence the hyperandrogenic phenotype of PCOS.
18192296 Observational study of gene-disease association. (HuGE Navigator)
18191848 The AR gene CAG repeat polymorphism may contribute to the serum concentration of free testosterone in polycystic ovary syndrome patients.
18191848 Observational study of gene-disease association. (HuGE Navigator)
18187183 We purpose that androgen receptor should be routinely measured for breast cancer.
18181049 Observational study of gene-disease association. (HuGE Navigator)
18181049 fewer number of CAG repeats and total repeats (CAG + GGC) in the AR gene may be associated with increased risk for prostate cancer.
18178153 Taken together, our findings indicate that HNF-3alpha is a novel corepressor of AR, and predict its effects on the proliferation of prostate cancer cells.
18174258 Androgen receptor regulates CD168 expression and signaling in prostate cancer
18172316 The work presented here provides the first evidence of synergy between AR and the prolactin signaling protein Stat5a/b in human prostate cancer cells.
18097504 Shorter lengths of repeats in the AR gene might act as low penetrance genetic background in varying manifestation of androgen insensitivity.
18084622 In etoposide-treated LNCaP cells, p53 bound the AR promoter, which contains a potential p53 DNA-binding consensus sequence. loss of p53 function in prostate cancer cells contributes to increased expression of AR.
18084330 Cyclin D3 is a critical modulator of the androgen response, whose deregulation may foster unchecked AR activity in prostate cancer.
18084323 ZIP kinase plays a crucial role in androgen receptor-mediated transcription.
18070607 ligand-mediated dynamic relationship of nuclear receptors with mitotic chromatin can be effectively exploited to study, analyze and authenticate therapeutic ligands
18037956 findings suggest that mutant androgen receptors, activated by alternative ligands, drive growth via different mechanisms to androgen-activated wild-type receptor
18022799 The promoter-selective effects seen for the AR acetylation site mutants strongly suggest this post-translational modification to be important in the fine-tuning of the effects of androgens on different target genes.
18007036 The interaction between AR and its corepressor SHP was studied using X-ray crystallography. Similarity of binding sites for coactivator peptides and SHP, suggests that transcriptional AR activity may be inhibited by SHP by competing with AR coactivators.
17997416 The findings indicate that a brain-specific expansion of androgen receptor triplet repeats is unlikely to underlie motor neuron loss in ALS or Progressive Muscular Atrophy.
17991730 novel role of androgen receptor mutations in prostate cancer development
17984247 Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17979523 Potentially different genetic mechanisms behind benign prostatic hyperplasia in Finnish and other Caucasian populations.
17975004 These results suggest a novel indirect mechanism of androgen action on FHL2 expression and provide evidence that SRF is an important determinant of AR action in prostate cancer cells.
17974989 These data identify novel nongenomic mechanisms involving androgen, AR, and Hsp27 activation that cooperatively interact to regulate the genomic activity of AR.
17972531 The aim of this study was to elucidate the prognostic value of the immunohistochemical detection of the androgen receptor status, assessment of neuroendocrine differentiation and the assessment of microvessel density in patients with prostate cancer.
17968460 Androgen receptor protein is present in a wide variety of human first trimester fetal tissues (thymus, bronchi, spinal cord, and heart) and shows the potential for androgen affecting tissues.
17940184 This review aims to provide an overview of the AR coregulator proteins identified to date and to propose a classification of these AR coregulator proteins according to the function(s) ascribed to them.
17937062 AR defects were found in 66.7% of patients with complete androgen insensitivity syndrome and 13.6% of patients with partial androgen insensitivity syndrome.
17936280 Weak linkages in AR can be identified and can be good information for the prediction of possible new mutations that can result in phenotype abnormality.
17932503 These data suggest that SGK-1 is an androgen-regulated gene that plays a pivotal role in AR-dependent survival and gene expression.
17932034 SUMO-specific protease 1 transcription is induced by the androgen receptor in prostate cancer cells
17926464 The PCR HUMARA technique adequately assesses reduction of Ph-positive clone in CML patients with CCR and points to polyclonal hemopoiesis.
17922225 Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma
17922225 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17919607 Expression of androgen receptor co-regulators in the testes of men with azoospermia.
17916185 Observational study of gene-disease association. (HuGE Navigator)
17914092 GnRH II is widely expressed in prostate cancer and is an AR-regulated gene.
17906287 ARs with short Q tracts (12Q), which are transcriptionally more active, induce earlier disease in the transgene-induced TRAMP prostate cancer model than alleles with median (21Q) or long (48Q) tracts.
17904846 an association for breast cancer risk between short (SS) alleles for the repeat variants of the ESR2 and AR genes was found in women of Greek descent.
17904846 Observational study of gene-disease association. (HuGE Navigator)
17889867 Show that there is no association between CAG repeat length variation and semen quality.
17885209 Results show that AR directly interacts with CRIF1 via the activation of function-1 domain of AR.
17873892 Polygonal and cuboidal cells in pulmonary sclerosing hemangioma exhibited a uniform pattern of monoclonality, indicating that both cell types are highly likely to originate from a common precursor
17855696 Observational study of gene-disease association. (HuGE Navigator)
17855696 data do not support major role for AR polymorphism as breast cancer risk factors
17803691 Data observed great variability in the degree of external genitalia virilization in both CYP21A2 genotypes, and we showed that the CAG repeats of the androgen receptor gene influences this phenotypic variability.
17785571 Observational study of gene-disease association. (HuGE Navigator)
17728669 Observational study of gene-disease association. (HuGE Navigator)
17728259 Using transient transfection assays in prostate cancer LNCaP and HeLa cells engineered to express the AR, study shows that synthetic androgen R1881 and dihydrotestosterone stimulate expression of a versican promoter-driven luciferase reporter vector.
17728127 Observational study of gene-disease association. (HuGE Navigator)
17728127 Results indicate that longer CAG(n)/GGN(n) combinations increase the risk of Breast Cancer and suggest that CAG and GGN AR polymorphisms should be considered in order to assess the BC risk.
17721441 Binding sequences for the avian erythroblastosis virus E26 homologue (ETS) transcription factor family were also highly enriched, and we uncovered an interaction between the AR and ETS1 at a subset of AR promoter targets.
17714709 Androgen receptor gene mutations located in the N-terminal transactivation domain, are a novel mutation c.118delA presumed to result in a complete loss of AR function and to be associated with complete androgen insensitivity syndrome.
17712477 Expression of saposin C-originated saposin C may upregulate AR gene expression and activate the AR transcriptional function in an androgen-independent manner in prostate cancer cells.
17706202 Observational study of gene-disease association. (HuGE Navigator)
17704139 Wwox suppresses Ap2gamma/ErbB2-induced prostate cancer cell growth, an effect that requires functional androgen receptor.
17698582 These data suggest that cyclin D3/CDK11p58 signaling is involved in the negative regulation of AR function.
17696745 Association of androgen receptor trinucleotide repeats with hormone refractory prostatic cancer patients in a north Indian population.
17696745 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17684052 Meta-analysis of gene-disease association. (HuGE Navigator)
17671686 STAT 3 and androgen receptor signaling are inactivated in androgen-dependent LNCaP cells after administration of Saw Palmetto
17669147 the number of CAG repeats in the AR gene was negatively correlated with prostate weight
17659846 findings show androgen receptor (AR) CAG repeat length (RL) might modify the association between endogenous total and bioavailable testosterone and depressive symptoms in younger black men
17656415 Human sperm express a functional AR that have the ability to modulate the PI3K/AKT pathway, on the basis of androgen concentration
17653089 Inappropriate activation of androgen receptor by relaxin via beta-catenin pathway.
17651405 Observational study of gene-disease association. (HuGE Navigator)
17635910 Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains
17634427 These results imply that c-Jun plays a pivotal role in the pathway that connects ligand-activated AR to elevated ETV1 expression, leading to enhanced expression of matrix metalloproteinases and prostate cancer cell invasion.
17627815 results suggest that both Runx2 and androgen receptors repress the transactivation function of the other protein by extracting it from its original compartment
17613104 Observational study of gene-disease association. (HuGE Navigator)
17613104 AR gene might be involved in the depressive upset in adolescents, and the age- and sex-related prevalent differences might also be associated to CAG rep
17611654 The mean percentage of cancer cells expressing AR among the 10 cancer samples was 74%.
17601880 Evidence of functional differences between two most common alleles of the AR GGN repeat, supporting its potential role in the development of human traits.
17601350 Observational study of gene-disease association. (HuGE Navigator)
17587566 ligand-dependent AR conformation is essential for the recruitment and nuclear translocation of PMRT2 which acts as AR-coactivator, presumably by arginine methylation.
17585029 These data show that androgen receptor expression in the prostate is suppressed by soy protein isolate consumption, which may be beneficial in preventing prostate cancer.
17579205 Observational study of gene-disease association. (HuGE Navigator)
17579205 Between-subject variability in serum free testosterone in healthy men is underlain in part by differences in androgen sensitivity and feedback set point, with a contributory role of AR polymorphism.
