| Tbio | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A |
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 4.7e-18 |
| malignant mesothelioma | 3232 | 1.7e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.3e-06 |
| tuberculosis | 2010 | 4.8e-06 |
| glioblastoma | 5792 | 8.5e-05 |
| adult high grade glioma | 3801 | 1.2e-04 |
| Rheumatoid arthritis | 1191 | 3.2e-04 |
| medulloblastoma | 720 | 9.3e-04 |
| Pick disease | 1894 | 1.0e-03 |
| ulcerative colitis | 1819 | 2.3e-03 |
| Astrocytoma, Pilocytic | 3081 | 7.4e-03 |
| non primary Sjogren syndrome sicca | 891 | 1.0e-02 |
| aldosterone-producing adenoma | 665 | 1.9e-02 |
| hereditary spastic paraplegia | 318 | 2.0e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.1e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.4e-02 |
| ovarian cancer | 8520 | 4.2e-02 |
| chronic rhinosinusitis | 512 | 4.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Urethra clear cell adenocarcinoma | 1 | 5.222 | 2.6 |
| Clear cell adenocarcinoma | 2 | 3.345 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.300 | 1.2e-04 |
| aldosterone-producing adenoma | -1.022 | 1.9e-02 |
| Astrocytoma, Pilocytic | 1.200 | 7.4e-03 |
| atypical teratoid / rhabdoid tumor | -1.400 | 2.3e-06 |
| chronic rhinosinusitis | -1.166 | 4.7e-02 |
| glioblastoma | -1.500 | 8.5e-05 |
| hereditary spastic paraplegia | -1.133 | 2.0e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.300 | 2.4e-02 |
| malignant mesothelioma | 1.100 | 1.7e-06 |
| medulloblastoma | -1.300 | 9.3e-04 |
| non primary Sjogren syndrome sicca | -1.100 | 1.0e-02 |
| non-small cell lung cancer | -1.306 | 4.7e-18 |
| ovarian cancer | 1.200 | 4.2e-02 |
| pancreatic ductal adenocarcinoma liver m... | -1.292 | 2.1e-02 |
| Pick disease | 1.200 | 1.0e-03 |
| Rheumatoid arthritis | 3.200 | 3.2e-04 |
| tuberculosis | -1.100 | 4.8e-06 |
| ulcerative colitis | 1.600 | 2.3e-03 |
MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 1 - 70 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAG 71 - 140 RTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPL 141 - 210 HAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAA 211 - 280 ASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 281 - 350 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC 351 - 420 LNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEY 421 - 490 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYH 491 - 560 GHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHS 561 - 630 ECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEE 631 - 700 CVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHET 701 - 770 CVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ 771 - 840 LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLIL 841 - 910 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 911 - 980 ATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIGGEQEYLYTDVDELNDSDS 981 - 1050 ETY 1051 - 1053 //
