Tbio ANKRD6 Ankyrin repeat domain-containing protein 6

Protein Summary

Description

Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.

Uniprot Accession IDs

• Q9Y2G4
• B3KUC3
• Q5JUJ4
• Q5JUJ5
• Q8IUQ8
• Q9NU24
• Q9UFQ9

Gene Name

• ANKRD6

Ensembl ID

• ENST00000339746
• ENSP00000345767
• ENSG00000135299
• ENST00000369408
• ENSP00000358416
• ENST00000447838
• ENSP00000396771
• ENST00000520793
• ENSP00000429782
• ENST00000522441
• ENSP00000430985

Symbol

• KIAA0957

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.8
disease perturbation	0.79
PubMedID	0.79
histone modification site profile	0.77
cell type or tissue	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.45   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.45   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0