Tbio ANKRD2 Ankyrin repeat domain-containing protein 2

Protein Summary

Description

Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q9GZV1
• Q3B778
• Q5T456
• Q70EZ9
• Q8WUD7
• Q96MG0
• Q9NQC9

Gene Name

• ANKRD2

Ensembl ID

• ENST00000298808
• ENSP00000298808
• ENSG00000165887
• ENST00000307518
• ENSP00000306163

Symbol

• ARPP
• ARPP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
cell type or tissue	0.84
gene perturbation	0.84
small molecule perturbation	0.58
biological process	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.21   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 79   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.21   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0