1. Home
  2. Targets
  3. transporter
  4. ion channel
  5. potassium channel
  6. voltage-gated potassium channel
  7. Aflatoxin B1 aldehyde reductase member 3

Tbio Aflatoxin B1 aldehyde reductase member 3

Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]

 Comments

Property Summary

NCBI Gene PubMed Count 13
PubMed Score 15.04
PubTator Score 6.26

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Expression

  Differential Expression (7)

Disease log2 FC p
nephrosclerosis -1.106 1.1e-02
adrenocortical carcinoma -1.097 2.5e-08
primary pancreatic ductal adenocarcinoma -3.272 3.6e-04
intraductal papillary-mucinous neoplasm ... -1.600 2.3e-02
lung carcinoma 1.100 1.5e-24
gastric carcinoma -2.500 3.2e-02
pancreatic cancer -3.100 1.6e-04

Synonym

Accession O95154 Q86SR4 Q8IVN6 Q8N5V6 Q8TAX1 Q9NUC3
Symbols AFAR2

Gene

AKR7A3

PANTHER Protein Class (4)

PDB

2CLP  

  Ortholog (1)

Species Source Disease
Chicken OMA EggNOG Inparanoid

 UniProt Keyword (9)

 GO Function (2)

 GO Component (2)

 GO Process (2)

 Compartment GO Term (17)

See all...

 HCA RNA Cell Line (55)

See all...

Pathway (6)

Protein-protein Interaction (5)

AKR7A2   AKR7L   COMMD9   GNB2   DDRGK1  

Gene RIF (1)

PMID Text
20453000 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence 

MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDC      1 - 70
RVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVEL     71 - 140
GLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYK    141 - 210
YEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGA    211 - 280
HGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVTHECPNYFR                       281 - 331
//

Text Mined References (15)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
21044950 2011 Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
20453000 2010 A Large-scale genetic association study of esophageal adenocarcinoma risk.
19056867 2009 Large-scale proteomics and phosphoproteomics of urinary exosomes.
18416522 2008 Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16341674 2005 Transcriptome analysis of human gastric cancer.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12879023 2003 Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10383892 1999 cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3.