| Tbio | Aflatoxin B1 aldehyde reductase member 3 |
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]
Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hepatomegaly | 285 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 1.5e-24 |
| adrenocortical carcinoma | 1428 | 2.5e-08 |
| pancreatic cancer | 2398 | 1.6e-04 |
| primary pancreatic ductal adenocarcinoma | 1109 | 3.6e-04 |
| nephrosclerosis | 333 | 1.1e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.3e-02 |
| gastric carcinoma | 807 | 4.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | -1.097 | 2.5e-08 |
| gastric carcinoma | -2.400 | 4.2e-02 |
| intraductal papillary-mucinous neoplasm ... | -1.600 | 2.3e-02 |
| lung carcinoma | 1.100 | 1.5e-24 |
| nephrosclerosis | -1.106 | 1.1e-02 |
| pancreatic cancer | -3.100 | 1.6e-04 |
| primary pancreatic ductal adenocarcinoma | -3.272 | 3.6e-04 |
MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDC 1 - 70 RVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVEL 71 - 140 GLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYK 141 - 210 YEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGA 211 - 280 HGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVTHECPNYFR 281 - 331 //
