Property Summary

NCBI Gene PubMed Count 37
PubMed Score 48.01
PubTator Score 100.33

Knowledge Summary


No data available


  Disease (3)

Disease Target Count
Spontaneous abortion 108
Disease Target Count P-value
malignant mesothelioma 3163 1.2e-07
Disease Target Count Z-score Confidence
Seminoma 15 5.031 2.5
Mucinous cystadenocarcinoma 4 3.025 1.5

MLP Assay (16)

AID Type Active / Inconclusive / Inactive Description
690 confirmatory 82 / 0 / 95782 Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase
696 confirmatory 1178 / 0 / 94561 Luminescent assay for HTS discovery of chemical activators of placental alkaline phosphatase
1017 confirmatory 24 / 0 / 43 Luminescent assay for identification of inhibitors of human intestinal alkaline phosphatase
1512 confirmatory 96 / 0 / 178 Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase confirmation
1577 summary 2 / 0 / 0 Summary luminescent assay for discovery of chemical inhibitors of placental alkaline phosphatase
488878 confirmatory 74 / 0 / 29 Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase
488879 confirmatory 35 / 0 / 99 Dose Response confirmation of uHTS inhibitors of Mouse Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase
488888 confirmatory 96 / 0 / 3 Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase
488892 confirmatory 21 / 0 / 2 Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase
493126 confirmatory 34 / 0 / 23 SAR analysis of small molecule activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase

Gene RIF (4)

23467613 aptamer-mediated identification of ALPPL-2 on the cell surface and cell secretions of pancreatic cancer cells supports its potential use in the serum- and membrane-based diagnosis of PDAC
17009260 Premature induction of hypertrophy-related molecules (type X collagen and matrix metalloproteinase 13) occurred before production of type II collagen and was followed by up-regulation of alkaline phosphatase activity.
16412386 These results indicate that IAP is strongly involved in chylomicron formation and fatty acid metabolism might change among ABO blood type.
12372831 the structural differences in human AP isoforms are demonstrated through models

AA Sequence


Text Mined References (38)

PMID Year Title
23467613 2013 Alkaline phosphatase ALPPL-2 is a novel pancreatic carcinoma-associated protein.
17009260 2006 Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice.
16412386 2006 Involvement of intestinal alkaline phosphatase in serum apolipoprotein B-48 level and its association with ABO and secretor blood group types.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12372831 2002 Structural evidence of functional divergence in human alkaline phosphatases.
11937510 2002 Function assignment to conserved residues in mammalian alkaline phosphatases.
11124260 2001 Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
10471145 1999 Elevated serum alkaline phosphatase may enable early diagnosis of ovarian cancer.
9823315 1998 Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning.
7166303 1982 A possible new locus of alkaline phosphatase expressed in human testis.
6814793 1982 A search for trace expression of placental-like alkaline phosphatase in non-malignant human tissues: demonstration of its occurrence in lung, cervix, testis and thymus.
6651840 1983 Purification and partial sequencing of human placental alkaline phosphatase.
3674755 1987 The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37.
3519002 1986 Tissue origin of serum placental-like alkaline phosphatase in cigarette smokers.
3512548 1986 Molecular cloning and sequence analysis of human placental alkaline phosphatase.
3461452 1986 Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids.
3459156 1986 Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells.
3443302 1987 Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases.
3422741 1988 Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme.
3387245 1988 5' nucleotide sequence of a putative human placental alkaline phosphatase-like gene.
3042787 1988 Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution.
3001717 1985 Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA.
2921344 1989 Serum placental-like alkaline phosphatase (PLAP): a novel combined enzyme linked immunoassay for monitoring ovarian cancer.
2834730 1988 Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene.
2745460 1989 Expression of the germ cell alkaline phosphatase gene in human choriocarcinoma cells.
2578098 1985 Characterization of the placental alkaline phosphatase-like (Nagao) isozyme on the surface of A431 human epidermoid carcinoma cells.
2297757 1990 Molecular cloning of complementary DNAs encoding alkaline phosphatase in human colon cancer cells.
2171580 1990 The expression of placental alkaline phosphatase (PLAP) and PLAP-like enzymes in normal and neoplastic human tissues. An immunohistological survey using monoclonal antibodies.
2162249 1990 Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas.
2153284 1990 Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase.
2009524 1991 Transcriptional regulation and the effects of sodium butyrate and glycosylation on catalytic activity of human germ cell alkaline phosphatase.
1730777 1992 Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein.
1722150 1991 Site-directed mutagenesis and epitope-mapped monoclonal antibodies define a catalytically important conformational difference between human placental and germ cell alkaline phosphatase.
1581814 1992 Germ cell alkaline phosphatase in human seminal plasma following vasectomy.