| Tbio | Activating molecule in BECN1-regulated autophagy protein 1 |
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).
Comments
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | -2.470 | 3.0e-07 |
| ovarian cancer | 1.700 | 6.0e-05 |
| PMID | Text | |
|---|---|---|
| 26763392 | Ambra1 is a crucial regulator of autophagy and apoptosis in ovarian cancer cells subject to cisplatin to maintain the balance between autophagy and apoptosis. Ambra1-targeting inhibition might sensitize ovarian cancer cells to chemotherapy. | |
| 26423274 | An increased expression of AMBRA1 and SQSTM1. | |
| 26086269 | Ambra1 mRNA translocation to P-bodies and translational suppression correlated with increased cell death. | |
| 25803737 | Both AMBRA1 and BECLIN 1 affect c-Myc regulation, but through two different pathways. | |
| 25499913 | AMBRA1 interacts with cullin E3 ubiquitin ligases to regulate autophagy dynamics | |
| 25438055 | a de-regulation of c-Myc correlates with increased tumorigenesis in AMBRA1-defective systems, thus supporting a role for AMBRA1 as a haploinsufficient tumour suppressor gene. | |
| 24587252 | Ambra1 is a crucial regulator of autophagy and apoptosis in colorectal cancer cells | |
| 23551272 | A schizophrenia-related risk variant in AMBRA1 (rs11819869) is involved in various aspects of impulsivity, and this involvement occurs on a behavioral as well as an imaging genetics level. | |
| 23524951 | findings show under non-autophagic conditions, mTOR inhibits AMBRA1 by phosphorylation, whereas on autophagy induction, AMBRA1 is dephosphorylated; in this condition, AMBRA1, interacting with TRAF6, supports ULK1 ubiquitylation by LYS-63-linked chains, and its stabilization, self-association and function | |
| 23429496 | Data suggest that activated autophagy is associated with the progression of pancreatic ductal adenocarcinoma and that the overexpression of autophagy-related proteins Atg5, Ambra1, beclin-1, LC3B and Bif-1 is significantly correlated with poor outcome. | |
| 23069654 | role that Ambra1 in the switch between autophagy and apoptosis | |
| 22441670 | Ambra1 is an important target of apoptotic proteases resulting in the dismantling of the autophagic machinery and the accomplishment of the cell death program | |
| 22190034 | HIV-1 Vif is identified to have a physical interaction with autophagy/beclin-1 regulator 1 (AMBRA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses | |
| 21358617 | In this study, the authors show that AMBRA1 binds preferentially the mitochondrial pool of the antiapoptotic factor BCL-2, and that this interaction is disrupted following autophagy induction. | |
| 20921139 | When autophagy is induced, ULK1 phosphorylates AMBRA1, releasing the autophagy core complex from dynein. |
MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLAS 1 - 70 THVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAI 71 - 140 ASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDE 141 - 210 PEIPIDGTELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTE 211 - 280 RPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFH 281 - 350 PPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT 351 - 420 RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQN 421 - 490 NSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNL 491 - 560 SRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEGQTPSSS 561 - 630 RLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLIS 631 - 700 LSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVE 701 - 770 GTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA 771 - 840 GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPS 841 - 910 SQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFR 911 - 980 LQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYYWD 981 - 1050 QLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTER 1051 - 1120 EVPEPGTAASGPGEGEGSEYGASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHR 1121 - 1190 SSQTGTEPGAAHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL 1191 - 1260 PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR 1261 - 1298 //
| PMID | Year | Title | |
|---|---|---|---|
| 26763392 | 2016 | shRNA-mediated AMBRA1 knockdown reduces the cisplatin-induced autophagy and sensitizes ovarian cancer cells to cisplatin. | |
| 26423274 | 2015 | AMBRA1 and SQSTM1 expression pattern in prostate cancer. | |
| 26086269 | 2015 | Prolonged Pseudohypoxia Targets Ambra1 mRNA to P-Bodies for Translational Repression. | |
| 25803737 | 2015 | AMBRA1 and BECLIN 1 interplay in the crosstalk between autophagy and cell proliferation. | |
| 25499913 | 2014 | AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics. | |
| 25438055 | 2015 | AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. | |
| 25215947 | 2015 | AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1. | |
| 25127057 | 2014 | TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. | |
| 24587252 | 2014 | Ambra1 is an essential regulator of autophagy and apoptosis in SW620 cells: pro-survival role of Ambra1. | |
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. | |
| 23974797 | 2013 | WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. | |
| 23954414 | 2013 | Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. | |
| 23551272 | 2013 | From gene to brain to behavior: schizophrenia-associated variation in AMBRA1 alters impulsivity-related traits. | |
| 23524951 | 2013 | mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. | |
| 23429496 | 2013 | Prognostic significance of autophagy-related protein expression in resected pancreatic ductal adenocarcinoma. | |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. | |
| 23069654 | 2013 | Ambra1 at the crossroad between autophagy and cell death. | |
| 22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. | |
| 22441670 | 2012 | Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response. | |
| 22190034 | 2011 | Global landscape of HIV-human protein complexes. | |
| 21753002 | 2011 | Parkin interacts with Ambra1 to induce mitophagy. | |
| 21358617 | 2011 | Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy. | |
| 20921139 | 2010 | The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy. | |
| 20694011 | 2010 | Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. | |
| 20562859 | 2010 | Network organization of the human autophagy system. | |
| 20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. | |
| 19690332 | 2009 | Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. | |
| 18691976 | 2008 | Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. | |
| 18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. | |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. | |
| 17622796 | A novel role for autophagy in neurodevelopment. | ||
| 17603510 | 2007 | Autophagy: a new regulator of development. | |
| 17589504 | 2007 | Ambra1 regulates autophagy and development of the nervous system. | |
| 16554811 | 2006 | Human chromosome 11 DNA sequence and analysis including novel gene identification. | |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 12107410 | 2002 | Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. | |
| 11214970 | 2000 | Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |
