Property Summary

NCBI Gene PubMed Count 3,775
PubMed Score 15380.36
PubTator Score 12114.18

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (8)

Disease Target Count Z-score Confidence
Alzheimer's disease 644 8.158 4.0
Cardiovascular system disease 194 0.0 2.0
Disease Target Count Z-score Confidence
Age related macular degeneration 84 3.795 1.9

Expression

Gene RIF (4249)

PMID Text
27117804 Higher peak velocity-reactivity in APOE epsilon4 carriers suggests vascular compensation for deleterious effects of this known risk allele for Alzheimer's disease and stroke
27078154 Data suggest that the apolipoprotein E (APOE) genotyping method with a flexible throughput is suitable for DNA template from different preparations.
27065111 The apolipoprotein E genotype is a powerful risk factor for late-onset Alzheimer's disease.
26998902 elderly community dwelling residents of Han ethnicity carrying the APOE epsilon3/epsilon3 genotype might have higher plasma glucose levels and a higher occurrence of diabetes.
26996551 Nevertheless, the expression levels of ApoA-1, ApoC-III, and ApoE were not correlated with SCLC staging
26980363 APOE status did not affect change in depressive symptoms in response to physical activity intervention in older adults.
26958821 Presence of epsilon4 allele was associated with lower odds of mobility deficit (OR = 0.65; 95%CI: 0.47-0.92) in the adjusted analysis.
26948379 Sporadic Abeta accumulation may be partly associated with increased amyloidogenic APP production, especially in APOE varepsilon4-negative subjects.
26945380 APOEepsilon4 allele possible risk factor for nonlesional mesial temporal lobe epilepsy
26903389 The APOE epsilon2 allele increases the risk of Frontotemporal Dementia in ALS patients.
26901792 The possession of the APOE epsilon4 allele has a small, nonsignificant effect on the presence of delirium. It seems that there is no association between APOE and the occurrence of delirium.[review; meta-analysis]
26877211 APOE*4 is not associated with the diagnosis of bipolar disorder and does not impact the occurrence of dementia in bipolar disorder. APOE*2 was more frequent in cognitively impaired bipolar disorder patients compared to Alzheimer's disease patients.
26876448 Serum apoE is associated with long-term risk of Alzheimer's disease in the general population, independent of APOE genotype.
26851028 E3/E3 genotype may be a potential risk factor for prostate cancer and high Gleason scoring. The E4 allele maybe a risk-reducing factor for prostate cancer.
26830841 study suggested that APOE polymorphism might be associated with intracranial aneurysms in Chinese population
26823800 suggested that ApoE may have a role in the pathogenesis and progression of HBV-related liver disease and indicated the possible underlying mechanisms
26800892 ApoE gene polymorphisms associate with CVD and affect the lipid profile. The epsilon4 allele is an independent risk factor for both T2DM and CVD.
26790728 The results of this study shows that the frequency of epsilon4 allele of ApoE is significantly lower among hypertensive patients on hemodialysis with the highest levels of Asymmetric dimethylarginine .
26768225 The ApoE E3 allele and the CYP2D6 rs1065852 polymorphism may provide clinically relevant information for predicting therapeutic responses to donepezil therapy.
26757188 BCHE-K is associated with a reduced risk for Alzheimer disease and Lewy body dementia whereas APOEvarepsilon4 is associated with more rapid cognitive decline.
26740500 There was no association between APOE varepsilon2/varepsilon3/varepsilon4 and obstructive sleep apnoea susceptibility.
26739741 Results suggest that APOE4 is associated with hypertriglyceridaemia, with a slightly increased risk for MetS, but APOE2 is associated with protection against MetS in Uyghur males in China
26738354 No statistically significant difference was detected either in APOE or APH-1a polymorphisms, not suggesting a strong susceptibility to the development of Alzheimer disease.
26738348 Frequency of APOE E4 allele was higher in Alzheimer disease than controls, supporting its use as a biomarker.
26720342 C2238/alphaANP downregulates ApoE in vascular smooth muscle cells through type C natriuretic peptide receptor-dependent activation of Egr-1 and the consequent upregulation of miR199a.
26717353 APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults.
26691908 Carrying APOE*4 alleles increases MetS in a dose-dependent manner, characterizing individual's APOE genotype might help identify at-risk subjects for preventive intervention.
26686670 combined hippocampal and entorhinal cortex amyloid loads with perceptual speed in the low Braak group after adjusting for age, gender and apolipoprotein E epsilon4 status
26686669 apolipoprotein APOE4 allele confers greater risk of Alzheimer's disease (AD) for women than men.
26669675 we did not observe a significant association between multiple sclerosis severity score and APOE rs429358 or rs7412.
26662731 ApoE mutations may have a role in increasing the development of diabetic nephropathy among the Egyptian individuals.
26661143 These findings suggest that apolipoprotein E-genotype exerts its impact on cerebral blood flow at least partly independently from amyloid beta-deposition.
26646927 APOE polymorphism in various neurological disorders is discussed (Review)
26639956 Subjective memory complaints was associated with high Abeta burden, especially in APOEepsilon4 carriers and younger subjects
26592663 Taken together, our study suggests that aging facilitates lesion development in apoE(-/-) mice with greater effect on male mice.
26586657 Report increased risk of dementia in APOE4 carriers.
26581118 The presence of one or more APOE E4 alleles had positive effects on spatial function and memory and object location memory.This study is the first to show that APOE E4 has a positive effect on spatial ability in young adults.
26579811 Meta-analysis indicates APOE epsilon4 is associated with the poor long-term functional outcome of patients with traumatic brain injury.
26574747 NO APOE genotype is associated with intelligence measures among young Chinese college students.
26564908 study demonstrated ApoE4-containing astrocyte-conditioned media increases mitochondria-associated endoplasmic reticulum membranes (MAM) function relative to ApoE3; data are consistent with a role of upregulated MAM function in the pathogenesis of Alzheimer disease and may help explain the contribution of ApoE4 as a risk factor in the disease
26552581 APOE-epsilon4 carriers showed an inability to effectively modulate posteromedial cortex during scene, but not face and object, working memory and perception.
26547561 Tissue or cellular hypoxic/ischemic injury within the globus pallidus may underlie the pathogenesis of pantothenate kinase-associated neurodegeneration due to PANK2 mutations and apoE aggregates.
26546821 CREB enhances KLF4 up-regulatory effect on apoE promoter.
26543236 Single-nucleotide polymorphisms in APOE gene is associated with Alzheimer's disease.
26535656 rs4420638 polymorphism of APOE significantly increases the risk of coronary heart disease(OR = 1.18, 95%CI = 1.14-1.22, P < 0.0001, fixed-effect method)(Meta-Analysis)
26519632 findings indicate that ApoE may be related to stress and trauma and the temporal severity of suicidal behaviour.
26503161 This study identified differences in task-dependent functional connectivity between APOEvarepsilon4 carriers and noncarriers during memory encoding and retrieval.
26495840 The interaction effect between APOE e4 genotype and hypercholesterolemia was statistically significant both in the KAROLA and ESTHER study (p = 0.021 and p = 0.017, respectively).
26481640 We demonstrated the benefits of a questionnaire-based approach for assessment of lifestyle risk factors to facilitate clinical interpretation of APOE genotyping genetic subgroup of dyslipidemic patients
26481403 presence of APOE epsilon4 and epsilon2 alleles was not associated with PHF-tau tangles in the absence of b-amyloid and an additional evidence that PHF-tau tangles in the absence of b-amyloid may reflect a pathologic process distinct from Alzheimer's disease.
26468283 data show how FH interacts with apoE molecules via domains 5-7 and regulates alternative pathway activation on plasma HDL particles.
26446211 This study showed how APOE2 provokes and APOE4 inhibits the cardinal Age-Related Macular Degeneration features, inflammation, degeneration, and exaggerated neovascularization.
26444786 The results suggest that education and female gender, not APOE genotype, may be important as independent strong predictive factors for disease progression in patients with early-onset Alzheimer's disease.
26430784 results suggest that Abeta and APOE epsilon4 interact to increase the rate of cognitive decline in CN older adults and provide further support for the use of Abeta and APOE epsilon4 as biomarkers of early Alzheimer's disease
26427386 Studies indicate that apolipoprotein E E2, E3 and E4 exhibit differences in lipid binding, integrating into lipoprotein particles and affinity for lipoprotein receptors.
26408498 Higher metabolism in higher (compared to lower) educated APOE epsilon4 carriers was found in brain regions that sustain episodic memory.
26405973 The present work indicates that SNP rs4846914 in GALNT2 gene is related to an increased risk of hypertension in China Han population, but the APOE gene is not.
26404360 APOE polymorphisms was associated with antioxidant parameters in plasma or erythrocytes.
26402762 this study showed that APOE genotype had no statistically significant effect on cognitive response to donepezil treatment.
26402101 Study suggests that the APOE epsilon 4 allele leads to a widescale impairment of brain white matter integrity, which is closely correlated with cognitive impairments
26402098 Results showed that women who possessed any APOE epsilon4 allele experienced a steeper decline in BMI in late life, after age 70 years, irrespective of dementia status
26402071 Results suggest that the APOE CpG island is differentially methylated in Alzheimer's Disease brain in a tissue- and APOE-genotype-specific manner
26402005 Results demonstrated that ApoE2 brain is associated with a more metabolically robust profile than both ApoE3 and ApoE4 brain, which provides a mechanistic rationale for its protective role against Alzheimer's disease
26401700 Study analyzed how age modulates the APOE genotype's influence on the volume and shape morphometrics of the hippocampus and the amygdala in both hemispheres based on a large sample of 540 subjects
26400930 ApoE4 affects brain function and suggest that inhibition of PKR is a way to restore memory impairment in early stages of sporadic Alzheimer disease.
26397226 APOE4 impact on brain metabolism and structure is modified by sex in a study on healthy volunteers
26387950 Apolipoprotein E regulates amyloid formation within endosomes of melanocytes.
26375028 Variants near APOE is associated with dyslipidemia.
26372448 This review showed that No association between ApoE and Schizophrenia.
26365620 The polymorphisms rs662799 near APOA5 and rs769450 in APOE had significant association with metabolic syndrome X and its components in Korean males.
26341746 APOE epsilon4, but not epsilon2, is associated with capillary amyloid angiopathy.
26340080 Considering biological markers such as degree of White Matter Hyperintensity and APOE epsilon4 status may be clinically relevant to predicting progression of geriatric depressive symptoms.
26333513 CYP7A1 and APOE isoform are associated with the extent of reduction in circulating LDL cholesterol in response to plant sterols consumption.
26318958 genetic association studies in population in India: Data suggest there are no significant differences in distribution of APOE3 genetic polymorphisms between case/controls with/without type 2 diabetes and coronary artery disease in population studied.
26314833 This present study revealed significant effects of the APOE promoter (rs405509) variation on cognitive performance in nondemented elderly people and explored the related topological alterations in the brain structural connectome
26314507 APOE-4 is associated with decreased problems in snoring and sleep apnea, in non-demented older adults.
26310205 No significant effects of APOE epsilon or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants
26306786 The data suggest that the APOE-epsilon4 allele is protective against attention deficit and especially against poor working memory in Hepatitis C virus-infected subjects with mild liver disease.
26302353 more than one-third of APOE4 noncarriers with the primary clinical diagnosis of mild to moderate Alzheimer dementia had minimal Abeta plaque accumulation in the cerebral cortex
26287823 There was no evidence of benefit of APOE epsilon4 allele on working memory
26284518 APOE gene polymorphism is associated with obstructive Sleep Apnea.
26264634 ApoE epsilon4 allele is not associated with migraine susceptibility, but is positively related to headache [meta-analysis]
26252210 Lower white matter integrity may represent one of several mechanisms through which APOE affects perceptual speed performance in elderly persons free of dementia and preclinical dementia.
26239178 APOE4 carriers showed steeper hippocampal volume reductions with Alzheimer's disease progression
26238230 In older surgery patients free of dementia, the findings do not support the hypothesis that the ApoE genotype does not confer either risk or protection in postoperative delirium incidence, severity, or duration.
26233231 Study did not find any differences in the frequencies of ApoE alleles or genotypes between febrile seizures and typically developing individuals
26213366 ApoE expression attenuated intracellular trafficking of APP and Alcbeta
26202245 We observed that cell-to-cell HCV viral spread was compromised after ApoE interference in donor but not in acceptor hepatocytes.
26201081 Depletion of endogenous APOE in human adipocytes severely impairs lipid accumulation, which is associated with an inability to initiate differentiation.
26191297 APOE, VHL and MTHFR gene polymorphisms were related to the risk of renal cell carcinoma
26189769 ApoE variants were not associated with the risk of prostate cancer or aggressive disease;; findings suggest that the mechanism of circulating cholesterol level affecting prostate cancer incidence may not rely on ApoE isoforms
26177270 APOE epsilon4 carriers present both increased and decreased functional connectivity in default mode network, which is correlated with clinical cognitive performances.
26161964 the organization of metabolic network in APOE epsilon4 carriers indicated a less optimal pattern and APOE epsilon4 might be a risk factor for Alzheimer's disease.
26142535 relationships between ApoE gene polymorphism and coronary heart disease in Asian populations[review]
26131702 A study of APOE gene polymorphisms in participants of the ERJ showed that the presence of the epsilon4 allele was more prevalent in young individuals with repeatedly abnormal lipid variables during longitudinal follow-up (tracking effect).
26130946 The results suggest that APOE genotype may influence C-reactive protein levels through non-inflammatory pathway.
26125935 Meta-analysis showed no association between Alzheimer's disease and the PPARgamma G allele in any of the study subjects with or without the APOE epsilon4 allele. (Meta-analysis)
26125153 APOE polymorphisms were not linked to the influence of cognitive reserve on cognitive function.
26120788 Children with a GH deficiency carrying apoE4 had higher baseline LDL-C concentrations and experienced a greater reduction in LDL-C after GH replacement therapy than those without apoE4.
26115730 APOE epsilon4 is associated with recurrent Inrtacerebral hemorrhage in nonlobar brain regions. No associations were identified between APOE e2 and recurrent nonlobar ICH.
26102276 Among those with one or more APOE epsilon4 alleles, having one or more copies of the CD33 C (risk) allele may further increase the risk of cognitive decline
26094530 significant differences were observed according to APOE gene polymorphism in correlations between LDL/HDL and CHOL/HDL ratios, and results in the processing speed and reaction time, as well as between the BMI and results in processing speed in the postmenopausal women examined
26088392 The findings of a strongly increased dementia mortality risk for ApoE epsilon4 carriers and the protective effect for epsilon2 carriers are in line with other reports using clinical dementia diagnoses as end point.
26085515 Data suggest that APOE genotype (homozygote vs. heterozygote for APOE4) and overweight (indicated by body mass index) are important variables that determine the plasma long-chain PUFA response to dietary fat manipulation (fish oil supplementation).
26079612 The clustered methylation and dihydroxylation of plasma ApoE proteins may play a role in breast cancer.
26073697 This study suggested APOE polymorphisms may affect neuron apoptosis after mechanical injury through different influences on intracellular calcium levels.
26058877 Studied and id'd proteins differentially abundant in current smokers vs. ex-smokers & never smokers; results demonstrated an increase of APOE in current smokers as compared to both never and ex-smokers.
26053677 The rest-stimulus interaction improved the detectability of network integrity changes in apolipoprotein E-epsilon4 carriers.
26046356 Data indicate apolipoprotein E (ApoE) and two isoforms of vitamin D binding protein (DBP) as biomarkers to subdivide the multiple sclerosis (MS) patients into subgroups correlated with clinical classification.
26035038 The absence of a depression by APOE interaction on cognitive abilities suggests that these synergistic effects only operate at the level of cognitive decline.
26019038 Data suggest that the Apo E4 allele could confer genetic susceptibility for the development of gallstone disease among the Mexican population.
26014924 CETP TaqIB and ApoE polymorphisms may not be considered as genetic risk factors for MetS in a Southern Thai population. epsilon4 allele, associated with one metabolic component, low HDL-C levels, might predispose the subjects to develop metabolic disturbances.
26006791 These results demonstrate that the impact of cerebrovascular risk on cortical thickness integrity may vary by the presence or absence of the APOE-4 allele, a well-known risk factor for Alzheimer's disease.
25988319 elevated brain iron adversely impacts Alzheimer's Disease (AD) progression, brain iron elevation is a possible mechanism for APOE-epsilon4 being the major genetic risk factor for AD
25982728 The result also shows that Apolipoprotein E4 induces the aggregation of ABETA 42 more specifically and rapidly than that of ABETA 40.
25979253 epsilon2/epsilon3 genotype likely provided a protective effect against depression in the overall population and the epsilon2 allele acted as a protective factor for depression in the Caucasian population--{REVIEW}
25968937 Variation in ApoE and physical activity intensity were associated with adiposity-related phenotypes in Mexican school children.
25963363 A meta-analysis supported a genetic association between APOE gene and coronary heart disease (CHD). epsilon4 increased the risk of CHD, whereas epsilon2 decreased the risk of CHD.
25956321 results suggest that elastase-like proteases in the microglial cells surrounding Abeta plaques are responsible for ApoE degradation in the brain.
25945528 The APOE-HhaI polymorphism is not associated with age-related macular degeneration.
25938810 Findings suggested that chronic stress affects anxiety-like behavior and spatial and non-spatial memory in GFAP-ApoE transgenic mice in an ApoE isoform-dependent manner.
25933487 Omega 3 PUFAs content in HDL and LDL were not APOE isoform-dependent in young participants. However, young E4+ participants already had a tendency toward lower baseline-DHA levels in LDL particles as well as a more atherogenic omega-6/omega-3 PUFA ratio in LDL...
25920955 Our findings suggest a modifying influence of APOE varepsilon2 on white matter hyperintensity volume caused by CADASIL .
25919635 present findings suggest that the effects of vitamin B12 and homocysteine on GM volume might be influenced by APOE genotype.
25904811 This meta-analysis provides cumulative evidence that the APOE-epsilon4 allele is important to the prognosis of paediatric traumatic brain injury--{REVIEW}
25903128 ApoE inhibits cerebrovascular pericyte mobility through a RhoA-mediated pathway
25899039 The combination of PCSK9 E670G and APOE polymorphisms may represent an independent factor for the determination of lipid levels.
25898889 this Scandinavian autopsy study shows that the apoE polymorphism is associated with the probability of Alzheimer's disease
25893192 BDNF, APOE, and HSP70-1 genes, but not GRIN2B, might be associated with a risk of POAG occurrence in the Polish population
25890021 polymorphisms associated with risk of primary hyperuricemia in Uygur men
25883965 APOE gene polymorphism and risk of coronary stenosis in Pakistani population.
25883527 Carrying the rs8702 C KLC1 allele was associated with a decreased cortical cataract risk among individuals devoid of the APOE4 allele, whereas it has no significant effect among APOE4 carriers.
25880550 APOE epsilon4 genotype was not directly associated with HIV-associated neurocognitive disorder, but moderated CSF levels of Abeta1-42 in a minority of participants.
25879865 MRI measures of medial temporal atrophy, ApoE-varepsilon4 genotype, and the protective effects of higher CR all predict the time to onset of symptoms associated with MCI in a largely independent, additive manner during the preclinical phase of Alzheimer's disease
25878259 Thus, ClfA recruitment of serum ApoE to the Staphylococcus aureus surface may sequester ApoE and blunt its host defence function against Staphylococcus aureus-invasive infections to humans.
25872266 low content of apoE in blood can be considered as a predictor of increasing of ratio apoB/apoA-1 in healthy persons.
25871773 increasing apoE2 in APOE4 carriers is a beneficial strategy to treat Alzheimer's disease, whereas increasing apoE4 in APOE4 carriers is likely harmful
25870958 Apo E alleles might influence improvement in lipid profiles after diet and exercise interventions
25869786 This study investigated olfactory functioning in homozygous varepsilon4/4 older adults diagnosed with probable Alzheimer's Disease.
25857685 This study showed that several PTSD-like behavioral, cognitive, and neuroendocrine alterations are more pronounced in mice expressing human E2
25853819 The interaction of BDNF and APOE has significant effect on Alzheimer's disease (AD). Interventions aimed to prevent AD should focus on these factors and also taking into account the APOE alleles.
25835425 This study identified that APOE varepsilon2/varepsilon3/varepsilon4 associated with Vascular Dementia.
25826114 Possession of the APOE-epsilon4 allele has become firmly established as a risk factor for the incidence of late-onset Alzheimer's Disease.
25820038 Healthy APOE epsilon4 carriers until the age of 65 years do not experience significantly different rates of cell division, cytotoxicity, and chromosomal DNA damage when compared with non-APOE epsilon4 carriers.
25819272 The APOE polymorphism did not modify the onset of strokes or migraine in our CADASIL sample
25808939 results of this exploratory investigation suggest that an APP SNP and an APH1B SNP are marginally associated with PD CSF Abeta42 levels in APOE varepsilon4 noncarriers
25796815 Effectiveness of treatment with donepezil hydrochloride for elderly dpatients with dementia is more pronounce in epsilon4 allele carriers compared with epsilon3/epsilon3 group.
25773779 a possible effect of APOEepsilon4 on early apoptosis via inhibiting Ik(DR) following injury which may adversely affect the outcome of traumatic brain injury
25757756 The blood-brain barrier is damaged in Alzheimer's disease, particularly in individuals carrying apolipoprotein E4 (APOE4) gene.
