| Tbio | Mitochondrial 10-formyltetrahydrofolate dehydrogenase |
This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 7.3e-12 |
| Astrocytoma, Pilocytic | 3081 | 9.2e-07 |
| pituitary cancer | 1972 | 5.1e-06 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 8.7e-06 |
| interstitial cystitis | 2312 | 3.9e-05 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 4.1e-05 |
| glioblastoma | 5792 | 2.6e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.7e-04 |
| ovarian cancer | 8520 | 9.2e-04 |
| sonic hedgehog group medulloblastoma | 467 | 3.2e-03 |
| osteosarcoma | 7950 | 4.5e-03 |
| adult high grade glioma | 3801 | 8.5e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 9.8e-03 |
| oligodendroglioma | 2850 | 4.1e-02 |
| pancreatic carcinoma | 562 | 5.0e-02 |
| pancreatic cancer | 2398 | 5.0e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.100 | 8.5e-03 |
| Astrocytoma, Pilocytic | 2.000 | 9.2e-07 |
| glioblastoma | 1.400 | 2.6e-04 |
| interstitial cystitis | 2.000 | 3.9e-05 |
| intraductal papillary-mucinous adenoma (... | -4.000 | 8.7e-06 |
| intraductal papillary-mucinous carcinoma... | -4.100 | 4.1e-05 |
| intraductal papillary-mucinous neoplasm ... | -3.900 | 3.7e-04 |
| non-small cell lung cancer | 1.174 | 7.3e-12 |
| oligodendroglioma | 1.200 | 4.1e-02 |
| osteosarcoma | 1.503 | 4.5e-03 |
| ovarian cancer | 2.500 | 9.2e-04 |
| pancreatic cancer | 1.100 | 5.0e-02 |
| pancreatic carcinoma | 1.100 | 5.0e-02 |
| pituitary cancer | -1.200 | 5.1e-06 |
| primary pancreatic ductal adenocarcinoma | -1.170 | 9.8e-03 |
| sonic hedgehog group medulloblastoma | 1.500 | 3.2e-03 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG |
MLRRGSQALRRFSTGRVYFKNKLKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGKADPLALAAEK 1 - 70 DGTPVFKLPKWRVKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSPKHGSIIYHPSILPRHRGASA 71 - 140 INWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPNDTVDALYNRFLFPEGIKAMVEAVQLIADGKA 141 - 210 PRIPQPEEGATYEGIQKKENAEISWDQSAEVLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSVPPGE 211 - 280 PLEIKGAKKPGLVTKNGLVLFGNDGKALTVRNLQFEDGKMIPASQYFSTGETSVVELTAEEVKVAETIKV 281 - 350 IWAGILSNVPIIEDSTDFFKSGASSMDVARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGED 351 - 420 QEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAK 421 - 490 DAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDK 491 - 560 IQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKF 561 - 630 AELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSP 631 - 700 LIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQ 701 - 770 NHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGD 771 - 840 IDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEAL 841 - 910 NEYLKTKTVTLEY 911 - 923 //