17570496 data demonstrated that chronic inflammation appeared to play roles in induction of CCAAT/enhancer-binding protein beta expression in prostate epithelium which was associated with increased Cyclooxygenase-2 expression and androgen receptor downregulation
17569297 Observational study of gene-disease association. (HuGE Navigator)
17569297 The number of CAG repeats was significantly greater in younger prostate cancer patients compared to controls. Comparing younger to older patients, the difference was not significant, but there was a trend towards less CAG repeats in older patients.
17568191 Review. The role of AR in controlling cell cycle progression & paradoxical roles of AR in survival signals are considered.
17563746 ErbB-2, via PYK2-MAP kinase, upregulates the adhesive ability of androgen receptor human prostate cancer cells.
17553795 Glyceraldehyde-3-phosphate dehydrogenase enhances transcriptional activity of androgen receptor in prostate cancer cells
17541959 Prostate cancer stem cells give rise to transiently amplifying epithelial cells populations with abnormal androgen receptor pathways.
17540719 Finding of anovel cytoplasmic actions for a splicing AR variant, suggesting a contribution in prostate cancer progression.
17538927 In a Chinese family affected with androgen insensitivity syndrome, the familial distinct feature is that all patients shared an identical Arg840Cys substitution in the AR but displayed high phenotypic variation in disorders of male sexual development
17534890 nonsense mutations that lead to carboxyl-terminal end truncated ARs are found at high frequency in metastatic PCas
17522416 L859F mutation resulted in highly significant loss of the ligand binding to the receptor.
17522055 3,3'-diindolylmethane -induced cell growth inhibition and apoptosis induction are partly mediated through the regulation of Akt/FOXO3a/GSK-3beta/beta-catenin/AR signaling
17507624 Observational study of gene-disease association. (HuGE Navigator)
17503469 findings support involvement of both androgen receptor (AR) and estrogen receptor-beta in mediating dehydroepiandrosterone (DHEA)-, dehydrotestosterone-, and estradiol-induced prostate specific antigen (PSA) expression in prostate cancer cells
17496156 A functional interaction of WT1 and AR might play a role during the development of the male external genitalia.
17494760 Ack1 activated by surface signals or oncogenic mechanisms may directly enhance AR transcriptional function and promote androgen-independent progression of prostate cancer.
17494760 Ack1 promotes prostate cancer progression to androgen-independence via androgen receptor tyrosine phosphorylation at Tyr-267 and Tyr-363, both located within the transactivation domain.
17487836 in vivo antitumor activity is promoted by combined decrease of NFkappaB and incresased thrombospondin 1
17477366 There may be a hormonal and hypoxia-independent regulatory mechanism coordinating the expression of HIF-1alpha, HIV-2alpha, VEGF, the androgen receptor, and FOXP1 in prostate tumors.
17476687 sFRP4 is an inhibitor of prostate cancer growth and invasion in vitro independent of androgen receptor (AR) signaling.
17470458 IGF-1 rescue of AR toxicity is diminished by alanine substitutions at the Akt consensus site
17465263 Observational study of gene-disease association. (HuGE Navigator)
17453687 Dominant expression of androgen receptors in penile tissues of children with hypospadias may be the postnatal finding of disrupted estrogen receptor interaction during intrauterine development of external genitalia.
17452459 These data demonstrated that PSF and p54nrb complex with AR and play a key role in modulating AR-mediated gene transcription.
17431729 Observational study of gene-disease association. (HuGE Navigator)
17431729 CAG but not GGC alleles in the AR polymorphism may play an important role in modulating the disease pattern of RA among Taiwanese women.
17426252 These results indicated that in prostate cancers, HIF-1 might cooperate with the AR to activate the expression of several genes related to tumor angiogenesis, invasion, and progression.
17416965 Data show that Gi and RGS proteins provide biochemical control of androgen receptor exclusion from the cell nucleus.
17413000 Synthetic progestins, such as medroxyprogesterone acetate (MPA), which are currently used in hormone replacement therapy may disrupt androgen receptor signaling and contribute to breast cancer developmoent. [REVIEW]
17376218 Observational study of genotype prevalence. (HuGE Navigator)
17376218 Distribution of polymorphisms in SRD5A2 and androgen receptor differed between prostate cancer low-risk population from Greenland and relatively high-risk Swedish male population.