25752291 The - 491A genotype of APOE promoter was a risk factor predisposing spontaneous subarachnoid hemorrhage patients to rebleeding.
25751510 Results demonstrated a significant negative relationship between the CysR/mole and severity of PTSD re-experiencing symptoms, adjusted for trauma.
25747767 The results off this study showed that apoE4 mice performed worse than apoE2 and apoE3 carriers in the acquisition period of the spatial task, and that apoE2 mice had poorer retention than the other two genotypes.
25744138 We report an association between APOE4 and neurocognitive function five years following cardiac surgery.
25741405 The frequency of the APOE E 2 allele (158Cys) was higher in patients with endometrial hyperplasia + endometrial carcinoma than in controls
25738563 Association of the APOE epsilon4 allele with brain volume loss was demonstrable only in Chinese participants.
25731628 This report significant differences in the genotype distribution for APOE epsilon-4 and epsilon-2 between South African individuals with and without a family history of Alzheimer's disease.
25731621 This study demonstrated that novel loci are associated with AD(Alzheimer disease) in APOE epsilon4 non-carriers. This study indicates the distinct genetic risk genes for AD non-carrying APOE epsilon4 and provides new insight into the molecular mechanisms of AD.
25730733 The joint presence of APOE epsilon4 and elevated systolic blood pressure, even at prehypertensive levels, is associated with lower cognitive performance in healthy, middle-aged adults
25730003 ApoE gene polymorphism was associated with a risk for cerebral infarction in a Chinese population.
25709077 The apolipoprotein E (APOE) epsilon4 allele has been implicated in a range of neuropsychiatric conditions.
25708227 The presence of the apolipoprotein E (APOE*E4) allele predicted future depression in this Swedish population study. Suggests that the APOE*E4 allele could potentially identify people at high risk for clinically significant depression.
25707516 No association between the frequency of ApoE-varepsilon4 and the occurrence of depression was found in patients undergoing hemodialysis.
25703783 Epilepsy, impaired fine motor function and gastrostomy tube feeding were less common in cerebral palsy children with single nucleotide polymorphisms in the APOE or TOMM40 genes
25688603 The apolipoprotein E (APOE) epsilon4 allele may be associated with microvascular brain injury in hypertensive older adults even in the absence of clinical Alzheimer's disease.
25673977 APOE epsilon4 is a strong risk factor of Alzheimer's Disease risk in Chinese Han population, and APOE epsilon4epsilon4 genotype might be related to the AAO of late-onset AD.
25673673 genotypes with at least one ApoE4 allele had significantly higher levels of mean luteal progesterone than women with genotypes without ApoE4, which indicates higher potential fertility.
25672924 The detrimental effects of vascular risk factors on white matter microstructure were exacerbated among APOE epsilon4 carriers.
25672766 These results provide tentative evidence that APOE genotype moderates the association between high blood pressure and cognitive decline in later life.
25670333 Interaction between APOE and depression to be dependent on timing of depression onset.
25670332 In carriers of the apolipoprotein E (APOE) genotype epsilon3/epsilon3 or epsilon3/epsilon4, the presence of a very long (VL) polyT repeat allele in (TOMM40) was less frequent in patients with sporadic inclusion body myositis.
25669588 Apolipoprotein E allele e2 and genotype e2/e3 were risk factors for type 2 diabetic nephropathy (T2DN) and allele e3 and genotype e3/e3 played a protective role in T2DN
25666727 APOE status appears to be associated with functional alterations in regions related to Alzheimer disease before behavioral differences can be detected
25656378 Genetic association study in population in United States: Data suggest that there is no association between genetic polymorphisms in ApoE and metabolic syndrome; data are from multicenter population-based study of predominantly White US men/women.
25653291 There was a synergistic interaction between depression or apathy and APOE epsilon4 in elevated risk for incident dementia.
25632120 This study suggested an important role for the APOE promoter polymorphism in the human brain and also provide valuable insights into how the rs405509 genotype shapes the neural system to modulate the risk of developing AD.
25624723 APOE polymorphism is associated with risk of developing inflammatory bowel disease and early age of onset in Saudi patients.
25624419 This study showed APOE genotypic effects on the cognitive profile and hippocampal structural and functional characteristics in patients at early stages of Alzheimer disease.
25623662 Carrying the APOEepsilon2 allele may imply developing a clinically and pathologically milder form of Alzheimer's.
25619771 Study demonstrated the profound effects of APOE4 on both cognitive performance and intrinsic functional brain networks in patients with Alzheimer's disease
25617864 APOE2 was significantly overrepresented in stillbirths but APOE genotype did not correlate with neuropathological findings.
25613112 Specific APOE genotypes are associated with OSAS in a high-risk population.
25609801 Together, these data indicate that hepatitis C virus hijacks apolipoprotein E to initiate its interaction with specific heparan sulfate structures.
25604058 Subretinal mononuclear phagocytes in age-related macular degeneration patients accumulate on the retinal pigment epithelium and express high levels of APOE.
25596901 Children with cerebral palsy were more likely than expected to carry the APOEepsilon3 allele
25591674 APOE haplotypes, marital status and history of depression were the most important factors to influence the age of Alzheimer disease onset in this sample.
25585996 Results indicate that ApoE4 has significant negative effect on the cognitive function of the elderly people who are 60 years and older.
25576704 ApoE4 may facilitate HHV-6B reactivation, DNA replication, virus protein expression and increase seizure frequency in mesial temporal lobe epilepsy.
25565166 The ApoE c.109G>A genetic polymorphism might influence the development of hemodialysis and could be a risk factor for assessing hemodialysis.
25559335 beta-amyloid positivity coupled with APOE varepsilon4 was associated with moderately increased decline in memory
25551132 All genotypes of ApoE epsilon4 allele, that is, epsilon2/4, epsilon3/4, and epsilon4/4, are associated with an increased risk of AD, whereas ApoE epsilon2/2, epsilon2/3, and epsilon3/3 are protective for AD.
25546376 ApoE and amyloid beta peptide complex formation and domain interaction interface
25545672 In the Czech population studied, ApoE genetic variations were not associated with susceptibility to CP or the presence of periodontopathic bacteria.
25530658 APOE E4 carrier status is associated with a steeper cognitive decline in a Korean population.
25502880 APOE genetic variation impacts HDL-cholesterol and triglycerides in addition to affecting LDL-cholesterol
25502789 Amphipathic alpha-helices in ApoB and ApoE are crucial to the formation of infectious hepatitis C virus particles.
25497326 APOE4 risk for prevalent amnestic mild cognitive impairment varies depending on the definition of objective neuropsychological impairment for MCI.
25482438 human-apoE-isoform-dependent differences modulate the cellular uptake of Abeta mediated by LR11/SorLA
25482294 Results highlight the complex role of the e4 allele in genetic susceptibility to health span.
25476875 These findings suggest that methylation may be a potential mechanistic explanation for APOE functions related to aging and call for further molecular mechanistic studies.
25469919 Low plasma levels of apoE are associated with increased risk of future dementia in the general population.
25452147 In Alzheimer's patients, higher DNA methylation levels were associated with the presence of APOE epsilon4 allele.
25440562 Apolipoprotein E4 allele was not significantly associated with telomere attrition in both dementia and cognitively normal group irrespective of comorbid diabetes mellitus type 2
25428203 Results show that APOE, DBP and AGT identified were associated with survival outcomes in metastatic colorectal cancer patients treated with chemotherapy and bevacizumab.
25420659 In conclusion, ApoE polymorphisms were not associated with lipodystrophy in patients undergoing antiretroviral therapy but influenced lipid alteration.
25413697 The association between ApoE gene and cardiovascular disease may be modulated by the presence of metabolic syndrome (MetS), with an increased cardiovascular burden observed among E4 allele carriers with the syndrome.
25403724 Results indicate that cognitively normal elderly APOEepsilon4 carriers already exhibit topological alterations in both white matter and functional brain networks
25388225 No association has been found between Apo E4 alleles, HIV infection, age, neuropsychological outcome, or death.
25377861 Seven highly conserved regions, representing approximately 47 amino acids (of 299) have been found. These regions are distributed throughout the protein and reflect ligand binding sites.
25377480 Report systemic changes in metabolite levels in plasma from APOE knockout mice with disturbed blood flow due to carotid ligation.
25369462 Our study casts doubt on the role of apolipoprotein E as a risk factor for an earlier age at onset for Machado-Joseph disease.
25365563 possible effects of the APOE epsilon4 allele on memory and executive functioning (EF); a lower executive functioning performance in cognitively intact older APOE epsilon4 allele carriers might be related to an early Alzheimer's dementia prodrome
25358504 Authors summarize current understanding of apoE function in the brain, with a particular emphasis on its role in synaptic plasticity and the underlying cellular and molecular mechanisms, involving low-density lipoprotein receptor-related protein 1 (LRP1), syndecan, and LRP8/ApoER2. [Review]
25356596 The APOE-epsilon2epsilon3 genotype and the APOE-epsilon2 allele are associated with serum uric acid levels in Chinese subjects, indicating that individuals carrying the APOE-epsilon2 allele have a higher risk of hyperuricemia than non-carriers.
25355028 cognitive function in postmenopausal women with breast cancer is modified by APOE genotype
25335802 Profound divergences were observed between APOE genotypes at the cerebrovascular interface, suggesting that APOE4-induced blood-brain barrier anomalies may contribute to Alzheimer's disease development.
25332476 These data indicate that APOE genotype had a modest impact on the postprandial response to meals of varying fat composition in normolipidemic men.
25319703 A detrimental effect of endogenously produced apoE4 on GABAergic interneurons leads to learning and memory deficits.
25319693 A relationship was found between APOE and brain connectivity and as a synaptic modulator in the brain.
25312789 APOE polymorphisms were associated with a requirement for lower warfarin dose for thrombosis.
25304991 APOE epsilon4 is associated with increased parietal lobe white matter.
25304313 study did not confirm the impact of rs2075650 on advanced AMD risk, indicating that rs2075650 is unlikely a superior marker for APOE/TOMM40 susceptible region with advanced AMD in Han Chinese population.
25300642 APOE Kyoto mutation was found in a new Chinese patient with Lipoprotein glomerulopathy, accompanied by Cys112Arg
25288138 This study demonstrated that APOE and BDNF polymorphisms moderate amyloid beta-related cognitive decline in preclinical Alzheimer's disease.
25282659 APOE epsilon2 allele is associated with worse early ND outcomes after cardiac surgery in neonates and infants.
25281910 The different conformational organizations of the N- and C-terminal domains have a minor effect on the steady-state lipid-binding behavior of apoE3 and apoE4.
25268647 The apolipoprotein E polymorphism rs7412 associates with body fatness independently of plasma lipids in middle aged men.
25262148 Our meta-analysis supports that the apolipoprotein E epsilon2 allele and acetyl-CoA carboxylase beta rs2268388 C>T might act as promotion factors of nephropathy in type 2 diabetes.
25261444 This study demonstrated that epigenetic control of APOA1 expression and DNA methylation levels are associated with episodic memory performance in older adults.
25256133 APOE epsilon4 carriers with self-assessed cognitive concerns appear to have worse memory, and possibly accelerated memory decline.
25247594 Two genetic risk factors for late onset Alzheimer's disease are in the apolipoprotein-e and translocase of outer mitochondrial membrane 40 (TOMM40) gene poly-T repeat loci.
25227179 APOE genotype does not alter postprandial serum levels of lipoproteins after intake of omega-3 fatty acids.
25218559 Apolipoprotein E epsilon4 allele has a role in modulating the immediate impact of acute exercise on prefrontal function
25199915 We did not identify new genome-wide significant associations with longevity and did not replicate earlier findings except for APOE and FOXO3. Meta-analysis.
25197062 genetic variants of apoE and ApoER2 impact cardiovascular health by differentially modulating endothelial function.
25196797 Development of diabetic nephropathy is associated with APO E polymorphisms in Asian populations, especially in East Asians.
25193018 Results indicate few effects of BDE-209 during development, while the vulnerability conferred by the apoE genotype may vary depending on age.
25178429 Variants of MAPT and SNCA were not associated with, but APOE epsilon4 allele was only associated with, lower performance on word list learning and semantic verbal fluency
25160043 Study measured small-vessel cerebrovascular reactivity to carbon dioxide (CO2-CVR) to characterize the effect of APOE on cerebral vasculature, and assessed the contribution of CO2-CVR to the pattern of APOE-related differences in the BOLD signal
25155022 End-stage renal disease patients who are e4 and e2 allele carriers are more likely to present an atherogenic lipoprotein profile.
25155015 No significant associations (P value, > 0.05) were observed between the N-acetyltransferase 2 or apolipoprotein E gene polymorphisms and any hearing factor.
25150286 APOE epsilon variants constitute strong risk factors for lobar warfarin-related intracerebral hemorrhage
25148110 The aim of this study was to explore the main and interaction effects of the APOE polymorphisms on treatment efficacy and cognitive side effects of electroconvulsive therapy
25132317 The main finding is a strong negative association between the presence of APOE epsilon4 allele and memory dimension in the mini-mental state examination.
25122793 Authors demonstrate that ApoE interacts with the hepatitis C virus envelope glycoproteins, most notably E2.
25114090 These results suggest that the APOE epsilon4 and epsilon2 alleles have the opposing effects on brain morphology across the spectrum of cognitive aging.
25111308 epsilon4 allele of ApoE is a risk factor for the development of MI and the epsilon2 allele of ApoE is a protective factor in the development of MI
25107496 It plays predictive and modifying roles in normal cognitive aging, mild cognitive impairment, and Alzheimer's disease
25098600 APOE is a potential indicator of metastatic lung adenocarcinoma; secretomes may offer a valuable resource for biomarkers of lung adenocarcinoma with lymph node metastases.
25092803 APOE varepsilon4 genotype specifically modulates astrocyte secretion of potent microglial chemotactic agents, including CCL3
25085564 study supports the possibility of a beneficial effect of rs429358 and APOE epsilon4 allele on cognition in subsets of the general population, specifically in the oldest men and suggests rs429358, and not the combination of other polymorphisms, may underlie the effect of the APOE epsilon4 allele
25085446 Lipid profiles were not increased after Paliperidone treatment under the control of ApoE gene polymorphism.
25079806 mild cognitive impairment APOE-epsilon-4 carriers showed a significant increase in relative power within a 4.5-6.5 Hz frequency range in the superior frontal gyrus resting state
25077528 In patients with neovascular age-related macular degeneration, the presence of the epsilon2 allele of the APOE gene was associated with having intraretinal fluid at baseline.
25073959 These data suggest that apoE and apoA5 variants have an effect on hemostatic parameters, but they neither influence nor predict cognitive performance in non-demented individuals.
25073452 APOE has little influence on physical capability. In addition, other LDL-C-related genotypes have little impact on these traits.
25062970 Our data support association of the Apo epsilon4 allele with recurrent pregnancy loss; however, in silico analysis predicted that the amino acid substitution at residue 112 (Apo epsilon4 allele) is a benign mutation.
25055800 epistasis study indicated significant association between ApoE and MTHFR polymorphisms and hypertension
25053873 The present meta-analysis indicated that the epsilon4/epsilon4 genotype is associated with increased risk of primary open-angle glaucoma in Asians.
25051269 Human schistosomiasis causes dyslipidemia and the associated changes in plasma lipid and lipoprotein levels depend on APOE gene polymorphism.
25029444 No significant association between APOE genotype and overall risk of colorectal neoplasms(CRN), however, persons with APOE epsilon4 genotype have significant decreased risk of suffering from proximal, but not distal CRNs.
25022885 APOE SNP is significantly associated with late onset Alzheimer disease.
25015123 When Abeta was co-treated with each apoE isoform, Abeta-induced shedding was reduced with apoE2 and apoE3. Lipoprotein receptor shedding in the presence of apoE4 increased. ApoE4 appears less efficient than other isoforms in regulating LDLR shedding.
25012224 A probabilistic generative model predicts with high confidence that the ceerebrospinal fluid (CSF) biomarkers become abnormal in a distinct sequence: amyloid-beta1-42, phosphorylated tau, total tau.
24996286 we found no difference in total APOE, APOE-005 or the common isoform, APOE-001, between AD cases and controls. Our findings are consistent with ApoE acting largely at the protein level to increase the risk for sporadic AD.
24986007 the possible involvement of ApoE epsilon4 in BDNF metabolism might be another molecular mechanism underlying the contribution of ApoE epsilon4 to the development of Alzheimer's disease
24985533 APOE epsilon4 increases the risk of beta-amyloid deposition in primary progressive aphasia and progressive speech apraxia but does not influence regional beta-amyloid distribution or severity.
24979464 ApoE variants constitute risk markers of type 2 diabetes mellitus in a Saudi population.
24973356 APOE is a strong genetic risk factor for dementia with Lewy bodies, confirming previous findings.
24967370 Computational design of apolipoprotein E4 inhibitors for Alzheimer's disease therapy from traditional Chinese medicine.
24966274 Obesity favors apolipoprotein E- and C-III-containing high density lipoprotein subfractions associated with risk of heart disease.
24965284 PON1 and ApoE4 genes showed synergistic epistasis, increasing the odds of having both Alzheimer disease and vascular dementia.
24956008 hypertension moderated the effects of APOE epsilon4 on the rate of change for cognitive flexibility, such that the presence of the APOE epsilon4 allele and hypertension was associated with steeper cognitive decline over a 21-year period
24953047 Compound heterozygotes for a novel mutation, apo E1 Nagoya (Arg142Ser) and Apo E2 (Arg158Cys) is associated with severe type III hyperlipoproteinemia and familial hypercholesterolemia.
24951635 Alzheimer's patients with the epsilon4 allele have a worse response to cholinesterase inhibitors treatment than those without the epsilon4 allele.
24948815 Lifetime cognitive activity moderates the APOE genotype effect in cerebral cortex deposition of beta-amyloid burden.
24946908 The APOE genotype modifies the relation between adiposity and plasma lipid levels in patients with vascular disease
24944262 findings suggest that patients with brain tumors who are carriers of the APOE epsilon4 allele may have increased vulnerability to developing memory and executive dysfunction, and that additional SNPs in the APOE gene may be associated with cognitive outcome
24936424 APOE4 genotype, parental family history of Alzheimer's disease, age, and sex are all associated with microstructural white matter differences in late middle-aged adults.
24929969 findings add to the growing evidence that effects of APOE epsilon4 on hippocampal size begin early in life, underscoring the importance of early interventions to increase reserve
24928988 Data suggest that the hepatitis C virus (HCV) entry inhibitor ficolin-2 is an antiviral innate immune molecule, whereas apolipoprotein E3 (ApoE3) blocks the effect of ficolin-2 and mediates an immune escape mechanism during chronic HCV infection.
24924924 PVRL2, TOMM40 and APOE might be associated with human longevity.
24924840 While there were no differences in cognitive performance between participants with and those without metabolic syndrome, ApoE and CYP46 genotypes did correlate with mental manipulation scores.
24922540 trait-specific genetic risk scores are robustly associated with 10-yr changes in lipid levels and three individual SNPs in APOE, TRIB1, and APOA1 were strongly associated with 10-yr changes in lipid levels
24919870 genetic polymorphism is associated with acenocoumarol treatment safety in patients with atrial fibrillation or venous thromboembolism
24918518 This study suggests that the APOE gene does not have a significant effect in ALS aetiopathogenesis.
24914687 These findings suggest that nondemented APOE epsilon4 allele carriers with memory complaints may have a greater genetic risk for Alzheimer's disease and should be monitored more closely.
24906966 Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.
24899141 Genetic analysis revealed that the Alzheimer disease groups (AD, limbis system-AD, and Hippocampual Sclerosis-AD) were more likely to be APOE epsilon4 carriers.
24887584 APOE varepsilon4 alleles contributed detrimental effects on cognitive function in the very old veterans who do not have dementia.
24885013 Apolipoprotein E gene epsilon4epsilon4 is associated with elevated risk of primary open angle glaucoma in Asians.
24884737 In sum, the present study yielded no evidence for a direct link between common genetic variants of the APOE gene and personality in young adulthood.
24880936 APOE E2/E2 genotype is a potential genetic risk factor for vertebral fractures in humans.
24879316 It was confirmed that apoE gene polymorphism e4 allele is one of genetic determinants responsible for the development of insulin resistance and metabolic syndrome.
24878738 APOE epsilon4 allele drives atrophy to the medial-temporal lobe region in AD
24875283 APOE4 carriers may be more vulnerable to the insults of poor glycemic control.
24871385 results show that the overall stability of the entire apoE molecule exerts a major influence on its lipid- and lipoprotein-binding properties
24867440 The findings of this study suggest APOE may be a "plasticity" gene that makes individuals more or less amenable to the influence of protective factors such as cognitively-stimulating lifestyle activities.
24857698 This study demonistrated that BDE-209 impaired cued fear conditioning in apoE2 and apoE3 mice, but not in mice carrying apoE4.
24856546 Remitted geriatric depression and APOE epsilon 4 allele and their interaction are associated with the imbalanced hippocampal functional networks, which may contribute to cognitive deterioration for subjects with a high risk of Alzheimer disease.
