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Tbio Activating molecule in BECN1-regulated autophagy protein 1

Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).

 Comments

Property Summary

NCBI Gene PubMed Count 33
PubMed Score 41.83
PubTator Score 27.97

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count
Schizophrenia 1160
Disease Target Count P-value
osteosarcoma 7950 3.0e-07
ovarian cancer 8520 6.0e-05
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.0
Kidney cancer 2613 0.0 0.5

Expression

  Differential Expression (2)

Disease log2 FC p
osteosarcoma -2.470 3.0e-07
ovarian cancer 1.700 6.0e-05

Synonym

Accession Q9C0C7 A6XN33 D3DQP8 G3V193 Q86XD6 Q9H8Z0 Q9NXE7
Symbols DCAF3
WDR94

Gene

AMBRA1

  Ortholog (12)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA

 UniProt Keyword (12)

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 GO Function (2)

 GO Component (8)

 GO Process (13)

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 Compartment GO Term (44)

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 MGI Phenotype (4)

 GWAS Trait (2)

 HCA RNA Cell Line (56)

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Pathway (8)

Gene RIF (18)

AA Sequence 

MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLAS      1 - 70
THVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAI     71 - 140
ASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDE    141 - 210
PEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTE    211 - 280
RPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFH    281 - 350
PPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT    351 - 420
RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQN    421 - 490
NSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNL    491 - 560
SRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTPSSS    561 - 630
RLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLIS    631 - 700
LSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVE    701 - 770
GTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA    771 - 840
GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPS    841 - 910
SQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFR    911 - 980
LQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYYWD    981 - 1050
QLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTER   1051 - 1120
EVPEPGTAASGPGEGEGSEYGASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHR   1121 - 1190
SSQTGTEPGAAHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL   1191 - 1260
PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR                                   1261 - 1298
//

Text Mined References (43)

PMID Year Title