17372242 Observational study of gene-disease association. (HuGE Navigator)
17372242 having a short CAG repeat length in AR increases ovarian cancer risk in African Americans
17365134 Observational study of gene-disease association. (HuGE Navigator)
17365134 The results suggest that shorter length of AR might influence the onset of MDD in female adolescents, a further elucidation of the mechanisms is warranted.
17363459 Presence of two AREs within the IGF-I upstream promoter that act in cis to activate IGF-I expression.
17356171 Androgen receptor antagonists are useful for inhibition of prostate cancer cell growth.
17342749 These findings suggest that reactive oxygen species is a common mediator responsible for ADAM9 protein induction in human prostate cancer cells, downstream from androgen receptor, and stress response signaling.
17336451 ARs having a Leu701His mutation AR(L701H) was highly dependent on Hsp90 for its hormone-independent activation, suggesting that this chaperone functions in AR(L701H) folding.
17334597 The number of CAG repeats in the androgen receptor gene within normal range is not a clinically relevant genetic risk factor for non-obstructive azoospermia & oligoasthenoteratozoospermia.
17334587 intracellular control of AR expression levels through the natural AR promoter might be needed for determining AR function in androgen-independent prostate cancer (AIPC) PC-3 cells.
17334586 The impact of androgens in various disorders and polymorphic variations in the AR gene is the main focus of this review.[review]
17322500 Observational study of gene-disease association. (HuGE Navigator)
17322500 CAG repeat length in androgen receptor gene modulated the relation between testosterone and body composition in elderly men
17321486 Observational study of gene-disease association. (HuGE Navigator)
17321486 Short [CAG]n repeat length(</=20) polymorphism is associated with poor prognosis in a subset of male patients with head and neck cancer and that AR gene microsatellite instability is uncommon in these tumors.
17262801 The AR(K580R) mutation promoted the malignant transformation of prostate epithelial cells in association with upregulation of placental alkaline phosphatase and activation of the Akt signaling pathway.
17259306 This study documents HBx as a previously undescribed class of noncellular positive coregulators for AR.
17257635 Observational study of gene-disease association. (HuGE Navigator)
17257635 results imply that prostate cancer risk is associated with androgen receptor(AR)-CAG repeat and kallikrein-2 polymorphisms in Indian population but no unambiguous association was observed with PSA and AR-GGN repeat polymorphism
17256155 the AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopecia.(451-7) Status: Complete Incomplete Delete
17244640 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
17244640 investigated which roles the AR polymorphisms as well as the R554K and P185A in the AHR and AHRR genes, respectively, may play in modifying the effect of exposure to organohalogen pollutants in regard to sperm Y : X ratio
17242169 Plays role in the regulation of epidermal growth factor receptor endocytotic trafficking and active signalling in prostate cancer cells.
17241382 Genetic variation in genes involved in steroid biosynthesis, metabolism and signal transduction is reported in Greek patients with cholelithiasis.
17230529 Observational study of gene-disease association. (HuGE Navigator)
17230529 Somatic mutations at the trinucleotide repeats of androgen receptor gene is associated with male hepatocellular carcinoma
17217995 findings suggest that AR gene amplification is an important molecular mechanism underlying the increase in proliferation rate of a substantial fraction of recurrent prostate carcinomas
17187234 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17187234 provide only minor support for the role of the AR and estrogen receptor 1 gene in the etiology of breast cancer
17178887 E;evated E2F1 transcription factor, through its ability to repress androgen receptor transcription, may contribute to the progression of hormone-independent prostate cancer.
17178871 Potential involvement of AR-bound calmodulin in calcium-controlled, calpain-mediated breakdown of AR in prostate cancer cells.
17170703 caspase-8 regulates androgen-receptor-driven gene expression
17160687 The expression levels of ER subtypes and AR may be important for the regulation of follicular mesenchymal cells in human scalp.
17116317 Observational study of gene-disease association. (HuGE Navigator)
17108148 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17082327 described transgelin as the first ARA54-associated negative modulator for AR. Transgelin suppressed ARA54-enhanced AR function in ARA54-positive cells and inhibited prostate cancer cell growth.
17077481 The crystal structure of the complex of LGD2226 with the androgen receptor ligand-binding domain (AR LBD) at 2.1 A was solved and compared with the structure of the AR LBD-R1881 complex.
17075604 Characterization of AR functions in prostate growth and differentiation.
17074594 Expression of AR gene alleles from each of the two X chromosomes was present in the chordoma tumor, indicating a polyclonal proliferation.
17073759 Identification and characterization of mutations found in prostate cancer and Kennedy's disease patients
17073749 AR-AF1 domain exhibits induced folding when contacted by transcription regulators (such as TFIIF) into a more compact and 'active' conformation.