24850492 The combined effects of HIV infection and APOE epsilon4 may lead to greater cognitive deficits, especially in those with greater neuroinflammation
24846706 APOE 2 allele is an independent risk factor for ulcerated carotid plaque
24838911 APOE varepsilon4 was associated with atrophic hippocampal volume in MRI markers, increased cerebral amyloid deposition and cerebral hypometabolism.
24838241 the complex formed by HCV E1E2, ApoB, and ApoE may initiate lipoviral particle morphogenesis
24830360 APOE [epsilon]4 carriers and noncarriers were affected differentially by ChEI treatment with respect to rs-fcMRI measures of resting state network integrity
24821312 REVIEW: APOE contributes to Aalzheimer Disease pathogenesis through both amyloid-beta (Abeta)-dependent and Abeta-independent pathways.
24818585 Microbleeds are present with cerebrospinal fluid (CSF) beta-amyloid 42 (Abeta42), total tau, and tau phosphorylated at threonine 181 (P-tau181) as well as a subset of APOE epsilon4 carriers and noncarriers.
24815086 remarkable association especially between the -1131C Apo A5 variant and increased tPA levels in asymptomatic dyslipidemic patients
24814213 Female APOE epsilon4 carriers showed overall significantly reduced functional connectivity between the hippocampus and precuneus/posterior cingulate cortex in healthy adults.
24810422 This study reveals complex ApoE- and gender-dependent effects on synaptic function.
24809632 association of epsilon4 allele with longevity varies among birth cohorts
24806679 CLU and ApoE Alzheimer risk variants had combined effects on both volumetric expansion and lateral ventricle surface morphology
24797962 Being Hispanic and having had a transient ischemic attack-like episode are predictors of cerebral amyloid angiopathy in persons with Alzheimer's disease who are carriers and noncarriers of the APOE epsilon4 allele.
24790992 In this large population-based study in children, we did not find any significant association between single locus of the four common ApoE polymorphisms (-491A/T, -427T/C, -219T/G, and epsilon2/3/4) and MR or borderline MR.
24789331 APOE4 was associate with decreased cognitive functioning in breast cancer patients treated with adjuvant chemotherapy. This was moderated by smoking history, that is, patients without a smoking history had significantly lower performance.
24786335 Our findings suggest that genetic variations in one of the sequences regulating the expression of APOE, may be associated with worse clinical outcome in children with cerebral palsy.
24783416 Our results suggest protective effect of apolipoprotein E epsilon2 allele on susceptibility for carotid plaque presence as well as low density lipoprotein cholesterol lowering effect in Serbian patients with carotid atherosclerosis
24782577 Certain APOE alleles and genotypes are associated with risk of psoriasis while others are protective for psoriasis in Saudis.
24755673 The apoE epsilon4 allele may be a risk factor for CHD in the Chinese population, however, epsilon2 allele has no significant association.
24751902 Heptatitis c virus uses apoE-SDC4 interactions to enter hepatoma cells and establish infection.
24749727 Spatial navigation deficits worsened in a dose-dependent manner as a function of APOE epsilon4 status. This was at least partially due to differences in right hippocampal volume.
24746929 the established association of APOE 4 with dementia was confirmed the first time in a Pakistani sample.
24746514 Gene-gene interaction between CETP and APOE polymorphisms confers higher risk for hypertriglyceridemia in oldest-old Chinese women.
24746364 APOE alleles might be genetic modifiers for spinocerebellar ataxia or Machado-Joseph disease.
24745159 it was not possible to conclude that the presence of APOE polymorphism is related to the effect of prolactin on cognitive functions of the examined menopausal women.
24744301 Thus, NR4A1 plays a role in hepatitis C virus replication through regulating the expression of hepatitis C virus receptors and ApoE, and facilitates hepatitis C virus entry and spread.
24732142 These findings suggest that ovarian hormones differentially modulate synaptic integrity in an apoE-dependent manner.
24731780 results support the reduction in association of APOE-e4 with dementia in extreme old age.
24730603 Study showed that APOE4 carrier participants with mild cognitive impairment had decreased walking speed compared with non-carrier participants.
24709297 demonstrate that except of TG, Apo A5 T-1131C (rs662799) and Apo E (rs429358, rs7412) polymorphisms have no remarkable effect on MetS characteristics
24706182 the present meta-analysis did not show any association between APOE alleles and genotypes with incidence of cancer in general.[meta-analysis]
24702820 Its genotype has a unique impact on cortical glucose metabolism.
24696712 these data support a role for the proteolytic cleavage of apoE in the Vascular dementia and support previous reports that APOE polymorphism is significantly associated with susceptibility in this disease.
24680324 Increased levels of OxLDL are not associated with the risk of dementia, AD, and vascular dementia.
24678786 ApoE epsilon4 gene may be responsible for up to 45% of the genetic component of the Alzheimer's disease, and may act as a discriminator between Alzheimer's disease and vascular dementia as well.
24674240 Data indicate that swainsonine alters leukocyte profiles in apolipoprotein E (ApoE) knockout mice.
24670469 The findings suggest TBI is associated with long-term cognitive impairment and decline across the adult lifespan. A role for APOE genotype was apparent in the younger but no evidence that it is associated with impairment in early old age.
24655576 Apolipoprotein E4 is associated with enhanced in vivo innate immune responses in human subjects.
24646656 The data suggest a role of the APOE genotype as a disease-modifying factor in patients with late-onset Parkinson's disease.
24644280 Data suggest that structural and functional changes underlie the observed added risk for late-onset Alzheimer disease development in carriers of apoE4[L28P].
24634178 Results suggest that the polymorphism at the +2836 G>A site in the apoE gene is strongly correlated with the susceptibility to essential hypertension in the Chinese Hui ethnic population.
24633805 findings show is no difference in total ApoE levels in plasma or CSF between Alzheimer's disease (AD) patients and non-AD individuals; CSF ApoE levels correlate positively to both tau and Abeta of which the latter findingwas evident in APOE epsilon4 carriers only
24632849 ApoE epsilon4 is a risk allele, and apoE epsilon3 is protective against the development of Alzheimer's disease in the Chinese population. (Meta-analysis)
24625799 Data confirm an increased susceptibility of mild cognitive impairment patients with APOE epsilon4 to develop dementia, show an association between functional and anatomic impairment of the cerebral vessels and APOE epsilon4+ genotype
24625478 ApoE polymorphisms are not associated with the development of complications from dopaminergic replacement therapy in Parkinson's disease.
24623176 APOE4 confers greater Alzheimer disease risk in women.
24621278 APOE epsilon 4 allele is associated with a higher risk of intracerebral hemorrhage. [Meta-analysis]
24613704 Data suggest a neural mechanism for APOE-PICALM interactions in patients with manifest Alzheimer's disease and indicate that the PICALM genotype modulates both brain atrophy and cognitive performance in APOE epsilon4 carrier
24607147 The ApoE p.V236E substitution was significantly associated with a marked reduction in risk of late-onset Alzheimer's disease
24603945 Age and APOE 4 genotype were associated with higher cerebral uptake of the amyloid tracer 11C-PIB; in this sample of cognitively healthy elderly individuals, men exhibited higher 11C-PIB uptake than women
24603451 In Alzheimer's disease APOE genotype was the risk factor for apraxia.The presence of apraxia in AD is related to APOE epsilon4.
24599963 results demonstrate that RXR/RA receptor agonists, including several RA isomers, are effective modulators of apoE secretion and lipidation and may be explored as potential drugs for AD therapy.
24595593 Report no evidence for a deleterious relationship between lipid biomarkers and the Omega-3 Index by APOE genotype.
24595197 Results suggest APOE genotype-dependent differences in L-carnitine synthesis or metabolism along Alzheimer's disease, and insinuate that L-carnitine treatments would be more beneficial for Alzheimer's disease patients not carrying the APOE4 isoform
24582638 Its allele is strongly associated with increased risk of cognitive impairments in older adulthood. There is also a possible link to enhanced cognitive performance and the APOE e4 allele may constitute an example of antagonistic pleiotropy.
24571688 APOE gene polymorphisms are associated with maximum oxygen uptake levels after exercise training in Chinese young adult.
24570178 review to understand the type of APOE mutations associated with lipoprotein glomerulopathy by comparing the differences in disease caused by a variety of APOE mutations with those of type III hyperlipoproteinemia
24558469 Our meta-analysis supports a lowered level of blood ApoE in Alzheimer's disease patients, and indicates its potential value as an important risk factor for AD.
24534555 The data suggest that ApoE might be a candidate to influence exceptional longevity.
24530172 APOE genetic variants correlate with specific aspects of cognitive impairment in Alzheimer's disease patients.
24522486 ApoE gene polymorphisms are a potential risk factor for CP in the Chinese population.
24521139 Extent to which environmental factors, specifically stress, influence the relationship between the APOE and cognitive functioning in African Americans vs Caucasians. Stressful late-lfe events impact the cognition of persons with an 4 allele.
24520345 The presence of ApoE4 may attenuate amylin's capacity to remove Abeta, especially Abeta1-40, from the Alzheimer's disease brain.
24508314 It is an Alzheimer-disease susceptibility gene.
24506254 findings suggest that ApoE effects on white-matter microstructure are less abundant than has been suggested in some previous studies
24504617 Apoe gene polymorphism is risk of Parkinson's disease.
24503939 APOE does not appear to be related in a direct way to the developmental sequelae of white or gray matter injury in extremely preterm infants.
24497847 The analyses suggest the existence of age- and gender-sensitive systemic mechanisms linking the e4 allele to lifespan which can non-additively interfere with cancer-related mechanisms.
24495404 findings indicate that decreased glucose metabolism in the temporoparietal junction associated with APOE epsilon4 is mediated by Amyloid beta deposition, and the effect of APOE epsilon4 on hypermetabolism in the frontal and temporal regions is independent of Ab.
24492349 findings suggest that ApoE2 protein abundance, coupled with its inability to bind to low-density lipoprotein receptors, may act to increase amyloid-beta (Ab) clearance
24479631 ApoE-epsilon4 non-carriers are protected from the detrimental affects of Alzheimer's disease on cortical thickness and neuropsychiatric symptoms.
24475827 In Alzheimer's disease, the APOE epsilon4 allele is associated with accelerated rates of atrophy in 13 distinct brain regions in limbic and neocortical areas.
24475734 The APOE4 allele may be used as a biomarker in predicting the prognosis of traumatic brain injury patients.[meta-analysis]
24473795 Elevated serum DDT levels are associated with an increased risk for AD and carriers of an APOE4 epsilon4 allele may be more susceptible to the effects of DDT.
24464001 APOE polymorphism assessment may be a factor in predicting the effect of hormone replacement on cognitive functioning in postmenopausal period.
24456740 APOE E3/E4 genotype is associated with a higher lower extremity deep venous thrombosis risk.
24453132 Study found significant morphological deformation in APOE e4 carriers relative to noncarriers in the entire cohort as well as in the nondemented (pooled MCI and control) subjects, and this effect was more pronounced in e4 homozygotes than heterozygotes
24453080 The APOE epsilon4 allele segregated dose-dependently and selectively with CA1 apical neuropil, or stratum radiatum/stratum lacunosum-moleculare thinning and worse episodic memory performance in a pool of older subjects across a cognitive spectrum
24448836 beta-amyloid imaging has prognostic value alone and in combination with memory performance, hippocampal atrophy, and apolipoprotein E epsilon4 status in nondemented, older individuals.
24447298 LDLR calcium-binding repeats (LRs), apoB and apoE3 bind at the hydrophilic convex face of LR5, forming complexes that are weakened at low [Ca(2+) ] and low pH.
24446209 This study suggests that the epsilon2 allele suppresses the initiation of alzheimer disease development by lowering the cholesterol levels in synaptic membranes.
24444806 Its allele may interact with testosterone and moderate the hormone's association with cognition.
24439487 results of this meta-analysis suggest that the ApoE epsilon2 and epsilon4 alleles may be associated with increased risks of T2DM and DN in Chinese Han population
24439168 Elevated levels of TOMM40 and APOE transcripts found in the brains of late-onset Alzheimer's disease-affected individuals compared with unaffected control brains
24435134 ApoE4 reduces brain insulin signaling and glucose level leading to higher insulin content.
24434953 findings showed that association of depressive symptoms on cognitive decline was increased among participants with one or more copies of the APOE epsilon4 allele compared with those without the allele
24434095 There was not relationship between APOE genotype and longitudinal change in depression symptoms, suggesting that depression symptoms may not be intrinsic to the early preclinical phase of Alzheimer's disease.
24423223 Two of the key risk factors for Alzheimer's disease are increasing age and carriage of the APOE 4 allele. [review]
24412220 Results demonstrate that the apoE-LDLR interaction affects regional brain apoE levels, brain cholesterol, and cognitive function in an apoE isoform-dependent manner
24411483 This study is the first to show that the ApoE-epsilon4 allele is directly associated with altered 3D profiles of longitudinal ventricular expansion rates and lateral ventricle surface morphology, both in dementia and in normal aging.
24407534 There is significant association of APOE4 allele observed with the development of coronary artery disease in Indian population.
24405372 ApoE mutations in Dysbetalipoproteinaemia And Atherosclerosis (Review)
24402318 Found no correlation between BMI and apo E polymorphisms in male coronary heart disease patients.
24401234 APOE polymorphism is associated with carotid atherosclerosis in a South Korean population, and this association was partly mediated through blood lipids.
24396563 ApoE polymorphisms in moroccan population and their impact on lipid metabolism.
24388885 Apolipoprotein E4 allele is associated with substantial changes in the plasma lipids and hyaluronic acid content in patients with nonalcoholic fatty liver disease.
24388797 This study demonstrated combined influence of APOE and CLU genotype on brain activity long before frank AD symptoms arise, and indicate executive attention as a neural marker of AD genetic risk in young people.
24386372 no systematic differences in QAlb between ApoE genotypes within the present study. Increased QAlb levels were shown for those without E3 allele in the subgroup of CJD patients when assuming a dominant genetic model
24386260 Hyperlipidemia-associated renal damage decreases Klotho expression in kidneys from ApoE knockout mice.
24385135 study found that CSF Apo-E protein levels are decreased in association with neuronal damage, as measured by t-tau, in cognitively impaired subjects compared to cognitively normal subjects and that baseline CSF Apo-E levels are associated with cognitive decline and brain atrophy which is independent of CSF t-tau/Abeta1-42 ratio
24359501 The APOE locus association in frontotemporal dementia were eventually diagnosed as "frontal variants" of Alzheimer's disease.
24349494 The epsilon2 allele of apoE gene might increase the risk of ESRD. E2 carriers expressed higher level of plasma apoE in patients with ESRD.
24349461 Influence of APOE genotype on whole-brain functional networks in cognitively normal elderly.
24349219 Results in this study identify the KIAA1462 locus as a candidate locus for late onset Alzheimer disease in APOE4 carriers.
24345162 Using human APOE2, 3, and 4 isoform-specific transgenic mice, we found a lower brain uptake of docosahexaenoic acid (DHA) in APOE4 than in APOE2 mice that may limit the biodistribution of DHA in cerebral tissues
24340925 Polymorphisms Ser447Ter of lipoprotein-lipase gene, Cys112Arg and Arg158Cys of apolipoprotein E gene in patients with obesity
24332811 Our results support an association between APOE polymorphisms and Creutzfeldt-Jakob disease
24328732 apoE4 delays total dendritic spine formation and may induce early synaptic dysfunction
24326531 study found the -419T allele frequency was significantly higher in the Alzheimer's disease (AD)patients group than in the controls group and may possibly constitute a significant risk factor for AD. The APOE epsilon4 allele did not influence the distribution of the -491 polymorphism after stratification
24322171 Neurodevelopmental disability was not associated with the APOE genotype in this cohort of hypoxic-ischemic encephalopathy survivors.
24321557 Results demonstrate that brain activation in the medial temporal lobe during memory processing is additively decreased by the presence of the APOE epsilon4 and the BDNF Met alleles.
24314366 An ApoB/TC ratio <0.15 do not have an increased likelihood of mutation in the APOE gene, and rare variants in the APOE gene are not important in the development of hypertriglyceridemia.
24314356 report expands the clinical description of inherited lipemic splenomegaly associated with the rare APOE p.Leu167del mutation
24312462 The presence of truncated apoE within Pick bodies suggests a broader role of apoE beyond AD and raises the question as to whether this protein contributes to pathogenesis associated with Pick's disease.
24312416 the APOE epsilon2/epsilon3/epsilon4 polymorphism is not associated with Primary open-angle glaucoma susceptibility in any populations(Meta-Analysis)
24309291 Sufficient evidence is lacking to prove that the T allele of SNP 19 rs2070045 is associated with varepsilon4 allele of ApoE gene in late-onset Alzheimer's disease.
24308640 Plasma PCSK9 levels were strongly associated with plasma triacylglycerols and cholesterol levels in homozygous carriers of ApoE2.
24305621 Elevated levels of CRP were linked to a decreased risk of longitudinal cognitive decline in the very old subjects not carrying an APOE e4 allele.
24296331 The results suggest functional alterations in the episodic memory network are modulated by the apolipoprotein E epsilon4 allele.
24293121 Apolipoprotein E, gender, and Alzheimer's disease; review of previous literature on the APOE4 by gender interaction with a particular focus on imaging-related studies
24291031 Significant associations between APOE epsilon2 allele with lower total cholesterol and LDL-cholesterol were found.
24281128 APOE epsilon4 allele conferred an increased risk of Alzheimer disease (odds ratio 2.91). There was also a synergistic interaction with the CTSD T allele leading to a 6.25-fold increased risk of the disease.
24277910 No association of CSF apoE levels and cognitive function in newly diagnosed Alzheimer disease patients could be demonstrated.
24276092 Infants who are carriers of APOE epsilon4 have early brain changes associated with the genetic predisposition to Alzheimer's disease.
24267230 an APOE p.Leu167del mutation has a role in familial hypercholesterolemia [case report]
24261350 we have found a novel relationship between ApoE 4 homozygosity and swallowing dysfunction in an otherwise healthy older popula- tion.
24260406 in a large community-dwelling sample of older adults, we found no effects of APOE epsilon or TOMM40 523 genotypes on hippocampal volumes.
24251389 Study shows that the levels of hippocampal ApoE receptors Lrp1 and Apoer2 in vivo are affected isoform specifically by ApoE4 and that the type of receptor affected is context dependent
24239320 study found likely millions of people worldwide derived from Sub-Saharan Africans are apolipoprotein E R145C; available evidence suggests it is a common cause of a mild triglyceride dyslipidemia
24232699 apolipoprotein E (APOE) genotype and sleep apnea severity affect atherogenic dyslipidemia in patients with obstructive sleep apnea
24222221 In a Mexican population CYP2C19 is more involved in acenocoumarol metabolism than CYP2C9 and APOE.
24221911 There is a close association between recurrent pregnancy loss and Apo E gene polymorphisms.
24204574 A deficiency of Herp, an endoplasmic reticulum stress protein, suppresses atherosclerosis in ApoE knockout mice by attenuating inflammatory responses.
24199961 It is related to cognitive impairment primarily through Ab deposition and tangles formation.
24196014 the deletion of apolipoprotein E increased the number of ovarian follicles and the ratio of ovarian follicle atresia and apoptosis
24193893 The results of this study support the compensatory recruitment hypothesis in older APOE varepsilon4 carriers, and confer the impact of the APOE genotype on the temporal dynamics of brain activity in older adults.
24183852 This review highlights the importance of studying the APOE varepsilon2 allele to understand individual differences in cognitive ageing
24175296 a relationship between increase of HDLc levels and APOE3 in homozygous was found in PD patients only.
24173232 In the absence of ApoE, release of core protein from infected cells is reduced, and production of extracellular and intracellular infectivity is ablated.
24168388 The APOEepsilon4 allele was associated with a significantly increased POCD risk about 1-week postsurgery, but the association depended on one large study. No association was found 1-3 months and 1-year postsurgery.
24166182 This study demonstrate that TMEM106B and APOE interact to increase late-onset Alzheimer's disease in Han Chinese.
24163986 ApoE4 genotype is associated with protection from type 2 DN, and subjects with e2 allele have increased risk of developing type 2 overt DN.
24161275 This study showed dysregulated expression of Pin1, Sirt1, and PS1 genes in different cerebral areas of apoE4 mice.
24160669 results showed that (i) the APOE epsilon polymorphism has the expected impact on the plasma lipid profile and (ii) the rs4420638 G allele may counterbalance the deleterious effect of the epsilon4 allele on LDL-cholesterol levels in an Algerian population
24154541 these results demonstrate that apoE4 tips the balance of the glial and neuronal Abeta toward the intraneuronal accumulation of Abeta.
24145819 This study cannot comment on the effect of sleep consolidation and APOE genotype on the temporal trajectory.
24145695 The association of APOE epsilon4 with cognitive decline was lower in obese participants compared with normal BMI participants. Cognitive decline in obese participants with APOE epsilon4 was not significantly different from normal BMI participants without APOE epsilon4.
24145446 ApoE4 reduces the ratio of soluble amyloid precursor protein alpha to Abeta, reduces Sirtuin T1 expression (reducing the ratio of neuroprotective SirT1 to neurotoxic SirT2), triggers Tau and APP phosphorylation, and induces programmed cell death.
24141900 The meta-analysis suggests an association between ApoE E4 mutation and increased risk of recurrent pregnancy loss
24140109 This study highlights the role of ApoE in neurogenesis, and shows for the first time an early inequality between the ApoE genotypes.
