Property Summary

NCBI Gene PubMed Count 131
PubMed Score 446.81
PubTator Score 1440.59

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (5)

Disease Target Count P-value
lung carcinoma 2844 7.71857155704518E-39
non-small cell lung cancer 2798 1.57478192161554E-16
lung adenocarcinoma 2714 5.83962099005911E-10
pilocytic astrocytoma 3086 2.88285842467443E-9
malignant mesothelioma 3163 2.07455700496424E-8
posterior fossa group A ependymoma 1511 3.25185755177088E-6
tuberculosis and treatment for 6 months 686 2.0081678367619E-5
lung cancer 4473 6.53968836628004E-5
glioblastoma 5572 1.29972081455969E-4
group 3 medulloblastoma 2254 5.11634472911086E-4
medulloblastoma, large-cell 6234 6.98009015972086E-4
ulcerative colitis 2087 7.8497859907821E-4
pediatric high grade glioma 2712 8.70463435616202E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00156919498565988
interstitial cystitis 2299 0.00203245589940134
pancreatic cancer 2300 0.00206751153854555
adrenocortical carcinoma 1427 0.00459795713459001
invasive ductal carcinoma 2950 0.00684706726123629
primary pancreatic ductal adenocarcinoma 1271 0.0111675052347156
primary Sjogren syndrome 789 0.0125985537911114
active Crohn's disease 918 0.0184877128456566
cutaneous lupus erythematosus 1056 0.0253920157120757
sarcoidosis 368 0.029394395618364
Down syndrome 548 0.0326911328148339
Disease Target Count
Stroke, Ischemic 3
Disease Target Count
Ischemic stroke 12

Expression

Synonym

Accession P20292 Q5VV04
Symbols FLAP

Gene

PANTHER Protein Class (1)

PDB

2Q7M   2Q7R  

  Ortholog (14)

Gene RIF (131)

PMID Text
26327594 THE 5-LOX interface involving the four cysteines 159, 300, 416 and 418 is important for the translocation to the nuclear membrane and the colocalization with FLAP.
26289316 findings show that several enzymes known to be involved in the biosynthesis of proinflammatory LTs, such as FLAP and cPLA2alpha, also contribute to LX and Rv formation
26159646 The results of this study supported the association of the epistatic interactions of ALOX5AP, THBD, and KNG1 and present novel evidence for the main effect of KNG1 gene on IS susceptibility
25862617 Genetic interaction of CD80 and ALOX5AP was observed in systemic lupus erythematosus in Asian populations.
25815512 Our study provides evidence that the promoter single nucleotide polymorphism (SNP) rs17222919 of the ALOX5AP is a potential genetic protective factor for IS in the Chinese Han population.
25721704 Report no association between ALOX5AP SNPs and atherosclerotic plaque phenotypes.
25534367 Genetic polymorphisms of ALOX5AP and CYP3A5 increase susceptibility to ischemic stroke and are associated with atherothrombotic events in stroke patients.
25242267 results of the meta-analysis indicate that ALOX5AP rs10507391/SG13S114 A>T polymorphism is not associated with the risk of cerebral infarction in the Chinese population.
25210744 Rs10507391, rs4769874 and its haplotypes in ALOX5AP are unrelated to ACS risk in the Chinese Han population of Changwu, but elevated serum LTB4 level is strongly associated withacute coronary syndrome risk
25034252 The roles of CLP and FLAP in in cellular leukotriene biosynthesis, were studied.
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AA Sequence

MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAV      1 - 70
LWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFG     71 - 140
SDFENYIKTISTTISPLLLIP                                                     141 - 161
//

Text Mined References (133)

PMID Year Title
26327594 2015 Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP.
26289316 2015 Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein.
26159646 2015 Variants in the Atherogenic ALOX5AP, THBD, and KNG1 Genes Potentiate the Risk of Ischemic Stroke via a Genetic Main Effect and Epistatic Interactions in a Chinese Population.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25862617 2016 Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations.
25815512 2015 A promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP gene is associated with decreased risk of ischemic stroke in two independent Chinese populations.
25721704 2015 Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study.
25534367 2015 Genetic polymorphisms of ALOX5AP and CYP3A5 increase susceptibility to ischemic stroke and are associated with atherothrombotic events in stroke patients.
25242267 2015 Association of ALOX5AP rs10507391/SG13S114 A>T polymorphism with cerebral infarction in the Chinese population: a meta-analysis study.
25210744 2014 Interrelationships between ALOX5AP polymorphisms, serum leukotriene B4 level and risk of acute coronary syndrome.
More...