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Tbio
AMIGO1
Amphoterin-induced protein 1

Protein Summary
Description
Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369862
  • ENSP00000358878
  • ENSG00000181754
  • ENST00000369864
  • ENSP00000358880

Symbol
  • ALI2
  • AMIGO
  • KIAA1163
  • ALI2
  • AMIGO
  • AMIGO-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
histone modification site profile
0.79
cell type or tissue
0.58
cell line
0.56
tissue
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.75   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.75   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0