24139138 Study demonstrates that the apoE-epsilon4 polymorphism is a strong independent risk factor for cognitive dysfunction at 1 month and as early as 1 day post-carotid endarterectomy
24132908 The apoE genotype moderates effects of psychological trauma on posttraumatic stress disorder pathogenesis.
24126160 Apolipoprotein E (APOE) alleles are associated with longevity in genome-wide scans, with epsilon4 correlated with shorter life, and epsilon2 with longer life, than epsilon3.
24119543 Spatial distribution of microbleeds is affected by its genotype.
24118648 The epsilon4 alelle of the apolipoprotein E gene is known to be a key genetic risk factor for Alzheimer's disease.
24116184 Results suggest an epistatic interaction between apolipoprotein E and hemoglobin S genes such that sickle cell trait only had an effect on parasite density in APOE E4 children.
24113560 ApoEepsilon4 carrier status enhances sporadic Alzheimer disease risk in a Chinese population with a ABCA7 genetic polymorphism.
24081379 In this study ApoE4 homozygosity is strongly associated with dementia in males and females combined, but is not represented among those remaining cognitively normal.
24073598 The -491 T allele of APOE polymorphism may be associated with a risk of POAG occurrence in the Polish population.
24059882 ApoE (E2,E3,E4) polymorphism and the TNF-alpha-308 G > A polymorphism are not associated with renal injury after CPB.
24055685 We found support for joint effects of BDNFVal(66)MetxAPOExHbA1c and BDNFVal(66)MetxAPOExage on rates of episodic memory change over ten years, after controlling for age, sex, education and cardiovascular diseases.
24049153 Light to moderate alcohol consumption during late life protects against decline in memory and learning for non-APOE e4 allele carriers, but not for older adults who carry one or more alleles.
24026386 Based on the results of large-scale cohorts, family-based study, and meta-analyses, the e2 allele of the APOE polymorphism is considered to be associated with genetic susceptibility to the development and progression of diabetic nephropathy.
24025644 Fenofibrate can induce lipoprotein glomerulopathy (APOE Kyoto mutation) remission and the fibrate effects depend on the degree of lipid control and baseline proteinuria.
24023758 This meta-analysis suggests that Apo E epsilon2/epsilon3/epsilon4 polymorphisms may not be associated with the risk of POAG.
24023310 study highlights the protective role of LXR-activated macrophages against breast cancer growth, and the implication of APOE protein in the anti-proliferative and pro-apoptotic effects observed
24009459 Case Report: extreme gestational hyperlipidemia with a partial LPL deficiency in the absence of an LPL gene mutation and the apolipoprotein E 3/2 genotype.
24005233 In type 2 diabetes, islet amyloidosis and arteriosclerosis share common pathophysiological features with ApoE polymorphism as a probable linking factor.
24001346 Subjects with apo4 allele have a much higher triglyceride level than those with apo2 allele, playing a major role in lipid transport and metabolism by acting as a ligand. [review]
23999864 hormonal modulators of glial ABCA1 and apoE
23998924 In centenarians APOE 4 is directly related to positive affect and is related to negative affect in interaction with life events.
23969090 There was no association between the presence of an APOEepsilon4 allele and the occurrence of delirium in the acute phase after stroke.
23965289 ApoE4+ Alzheimer's disease patients show lower global amyloid burden and greater medial temporal hypometabolism compared with matched ApoE4- patients
23957944 Our results support the hypothesis that ApoE alleles modify the inflammatory responses in the brain and the periphery, thus contributing to altered functional outcome following stroke.
23948883 This study found that in the absence of ApoE4, subjects who had been taking central ACE inhibitor use or peripheral ACE inhibitor use had lower incidence of AD compared with those who had not been taking an ACE inhibitor.
23948881 The current findings suggest that in APOE E4 non-carriers with AD, executive dysfunction is closely linked to frontal gray matter atrophy and predictive of progression to dementia
23934233 Our exploratory results suggest a relationship between prostate aggressiveness, ApoE isoforms and cholesterol imbalance.
23919842 Our data suggest a gender difference in the associations between APOE, SCARB1, PPARa genotypes and lipid levels.
23911886 activation of beta-adrenoceptor reduce the plaque area in the thoracic aorta and play an important anti-atherosclerotic role by regulating lipid metabolism disorders and the SR-B1 signal transduction pathway
23902937 Coronary endothelin (ET)-1 overexpression induces development of compensatory mechanisms in the arteries of ApoE-knockout mice that have severe endothelial dysfunction.
23902936 The findings suggest that in the absence of clinically salient dementia pathology, APOE epsilon2 and epsilon4 alleles do not exhibit antagonistic pleiotropy in relation to cognition between the ages of 20 and 72 years.
23902934 the APOE epsilon4 allele is associated with increased risk of gait speed decline and disability in older men.
23896613 Results demonstrate an interaction between APOE genotype and age in cross-sectional and longitudinal cognitive and morphometric manifestations of Alzheimer's disease
23895740 Cell-type and cycle-dependent expression of ApoD and ApoE within human endometrium suggests their role in endometrial modulation.
23892237 These findings implicate a novel functional role for a 3'-exon CGI and support a modified mechanism of action for APOE in disease risk.
23888546 In Conclusion, the APOE epsilon4 and E2 alleles are associated with higher risk of coronary artery disease in type2 diabetes mellitus than epsilon3 allele
23887281 The present study suggests that the ApoE epsilon4 allele is a risk factor for frontotemporal dementia and Alzheimer's disease
23876113 The interaction between age and APOE genotype on rate of decline suggests that preclinical disease may be overrepresented in older epsilon4+ individuals.
23871727 The present study is the first to establish a relationship between APOE epsilon4 and concomitant Alzheimer disease and stroke in the Tunisian
23865355 ApoE polymorphism genotypes were studied, and the difference in distribution of genotypes between preeclampsia patient subjects and normal pregnancy controls was found to be not significant.
23855979 effects of the APOE epsilon4 allele were, however, reduced to a nonsignificant level in all tests except 1 after accounting for incident dementia
23844141 Data indicate the physiological importance of apolipoprotein E (apoE) and heparan sulfate proteoglycan (HSPGs) in the hepatitis C virus attachment to hepatocytes.
23831342 In a healthy aging normal population, choline/creatine and myo-inositol/creatine ratios were significantly increased in APOE E4 carriers, suggesting the presence of neuroinflammatory processes and greater membrane turnover in older carriers
23828408 TAM treatment induced similar plasma triglyceride increases in patients with positive or negative APOE genotype.
23828104 Apolipoprotein E epsilon4 significantly accelerated rates of Alzheimer disease decline, and women in all cohorts had higher rates of decline than men.
23827224 It seems that the potential modest risk effect of the ABCG2 C/C genotype on Alzheimer disease risk is more pronounced in combination with the APOE varepsilon4 allele
23826174 The present meta-analysis suggests an association between ApoE epsilon4 allele and increased risk of coronary artery disease in Chinese population.
23817635 evaluation of urinary Gla excretion in relation with apo E genotype
23815818 ApoE genotype does not predict the efficacy of ezetimibe treatment on serum lipid parameters
23808899 These data do not support the recently published evidence of the association between APOE e4 genotype and smoking outcomes.
23801662 association between dietary fat and plasma concentrations of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in elderly persons, taking the APOE4 genotype into account
23794363 This study demonistrated that A large ApoE epsilon4/epsilon4 homozygous cohort reveals no association with Parkinson's disease.
23786792 Quantitative EEG (qEEG) separates between patients with amnestic MCI and patients in early stages of probable AD. Adding information about Apo epsilon4 allele frequency slightly enhances diagnostic accuracy.
23779114 Lipidation states of APOE and amyloid-beta peptides in the brain differ depending on apolipoprotein (APO)E genotype and cognitive diagnosis.
23773371 In non-obese postmenopausal women, alcohol consumption is associated with systolic and diastolic hypertension early in those with the epsilon3/3 ApoE genotype, and late in epsiuln4 carriers.
23771217 This study demonstrated that APOE genotype correlations with Abeta deposition in cerebral amyloid angiopathy only incompletely correspond to other alzheimer disease-linked brain pathologies.
23769398 The results of this study suggested that amyloid beta burden can occur in patients with and without subcortical cerebrovascular disease, and that it is associated with APOE4
23761065 Results suggest that the APOE epsilon2 allele operates as a susceptibility gene for combat-related PTSD, with the relationship between alcohol use and PTSD differing according to the epsilon2-allele status.
23746632 No significant differences are found in the frequencies of APOE genotypes and alleles between polycystic ovary syndrome and control groups.
23744346 Neuroepithelial progenitor cell cultures recognize HIV and respond to it by mounting an innate immune response with a vigor that is influenced by the ApoE genotype of the cells.
23743349 Subjects with the apoE3/E2 genotype and PCSK9 R46L have increased plasma insulin, homeostasis model assessment of insulin resistance, and leptin, an intriguing finding that warrants further investigation.
23737466 The results of this study supported the prodromal/preclinical Alzheimer's disease hypothesis and do not support the concept of a distinctive epsilon4-related cognitive phenotype.
23731072 This study demonistrated that differences in OERP activity as a function of age, ApoE epsilon4 status, response type, and electrode site.
23729930 APOE4 carrier state with moderate to severe sleep disordered breathing associated with poorer performance on cognitive tests of memory and executive function
23728617 Treatment of human primary astrocytes with HIV-1 Vpr upregulates expression of six genes, APOE, CCL5, DGKK, GPX5, NOS2, and PXDNL
23723060 apoE mediates the effects of leptin on vascular lesion formation by stabilizing cav-1-enriched cell membrane microdomains in smooth muscle cells, thus allowing NADPH oxidase assembly and ROS-mediated mitogenic signalling.
23715769 ApoE is located in the nucleus and on the ApoD promoter in human hepatic and glioblastoma cells lines.
23706516 Results indicate that APOE epsilon4 has a moderate effect on white matter (WM) integrity in healthy controls, but no effect on WM integrity in manifest Alzheimer's disease
23701536 ApoE gene may not be a risk factor for functional decline among older Taiwanese adults
23688578 This study study provides evidence for an association between the APOE epsilon4 allele and frontotemporal lobar degeneration.
23687437 Association of LOXL1 with exfoliation syndrome and exfoliation glaucoma was investigated and apolipoprotein E and MTHFR polymorphisms as genetic risk factors for both conditions, were evaluated.
23684315 These findings show that apoE4 stimulates the accumulation of Abeta42 and hyperphosphorylated tau and reduces the levels of VGlut in hippocampal neurons of young apoE4-targeted replacement mice
23669301 Interactions between the APOE epsilon4 allele and ABGA7 SNPs are associated with all three cognitive factor scores in Alzheimer's disease patients.
23668794 This study, in confirming the occurrence of oxidative stress in AD and MCI patients, shows how it can be related, at least for superoxide dismutase activity in MCI, to APO E4 allele risk factor.
23663404 The results of this study demonstrated that AD pathology may manifest itself differently based on ApoE genotype and suggest that ApoE carriers and non-carriers may have different patterns of AD neuropathology location and density.
23660682 The study found no significant association between the tested variants and migraine for any of the APOE variants investigated
23652625 These data further support a role for fibrinogen in Alzheimer's disease pathophysiology and link the APOE genotype with increased thrombosis
23642733 Postprandial cholesterolemia was higher in APOE varepsilon4 than in varepsilon2 carriers, whereas under intense intermittent exercise, total and LDL cholesterolemia were higher in varepsilon4 than in varepsilon2 and varepsilon3 carriers.
23631828 Six apolipoproteins (APOA1, APOA2, APOB, APOC2, APOC3, and APOE) were able to differentiate bladder cancer from hernia. SAA4 was significantly increased in bladder cancer subgroups, whereas ProEGF was significantly decreased in bladder cancer subgroups.
23631810 These results indicate that DHA metabolism is disturbed in E4+, and may help explain why there is no association between DHA levels in plasma and cognition in E4+ (epsilon4 allele carriers).
23627755 Positive diabetes mellitus type 2 status appears to exacerbate alzheimer disease neuropathology in the presence of ApoE epsilon4
23624169 Neuritic amyloid plaque load across progressive clinical stages of Alzheimer's disease varies strongly by ApoE4 genotype
23620513 apoE influences sAbeta metabolism not through direct binding to sAbeta in solution but through its actions with other interacting receptors/transporters and cell surfaces
23613766 APOE genotypes are associated with lipid levels in patients with rheumatoid arthritis.
23612909 No significant difference was observed in CSF ApoE concentrations between the patients with Alzheimer's disease and the controls.
23611364 Depressive symptoms predict time to conversion to Mild Cognitive Impairment in cognitively normal people who do not carry the APOE epsilon4 allele.
23603214 ApoE modifies the adverse effects of cord blood mercury on neurodevelopment at the age of two years.
23601373 The present findings revealed a subgroup at increased risk for cognitive decline (APOE epsilon4 carriers with midlife exposure to vascular risk factors)
23593485 Mass spectrometry quantification revealed accumulation of C-terminal fragment of apolipoprotein E in the Alzheimer's frontal cortex.
23590983 Apo E4 allele is higher in patients with left ventricular dilatation and failure.
23589355 Voxel-based DTI analysis can be performed on low signal to noise ratio images to detect subtle regional differences in cohorts using the proposed preprocessing techniques.
23588940 SNP modulating serum LDL cholesterol via APOB, LDL receptor and APOE influence the risk, activity, and severity of rheumatoid arthritis.
23587689 The results show evidence that the ApoE genotype may be associated with accelerated brain atrophy
23587637 carrier of its allele in patients with Alzheimer disease show severe slowing of ascillatory brain activity.
23584199 APOE4 genotype is associated with the severity of axonal injury in acute traumatic brain injury.
23583468 ApoE4-PPARA V162 allele combination was found to have higher frequencies in coronary heart disease patients with diabetes.
23581910 ApoE epsilon4 carrier status was found to increase all-cause and cardiovascular mortality risks and interacted with sex and time-dependent AD status to affect all-cause mortality.
23576895 The results of this study findings suggested that an interaction between apoE and HDL is facilitated by APOE4, and is possibly linked with an enhancement of neuroplasticity and with resultant protective effects on cognitive function in later life.
23573206 Single nucleotide polymorphisms in APOE-epsilon4, CLU and MS4A4A influence both Alzheimer disease risk and cerebrospinal fluid Amyloid-beta1-42 levels.
23571734 our study suggests that APOE epsilon4 allele is associated with an increased risk of developing cerebral infarction in Chinese population.
23571587 in this largest GWAS of late-onset AD in African Americans ever assembled, aside from SNPs associated with APOE, the top-ranked SNP observed in this study was located in ABCA7 and had an effect size comparable with that of APOE 4
23567388 Among patients with mild cognitive impairment, APOe4 was more frequent in those with subsyndromal symptoms of depression.
23567387 In cognitively intact older adults, the apoe4 allele was not associated with subjective memory complaints.
23567378 epsilon4 carriers had significantly poorer initial memory performance and greater decline in processing speed and word recognition than epsilon2 and epsilon3 carriers. After excluding participants with low global cognition scores, all genotype effects were nonsignificant.
23553344 Hypertension, a prevalent vascular risk factor in aging populations, interacts with APOE 4 genotype to increase amyloid deposition in cognitively healthy middle-aged and older adults.
23546960 that hyperlipidemia in nephrotic children is not associated with apolipoprotein B (apoB) gene 3' variable number of tandem repeat (VNTR) polymorphism.
23541187 The results suggest that plasma Abeta is a potential Alzheimer's disease biomarker and highlight the importance of apoe4 genetic variation in interpretation of plasma Abeta levels.
23537987 Lipid parameters were not statistically different among various ApoE genotypes.
23525328 results are consistent with the well-established role of the APOE*4 allele as a risk factor for sporadic Alzheimer disease. GAB2 and GSK3B polymorphisms and the well-established genetic factor APOE may modify the overall risk of AD.
23522842 TOMM40 and APOE common genetic variants are not Parkinson's disease risk factors.
23503772 This study demonistrated that cysteine residues per mole in apolipoprotein E affects systematically synchronous neural interactions in women's healthy brains.
23492875 Results show that the presence of at least one apolipoprotein E epsilon4 allele might act as a genetic factor predisposing individuals to develop fragile X-associated tremor/ataxia syndrome.
23475756 Results suggest that FBL in the UF is influenced by the presence of an ApoE e4 allele (ApoE4) in healthy older adults.
23474043 The relationship between beta-amyloid plaques and dementia in the oldest-old may vary by APOE genotype.
23466070 These results indicate a significant contribution of the APOE genotype to the EPA-lipid profile relationship; however, the results do not explain the differences in previous findings regarding LDL-C, triglycerides or total cholesterol.
23430745 Binding of apolipoprotein E inhibits the oligomer growth of amyloid-beta peptide in solution as determined by fluorescence cross-correlation spectroscopy.
23430611 rs769446 is a functional polymorphism involved in the regulation of the plasma APOE concentration.
23429815 The APOE E4 allele was observed to have a dramatic effect on cognitive impairment, especially in homozygotes, which comprised approximately 2% of the population.
23424640 effect of apolipoprotein E epsilon 4 on the intrinsic cognitive networks
23419831 results confirm the association of APOE with Abeta deposition and represent the largest known effect of BCHE on an AD-related phenotype.
23415434 in patients with hyperlipidemias, G allele of NPC1L1 and APO E4 could account for some of the inter-individual variability in cholesterol absorption
23413428 ApoE4 possesses enhanced lipid and VLDL-binding ability relative to apoE3, which gives rise to impaired lipolytic processing of VLDL in apoE4-expressing mice.
23411028 LOXL1 is more abundant in the deposits in the iris region and, alternatively APOE is concentrated in the PEX material accumulated in the pupillary area of the anterior lens capsule.
23408335 Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders.
23407718 APOE4 allele is a strong risk factor across the Lewy Body Dementia spectrum and occurs at increased frequency in pure Lewy Body Dementia relative to Parkinson disease dementia.
23407349 These results suggest that the counterpart APOE allele is not likely associated with the onset of LPG.
23396426 A role of the genotype of apolipoprotein E (epsilon4 allele) in the pathogenesis of stroke.
23385359 9 different proteins (haptoglobin, transthyretin, apolipoprotein A-1, serum amyloid P component, apolipoprotein E, complement factor H, fibrinogen gamma, thrombin, complement C3) were identified as a potential diagnostic pattern of Parkinson's disease.
23384292 The presence of the epsilon4-allele of the apolipoprotein-E (APOE) gene has been implicated in short-term cognitive dysfunction after cardiac surgery.
23384034 Here, the signal transduction pathways of apoE and its role of gene expression in the pathogenesis of glomerulus diseases were reviewed.
23382465 Results show this allele in current smokers increases cardiovascular and all cause mortality
23380990 APOE epsilon4 predicted the onset of Alzheimer's disease-type dementia in middle and high but not in low educated subjects
23372804 Peroxisome proliferator activated receptor-alpha/hypoxia inducible factor-1alpha interplay sustains carbonic anhydrase IX and apoliprotein E expression in breast cancer stem cells.
23371373 A significant association of the epsilon4 allele, especially the E3/E4 genotype, with myocardial infarction was observed.
23364031 The APOE epsilon4 allele is related to faster decline in semantic memory and working memory for whites but not for blacks.
23324992 Data from a population-based prospective study were used to examine longitudinal changes in blood pressure (BP) and seek interactions between apolipoprotein E (ApoE) genotypes, smoking and alcohol in a cohort of 557 elderly Brazilian men
23321337 APOEepsilon4 genotypes affected the serum concentration of vitamin A and vitamin E in subjects with mild cognitive impairment.
23320904 APOE e4 allele and APOB CC genotype can play detrimental, neutral, and protective sex-specific roles in the etiology of cardiovascular disease at different ages and in different environments.
23317568 Our results suggest that MAPT, PGRN and APOE play limited roles in frontotemporal lobar degeneration pathogenesis among Indians
23312054 Neither APOE nor APOA5 polymorphisms showed a significant effect on the lipid responses to rosuvastatin in Chinese patients with hyperlipidemia.
23302659 This study demonistrated that an interaction between age and APOE genotype in the left anterior cingulate cortex (ACC) was characterized by reduced CBF in older epsilon4 carriers and increased CBF in young epsilon4 carriers.
23296339 we consider how to design effective strategies for Alzheimer disease therapy by targeting Apo-E--{REVIEW}
23293020 apoE isoform-specific formation of soluble apoE/Abeta modulates oAbeta levels, suggesting a basis for APOE4-induced AD risk and a mechanistic approach to AD biomarkers
23292450 Apo E4 polymorphism seems to be contributing to the thrombophilic risk factors as a background to recurrent pregnancy loss
23291160 In young adult mice, ApoE-4 transgenic subjects outperform ApoE-3 transgenic subjects on learning and memory hippocampus-dependent tasks.
23290018 The apolipoprotein E polymorphism may confer genetic susceptibility for perinatal arterial ischemic stroke. Larger population-based studies are required to confirm this finding.
23289212 carriage of L33P polymorphism for the ITGB3 gene, does not influence on predisposition to the longevity.
