| Tbio | Mitochondrial 10-formyltetrahydrofolate dehydrogenase |
This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2798 | 7.3e-12 |
| pilocytic astrocytoma | 3086 | 8.1e-07 |
| pituitary cancer | 1972 | 5.1e-06 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 8.7e-06 |
| interstitial cystitis | 2299 | 3.9e-05 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 4.1e-05 |
| glioblastoma | 5572 | 2.6e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 3.7e-04 |
| pediatric high grade glioma | 2712 | 4.9e-04 |
| ovarian cancer | 8491 | 9.2e-04 |
| pancreatic cancer | 2300 | 1.3e-03 |
| sonic hedgehog group medulloblastoma | 1482 | 3.2e-03 |
| osteosarcoma | 7933 | 4.5e-03 |
| primary pancreatic ductal adenocarcinoma | 1271 | 9.8e-03 |
| oligodendroglioma | 2849 | 4.1e-02 |
| pancreatic carcinoma | 567 | 5.0e-02 |
| Disease | log2 FC | p |
|---|---|---|
| pancreatic cancer | -1.500 | 1.3e-03 |
| oligodendroglioma | 1.200 | 4.1e-02 |
| osteosarcoma | 1.503 | 4.5e-03 |
| glioblastoma | 1.400 | 2.6e-04 |
| primary pancreatic ductal adenocarcinoma | -1.170 | 9.8e-03 |
| non-small cell lung cancer | 1.174 | 7.3e-12 |
| intraductal papillary-mucinous adenoma (... | -4.000 | 8.7e-06 |
| intraductal papillary-mucinous carcinoma... | -4.100 | 4.1e-05 |
| intraductal papillary-mucinous neoplasm ... | -3.900 | 3.7e-04 |
| interstitial cystitis | 2.000 | 3.9e-05 |
| pediatric high grade glioma | 1.400 | 4.9e-04 |
| pilocytic astrocytoma | 2.000 | 8.1e-07 |
| sonic hedgehog group medulloblastoma | 1.500 | 3.2e-03 |
| pancreatic carcinoma | 1.100 | 5.0e-02 |
| ovarian cancer | 2.500 | 9.2e-04 |
| pituitary cancer | -1.200 | 5.1e-06 |
| PMID | Text | |
|---|---|---|
| 22082156 | Knockdown of aldehyde dehydrogenase 1 family, member L2 (ALDH1L2) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N | |
| 21238436 | ALDH1L2 has enzymatic properties similar to its cytosolic counterpart | |
| 20877624 | Observational study of gene-disease association. (HuGE Navigator) | |
| 20498374 | a gene at chromosome locus 12q24.11 of the human genome, the product of which has 74% sequence similarity with cytosolic FDH | |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | |
| 19933275 | Our study identifies human PPT as the FDH-modifying enzyme and supports the hypothesis that mammals utilize a single enzyme for all phosphopantetheinylation reactions. |
MLRRGSQALRRFSTGRVYFKNKLKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGKADPLALAAEK 1 - 70 DGTPVFKLPKWRVKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSPKHGSIIYHPSILPRHRGASA 71 - 140 INWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPNDTVDALYNRFLFPEGIKAMVEAVQLIADGKA 141 - 210 PRIPQPEEGATYEGIQKKENAEISWDQSAEVLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSVPPGE 211 - 280 PLEIKGAKKPGLVTKNGLVLFGNDGKALTVRNLQFEDGKMIPASQYFSTGETSVVELTAEEVKVAETIKV 281 - 350 IWAGILSNVPIIEDSTDFFKSGASSMDVARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGED 351 - 420 QEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAK 421 - 490 DAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDK 491 - 560 IQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKF 561 - 630 AELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSP 631 - 700 LIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQ 701 - 770 NHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGD 771 - 840 IDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEAL 841 - 910 NEYLKTKTVTLEY 911 - 923 //
| PMID | Year | Title | |
|---|---|---|---|
| 25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. | |
| 23533145 | 2013 | In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. | |
| 23382691 | 2013 | Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. | |
| 21789175 | 2011 | Identification and analysis of intermediate size noncoding RNAs in the human fetal brain. | |
| 21238436 | 2011 | Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase. | |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | |
| 20498374 | 2010 | ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. | |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | ||
| 19933275 | 2010 | Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase. | |
| 19608861 | 2009 | Lysine acetylation targets protein complexes and co-regulates major cellular functions. | |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. | |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
