Tbio ANO6 Anoctamin-6

Protein Summary

Description

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q4KMQ2
• A6NNM6
• B9EGG0
• E7ENK4
• E9PB30
• E9PCT2
• Q8N3Q2

Gene Name

• ANO6

Ensembl ID

• ENST00000320560
• ENSP00000320087
• ENSG00000177119
• ENST00000423947
• ENSP00000409126
• ENST00000425752
• ENSP00000391417
• ENST00000441606
• ENSP00000413137

Symbol

• TMEM16F
• SCTS
• BDPLT7
• TMEM16F

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.97
molecular function	0.96
transcription factor binding site profile	0.96
microRNA	0.9
transcription factor	0.78

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium-dependent Chloride Channel (Ca-clc) Family / Anoctamin-6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.51   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 119   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.51   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0