23288845 PKC regulates the secretion of apoE from primary human macrophages
23286790 APOE locus is a longevity gene in humans.
23275593 APOE genetic polymorphisms may affect brain functioning in subjects without dementia.
23273617 Our study proposes the possible involvement of the APOE epsilon4 allele in cognitive impairment in patients with epilepsy which is further worsened by phenytoin monotherapy.
23272070 Sequence variants of TLR4 are associated with an increased risk of late-onset Alzheimer's disease, especially in ApoE e4 non-carriers and in hypertensive patients
23270420 In Alzheimer's disease, the E4 allele of APOE is differentially associated with delusions and hallucinations in Alzheimer's disease.
23255822 These findings suggest that APOE genotype has a differential effect on the distribution of amyloid plaques and glucose metabolism in Alzheimer's disease.
23255503 Apolipoprotein e 3/4 genotype and baseline depression had a 7.97 fold greater risk of incident dementia.
23251595 APOE epsilon3/epsilon4 group may have a different off-line memory consolidation process compared to epsilon2/epsilon3 group.
23247007 The epsilon4 homozygote substantially accelerates progression from mild cognitive disorder to dementia, and anticipate dementia occurrence by more than 3 years in people with mild cognitive disorder.
23242623 APOE epsilon4-allele conferred increased risk for progression to dementia in mild cognitive impairment subjects based on meta-analysis.
23242296 No statistically significant association was found between the polymorphisms of the APOE gene and Down syndrome.
23238736 These results show that ApoE genotype, and not aggregated fibrillar forms of Abeta, contributes to reduced glucose metabolism in aging
23232444 Cognitive enhancement by nicotine selectively benefits APOEepsilon4 carriers and genotype-specific differences are found in prospective memory.
23213264 The association of vitamin B12 status with cognitive test performance is stronger in the presence of the ApoE epsilon4 allele.
23207651 The APOE region is significantly associated with nonpathological cognitive ageing.
23204275 diabetes-induced proinflammatory changes in the vasculature and the hLDLR-mediated cholesterol accumulation in macrophages synergistically trigger atherosclerosis in mice with human apoE4, although neither alone is sufficient.
23186985 This study demonistrated that associations of increased risk for vascular cognitive impairment was found for APOE epsilon4 (1.818 (95% CI = 1.611-2.053), p < 0.001; n = 3,554 cases, n = 12,277 controls).
23183136 TOMM40 intron 6 poly-T length may explain some of the variation in age at onset in PSEN2 familial Alzheimer's disease (AD) and may be associated with AD neuropathology in persons with APOE epsilon3/epsilon3
23175721 APOE epsilon2 or epsilon4 genotype was associated specifically with lobar intracerebral hemorrhage.
23171142 Peripheral expression of ApoE mRNA was lower in the PSD group than the control stroke group (p<0.701) while serum ApoE was higher than in the control stroke group (p<0.05), possibly reflecting a feedback reduction in expression
23159296 study showed APOE alleles had a very different distribution in Chinese aircrews compared with the general population; results demonstrated an association between the APOE polymorphisms and dyslipidemia with these subjects
23159043 In APOE epsilon 4 carriers, there is a moderate negative relationship between cerebral beta-amyloid and episodic memory.
23152815 Possession of the ApoE4 allele may lead to greater predilection for right hemisphere atrophy even in healthy young subjects in their twenties.
23146133 Severe WMHs appear to be predominantly associated with frontal/executive dysfunction, irrespective of APOE epsilon4 allele presence. WMH severity and APOE epsilon4 had an interactive effect on memory function.
23142524 results indicated that the epsilon2 allele was associated with increased risk of psoriasis, whereas the epsilon3 allele and epsilon3/epsilon3 genotype may decrease risk of psoriasis
23142051 Study identifies miR-1908, miR-199a-5p, and miR-199a-3p as endogenous promoters of metastatic invasion, angiogenesis, and colonization in melanoma. These miRNAs convergently target ApoE and the heat shock factor DNAJA4.
23134962 An association exists between IVS2 + 335T < A and the development of late onset Alzheimer's disease in ApoEepsilon 4 carriers within the northern Chinese population.
23134888 genetic association studies in population of adults in United Kingdom: Data indicate greater sensitivity of fasting triglyceride and C-reactive protein level in serum to dietary fat manipulation with APOE3/E4 genotype (compared to APOE3/E3 genotype).
23132858 ApoE3 more efficiently facilitates Abeta trafficking and degradation than apoE4.
23123227 Our findings suggest that the associations between APOE epsilon4, dementia, and mortality are age dependent, and that APOE epsilon4 no longer plays a role in dementia and mortality at very old ages.
23113606 The results suggest that left-handedness in adults is not related to APOE genotype.
23110818 ApoE3 N-terminal domain unfolding due to mutation may constitute a common mechanism underlying the protein's association with the pathogenesis of lipoprotein glomerulopathy
23110764 apolipoprotein E ~4 allele was more frequent in episodic memory decliners
23103838 The number of epsilon4 alleles was related to hippocampal volumes in mild cognitive impairment, and this may explain the relationship between ApoE genotype and some aspects of memory performance.
23102119 Both TOMM40 and APOE significantly influence age-related memory performance, but they appear to do so independently of each other
23100439 This study demonistrated taht Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid beta peptide.
23100402 This study demonstrated altered white matter microstructure in APOE [epsilon]3/[epsilon]4 carriers compared with [epsilon]3/[epsilon]3 carriers.
23098561 Our study reports for the first time a protective effect of the epsilon2 allele against gastric cancer
23096223 Circulating apo-E predicted in both genders age-adjusted prevalent and incident coronary heart disease (CHD), independent of apo-E genotype and C-reactive protein (OR 1.32 [95 % CI 1.11; 1.58]).
23091810 the ApoE epsilon3/3 genotype frequency was higher in patients with hepatitis B virus-associated liver cirrhosis than in the controls
23088986 Urinary concentration of Apoliporotein E is increased in patients diagnosed with bladder cancer.
23079898 In this study APOE4 genotype was associated with personality traits of neuroticism/anxiety and extraversion as well as with poor cognitive function in individuals >72 years of age.
23076161 The APOE epsilon4 genotype plays a major role in the prediction of breast cancer and the PPARalpha mutation enhances this in a Taiwanese population.
23071163 The APOE epsilon4 genotype was associated with a decline in visual memory
23067351 Single nucleotide polymorphism rs7412 in APOE was strongly associated with LDL-C in African Americans.
23064258 Mild cognitive impairment patients with MAPT and APOE epsilon4 effects have gray matter loss in frontal and parietal cortex that could be due to changes in APOE epsilon4 expression.
23063453 These data provide clear support for an antagonistic pleiotropy hypothesis--that the e4 allele confers some cognitive advantage in early life despite adverse consequences in old age
23060451 APOE differentially regulates multiple aspects of Abeta accumulation.
23056479 Lactobacillus reuteri modulates the metabolic syndrome in Apoe-/- mice
23051975 The APOE epsilon2 allele may be protective on cognitive decline among the oldest old. A 22% increased mortality risk for APOE epsilon4 carriers was found. No protective effect of the APOE epsilon2 allele on mortality compared with the APOE epsilon3 allele.
23051684 Moderately severe Alzheimer Disease patients with the APOE 4 allele may respond more favorably to memantine plus rivastigmine patch than allele 4 noncarriers.
23050006 Patients with AD exhibited reduced parieto-occipital alpha oscillations compared with controls, and those carrying the APOE-4 allele had reduced alpha activity in the left inferior parietal and temporo-occipital cortex relative to noncarriers.
23049877 Apo E gene epsilon4 allele is a risk factor of gallbladder stone disease, especially in elder people and Chinese population
23042215 This study demonistrated that APOE E4 allele frequency was significantly higher in cognitive impairment no dementia patients versus healthy controls
23042108 Cognitive function may be affected by ApoE and neuroticism acting in tandem.
23040522 Our findings support the hypothesis that both reduction in the frequency of the epsilon4 allele and increase in the frequency of the epsilon2 allele contribute to longevity.
23038715 Strong association between ApoE e4 allele and AD.
23036023 Our data suggest that brain BACEl levels may be influenced by the apolipoprotein E genotype before the onset of Alzheimer's disease
23023254 A review of genetic association studies suggests that APOE appears to be associated with global outcomes after traumatic brain injury in children.
23022416 Our findings suggest complex mechanisms underlying the interaction of CR1, APOE, and brain amyloid pathways in Alzheimer disease
23011382 Our findings suggest that functional MRI abnormalities may be detectable well before cognitive decline or white matter changes among healthy middle-aged ApoE4 carriers
22991192 The current data strongly underline the general importance of apoE as a regulator of bone metabolism and identifies the APOE epsilon2 allele as a potential genetic risk factor for low trabecular bone mass and vertebral fractures in humans.
22986607 AD patients with mutant allele (*10) in CYP2D6 gene may respond better to donepezil than those with wild allele (*1). We did not find the relationship between APOE [Latin Small Letter Open E]4 status and the efficacy of donepezil in our study.
22984509 Apolipoprotein E4 is deficient in inducing macrophage ABCA1 expression and stimulating the Sp1 signaling pathway
22982410 The present meta-analysis provides evidence that ApoE epsilon2 mutation is associated with MS risk. In addition, ApoE epsilon3/epsilon4 genotype appears to be a protective factor for MS.
22976236 We propose a model of a pathogenic cascade underlying preclinical Alzheimer's disease in which APOE epsilon4 primarily influences the pathology of Alzheimer disease via Abeta-related mechanisms, and Abeta-associated neurodegeneration occurs only in presence of p-tau.
22972946 It is unlikely that the two APOE missense Single nucleotide polymorphisms (SNPs) rs429358 (epsilon4) and rs7412 (epsilon2) exert any relevant effects on multiple sclerosis susceptibility.
22971752 Meta-Analysis: apoE gene polymorphisms increase risk of essential hypertension.
22967844 APOE may influence the severity of cerebral amyloid angiopathy through altered expression of LRP1.
22961083 The data showed that impaired plasma clearance of apolipoprotein E2-containing, triglyceride-rich lipoproteins promotes lipid redistribution to neutrophils and adipocytes to accentuate inflammation and adiposity.
22955176 APOE4 is not a risk factor for iNPH and does not predict the response to shunt.
22949395 Data indicate the involvement of the APOE p.Leu167del in autosomal dominant hypercholesterolemia (ADH).
22936261 The presence of epsilon2/epsilon3 polymorphism of APOE gene impacted positively the obtained results of cognitive functions among postmenopausal women, whereas the presence of epsilon3/epsilon4, or epsilon4/epsilon4 polymorphisms worsened the obtained results.
22935789 [review] The ApoE (epsilon4) genotype is associated with a higher risk of Alzheimer's disease and an earlier onset of dementia in people with Down's syndrome, in the same way as in the general population.
22927174 We found that APOE epsilon4 carrier status and neuropsychiatric symptoms (both presence/absence and total score on the NPI) were independently associated with greater odds of dementia and cognitive impairment, no dementia versus normal cognitive status
22921891 APOE polymorphism is associated with obesity.
22918225 Neither total ApoE and ApoE4 levels nor the ApoE/ApoE4 ratio correlated with the diagnosis of Alzheimer's disease.
22914594 High density lipoprotein(HDL)-ApoE3, acting as an amyloid-beta chaperone molecule, significantly reduces the death of cerebrovascular smooth muscle cells that results from low density lipoprotein receptor-related protein (LRP)-1-mediated uptake of amyloid-beta.
22914590 Young, non-demented persons carrying the ApoE 4/4 genotype show molecular changes that are involved in specific processes associated with the pathophysiology of Alzheimeer's disease.
22904031 Study found gene-environment interaction between APOE e4 allele status, serum lipids and serum organochlorine pesticides.
22902767 A novel cleavage event of ApoE4 generates an amino-terminal fragment that localizes within neurofibrillary tangles of the Alzheimer's disease brain.
22899317 The carriers of ApoE epsilon4 have an earlier onset of alzheimer's disease (76.9 years) (p = 0.001) than ApoE epsilon3.
22898894 In chronic hepatitis C, genetic heterogeneity in the APOE/TOMM40 genomic region is significantly associated with variation in serum ApoE and ApoB levels, and also with fibrosis suggesting a pleiotropic attribute of this genomic region.
22890095 Chinese diabetics carrying the APOE epsilon4 allele had an increased likelihood of having dementia compared with non-carriers.
22890094 APOE epsilon4 allele is an independent risk factor for both Alzheimer's disease and mild cognitive impairment.
22889670 ApoE is increased in Parkinson's patients' cerebrospinal fluid relative to normal controls.
22883908 Mice overexpressing human ApoE4 already, at an early age, exhibited increased eIF2alpha phosphorylation together with mild impairment in cognitive tasks, compared with ApoE3 mice
22883220 apoE2 isoform is associated with deficit in extinction of conditioned fear in a human targeted replacement in a mouse model.
22874659 among patients with amnestic mild cognitive impairment apolipoprotein E epsilon4 allele carriers had elevated current Frontal Systems Behavior Scale Executive Dysfunction scores in comparison with noncarriers.
22869155 APOE alleles epsilon2, epsilon3, and epsilon4 account for essentially all the inherited risk of Alzheimer disease associated with this region.
22868934 APOE genotype affects medial temporal lobe activation during an fMRI episodic memory task but does so in a predictable, age-dependent manner.
22863665 Examined ApoE in the oldest old and explore its association with quality of life and no association was found between ApoE epsilon4 and QOL.
22862561 This study found that levels of glutamine synthetase and glutamate uptake transporters were unchanged among the APOE genotypes.
22848551 possession of the APOE epsilon4 allele is associated with disruption of perivascular drainage of Abeta from the brain
22844488 APOE genotypes, SFA intake, and obesity were found to be associated with blood lipid levels in Lithuanian adult population
22837136 results show predominantly focal form of coronary artery disease in patients with ApoE epsilon2/epsilon3 genotype
22826377 The epsilon4 carrier status appears to be associated with severe peripheral neuropathy in type 2 diabetes.
22825739 This study demonistrated that the epsilon4 allelic variant of ApoE is associated with memory impairment and white matter damage of the corpus callosum in HIV-positive subjects.
22821396 genome-wide association study to identify genetic variants associated with CSF APOE levels
22815080 APOE epsilon4 carriers had a higher percentage of Alzheimer Disease diagnoses at follow-up than non-APOE epsilon4 carriers. APOE genotyping may be helpful in diagnosing AD especially in patients presenting with atypical features or early age of onset of dementia.
22796460 Thus, increased susceptibility of the WM structures underpinning the entorhinal-hippocampal network, offers a plausible explanation for the earlier onset of cognitive decline previously reported in APOE epsilon4 carriers.
22787761 More than 1/2 of Alzheimer patients are known to possess APOE epsilon 4allele.
22785395 the APOE epsilon4 appeared to be a risk variant for late onset Alzheimer's disease, while the APOE epsilon3 showed a protective effect
22784692 APOE epsilon3/epsilon3 carriers had significantly decreased gray matter density in the left parahippocampal area compared with the APOE epsilon4 carriers
22771913 examined the APOE epsilon4 allele, a known risk factor for Alzheimer's disease, and the COMT Val 158 polymorphism, previously implicated in schizophrenia, for association with lowered memory functioning in healthy adults
22760259 Genetic polymorphisms of apoE are a risk factor for nephrotic syndrome susceptibility. [Meta-analysis]
22755192 Current findings established the involvement of APP, PS1, and PS2 in familial case of Alzheimer disease, while APO polymorphism suggests the existence of other unknown genetic factors or risk factors in the cause of this disease.
22735491 ApoE4 and apoE2 transgenic mice show a worse performance during acquisition of a spatial task compared to apoE3 mice, and apoE2 mice show a worse performance compared to the other two genotypes.
22730380 The reduction of ER stress in macrophages may be a viable option to reduce inflammation and inflammation-related metabolic disorders associated with the apoE4 polymorphism.
22728266 ORP1S is a cytoplasmic sterol sensor, which transports sterols to the nucleus and promotes LXR regulated trans-activation of apoE.
22721421 this study was unable to replicate a previous report finding left-handed adolescents were more than three times likely to have an apolipoprotein e2 allele.
22712640 The distribution of APO E genotype and allele frequency does not differ between the Uighur and Han ethnicities. The APO E epsilon4 allele is a risk factor of AD for both populations.
22710912 APOE single nucleotide polymorphisms are observed in primary progressive aphasia (PPA), but not in patients with a behavioral variant of frontotemporal dementia, nor in controls.
22699906 results demonstrate that gender influences the effect of APOE genotype on both DMN connectivity and CSF tau levels.
22698480 individuals carrying APOE-epsilon4 allele and/or APOE-epsilon3epsilon4 genotype develop MS two times more than non-carriers. Also APOE-epsilon2epsilon3 genotype or APOE-epsilon2 allele may have a protective role against MS development in Iranian population.
22689192 This study demonstrated altered inflammatory responses in young and middle adulthood in epsilon4 carriers that may relate to Alzheimer disease risk later in life
22676395 protective role for APOE epsilon2 allele against severe preeclampsia in Kurdish population
22675504 The fractional turnover rates of ApoE isoforms in 18 cognitively-normal adults were measured.
22642392 The study concluded that the combination of APOE-epsilon4 allele and high educational attainment may be a risk factor for accelerated cognitive decline in older age.
22637583 data suggest that apolipoprotein E4 is a co-factor that enhances the toxicity of oligomeric amyloid-b both by increasing its levels and directing it to synapses.
22635103 Transgenic mice bred on a human APOE2 background show reduced levels of cerebral amyloid angiopathy and emergence of parenchymal plaque amyloid.
22633529 The APOE4 allele and aging are independently associated with amyloid accumulation in the brain, although there are clear interactions between these important risk factors for Alzheimer's disease.
22632920 The presence of the apo E4 isoform was associated with a higher level of Lp-PLA(2) index, a marker of vascular inflammation, synergistically increasing cardiovascular risk.
22621984 Given the established relationship between apolipoprotein E and vasculopathic changes in cerebral amyloid angiopathy, our findings suggest that both hemostatic factors and vessel pathology influence spot sign presence
22615372 Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease.
22612575 This study observed a synergistic negative effect of APOE epsilon4 allele and elevated pulse pressure on episodic memory in a life span sample of healthy, normotensive, adults.
22596266 The APOEepsilon4allele is a strong genetic susceptibilityfactor for AD and other neurodegenerative and vascu-lar diseases.
22580620 Our data confirm the association between the ApoE4 allele and Alzheimer's disease, and point out the E2 allele of ApoE gene as the possible risk factor for type 2 diabetes
22568769 Distribution of APOE genotypes and alleles differed between fertile and infertile Iranian men and may be a risk factor for male infertility.
22562716 This tonic EEG analyses complement those of previous reports in that the ApoE epsilon4 allele has a negative impact on regional neural synchronization and inter-regional neural interaction.
22558310 there are subtle white matter differences between healthy young ApoE4 carriers and non-carriers.
22549621 Cognitive status and APOE genotype have interactive effects on cerebral blood flow.
22544617 Functional imaging data were corrected for partial volume effects to avoid confounding effects due to regional brain atrophy, and all analyses included the presence of the APOE epsilon4 allele as a confounding covariate.
22542837 This study suggested that the APOE-epsilon4 allele contributes to age-related hearing loss.
22539578 The SNP genotype pattern at the APOE gene is associated with episodic memory.
22535266 Possession of APOE epsilon2 predisposes individuals with lobar ICH to hematoma expansion.
22534472 Anticholinergic medication use was associated with poorer performance on measures of cognition, sleep, and mood only in older persons who carried 1 or more epsilon4 alleles of the APOE gene.
22532692 Collectively, these findings demonstrate that apoE mediates HCV attachment through specific interactions with cell surface heparan sulfate.
22520940 Results indicate that apoE genetic polymorphisms influence on lipid profiles and are associated with the development of both type 2 diabetes mellitus with and without coronary artery disease.
22502727 APOE epsilon3,3 genotype better protects neurons subjected to the hyperexcitability of epilepsy and thus confers less risk of AD (Alzheimer's disease).
22492035 ApoE has a gene dose-dependent effect on amyloidbeta transgene accumulation in aged mice.
22490376 APOE polymorphism is not associated with semen quality, as it is present to a similar extent in both normal and impaired or absent spermatogenesis.
22487820 An apoE gene mutation was identified in the patient's family.
22481068 Report APOE mutations in Spanish subjects with mixed hyperlipidemia and a clinical diagnosis of familial combined hyperlipidemia.
22465377 A longitudinal study of Chicago older adults concluded there is a simultaneous influence of social and genetic risk factors for cognitive decline linking APOE-E4 genotype with with neighborhood social disorder.
22462403 The statistical analysis indicated no significant association between APOE genotype and rebleeding in a Chinese population.
22445724 a specific apoE4 fragment with molecular mass similar that of apoE4 fragments detected in Alzheimer's disease patients' brain, can influence the level of inflammatory molecules in brain cell lines.
22440829 The study suggests that the risk of developing and dying from cardiovascular disease, including coronary heart disease and cerebrovascular disease, is influenced by the apolipoprotein E polymorphism.
22419519 Variation in genes encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1, was examined.
22414959 This review discusses the association of behavioral symptoms with the APOE epsilon4 allele Cys112Arg and Arg158Cys, one of 7 genes that implicates increased risk of missense substitutions in Alzheimer's disease.
22414761 In hepatitis C virus-G1, interferon sensitivity is characterised by low lipoviral particle ratios and low apoE levels.
