AP1S1
AP-1 complex subunit sigma-1A
Protein Summary
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. [provided by RefSeq, Jul 2008]
- ENST00000337619
- ENSP00000336666
- ENSG00000106367
- ENST00000443943
- ENSP00000410780
- AP19
- CLAPS1
- AP19
- EKV3
- CLAPS1
- MEDNIK
- SIGMA1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.95 | ||
cellular component | 0.85 | ||
interacting protein | 0.72 | ||
small molecule perturbation | 0.72 | ||
tissue sample | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 67.14 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 118 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 67.14 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 118 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0