Tbio AP3D1 AP-3 complex subunit delta-1

Protein Summary

Description

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Defects in this gene are a cause of a new type of Hermansky-Pudlak syndrome. [provided by RefSeq, Feb 2017]

Uniprot Accession IDs

• O14617
• O00202
• O75262
• Q59HF5
• Q96G11
• Q9H3C6

Gene Name

• AP3D1

Ensembl ID

• ENST00000345016
• ENSP00000344055
• ENSG00000065000
• ENST00000355272
• ENSP00000347416
• ENST00000643116
• ENSP00000495274

Symbol

• ADTD
• HPS10
• hBLVR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
drug perturbation	0.96
disease perturbation	0.87
virus perturbation	0.83
cellular component	0.81

Protein Classes

PANTHER Classes

Protein / Transporter / Ap-3 Complex Subunit Delta-1

DTO Classes

Protein / Transporter / Ap-3 Complex Subunit Delta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.56   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.56   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0