22410653 APOE polymorphism may contribute to the recurrence of hypertensive intracerebral hemorrhage.
22398564 Sex hormones and APOE epsilon4 status synergistically influence some neuropsychiatric symptoms among female but not male Alzheimer's disease patients
22396775 analysis of ApoE-modified nanoparticle uptake on brain capillary endothelial cells
22394699 Results suggest that the polymorphism associated with atherosclerosis in type1 diabetes mellitus (DM) is Apo E4/E4.
22392034 With the factors of sex, age, major depressive disorder, and Apoepsilon4 controlled, PGC-1alpha still increased the risk for insomnia
22383685 apoE overexpression increases i) SR-BI-mediated selective uptake into the liver and ii) ABCA1-mediated efflux of RCT-relevant cholesterol from hepatocytes back to the plasma compartment
22383234 apoE epsilon2 carriers harbor more robust white matter integrity that may be associated with decreased vulnerability to developing alzheimer's disease.
22381401 the present meta-analysis suggests an association between ApoE E4 mutation and increased risk of vascular dementia.
22365656 Association between the APOE genotype and cardiovascular disease risk is unlikely to be homogenous. Highlights risk of inaccurate estimations of genotype-phenotype associations in populations without appropriate stratification for sex and adiposity.
22359096 In summary, the reviewed data indicate that APOE-4 carrier status modulates brain structure and function. [Review Article]
22357643 SA exposure earlier in life may increase risk for declines in EF 50-60 years later in old age, particularly in the context of the APOE epsilon4 allele
22353753 Our data suggested that SORCS1 was in interaction with APOE in the development of late-onset Alzheimer's disease in a Northern Han Chinese population
22350157 study reports a protective effect of the epsilon4 allele towards nonalcoholic fatty liver disease that might be attributable to its role in the regulation of hepatic triglycerides rich very low-density lipoproteins secretion
22349451 There is no association between APOEepsilon2 alleles and Parkinson's disease.
22348880 hypothesis-testing analysis results showed strong correlations between FDG PET-MRI gray matter scores and APOE-epsilon4 gene dose
22344634 This study eemonistrated that Carrying at least one APOE epsilon4 allele is associated with more rapid cognitive decline in Parknison disease.
22343410 A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline
22334766 In a nationally representative sample, PA was associated with enhanced cognition, an effect that was differentially influenced by apolipoprotein E genotype
22329498 no APOE epsilon4-related cognitive benefits in young adults, adolescents and children, and findings were not moderated by the level of executive demands in a cognitive task.
22328704 Study confirms the APOE epsillon 2 allele as a ''risk allele'' for early age-related macular degeneration (AMD); however, the relation of the APOE genotypes with AMD varied by smoking status.
22322856 Patients with the APOE epsilon4 allele may be more predisposed to brain cellular damage measured as S-100B and neuron-specific enolase (NSE).
22311091 The presence of the APOE epsilon4 allele, and not the alleles of ER SNPs, is a risk factor for MCIa. Furthermore, APOE genotype seems to predict the conversion from MCIa to AD.
22291217 There was a strong association between the APOE epsilon4 allele and Alzheimer's type pathology
22285757 suggest that an interaction between APOE and HDL is facilitated by APOE4, and is possibly linked with a protective effect on cognitive decline in later life
22272623 This study showed that plasma cyto-chemokine levels along with ICAM-1, Abeta and ApoE genotyp in Alzheimer disease.
22272622 This study revealed that engagement in leisure time physical activity, but not ognitively stimulating activity is associted with a reduced probability of cognition decline over 18 month in health older APOE4 carriers.
22269984 This study demonistrated that a modest association between ApoE epsilon4 carrier status and reduction in white matter tract integrity at medial temporal and limbic regions in both healthy and AD subjects.
22266326 Data suggest that there may be an association between APOE allelic frequency and spontaneous pregnancy loss in patients with endometriosis, which appears to be independent of mechanisms associated with infertility.
22264578 The ApoE4 allele may be associated with an increased risk for development of atherosclerosis by elevated levels of total cholesterol in children with family history of coronary artery disease.
22251476 One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to apoE genetic polymorphisms and comorbid factors such as diabetes and, especially, alcohol consumption.
22246233 higher association of anxiety with the ApoE epsilon4 allele; a significantly higher frequency in the ApoE epsilon4 homozygotes when compared to the heterozygotes
22245009 This study demonistrated that in healthy older carriers of the APOE4 allele clinically unremarkable increase in vascular risk may be associated with reduced frontal volumes and impaired cognitive functions.
22244650 This study demonistrated that a nondemented elderly population, persons with the APOE4 allele have a smaller hippocampal volume
22238606 LRP1 enables apoE to accumulate in an early endosomal recycling compartment that serves as a pool for the intracellular formation and subsequent re-secretion of apoE-enriched HDL particles.
22234866 In a case-control study of 1,089 oldest-old (ages 92-93) and 736 middle-aged Danes, the minor allele frequency (MAF) of rs769449 (APOE) was significantly decreased in the oldest-old.
22232206 The results of this study suggested that cognitively normal sedentary APOE epsilon4-positive individuals may be at augmented risk for cerebral amyloid deposition.
22228589 This study demonstrated that APOE genotype affects several aspects of the inflammatory response in mouse brains, leading to increased neuronal damages in APOE4 mice
22226798 This stuidy demonistrated that fitness differentially affects cerebral metabolism in apoe4 carriers only.
22226379 Elderly in India with an ApoE4 allele have 4.7 times more risk of developing depression in old age.
22225956 Apolipoprotein E levels predict incident cardiovascular disease risk in women with high levels of HDL cholesterol and C-reactive protein but not in men.
22221592 In women, APOE epsilon4-positive genotype is associated with earlier onset of WD symptoms, particularly among ATP7B p.H1069Q homozygous patients
22221491 This study demonistrated that Genetic factors, particularly the ApoE epsilon4 polymorphism, might contribute to variability in outcomes after stroke.
22211488 Reduction of rapid eye movement sleep in mild cognitive impairment patients with ApoE varepsilon4 is more noticeable than in varepsilon4 non-carriers.
22206848 This study demonistrated that The older ApoE-epsilon4 carriers had smaller HV-induced changes in EEG relative powers than the older ApoE-epsilon4 noncarriers
22206590 This community-based study shows that varepsilon2 allele is helpful on lipid changes.
22204031 It has been elucidated that APOE gene is a risk gene of neuro-psychiatric diseases including Alzheimer's disease of the aged.
22200909 Data suggest that apolipoprotein E2 genotype contributes to increased risk of cardiovascular complications in acromegaly since it is concurrently present with other risk factors; apolipoprotein E4 genotype more common in subjects with acromegaly.
22189452 APOE isoforms modulate the harmful effects of amyloid beta on cognitive function
22185986 Serum ApoE level was independently associated with urinary albumin excretion in type 2 diabetic patients from Shanghai, China.
22179327 APOE e4 genotype prevalence varies among alzheimer's disease patients by region and within each country
22178110 ApoE detection provided a novel diagnostic marker for invasive bacterial infections in pediatric patients.
22178106 The correlation between osteoporosis and carotid atherosclerosis (CA)was analyzed by exploring the effects of ApoE gene polymorphisms on bone mineral density (BMD) of the lumbar spine and CA.
22174202 The frequency of ApoE polymorphisms did not differ between patients with RA and controls. ApoE genotypes are strongly linked to inflammation and lipid levels in RA, raising interest in the prognostic implications of ApoE genotypes.
22173784 We show that education and occupation act as proxies for reserve in Apolipoprotein Eepsilon4 carriers with early probable Alzheimer's disease
22165672 study established male patients with multiple sclerosis had a higher APOE epsilon4 frequency and disease severity, but were likely to have lower serum ApoE levels
22159114 Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-beta amyloidosis.
22159055 The polymorphism at the APOE gene plays a role as a genetic modifier of Machado-Joseph disease phenotype
22138302 ApoE-containing astrocyte lipoproteins exhibit the most robust interactions with Abeta.
22134129 Our results are consistent with an influence of APOE status on Propositional density in young adulthood that is independent of the Alzheimer's disease risk
22130662 apoE-induced intracellular Abeta degradation is mediated by the cholesterol efflux function of apoE, which lowers cellular cholesterol levels and subsequently facilitates the intracellular trafficking of Abeta to lysosomes for degradation.
22129783 APOE epsilon4 is overrepresented in primary progressive aphasia, thus likely acting as genetic risk factor on disease development.
22113353 ApoE4 allele was associated with high total cholesterol and LDL cholesterol, and development of hypertension in an Asian population.
22110642 homozygous APOE epsilon4 carriers aged 35 years or older had worse cognitive function than heterozygous carriers and noncarriers
22108393 there was a strong association between the apolipoprotein E epsilon4 and postoperative cognitive dysfunction in elderly patients undergoing inhalation anesthetics
22106308 analysis of brain network local interconnectivity loss in aging APOE-4 allele carriers
22102296 The epsilon4 allele of the apolipoprotein E gene is a genetic risk factor for Alzheimer's disease and is associated with decrements in memory and in olfactory function.
22101914 study concludes that, in middle-aged women, APOE -491 T allele contributes keeping lower levels of LDL cholesterol in the population studied, and would have a putative protective effect for the development of coronary artery disease
22101883 APOE gene polymorphism seems be an important genetic contributor to frailty development in the elderly
22101739 A molecular understanding of the interactions of apoE4 with Abeta, nitric oxide and IL-1beta on the regulation of the COX-2/prostaglandin pathway may open new avenues in understanding the mechanism of development of neurodegenerative disease.
22100309 The P3 latencies were significantly longer in epsilon4 young and middle age participants in olfactory event-related potential.
22089642 The main novel finding of this investigation was that multiple APOE locus cis-elements influence both APOE and TOMM40 promoter activity according to haplotype and cell type.
22074026 In our population, APOE epsilon2 allele confers protection against hypercholesterolemia and a less atherogenic lipid profile
22071360 Report interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women.
22069485 Mutations in apolipoprotein E3 is not associated with its structural variation and type III hyperlipoproteinemia.
22069463 Single nucleotide polymorphisms in APOE is associated with obesity and adiposity.
22068907 Although the e3 allele has been considered neutral in several studies, our results suggest that it acts as a protective factor against Alzheimer disease in the population studied
22058162 polymorphic ApoE alleles differentially modulate house dust mite-induced airway disease, which can be stratified, in order of increasing severity, epsilon3 < epsilon4 < epsilon2; results raise possibility that polymorphic apoE alleles may modify asthma severity
22056562 these data suggest a new mechanism by which apoA-I stimulates CETP secretion, in addition to apoE, from lipid loaded macrophages, a process involving NF-kappaB inhibition and/or PKA pathway activation.
22056199 This study suggests that genetic (APOE epsilon4) and environmental (education) factors are not only independently but also interactively related to dementia risk and that high education may buffer the negative effect of APOE epsilon4 on dementia occurrence.
22055839 The results suggest that olfactory processing speed may be a useful measure for detecting and following the effects of adiposity on brain integrity and cognitive function in those at genetic risk for AD.
22039842 findinfgs show apolipoprotein E4 allele may be related to the development of ischemic heart disease in patients with or without type 2 diabetes in Kuwait
22028770 polymorphism -491A/T and ATF4 elicit independent control of APOE gene expression
22016612 Data suggest that the E (APOE) E4 allele may serve as a genetic marker for susceptibility to higher lipid profiles in the Guangxi Zhuang children.
22016362 These findings suggest that shortened telomere length may be associated with the ApoE4 homozygote in AD patients.
22015765 The APOepsilon4 allele enhances electroencephalographic abnormalities at the early stage of traumatic brain injury.
22013795 Apo E epsilon 4 allele was a susceptible allele for coronary heart disease.
22012848 This study demonistrated that Apolipoprotein epsilon4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer's
22010136 Apolipoprotein E4 does not increase coronary heart disease risk in carriers of LDLR mutations.
22006422 An association was found between the ApoE epsilon2 allele and deep venous thrombotic events in women.
21992747 Significant differences were found in the response to induced ketosis among non-carriers of the APOE4 gene, with notable improvement among the E3/E3 genotype group.
21984189 The results suggest that ApoE polymorphism is significantly associated with susceptibility to vascular dementia in Chinese population.
21973221 Study suggests that APOE may not be associated with spontaneous abortions in Caucasians.
21971450 This study demonistrated that ApoE epsilon4 allele associated with thinner frontal cortex in middle age in men of Vietnam.
21958003 The current knowledge regarding the APOE polymorphism, is reported.
21954452 The unique composition of fetal HDL (apoE-HDL)affects key functions of the growing fetal tissues.
21952537 The APOE epsilon4 allele frequencies in subjects with subjective cognitive impairment and amnestic mild cognitive impairment have a north-south gradient. The relation between the APOE epsilon4 allele and cognition is region dependent.
21945984 APOE E4 carriers with MS have worsening progression of cognitive deficits than noncarriers.
21943158 variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
21939561 genetic association studies in populations in the United States: Findings suggest that APOE4 carrier status does not modify the association between increasing BMI and decreasing HDL levels
21934306 Single polymorphisms within the saitohin gene were associated with increased cognitive impairment and functional dependence persons with moderate-to-advanced Alzheimer disease. APOE-epsilon4 was associated with increased baseline physical agitation.
21911656 EOAD is a purely dominant, mitochondrial, X-linked, or polygenic disorder. The most likely explanation of the data is that approximately 4% of EOAD cases are due to apoe.
21908077 The results of this study suggested that the APOE epsilon4 allele has a differential effect on change in verbal memory performance depending on age, consistent with the hypothesis of antagonistic pleiotropy.
21905100 findings did not suggest significant association between APOE polymorphism and presence of neuropsychiatric symptoms in Alzheimer's disease patients
21895520 To identify possible prognostic biomarkers, use of APOE3 and APOE4 transgenic mice demonstrates relatively favorable and unfavorable outcomes respectively, following traumatic brain injury.
21892657 CETP may contribute to the genetic variability of brain structure and dementia susceptibility in an APOE-dependent manner.
21889115 APOEepsilon4 carrier status amplifies the degree of neurodegeneration in mild cognitive impairment.
21882290 pooled analysis demonstrating associations between late age-related macular degeneration and APOepsilon4 and APOepsilon2 following adjustment for age group and sex within each study and smoking status
21873229 Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions.
21869487 APOE epsilon-3 a favourable factor for the longevity: an association study in Chinese population
21864519 the presence of APOE epsilon2 allele may serve as a biological marker for the identification of a subgroup of patients who are more likely to suffer with OSAS detrimental effects on sleep, impacting not only the daily functioning, but also their quality of life
21857382 The iNOS-231 T allele and the apoE epsilon4 allele were more common in patients than in controls, but not significantly associated with Cerebal Palsy.
21856047 These cross-sectional data suggest leisure activity is associated with tissue volumes in the brain irrespective of the APOE epsilon4 risk allele status.
21851856 APOE appears to have an intrinsic effect on the differentiation of functional networks in the brain
21849821 Non-APOE4 carriers showed improved cognitive performance in the memory domains at follow-up, while performance of APOE4 carriers did not change.
21848287 overall structures are similar, with the exception of M108 in ApoE4 which is more solvent-accessible in this isoform than in ApoE2 and ApoE3
21845926 Evidence for different allele frequencies between Tsimane and other populations; correlations of CRP and apoE alleles suggest these variants are under selection in response to a high infection environment.
21845591 at least in East Asian origin populations, the APOE e4 allele is a stronger predictor of incident dementia in the presence of depressive syndrome, and particular depressive symptoms.
21840004 ApoE epsilon2 carriers were less likely to have at-risk levels of high-density lipoprotein and total cholesterol (total-C) than non-carriers. ApoE epsilon4 carriers were less likely to have elevated levels of Creactive protein than non-carriers
21835633 ApoE4 status significantly modified a number of associations. Specifically, we observed a significant negative relationship between Q4-waist hip ratio and a measure of executive function in the apoE4(+) group but not in the apoE4(-) group.
21829380 We found that in three loci (PCSK9, APOE, and LDLR) there were additional variants independently associated with LDL-C.
21825236 The polyT polymorphism is associated with risk of late-onset Alzheimer disease in APOE 3 homozygotes in a large case-control series of APO3-TOMM40 haplotypes
21822540 The APOE gene polymorphism can, to some degree, reflect the Traditional Chinese Medicine syndrome types of T2DM patients with macroangiopathy.
21819245 The APOE genotype is associated with the risk of intracerebral hemorrhage in Chinese Han patients.
21803501 increase in CSF cortisol associated with the presence of the APOE e4 allele was only detected when a short TOMM40 poly-T variant, shown to associate with later age of onset of AD in e4 carriers, was not present.
21803164 APOEepsilon4 allele(s) may lead to premature aging with neurodegeneration in younger HIV patients
21799773 genetic interaction between APOE and PRNP
21799244 This study suggested that two synergistic interactions between subhaplogroup H5 and APOE4 status (p = 0.009) and between TFAM rs1937 and APOE4 status (p < 0.001) were detected, influencing LOAD risk.
21798539 Hepatocyte-specific IKKbeta expression activates NFkappaB and aggravates atherosclerosis development in APOE*3-Leiden mice.
21798384 A brief background introduction into the structure, established physiological and pathophysiological functions of apoE, and the emerging role of apoE in bone, are discussed.
21792545 ApoE genotype is significantly linked to the age at natural menopause.
21790705 genetic polymorphisms modifies the association between central obesity and lung function in taiwan asthmatics
21788110 Elevated levels of ApoE3 may play a role in controlling the formation of neurofibrillary tangles in subacute sclerosing panencephalitis.
21782446 In this first study of a Thai population, a higher frequency of APOE-epsilon2 allele is identified among patients with Parkinson disease than is found among controls.
21769591 among all single nucleotide polymorphisms of ApoE, the mutation in rs11542041 (R132S) has the most significant effect on functional variation in Alzheimer disease. [review]
21768502 Interaction between carrying APOE4 allele and chronic life stressors has significant impacts on self-reported health while controlling for various sociodemographic and health behavior factors.
21767357 CETP Ile405Val and APOE Cys112Arg are associated with both the prevalence of low HDL-cholesterol level and with the prevalence of abdominal obesity
21763789 [review] Current cumulative evidence based on a few existing longitudinal studies shows no association of APOE genotypes with neuropsychiatric symptoms as a whole in late-onset Alzheimer's disease.
21760580 one copy of this variant, called APOE4, increases Alzheimer's Disease risk fourfold; two copies raise the risk about tenfold
21756796 The polymorphisms of MIP-1alpha -906 (TA)(6)/(TA)(6) and ApoE are independent genetic risk factors for ulcerative colitis.
21743131 These data suggest that ApoE4 plays an important role in learning and memory impairment.
21743035 Data suggest that abnormalities in adipose tissue that accompany expression of the apoE2 cannot be ascribed to adipocyte-specific effects on lipid metabolism. of this isoform on adipocyte lipid metabolismDU
21741316 Vasculopathic changes associated with the APOE epsilon2 allele might have a role in the severity and clinical course of lobar intracerebral hemorrhage.
21740922 A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals.
21728427 This study supported that the apoe genotype a biomarker for mild cognitive impairment.
21723395 This study refutes a role for the epsilon4 allele of APOE in MRI abnormalities in multiple sclerosis
21714688 study shows that despite a low incidence of dementia in North Indian population, APOE epsilon4 heterozygous/homozygous state is associated with risk of all types of dementia
21714002 Psychotic symptoms were not associated with the presence of any examined polymorphisms in the apolipoprotein.
21710128 High APOE epsilon 4 allele frequencies were associated with Alzheimer disease in a Tunisian population
21703254 APOE genotype and haplotype distributions differ significantly along the age classes (Genotype: p=0.014; Haplotype: p=0.005) with APOE*epsilon4 genotype status and haplotype displaying negative association (Genotype: O.R.=0.377, p=0.002, Haplotype: O.R.=0.447, p=0.005
21701228 This study providence that APOE epsilon4 offered information on the risk of cognitive decline in this longitudinal study in chinease elders.
21689001 The APOE gene might not contribute to the risk of diabetic nephropathy in Taiwanese patients with T2D.
21685781 findings suggest that the APOE-epsilon2 allele provides a buffer against significant hanges in daily functioning over time and is associated with better neuropsychological performance.
21679970 This meta-analysis of 20 case-control studies suggests that APOE epsilon4 (2 alleles) is not associated with multiple sclerosis susceptibility.
21676498 Increased expression of ApoE may not only disrupt cholesterol homeostasis but may also contribute to some of the neurobiological features of Alzheimer Disease, including plaque deposition.
21670560 Apolipoprotein E2 mutation is associated with lipoprotein glomerulopathy.
21659554 This study presents experimental and epidemiological evidence that the APOE epsilon4 allele is associated with higher serum vitamin D in mice and humans.
21654062 These results suggest that cortical and cerebrovascular Abeta depositions are useful quantitative traits for genetic studies, as highlighted by the strong associations with the APOE epsilon4 variant.
21651315 ApoE varepsilon4 allele may be associated with poorer long-term outcome, but not acute injury severity in traumatic brain injury
21617520 ApoE epsilon4 carriers had higher factor scores in the agitation/aggression-delusion subsyndrome in patients with Alzheimer disease.
