Protein angel homolog 2

Property Summary

NCBI Gene PubMed Count	5
PubMed Score	2.10

PubTator Score	1.70

Knowledge Summary

Patent

No data available

TINX Plot

Disease (2)

Expression Atlas
JensenLab Experiment COSMIC

Disease	Target Count	P-value
osteosarcoma	7950	3.3e-10
tuberculosis	2010	3.3e-08
ovarian cancer	8520	4.2e-07
Amyotrophic lateral sclerosis	451	1.8e-06
psoriasis	6694	2.1e-04
lung cancer	4740	2.9e-04
medulloblastoma, large-cell	6241	1.7e-03
ductal carcinoma in situ	1745	2.0e-02

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.7

Differential Expression (8)

Disease	log2 FC	p
Amyotrophic lateral sclerosis	1.012	1.8e-06
ductal carcinoma in situ	1.100	2.0e-02
lung cancer	1.600	2.9e-04
medulloblastoma, large-cell	1.200	1.7e-03
osteosarcoma	-2.418	3.3e-10
ovarian cancer	-1.800	4.2e-07
psoriasis	-1.500	2.1e-04
tuberculosis	-1.300	3.3e-08

Uterus 17,618

Nerve - Tibial 18,007

Spleen 17,614

Brain - Cerebellar Hemisphere 18,015

Ovary 17,971

Brain - Cerebellum 17,983

Small Intestine - Terminal Ileum 17,954

Cells - Transformed fibroblasts 17,577

Cells - EBV-transformed lymphocytes 18,186

Vagina 17,834

Adipose - Subcutaneous 18,110

Thyroid 18,024

Breast - Mammary Tissue 18,103

Artery - Coronary 17,949

Brain - Nucleus accumbens (basal ganglia... 18,024

Esophagus - Gastroesophageal Junction 18,000

Skin - Not Sun Exposed (Suprapubic) 18,081

Skin - Sun Exposed (Lower leg) 17,968

Adipose - Visceral (Omentum) 17,937

Esophagus - Muscularis 18,017

Prostate 18,213

Lung 18,057

Colon - Sigmoid 18,089

Artery - Aorta 17,896

Pituitary 18,147

Brain - Caudate (basal ganglia) 18,001

Brain - Spinal cord (cervical c-1) 17,973

Artery - Tibial 17,631

Testis 18,518

Brain - Frontal Cortex (BA9) 18,069

Adrenal Gland 18,071

Brain - Putamen (basal ganglia) 17,863

Brain - Amygdala 18,006

Minor Salivary Gland 18,005

Brain - Cortex 18,039

Brain - Hippocampus 18,011

Colon - Transverse 17,825

Stomach 17,879

Brain - Hypothalamus 18,169

Esophagus - Mucosa 18,076

Brain - Anterior cingulate cortex (BA24) 17,989

Brain - Substantia nigra 17,981

Heart - Atrial Appendage 17,896

Liver 18,071

Kidney - Cortex 17,329

Pancreas 18,123

Muscle - Skeletal 17,778

Heart - Left Ventricle 18,006

Whole Blood 17,439

CD4 Cells 7,773

Fetal Ovary 9,118

Fetal Heart 9,228

Adult Testis 10,836

CD8 Cells 9,840

Adult Ovary 10,192

Adult Retina 10,115

NK Cells 8,475

Heart

Natural killer cell

Ovary

Retina

Testis

BTO:0004410

BTO:0005453

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Brain 7,346

See source...

Synonym

Accession	Q5VTE6 B7Z2U4 D3DTA3 Q86X13 Q8NHH3
Symbols	Ccr4d KIAA0759L

Gene

ANGEL2

PANTHER Protein Class (3)

nucleic acid binding 1,006

nuclease 110

exoribonuclease 21

Ortholog (14)

Species	Source	Disease
Anole lizard 10,585	Inparanoid OMA EggNOG
Xenopus 10,463	Inparanoid OMA EggNOG
Zebrafish 9,725	Inparanoid OMA
Chimp 14,136	OMA EggNOG
Macaque 12,758	Inparanoid OMA EggNOG
Mouse 16,567	Inparanoid OMA EggNOG
Rat 15,112	Inparanoid OMA EggNOG
Dog 15,069	Inparanoid OMA EggNOG
Horse 14,249	Inparanoid OMA EggNOG
Cow 15,316	Inparanoid OMA EggNOG
Pig 10,164	Inparanoid OMA EggNOG
Opossum 12,223	Inparanoid OMA EggNOG
Platypus 5,699	Inparanoid OMA EggNOG
Chicken 7,823	Inparanoid OMA EggNOG

UniProt Keyword (4)

Complete proteome 20,231

Polymorphism 12,194

Reference proteome 20,231

Alternative splicing 10,528

GO Function (1)

mRNA 3'-UTR binding 58

GO Component (2)

cytoplasm 4,094

Cajal body 50

GO Process (2)

negative regulation of mitotic cell cycl... 27

3'-UTR-mediated mRNA stabilization 18

Compartment GO Term (25)

CAF-1 complex 28

CCR4-NOT complex 33

Cajal body 65

Cell 16,178

Cell part 16,177

Cytoplasm 10,983

Intracellular 14,108

Intracellular membrane-bounded organelle 10,341

Intracellular organelle 12,025

Intracellular organelle lumen 5,090

Intracellular organelle part 8,784

Intracellular part 13,972

Mitochondria 998

Nuclear body 725

Nuclear lumen 3,968

See all...

IMPC Phenotype (1)

decreased threshold for auditory brainst... 26

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493