Tbio ALPK2 Alpha-protein kinase 2

Protein Summary

Description

Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

Uniprot Accession IDs

• Q86TB3
• Q6ZUX0
• Q8NAT5
• Q96L95

Gene Name

• ALPK2

Ensembl ID

• ENST00000361673
• ENSP00000354991
• ENSG00000198796

Symbol

• HAK
• HAK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
molecular function	0.9
transcription factor perturbation	0.61
gene perturbation	0.6
phenotype	0.56

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Atypical Group / Alpha Family / Alpha-protein Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.57   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.57   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0