21613490 Middle-aged and elderly APOE epsilon4 carriers have increased hippocampal default mode synchronization during rest.
21606569 healthy young APOE epsilon4 carriers have smaller hippocampal volumes than APOE epsilon2 carriers. The difference in morphology is clinically silent in young adulthood, but could render APOE epsilon4 carriers more prone to the later development of Alzheimer disease.
21605063 SIGMAR1 and APOE interact to influence Alzheimer's disease severity across ethnic populations.
21595502 Effect of obesity, serum lipoproteins, and apolipoprotein E genotypes on mortality in hospitalized elderly patients
21593560 among individuals with a history of stroke or myocardial infarction at baseline, progression of Alzheimer's disease is influenced by APOE epsilon4 carrier status
21576687 Retrospective review of clinical data (age at onset, family history, clinical presentation, diagnostic delay, diagnosis) and APOE genotype of patients with neuropathologically confirmed early-onset Alzheimer disease
21575667 found an interaction between the polymorphisms APOE and IL-1RA (86 bp)n (higher lethality in the presence of IL-1RA heterozygosity and APOE epsilon2epsilon3 or epsilon3epsilon4 genotypes).
21570960 association between metabolic syndrome (MS) and ApoE polymorphism; the morbidly obese patients had a higher incidence of MS and a different allelic distribution compared with others; the epsilon4 allele was associated with absence of MS and hypertension
21556001 stratification of our data by age groups clearly demonstrates that APOE4 is a risk factor not only for late-onset but for early-onset AD as well.
21555637 Results suggest an involvement of the APOE gene locus in the genetics of FTD (Fronto-Temporal Dementia) and PPA (Primary Progressive Aphasia).
21555604 Decreased in-phase connectivity in regions of the posterior default mode network are found in APOE epsilon4 carriers relative to APOE epsilon4 noncarriers.
21552550 APOE4 genotypes were similar in Alzheimer's disease and dementia with Lewy bodies
21550086 Common polymorphism of ApoE gene is associated with the presence of MetS in an elderly Chinese population.
21549723 APOE varepsilon4 carriers showed less activation in the hippocampus proper during encoding. Specifically, when spatial encoding was contrasted against the dot-control task, encoding-related activation was significantly lower in carriers than non-carriers.
21545304 [review] APOE epsilon4 allele has been found to be potentially linked to Abeta accumulation and accrual, in turn contributing to Alzheimer disease pathology, despite its significant role in processing of amyloid precursor protein (APP) and lipid metabolism.
21541275 There is no evidence to support an association of APOE polymorphisms with early or exudative age-related macular degeneration (AMD), suggesting that APOE is less likely to be a major AMD susceptibility gene in the Chinese population.
21534737 preliminary findings suggest no clear APOE genotype influence on neuropsychological outcome in mild and moderate traumatic brain injury patients.
21533863 Results describe the association of ACE and APOC1 gene polymorphisms with susceptibility to Alzheimer's disease and dementia in general, both alone and combined with the APOE gene.
21517181 apolipoprotein E (ApoE) gene plays a role in odor identification errors
21500980 APO E epsilon 2/3 genotype may be linked to a risk for diabetic nephropathy in Turkish type 2 diabetes patients
21493755 The APOE-epsilon4 allele is associated with a moderately increased risk for progression from mild cognitive impairment to Alzheimer's disease [Meta-analysis]
21488185 Polymorphism within the ApoE gene is associated with serum LDL cholesterol in postmenopausal women with obesity and metabolic syndrome.
21482441 In ApoE e4 carriers, the negative association between the ratio of campesterol to cholesterol and memory reached borderline significance.
21478199 apoE plays isoform-specific roles in determining the protein composition of peripheral nerves as well as regulating nerve regeneration pathways in vivo.
21474934 Associations were found between the APOE-epsilon4 allele and mixed dementia, infarct/stroke dementia and subcortical ischemic vascular dementia
21474829 Results demonstrate a necessary but quantitatively different role of PPARalpha in the modulation of liver metabolism, inflammation, and atherogenesis in ApoE2 knock-in mice.
21471207 TJ integrity in BBB is regulated by apoE in an isoform-dependent manner.
21464541 ApoE polymorphism may be not a major genetic factor that influences the individual dose for warfarin maintenance.
21461956 Polymorphisms in the ApoE,ACE, MTHFR and LDLR genes, implicated in the pathogenesis of many diseases, including Alzheimers and myocardial infarction, were found to be prevalent in Angami and Lotha Naga populations in India. Lifestyle increase risk.
21454574 Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors
21453125 the role of EDNRA -231 G>A and APOE HhaI polymorphism for a possible association with migraine
21451572 NLRP3 inflammasome is not critically in atherosclerosis progression in the ApoE mouse model.
21450082 Apolipoprotein E epsilon-4 polymorphism is associated with younger age at referral to a lipidology clinic and a poorer response to lipid-lowering therapy.
21443344 Approximately half of the adults in each group were ApoE e4 carriers and half were noncarriers.
21443265 S-nitrosylation of ApoE proteins may play an important role in regulating lipid metabolism and in the pathogenesis of late-onset Alzheimer's disease.
21435264 the effects of ethnic identity and genetic admixture on APOE genotype, its association with dementia, and dementia prevalence
21420681 LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE--carrying lipoproteins
21418511 Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
21411037 The results of this study showed higher conversion to Alzheimer's disease (AD) in MCI epsilon4 carriers than in non epsilon4 carriers. These
21409287 Findings extend understanding of ApoE/Abeta interaction and may guide the discovery of inhibitors that treat AD by antagonizing ApoE/Abeta interaction.
21407046 findings suggest that plasma apoE have a positive influence on cognitive function in both E4 (-) and E4 (+) groups.
21402364 These data suggest that specific interactions between genetically susceptible individuals (those with at least one copy of the Apo E4 allele) and the environment may contribute to the risk of being diagnosed with fibromyalgia syndrome.
21401257 Investigate if apolipoprotein epsilon4 allele moderates the influence of earthquake exposure on survivor health. Findings suggest a genetic variation in the apolipoprotein E gene may modify the health effects of the stress from natural disaster exposure.
21396385 We found no evidence of higher cognitive performance in young apoe4 carriers, or cognitive deficits in older apoe4 carriers.
21388338 REVIEW: even if the presence of ApoE4 is not a deterministic factor for Alzheimer's disease, it seems to shift the progression of the disease towards a younger age and faster progression
21383266 Living in a psychosocially hazardous neighborhood was associated with worse cognitive function in persons with the APOE epsilon4 allele, evidence of a novel gene x environment interaction.
21380728 determined the distribution of the polymorphic variants of CETP TaqIB and ApoE genes and their association with lipid and anthropometric parameters in hyperlipidemic and normolipidemic Asian Indians
21379329 There was evidence of association for recently-reported late-onset Alzheimer's disease risk loci, including BIN1 and CLU and CUGBP2 with APOE.
21372127 long range genomic interactions have a role in macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1
21360299 APOE polymorphism might play an important role in Parkinson disease susceptibility in our Japanese population.
21350196 ApoE signaling via VLDL-R or apoER2 promotes macrophage conversion from the proinflammatory M1 to the antiinflammatory M2 phenotype.
21347323 a significant reduction in tau phosphorylation at the Ser202/Thr205 epitope in APOEepsilon3 animals only
21346518 the apolipoprotein epsilon gene did not influence the age of symptom onset or aid in the prediction of Alzheimer disease pathology in primary progressive aphasia
21346330 Our study suggests the apo E4 carrier might serve as a predictor of diabetic nephropathy progression in Taiwan.
21332925 the e4 allele polymorphisms carriers:effect on lifespan and ages at onset of cardiovascular diseases and cancer
21325775 Apolipoprotein E mutation is associated with dyslipidemia and lipoprotein glomerulopathy.
21325652 CV risk factors influence age-related memory decline in APOE epsilon 4 homozygotes.
21324458 variants of APOA5 (rs662799) and APOE (rs429358) were associated with HDL-C and LDL-C responses in metabolic syndrome subjects
21324265 Decline of gray matter volume(GMV) and brain parenchymal volume were significantly faster in Apolipoprotein E eta4-positive than -negative patients in a 15-year-from-disease-onset model. Only GMV had the same trend in a 4-year model.
21322570 Oligomers of apoE first need to dissociate to monomers before binding to phospholipid liposomes, a step that is then followed by a large conformational reorganization of the monomer.
21317045 APOE epsilon4 is not associated with significant hippocampal, hemispheric, or whole brain atrophy in patients with medically intractable temporal lobe epilepsy.
21310412 the alleles epsilon4 and epsilon2 were associated with decreased and increased concentrations of CRP, respectively, compared to the wild-type allele epsilon3.
21297948 a pathway by which isoform specific conformational differences increase the level of cleavage at the hinge region of ApoE4, leading to a loss of ApoE function to mediate clearance of Abeta and increase the risk of AD for carriers of the APOEepsilon4 allele.
21297273 The APOE epsilon4 allele was more prevalent in those with alzheimer disease than in those with Subcortical Ischemic Vascular Dementia.
21296594 The low prevalence of extracranial carotid stenosis in this population might result from low frequencies of the APOE epsilon4 allele.
21290252 ApoE genotype was not associated with insulin resistance or altered insulin secretion.
21289314 ApoE and apoE-mimetic peptides antagonize SET nuclear oncogene/inhibitor of protein phosphatase 2A (PP2A), increase cellular PP2A phosphatase activity, and decrease activation of inflammatory signal transduction pathways.
21284913 The apolipoprotein E4 allele (ApoE4) is an established genetic risk factor for Alzheimer's disease.
21283811 APOE rs439401 TT-genotype is associated with an adverse metabolic profile in a population of psychologically stressed Danish men.
21283692 alternative splicing and promoter usage of the APOE gene in AD brain tissue might reflect the progression of neurodegeneration.
21276236 Findings suggest a possible correlation between the use of dietary supplements and APOE4.
21266538 Observations suggest that apoE4 strongly stabilizes Abeta oligomers, the pathological species responsible for Alzheimer's disease.
21266206 APOE genotypes -219T/T and +113C/C could be genetic markers for cortical bone strength
21263443 APOE E4 was associated with a higher relative rate of cognitive decline in the 9th decade for verbal memory & abstract reasoning, but not verbal fluency.
21263195 The association between APOE4(-219T) and Alzheimer's disease, highlight the importance of the phase of the alleles for the observed effects on Alzheimer's disease risk.
21261723 Some of the variability in the natural history of patients with persistently normal transaminases with initially mild hepatitis C can be related to their Apo E genetic background.
21254576 Clinical and prognostic significance of genetic markers of ApoE gene in traumatic brain injury
21254242 genetic association studies: APOE-epsilon4 and -epsilon2 allele frequencies are higher in patients with coronary stenosis than in controls in study using Iranian subjects; APOE alleles have no association with severity of disease
21252542 The association between Apo epsilon4 and younger age at onset was significant in Caucasians and African Americans, where the epsilon4 allele was also most frequent
21252539 Presence of both ApoE epsilon4 and IL-6 C genes increases the risk of having Alzheimer's and vascular dementia markedly
21252538 The study confirmed the positive association of the ApoE4 polymorphism in dementia, both in the Alzheimer's and vascular etiology subgroups
21251163 Men are normally protected by androgens against bulbar amyotrophic lateral sclerosis; the APOepsilon4 allele inhibits this protection, perhaps by interfering with the androgen pathway.
21245410 In patients with neovascular age-related macular degeneration, the presence of the APOE epsilon4 allele conferred significantly better visual outcomes after anti-VEGF treatment than did the epsilon2 allele.
21244662 APOE plays an important role in obesity development in the Roma population.
21244352 total cholesterol and low density cholesterol-plaque correlations were also stronger for the subgroup of 87 subjects with an APOE epsilon4 allele
21243303 interaction between stress and presence of E*2 allele; fibromyalgia was more frequent in patients with high stress levels that were E*2 non-carriers compared to patients with same stress level, but E*2 carriers.
21240353 Statistically significant associations between genotypes of APOE gene coding part polymorphism and some key lipid risk factors (blood total and LDL cholesterol, atherogenic index, etc.) for coronary atherosclerosis were found in males in West Siberia.
21232817 The often-assumed link between APOE, the blood oxygenation level dependent response, and Alzheimer disease risk show an effect of APOE genotype on brain function.
21228824 ApoE epsilon4 allele is associated with a twofold increased risk of developing hypertension in Chinese.
21225522 Current findings related to the association between different isoforms of apoE and haemorrhagic stroke due to CAA do not allow us to formulate any clinical recommendations yet.
21224004 These findings show that hippocampal atrophy is greater in APOE4 carriers in regions typically affected by Alzheimer pathology
21222606 The objective of this study was to elucidate an association between Apo- Eepsilon4 allele and CSF biomarkers Abeta42 and tau for the diagnosis of Alzheimer's Disease (AD) patients
21219628 apoE4-(72-166) peptides displayed a higher lipid-binding and comparable receptor-binding ability as to full-length apoE
21218563 the APOE epsilon 4 allele and reduced left hippocampal volume were associated with CD.
21208197 No association between cognitive impairment and ApoE-4 or clinical markers was detected in the study sample of multiple sclerosis patients.
21192235 ApoE genotype seems to influence cortical activation in patients with aMCI and to a lesser degree in healthy controls as well
21192234 The results suggest a relatively specific impact of apolipoprotein E (APOE) epsilon4 burden in mild cognitive impairment and underline the value of linguistic assessment in preclinical diagnosis
21190051 analysis did not reveal an impact of gene-gene interaction between BDNF and ApoE genes on hippocampal volumes or memory performance
21184197 we show further evidence for the role of APOE epsilon 4 in promoting cognitive impairment in HIV-infected patients
21169230 mechanism for colocalization of apoE with caveolin
21163916 Alzheimer APOE4 carriers with cognitive decline undergo faster GM atrophy than do noncarriers.
21163235 Findings of a recent meta-analysis have not supported a role for APOE in MS susceptibility or severity. We have not found, in our data, any influence of this gene in the RRMS response to INFbeta
21159973 APOE4 allele carriers (E4+) differed significantly from E4-in functional connectivity of the precuneus to several brain regions.
21143177 there is a positive correlation between the expression of APOE and each of VEGF and eNOS in the capillaries of alzheimer disease brains
21132529 the APOE epsilon4 allele is associated with outcomes after spinal cord injury
21132386 The aim of this study was to determine the allelic and genotypic distributions of the APOA5-1131T>C (rs 662799) and the APOE HhaI polymorphisms.
21124030 APOE4 genotype frequency varies among Alzheimer's disease patients in regional patterns similar to that of the general population--{REVIEW}
21124005 We found more profound deficits in spatial navigation in APOE epsilon4 allele+ relative to APOE epsilon4 allele-epsilon4- amnestic mild cognitive impairmentpatients.
21116929 This study suggested that the patients with APOEepsilon4 allele predispose to cerebral vasospasm after spontaneous subarachnoid hemorrhage.
21116912 This study suggested that APOEepsilon4 allele is a risk factor to brain function aggravation in the early stage of aneurysmal subarachnoid hemorrhage and it may contribute to early brain injury after aneurysmal subarachnoid hemorrhage.
21114327 Apolipoprotein E4 exhibits better lipid binding ability than apolipoprotein E3 as a consequence of a rearrangement involving the segment spanning residues 261-272 in the C-terminal domain.
21110240 Our findings suggest that the presence of the epsilon2 and epsilon4 alleles may play a role in the development of the disease. However, if any type of the disease has already developed the alleles show no association with the clinical parameters
21108621 APOE polymorphisms were found not to be associated with either the occurrence or the time to development of levodopa-induced dyskinesia.
21098974 Possession of the epsilon4 allele for ApoE is associated with greater temporal and hippocampal atrophy well before the onset of cognitive deficits.
21084733 this study suggested that the decrease of Abeta1-42, but not the increase of pTau181 CSF levels is accelerated by the APOEepsilon4 genotype in middle-aged and older adults with normal cognition.
21084733 Observational study of gene-disease association. (HuGE Navigator)
21080234 Data suggest that apoC-III attenuates the binding of apoE to the lipoprotein surface and apoE-mediated cellular uptake of lipoprotein remnants.
21079443 Carriers of all 3 APOE rare (or minor) alleles were nearly 10 times more likely to report a previous concussion. Promoter minor allele carriers were 8.4 times more likely to report multiple concussions.
21079443 Observational study of gene-disease association. (HuGE Navigator)
21074899 Observational study of gene-disease association. (HuGE Navigator)
21073671 Prescence of of APOEepsilon4 allele and MAPT H2 haplotype in frontotemporal lobar degeneration had a significant influence on the expression of synaptophysin and SNAP-25
21073671 Observational study of gene-disease association. (HuGE Navigator)
21063236 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21061402 This study demonstrated that an additive model for these APOE variants is superior to other forms of genetic risk modeling previously applied.
21061402 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
21059989 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
21059196 The epsilon4 allele of the APOE gene is associated with a worse lipid profile in the Brazilian urban population.
21059196 Observational study of gene-disease association. (HuGE Navigator)
21054877 Observational study of gene-disease association. (HuGE Navigator)
21048770 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
21039385 Observational study of gene-disease association. (HuGE Navigator)
21033077 Observational study of gene-disease association. (HuGE Navigator)
20980669 A slower rate of hippocampal atrophy in normal APOE2 carriers is consistent with the lower risk of Alzheimer disease in these individuals.
20975297 Dysregulation of genes such as CES1 and APOE seems to be associated with some physiopathological markers of insulin resistance and cardiovascular risk factors in obesity.
20972250 Observational study of gene-disease association. (HuGE Navigator)
20971101 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20966513 the role of APO E polymorphisms in cerebrovascular and coronary heart diseases (Review)
20964956 The APOE genotype may play a role in the regulation of both cholesterol and apoE levels in grey matter.
20964956 Observational study of gene-disease association. (HuGE Navigator)
20961200 the ApoE gene polymorphism was associated with HBV infection, and the varepsilon2 allele showed positive correlation with HBV infection in northern China.
20961200 Observational study of gene-disease association. (HuGE Navigator)
20961174 Results did not definitively support a role for the APOE genotype in post-traumatic seizure susceptibility and indicates that larger populations are needed to fully evaluate the potential impact of APOE on post-traumatic seizure.
20961174 Observational study of gene-disease association. (HuGE Navigator)
20954076 Observational study of genetic testing. (HuGE Navigator)
20951774 This study demonstrated that expression of human apoE4 contributes to functional deficits in the amygdala very early in development and may be responsible for altering neuronal circuitry.
20951391 Observational study of gene-disease association. (HuGE Navigator)
20947215 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20946940 Single nucleotide polymorphisms are found in APOepsilon4 associated with dementia of Alzheimer's disease in subjects with Down syndrome.
20946940 Observational study of gene-disease association. (HuGE Navigator)
20940625 Observational study of gene-disease association. (HuGE Navigator)
20935323 Observational study of gene-disease association. (HuGE Navigator)
20932310 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20930301 Our results suggest that both MAPT H1/H1 genotype and APOE epsilon4 allele lead to a more rapid progression to dementia among MCI subjects, probably mediating an increased rate of amyloid-beta and tau brain deposition.
20930301 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20930297 Observational study of gene-disease association. (HuGE Navigator)
20930274 Observational study of gene-disease association. (HuGE Navigator)
20919569 The work was aimed to study blood lipid spectrum in 133 patients with cholelithiasis and 159 with gallbladder cholesterosis as well as apoE genotypes in 49 and 36 respectively.
20919569 Observational study of gene-disease association. (HuGE Navigator)
20889503 Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function.
20888920 this study supports the association between the possibly protective GAB2 haplotype and the risk of late-onset Alzheimer's disease in APOEepsilon4 carriers
20888920 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20884673 Observational study of gene-disease association. (HuGE Navigator)
20883677 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20880607 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20880354 APOE genotype is associated with each of the key features of Alzheimer disease pathology but not with cerebrovascular disease other than cerebral amyloid angiopathy
20880354 Observational study of gene-disease association. (HuGE Navigator)
20880000 Observational study of gene-disease association. (HuGE Navigator)
20877692 Observational study of gene-disease association. (HuGE Navigator)
20876472 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
20872969 These results demonstrate that no association exists between apoB-100, apoE, and CYP7A1 polymorphisms and cholelithiasis in a Mexican population.
20868652 Patients with APOE -219T promoter polymorphism are susceptible to cerebral vasospasm after spontaneous subarachnoid hemorrhage.
20864672 Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
20861397 Our study provides novel evidence of a possible protective effect of the apolipoprotein E gene, epsilon2 allele against head and neck cancer
20861397 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20861163 the apoE4[R142C] mutant dramatically increased plasma cholesterol, triglyceride, and apoE levels; decreased esterification of cholesterol in all lipoprotein fractions; promoted formation of discoidal HDL; and caused accumulation of apoE.
20858975 Increases in cortisol levels and mineralocorticoid receptor expression in Alzheimer's disease patients are associated with an apoE4 genotype.
20858975 Observational study of gene-disease association. (HuGE Navigator)
20858958 Apolipoprotein E4 (ApoE4), the most prevalent genetic risk factor for Alzheimer's disease, triggers the accumulation of intraneuronal oligomerized amyloid-beta following activation of the amyloid cascade.
