| Tbio | Amyloid-like protein 1 |
The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 1.3e-59 |
| oligodendroglioma | 2850 | 1.5e-12 |
| glioblastoma | 5792 | 3.9e-08 |
| Astrocytoma, Pilocytic | 3081 | 2.6e-07 |
| malignant mesothelioma | 3232 | 1.4e-06 |
| adult high grade glioma | 3801 | 1.4e-04 |
| medulloblastoma, large-cell | 6241 | 3.0e-04 |
| pancreatic cancer | 2398 | 2.2e-03 |
| group 3 medulloblastoma | 4104 | 2.4e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.7e-03 |
| osteosarcoma | 7950 | 4.8e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 4.8e-03 |
| aldosterone-producing adenoma | 665 | 2.2e-02 |
| astrocytic glioma | 2597 | 2.4e-02 |
| gastric carcinoma | 807 | 2.9e-02 |
| subependymal giant cell astrocytoma | 2287 | 3.0e-02 |
| ependymoma | 4679 | 4.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neurodegenerative disease | 414 | 0.0 | 4.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Alzheimer's disease | 658 | 5.105 | 2.6 |
| Subendocardial myocardial infarction | 1 | 3.715 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.700 | 1.4e-04 |
| aldosterone-producing adenoma | -1.078 | 2.2e-02 |
| astrocytic glioma | -1.300 | 2.4e-02 |
| Astrocytoma, Pilocytic | -1.600 | 2.6e-07 |
| atypical teratoid / rhabdoid tumor | -1.100 | 2.7e-03 |
| ependymoma | -1.400 | 4.3e-02 |
| gastric carcinoma | -1.700 | 2.9e-02 |
| glioblastoma | -1.800 | 3.9e-08 |
| group 3 medulloblastoma | -1.200 | 2.4e-03 |
| lung carcinoma | 3.600 | 1.3e-59 |
| malignant mesothelioma | -1.200 | 1.4e-06 |
| medulloblastoma, large-cell | -1.100 | 3.0e-04 |
| oligodendroglioma | -1.400 | 1.5e-12 |
| osteosarcoma | 1.170 | 4.8e-03 |
| pancreatic cancer | -1.500 | 2.2e-03 |
| primary pancreatic ductal adenocarcinoma | -1.448 | 4.8e-03 |
| subependymal giant cell astrocytoma | -2.377 | 3.0e-02 |
MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLR 1 - 70 TGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRC 71 - 140 LPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCC 141 - 210 PPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAV 211 - 280 VGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQAL 281 - 350 NEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 351 - 420 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHL 421 - 490 GPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPF 491 - 560 HSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTLEEQQL 561 - 630 RELQRHGYENPTYRFLEERP 631 - 650 //