17065579 Strong expression of AR was found in peritubular cells (PCs).
17055455 These findings collectively suggest that hinokitiol is potentially effective against prostate cancer in vitro, and thus it might become a novel chemopreventive or chemotherapeutic agent for prostate cancer.
17054461 study found 20 mutations (7 novel) in 26 of 1517 male infertility patients; a high number of mutations localized in exon 1 of the AR gene coding for the transactivation domain of the protein
17043241 increased cyclin-dependent kinase 1 activity is a mechanism for increasing AR expression and stability in response to low androgen levels in androgen-independent prostate cancer
17034507 Observational study of gene-disease association. (HuGE Navigator)
17015840 Androgen-sensitive (AS) prostate cancer cells do not express androgen receptor (AR) protein during mitosis, either in vitro or in vivo, consistent with AR functioning as a licensing factor for DNA replication in AS prostate cancer cells.
17011549 c-Rel, like AR, is a part of the nucleoprotein complex regulating the androgen-responsive prostate-specific antigen (PSA) promoter
17010601 Observational study of gene-disease association. (HuGE Navigator)
17003774 AR induction of MRP4 mediates resistance of PC cells to nucleotide-based chemotherapeutic drugs.
16987421 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16987421 Among postmenopausal Caucasian women, common variants of the AR gene are not associated with risk of breast cancer.
16980632 Increased AR ligand sensitivity as well as locus-specific chromatin alterations contribute to basal gene expression of a subpopulation of specific AR target genes in androgen-independent PCa cells.
16969583 Observational study of gene-disease association. (HuGE Navigator)
16969583 specific GGN/CAG haplotypes (CAG 21) of AR gene increase the risk of prostate cancer
16969502 expression of AR down-regulates the migratory responses of human prostate cancer cells via CXCR4 and CCR1
16957138 Observational study of gene-disease association. (HuGE Navigator)
16957138 association of CAG/GGN trinucleotide repeats in the androgen receptor gene with cryptorchidism and hypospadias in an Iranian population
16950754 R831X mutation in exon 7 of the androgen receptor gene associated with Complete Androgen Insensitivity Syndrome.
16923962 evidence for an androgen receptor (AR) regulatory pathway controlled by SIRT1; SIRT1 antagonists induce endogenous AR expression and enhance dihydrotestosterone-mediated AR expression
16921507 AR and ACTR may play important roles in androgen ablation resistance by controlling key cell cycle gene expression
16920725 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16918952 Observational study of gene-disease association. (HuGE Navigator)
16914734 Human PIRH2 as a key modulator of AR function, opening a new direction for targeted therapy in aggressive human prostate cancer.
16868150 Observational study of gene-disease association. (HuGE Navigator)
16868150 Short GGN repeats seem to be associated with decreased semen volume, possibly due to suboptimal AR activity
16865726 Neuroendocrine (NE) cells of prostate cancer constitute a unique subset of cancer cells, which have a unique immunohistochemical profile. They do not express AR, consistent with their resistance to hormonal therapy.
16865224 Observational study of gene-disease association. (HuGE Navigator)
16865224 polymorphism analysis of the AR gene suggests that the fertility of children conceived by ICSI may be conserved.
16860317 These results identify HDAC7 as a novel Androgen receptor corepressor whose subcellular and subnuclear compartmentalization can be regulated in an androgen-selective manner.
16859836 Observational study of gene-disease association. (HuGE Navigator)
16847812 androgen receptor CAG repeat length may have a role in the tumorigenic process of the prostate
16835890 Expression of AR protein in PC3-Lenti-AR cells resulted in transactivation of p21 and growth inhibition in culture and in mouse xenografts. Such inhibition was due to induced G1 arrest as documented by expression changes in p27 and p45(SKP2) proteins.
16813680 Observational study of gene-disease association. (HuGE Navigator)
16809273 Observational study of gene-disease association. (HuGE Navigator)
16793958 Observational study of gene-disease association. (HuGE Navigator)
16791593 Observational study of gene-disease association. (HuGE Navigator)
16791593 Longer Tandem Repeats in androgen receptor is associated with breast cancer
16774685 In LNCaP cells CCAAT/enhancer binding protein alpha over expression inhibits expression of prostate specific antigen by Androgen receptor-dependent mechanism
16759930 The novel c.C2812T transition that might impair dimerization of the receptor is responsible for the clinical symptoms of complete androgen insensitivity syndrome in the affected individuals.