20855565 Observational study of gene-disease association. (HuGE Navigator)
20851099 the Apolipoprotein E LDL receptor-binding domain-containing high-density lipoprotein could be a nanovehicle to transport curcumin
20850903 Observational study of gene-disease association. (HuGE Navigator)
20849521 Increased effect of the ApoE gene on survival at advanced age in healthy and long-lived Danes: two nationwide cohort studies
20849521 Observational study of gene-disease association. (HuGE Navigator)
20847559 Midlife smoking was associated with an increased risk of dementia and Alzheimer's disease later in life only among those individuals carrying the APOE epsilon4 allele
20847559 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20847553 The APOE epsilon2 allele is associated with larger regional cortical thicknesses and volumes in mild cognitive impairment and Alzheimer's disease
20847553 Observational study of gene-disease association. (HuGE Navigator)
20847432 The dichotomy of effects of APOE polymorphisms represents one of the best examples of genetic pleiotropy for complex traits known and illustrates the importance of allelic heterogeneity in APOE.
20847408 Young adult carriers of APOE epsilon4 allele have lower mitochondrial cytochrome oxidase activity than noncarriers in posterior cingulate cortex.
20847408 Observational study of gene-disease association. (HuGE Navigator)
20847397 The ApoE4 allele may modulate age of onset of Alzheimer's disease by interacting with the effect of calcium homeostasis modulator 1 (CALHM1).
20847397 Meta-analysis of gene-disease association and gene-gene interaction. (HuGE Navigator)
20845403 Meta-analysis of gene-disease association. (HuGE Navigator)
20838585 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20837363 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20833446 ApoE4 shows an independent effect on hippocampal atrophy in mild cognition disorder and Alzheimer disease.
20832534 Renal transplant recipients are liable to develop hyperlipidemia, particularly hypertriglyceridemia among recipients with ApoE genotypes.
20826689 The ectopic expression of the ApoE2 resulted in poor recovery of infectious hepatitis C virus, whereas the expression of ApoE3 and ApoE4 rescued the production of infectious virus.
20825268 These findings suggest that the APOE epsilon4 allelic variant in HIV-positive individuals is not associated with the development of HAD in Southern Africa.
20825268 Observational study of gene-disease association. (HuGE Navigator)
20820167 The APOE varepsilon4 allele modulates brain WM structure before any clinical or neurophysiological expression of impending disease.
20820167 Observational study of gene-disease association. (HuGE Navigator)
20820000 Observational study of gene-disease association. (HuGE Navigator)
20819998 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20818931 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20817608 The cholesterol transporters apolipoprotein E (APOE), APOC1 and APOJ are recognized major genetic risk factors for common Alzheimer's disease.
20817350 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20815153 Observational study of gene-disease association. (HuGE Navigator)
20813342 These findings demonstrate that APOE varepsilon4 genotype is predictive of increased general rates of decline with global measures of cognition and function most affected.
20813341 These findings highlight the value of genetic and volumetric MRI information as predictors of functional decline, and thus disease progression, in cognition diosorder.
20810324 Observational study of gene-disease association. (HuGE Navigator)
20810250 A significant association is detected between prior trauma and the ApoE epsilon4 allele in Chinese Han with temporal lobe epilepsy.
20808139 in Choctaw Indians modifiable risk factors may play more of a role in disease pathogenesis than in whites and that nonmodifiable risk factors such as apoE4 may play less of a role.
20808139 Observational study of gene-disease association. (HuGE Navigator)
20804847 results provide further evidence that APOE epsilon4 has a significant impact on the trajectory of age-related cognitive functioning in older adults
20804847 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20739760 the frequency of apolipoprotein genotype E2/E3 and E2/E4 was significantly higher in patients with normal total serum cholesterol level compared to patients with abnormal cholesterol
20739760 Observational study of gene-disease association. (HuGE Navigator)
20739349 The deleterious effects of beta-amyloid on cognition may be delayed in those subjects with larger brain (temporal) volume. APOE epsilon4 carriers are more likely to have higher Abeta load than non-carriers.
20734437 Results lend mixed support for a link between past temperature and human APOE allele distribution and point to the need to develop better models of past climate in future analyses.
20734437 Observational study of gene-disease association. (HuGE Navigator)
20734064 Observational study of gene-disease association. (HuGE Navigator)
20733306 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20729559 Data suggest taht APOE polymorphisms are important determinants of triglyceride concentrations, especially in the fasting state.
20729559 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20729396 Observational study of gene-disease association. (HuGE Navigator)
20727736 Observational study of gene-disease association. (HuGE Navigator)
20725527 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20724907 Observational study of gene-disease association. (HuGE Navigator)
20723945 Apolipoprotein E promoter polymorphisms and their diplotypes were independently related with insulin resistance and serum fasting insulin levels among Turks.
20723945 Observational study of gene-disease association. (HuGE Navigator)
20719944 the specific apoE-NS5A interaction is required for assembly of infectious HCV
20715976 We observed an ethnicity-specific variability in ApoB levels across the ApoE - 491 A/T polymorphism and a modulatory impact on this pattern by ApoE2/E3/E4 isoforms in coronary artery disease.
20715976 Observational study of gene-disease association. (HuGE Navigator)
20714348 Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
20713315 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20711061 Observational study of gene-disease association. (HuGE Navigator)
20709332 Observational study of gene-disease association. (HuGE Navigator)
20705142 Observational study of gene-disease association. (HuGE Navigator)
20700730 Apolipoprotein E, growth factor receptor-bound protein 2, Golgi SNAP receptor complex member 1, and glucosidase, beta, acid may play a neurodegenerative role in stress urinary incontinence development.
20700462 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20697532 Observational study of gene-disease association. (HuGE Navigator)
20697334 Observational study of gene-disease association. (HuGE Navigator)
20697030 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20693633 Observational study of gene-disease association. (HuGE Navigator)
20693622 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20693183 APOE4 carriers are at higher risk of cardiac death in community-based Australian type 2 diabetic patients.
20693183 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20691792 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20691505 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20689279 Observational study of gene-disease association. (HuGE Navigator)
20688498 We have found a strong association between the APOE polymorphism and LDL-C concentrations as well as a dietary modulation in determining coronary heart disease risk.
20688498 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20687780 Observational study of genotype prevalence. (HuGE Navigator)
20686979 There are biological, psychological, and social variables associated with increased risk for cognitive impairment among individuals with the APOE epsilon4 allele.
20686979 Observational study of gene-disease association. (HuGE Navigator)
20686185 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20682755 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
20682673 Observational study of gene-disease association. (HuGE Navigator)
20682199 Study findings did not confirm that epsilon polymorphism of the apolipoprotein E gene is a risk factor of ischemic stroke in children.
20682199 Observational study of gene-disease association. (HuGE Navigator)
20679960 Observational study of gene-disease association. (HuGE Navigator)
20679343 Spectroscopic studies of GSK3{beta} phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E.
20678545 These findings provide further support of the negative impact of the epsilon4 allele in cognition.
20678545 Observational study of gene-disease association. (HuGE Navigator)
20677882 Observational study of gene-disease association. (HuGE Navigator)
20674675 In this review, apoE is a major Alzheimer's disease susceptibility gene implicated directly in the life cycle of the herpes simplex virus by the binding activity of the virus.
20674461 The present study provided no evidence of an association between age at onset or cognitive dysfunction of PD and ApoE 4 in Korean population.
20674461 Observational study of gene-disease association. (HuGE Navigator)
20673868 Observational study of gene-disease association. (HuGE Navigator)
20667857 Observational study of gene-disease association. (HuGE Navigator)
20667498 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20663622 The present study exposed a susceptibility haplotype CGTC, within APOE gene, which was found to be associated with BMD and risk of osteopenia and osteoporosis in postmenopausal females of India.
20663622 Observational study of gene-disease association. (HuGE Navigator)
20660919 epsilon4 increased the risk of developing Alzheimer's disease both in amnestic mild cognitive impairment and in normal ageing in a clinic-recruited ethnic Chinese population
20660919 Observational study of gene-disease association. (HuGE Navigator)
20658496 Observational study of gene-disease association. (HuGE Navigator)
20644562 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20644276 This study suggested that the presence of Apo-E4 allele might influence seropositive status in patients with MG and seems an associated susceptible factor in female patients.
20644276 Observational study of gene-disease association. (HuGE Navigator)
20643407 an exaggerated postprandial lipaemia contributes to the increased coronary heart disease risk associated with carriers of the APOE E4 allele
20643407 Observational study of gene-disease association. (HuGE Navigator)
20640544 Observational study of gene-disease association. (HuGE Navigator)
20637261 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20634891 Observational study of gene-disease association. (HuGE Navigator)
20634590 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20625167 Observational study of gene-disease association. (HuGE Navigator)
20625090 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20620666 Observational study of gene-disease association. (HuGE Navigator)
20620664 A modest but significant effect of APOE epsilon4 genotype is observed on annualized atrophy rates in the hippocampus and entorhinal cortex in early Alzheimer's disease and mild cognitive impairment.
20620664 Observational study of gene-disease association. (HuGE Navigator)
20620663 Observational study of gene-disease association. (HuGE Navigator)
20619505 This study showed that the association between ApoE epsilon4 allele and cognitive decline in specific domains including verbal memory and learning is not sex neutral because women are at higher risk compared with men when possessing the epsilon4 allele
20619505 Observational study of gene-disease association. (HuGE Navigator)
20606435 Stroke patients carrying the APOE-epsilon4 allele more often suffered a lacunar infarction than non-carriers. The APOE-epsilon4 allele had no effect on cognitive functioning during the follow-up.
20606435 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20602615 Observational study of gene-disease association. (HuGE Navigator)
20600372 Meta-analysis of gene-disease association and gene-gene interaction. (HuGE Navigator)
20599283 Observational study of gene-disease association. (HuGE Navigator)
20598287 Observational study of gene-disease association. (HuGE Navigator)
20592574 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20592257 Observational study of gene-disease association. (HuGE Navigator)
20583903 A possible association between particular subtypes of schizophrenia and APOE epsilon3/epsilon3 genotype compared to epsilon4 allele shows a tendency toward positive association with response to typical neuroleptics in Serbian patients.
20583903 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20580132 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20577623 Observational study of gene-disease association. (HuGE Navigator)
20576093 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20574532 Observational study of gene-disease association. (HuGE Navigator)
20573574 Observational study of gene-disease association. (HuGE Navigator)
20571754 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20570406 In ApoE-epsilon4 carriers, long-chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may slow cognitive decline in visual working memory of subjects with depressed symptoms.
20570406 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20570401 Observational study of gene-disease association. (HuGE Navigator)
20569235 The APOE gene interact genetically with HRAS1 and LASS1 genes to reduce agerelated increase in lipotoxic events, and that a combination of variants or haplotypes in these three genes is associated withexceptional survival.
20569235 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20567859 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20565774 Observational study of genotype prevalence. (HuGE Navigator)
20562467 Observational study of gene-disease association. (HuGE Navigator)
20561715 Observational study of gene-disease association. (HuGE Navigator)
20560916 Observational study of gene-disease association. (HuGE Navigator)
20558387 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20558149 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20555142 role of ApoE isoforms on the peripheral clearance of Abeta from the blood may impact on clearance from the brain
20554432 the ApoE epsilon4 isoform is a genetic factor that might influence the age at onset of temporal lobe epilepsy.
20554432 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
20553853 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20552590 The apo E4 allele may serve as an independent genetic marker predicting severity of coronary artery disease (CAD). Other CAD risk factors may accelerate the process of pathogenesis. The apo E2 allele may play a protective role.
20552590 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20548041 Observational study of gene-disease association. (HuGE Navigator)
20547867 role of ApoE in the localization and intracellular trafficking of lipoprotein and glutamate receptors reveals a mechanism by which ApoE4 may accelerate onset of dementia and neuronal degeneration by impairing the maintenance of synaptic stability
20546958 This study demonstrated an association between APOE +113C/G (rs440446) polymorphism with measures of bone mineral density in Singaporean Chinese females.
20546958 Observational study of gene-disease association. (HuGE Navigator)
20546752 ApoE genotype may have a role in development of cardiovascular disease in dialysis patients
20546752 Observational study of gene-disease association. (HuGE Navigator)
20543710 Our data show that APOE genotypes are not associated with pseudoexfoliation syndrome and pseudoexfoliation glaucoma in either Germans or Italians
20543710 Observational study of gene-disease association. (HuGE Navigator)
20541611 Observational study of gene-disease association. (HuGE Navigator)
20541374 Observational study of gene-disease association. (HuGE Navigator)
20538553 Observational study of gene-disease association. (HuGE Navigator)
20538375 Observational study of gene-disease association. (HuGE Navigator)
20538374 Abnormally high levels of ApoE may play a causative role in the pathological events of Alzheimer's disease (AD), particularly those involving the early cholinergic deficit in the AD brain, through modulation of cholinesterase activities.
20538373 Hippocampal loss of Alzheimer's disease biomarkers is steeper and occurs earlier in time in APOE epsilon4 carriers than in non-carriers.
20538372 The significance of the temporal order of MAPT biomarker abnormalities in Alzheimer disease correlates with hippocampal volume and radial distance compared with apolipoprotein E4 carriers and noncarriers.
20538124 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20537614 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20536507 Observational study of gene-disease association. (HuGE Navigator)
20535486 The results indicated that AD cases with capillary CAA differ significantly from other AD cases both genetically and morphologically, thereby pointing to a specific capillary CAA-related and APOE epsilon4-associated subtype of AD.
20535486 Observational study of gene-disease association. (HuGE Navigator)
20534961 The ApoE polymorphism and its influence on plasma lipid were investigated in healthy woman workers. ApoE polymorphism was associated with variations in plasma HDL-cholesterol lipid profile.
20534961 Observational study of gene-disease association. (HuGE Navigator)
20534741 Data confirmed genetic associations for Alzheimer's disease with APOE, CLU, PICALM and CR1 SNPs.
20534741 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20533968 risk reduction of statins for Alzheimer's disease varies by age but not presence of apolipoprotein E (APOE) epsilon4 allele
20533968 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20533025 Meta-analysis of gene-disease association. (HuGE Navigator)
20529013 With publicly available genome-wide genotyping data, use of genotype imputation methods is becoming common; this study shows that such an analysis can miss strong genetic association signals, such as that of the apo-e gene in late-onset Alzheimer disease.
20523031 Observational study of gene-disease association. (HuGE Navigator)
20515477 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20514637 Observational study of gene-disease association. (HuGE Navigator)
20508347 This study does not support the current contention that the presence of APOE e4 allele should have a significant negative effect on the outcome after traumatic brain injury.
20508347 Observational study of gene-disease association. (HuGE Navigator)
20502990 abnormally high activation in fronto-temporal brain areas are present in both younger and older APOEepsilon4 carriers confronted with a working memory task when compared to non-APOEepsilon4 carriers, an effect which diminishes with age
20502990 Observational study of gene-disease association. (HuGE Navigator)
20499136 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20498921 This study examines the association between APOE/C1/C4/C2 gene cluster variation using tagging single nucleotide polymorphisms and plasma lipid concentration along with risk of coronary heart disease in a prospective cohort.
20498921 Observational study of gene-disease association. (HuGE Navigator)
20493925 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20493672 Observational study of gene-disease association. (HuGE Navigator)
20491609 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20488256 Observational study of gene-disease association. (HuGE Navigator)
20479360 This study does not support a role for the APOE-epsilon4 allele in cognitive dysfunction in multiple sclerosis.
20479360 Observational study of gene-disease association. (HuGE Navigator)
20479234 convergent cognitive and neuroanatomic findings in individuals with a CSF molecular profile consistent with AD support the hypothesis that APOE genotype modulates the clinical phenotype of AD through influence on specific large-scale brain networks
20479234 Observational study of gene-disease association. (HuGE Navigator)
20473139 Results show that CVD increases the risk of AD in carriers (but not noncarriers) of the ApoE4 allele (hazard ratio 2.39, 95% confidence interval 1.15-4.96).
20471857 We found significant interactions between the presence of the apoE4 allele and the top sex-specific quartile of the stroke risk profile and their effects on verbal memory
20471857 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20469680 APOE gene polymorphism in the women with GSD did not differ from those registered in control group from women population.
20469680 Observational study of gene-disease association. (HuGE Navigator)
20468060 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20467002 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20463109 The authors present a literature review exploring the possible association between APOE epsilon4 and cognitive dysfunction in multiple sclerosis.
20459474 Observational study of gene-disease association. (HuGE Navigator)
20456244 No association was observed between any APOE alleles and susceptibility to PD or age at onset in Parkinson disease.
20456244 Observational study of gene-disease association. (HuGE Navigator)
20455863 The results of this study suggested that Atheromatosis extent in coronary artery disease is not correlated with apolipoprotein-E polymorphism and its plasma levels, but associated with cognitive decline
20455863 Observational study of gene-disease association. (HuGE Navigator)
20455859 Observational study of gene-disease association. (HuGE Navigator)
20453509 Observational study of gene-disease association. (HuGE Navigator)
20452482 Observational study of gene-disease association. (HuGE Navigator)
20450896 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20446941 Mutations not associated with spontaneous cervical artery dissection.
20446941 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
20444273 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20442634 The APOE epsilon4 allele was associated with increased risk for cognitive deficits, whereas the MBL2 O/O genotype was associated with increased risk for progressive cognitive decline in Chinese infected with HIV through contaminated blood products.
20442634 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20437541 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20437058 Observational study of genetic testing. (HuGE Navigator)
20436990 Observational study of gene-disease association. (HuGE Navigator)
20436440 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20432703 Development of hypertriglyceridemia in inhabitants of the European North was observed at lower level of serum apolipoprotein-E in comparison with normolipidemia.
20431431 Genetic variation at the APOE gene may contribute to some depressive symptoms in late-onset depression, rather than being a specific risk factor
20431431 Observational study of gene-disease association. (HuGE Navigator)
20430978 it appears that the ApoE epsilon4 allele mainly promotes neuronal dysfunction rather than aggravates neurovascular dysfunction
20430978 Observational study of gene-disease association. (HuGE Navigator)
20430468 over-expression of ApoE was independently associated with poor survival in lung adenocarcinoma patients who had malignant pleural effusions at the time of diagnosis (P<0.001).
20430392 Observational study of gene-disease association. (HuGE Navigator)
20430066 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20429872 Our results showed a significant independent additive effect on TG levels of the LPL polymorphisms HindIII, S447X, D9N and N291S; the S19W and -1131T/C variants of APOA5, and the epsilon4 allele of APOE in our study population.
20429872 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20427016 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20425806 Observational study of gene-disease association. (HuGE Navigator)
20423919 Observational study of gene-disease association. (HuGE Navigator)
20417063 Observational study of gene-disease association. (HuGE Navigator)
20416362 Human APOE epsilon2, epsilon3 & epsilon4 knock-in mice showed increased 27-hydroxycholesterol and decreased lathosterol. APOE epsilon2 had the lowest oxidized cholesterol metabolites.
20416077 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20414590 Observational study of gene-disease association. (HuGE Navigator)
20413898 Our findings suggest that hypertension is directly related to tau pathology in APOE epsilon4 homozygous carriers
20413898 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20413671 effect of apolipoprotein (apo) E genotype on apoB-100 metabolism
20413671 Observational study of gene-disease association. (HuGE Navigator)
20413122 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20410080 Observational study of gene-disease association. (HuGE Navigator)
20409610 The review discusses the interpretation of BOLD differences between epsilon4 carriers and noncarriers, provides suggestions for future studies, and highlights important limitations of this type of research
20406466 Observational study of gene-disease association. (HuGE Navigator)
20406267 The results of this study suggested that allele*4 was associated with worse performance in a few executive tasks. APOE*3*3 was associated with overall severe dysfunction on cognitive performance. In young individuals with nontreated BD-type I.
20406267 Observational study of gene-disease association. (HuGE Navigator)
20403997 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20401432 APOE4 protects shanty town children against heavy diarrhea outcomes, and among those with heavy diarrhea it protects against the long-term cognitive sequelae of the condition.
20401432 Observational study of gene-disease association. (HuGE Navigator)
20396431 Observational study of gene-disease association. (HuGE Navigator)
20395015 These observations suggest that the epsilon4 allele is associated with abnormal cell turnover of functional and possibly clinical significance.
20395015 Observational study of gene-disease association. (HuGE Navigator)
20394740 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
20389122 Observational study of gene-disease association. (HuGE Navigator)
20388089 Observational study of gene-disease association. (HuGE Navigator)
20385913 Observational study of gene-disease association. (HuGE Navigator)
20382449 The results suggest that APOE epsilon4 modulates the structural integrity of critical nodes in brain attentional networks
20381870 Observational study of gene-disease association. (HuGE Navigator)
20381392 E2 allele of ApoE seems to be a moderate risk factor for T2DM. Meta-regression analysis provided some weak evidence that the risk conferred by E2 allele is mediated through altering serum lipid levels.
20381392 Meta-analysis of gene-disease association. (HuGE Navigator)
20381197 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20381076 Observational study of gene-disease association. (HuGE Navigator)
20377344 APOE genotype seems to be associated with the trajectory of cognitive recovery after traumatic brain injury, but does not play a determinant role in the efficacy of memory rehabilitation in this population.
20377344 Observational study of gene-disease association. (HuGE Navigator)
20376800 The NEP and ApoE gene polymorphisms may be associated with sporadic Alzheimer's disease.
203